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Vanitas no Karte

The Case Study of Vanitas

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The Case Study of Vanitas

The Witch and the Young Man

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© 2022 Jun Mochizuki / SQUARE ENIX, "The Case Study of Vanitas"

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The Case Study of Vanitas Season 1 Streaming: Watch & Stream Online via Crunchyroll

The Case Study of Vanitas Season 1 Streaming: Watch & Stream Online via Crunchyroll

By Ritika Singh

If you are looking for information on where to watch The Case Study of Vanitas Season 1 online, look no further, as we have all the streaming details. The anime focuses on a vampire, Noe Archiviste, who meets Vanitas, a human-vampire doctor curing vampires of the misnomer that forces vampires to go out of control against their will.

Here’s how you can watch and stream The Case Study of Vanitas Season 1 via streaming services such as Crunchyroll.

Is The Case Study of Vanitas Season 1 available to watch via streaming?

Yes, The Case Study of Vanitas Season 1 is available to watch via streaming on Crunchyroll .

The anime is loosely based on its manga series by Jun Mochizuki. The first episode shows Noe, the vampire, being bitten by another vampire driven by bloodlust as he is looking for his teacher called the Book of Vanitas. He is rescued by Vanitas, and the two join hands to cure the rest of the vampires before the poison takes over the entire vampire world.

The show features talented voiceovers of Natsuki Hanae and Kaito Ishikawa as Vanitas and Noe, respectively.

Watch The Case Study of Vanitas Season 1 streaming via Crunchyroll

The Case Study of Vanitas Season 1 i s available to watch on Crunchyroll. Crunchyroll is a popular streaming service specializing in anime, manga, and Asian dramas. It offers a vast library of licensed content, including simulcasts of ongoing anime series, classics, and exclusive titles.

You can watch via Crunchyroll by following these steps:

  • Go to CrunchyRoll.com
  • $7.99 per month (Fan)
  • $9.99 per month (Mega Fan)
  • $14.99 per month (Ultimate Fan)
  • Enter your personal information and select ‘Create Account’

The Crunchyroll Fan plan lets users stream the service’s entire library ad-free, watch new episodes shortly after they air in Japan, and read digital manga.

The Mega Fan plan offers the same service but also lets users stream on up to four devices at a time, allows offline viewing, and provides a $15 discount off $100+ purchases in the Crunchyroll Store every three months.

The Ultimate Fan plan offers all of the above on up to six devices at once, $25 off Crunchyroll Store purchases over $100 every three months, free shipping on all purchases, and an exclusive “swag bag” after 12 months of subscribing.

The Case Study of Vanitas Season 1’s synopsis is as follows:

”In 19th-century Paris, young vampire Noé finds the Book of Vanitas in human hands. Calling himself Vanitas, this doctor wields its power and tempts Noé with a plan to “cure” all vampires. Allying with him may be dangerous, but does he have a choice?”

NOTE: The streaming services listed above are subject to change. The information provided was correct at the time of writing.

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Jun Mochizuki Wiki

  • House de Sade

The Teacher

  • View history

The Teacher, ( 先 ( せん ) 生 ( せい ) , Sensei ) also known as The Shapeless One ( 貌 ( かたち ) 持 ( も ) たざる 者 ( もの ) , Katachi Motazaru-mono ), and the Comte de Saint Germain (サンジェルマン 伯 ( はく ) 爵 ( しゃく ) , San Jeruman Hakushaku ), is a character from Jun Mochizuki 's The Case Study of Vanitas . As the Teacher is known to frequently change his name, being so particular as to resort to violence when an incorrect one is used, he is exclusively referred to via epithets. Even Noé Archiviste , his student since a child, does not know the name he currently uses. After receiving word that the legendary the Book of Vanitas had been found in Paris , he sends Noé to discover its "true nature."

Icon murr transparent

One of the oldest known Vampires, Teacher was the first Vampire to serve Queen Faustina , and stayed as her vassal the longest. Despite this, he never accepted a position in high society, though he was being given land and power by the Queen. Instead, this was passed onto his adopted son, the Count de Sade. He moved deep into the country, to the town of Averoigne , where he lived with little interest in Vampire political affairs. Circa 1869 A.D., his adoptive son sired twins, a boy and a girl. As twins were a taboo in Vampiric society, they chose one child to keep and the other to kill to preserve the de Sade family 's reputation. However the Teacher interfered and took in the to-be-executed boy to raise himself.

A few years later, the Teacher bought a child Noé off an auction who was being sold as an Archiviste survivor, raising him as a student alongside the boy Louis and his sister Dominique , whereupon the trio became dear friends with one another. The Teacher raised Louis under the impression that he was older than Dominique and disowned from the de Sades due to harboring an illness. Due to the deceitful machinations designed by the Teacher, Louis came to believe that he was a curse-bearer and doomed to lose his sanity before painfully dying. In their teens when Dominique and Noé's lives were found to be in danger, Louis was tricked into actually contracting a Malnomen, begging for Noé to take his life in place of a stranger. Noé could not and the Teacher instead decapitated his own grandson.

  • 1 Appearance
  • 2 Personality
  • 4.1 Bal Masqué Arc
  • 4.2 Amusement Park Arc
  • 5 Powers and Abilities
  • 6.1 Noé Archiviste
  • 6.2 Dominique de Sade
  • 6.3 Louis de Sade
  • 6.4 August Ruthven
  • 6.5 Vanitas of the Blue Moon
  • 6.6 Mikhail
  • 8 Appearances
  • 10 References
  • 11 Navigation

Appearance [ ]

The Teacher usually takes the form of a tall, thin, pale skinned man with short blonde hair. His appearance is otherwise ambiguous, and it is implied by August Ruthven that he frequently changes physical form. The Teacher is often seen wearing a long black coat over a white shirt with a mandarin collar, along with a top hat. He also carries a walking stick with two six-pointed star charms, which he seems to use as a weapon. Earlier in the story, on the rare occasions when the Teacher’s face is clearly visible, his eyes were usually not drawn. After the reveal of his face, he's shown to have a jovial face, small eyebrows and droopy eyes. Also, The Teacher has heterochromia , his left eye being the same blue as Vanitas ', and the other is purple, just like Murr .

Personality [ ]

The Teacher is a mysterious and contrary vampire. He seems to prefer a peaceful life in the country over the wealth and fame of a position at the Queen’s side. He frequently shapeshifts and changes his name, and nearly kills anyone who calls him by the wrong name. Most vampires fear the Teacher and refer to him as a monster.

The Teacher is a highly observant person who wants to study and know more about the behavior of both humans and vampires. He’s intrigued by cursebearers and the Book of Vanitas. One of his observation subjects was his grandson, Louis, who frequently described Teacher as a man with horrible and sadistic taste.

The Teacher raised Noé to not have any biases towards vampires or humans, which suggests that The Teacher shares this opinion— he seems to see all humans and all vampires as information to observe and gather.

History [ ]

Also known as "The Shapeless One" due to the frequency with which he changes his name and form, Noé's teacher was the first vampire to serve the Queen and did so for the longest duration. Nothing is known about his life prior to serving the queen, and the Teacher is known as one of the oldest and most mysterious vampires in existence.

After serving the queen (presumably following the end of the war between humans and vampires), the Teacher gave his titles and land to his adopted child, Count de Sade, and retreated to live in the country. Despite living a life out of the spotlight the Teacher retained a huge amount of authority in the vampiric world. Vampires largely fear him and see him as a monster. At some point before adopting Noé, the Teacher developed an intense hatred towards August Ruthven .

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The Teacher seems to have had little interaction with his oldest two grandchildren, Antoine and Veronica. When Dominique and Louis were born, the Teacher decided to keep Louis at his estate rather than let the infant be killed. It seems as though the Teacher did some sort of strange experiment on Louis, making him into a cursebearer. The Teacher also made Count de Sade let Dominique interact with her brother monthly, most likely to give Louis a close bond with someone (to exploit) and to use as a control for his experiments on Louis.

The Teacher later bought Noé at a slave market and brought him to live with Louis at their residence. He treated Noé as a student and taught him about various aspects of vampire culture and history. He also taught Noé how to reverse gravity and how to fight.

When Louis finally gave in to Naenia and fully transformed into a cursebearer, the Teacher observed his actions for a while and stepped in to save Noé once he judged Noé was in mortal danger, beheading Louis.

Following this, Noé fell unconscious for a time. After this, Noé continued to live at Teacher’s estate, while Domi’s visits seem to have become less frequent. A short time before the start of the manga, the Teacher sent Noé a letter asking him to investigate the Book of Vanitas and discern its true character.

Bal Masqué Arc [ ]

While Noé is asleep after collapsing at the end of the Bal Masqué, he sees Teacher. Noé tells Teacher that he needs to apologize to Vanitas for forcing his own ideals and hopes onto him. The Teacher reassures Noé and tells him to engage with the tale and the people surrounding the Book of Vanitas. Noé wakes up from his unconscious state and notices that the chair he saw Teacher in is still warm.

Amusement Park Arc [ ]

Coming soon!

Powers and Abilities [ ]

See also: Vampires

  • Shapeshifting : The Teacher has the ability to shape shift, and seems to do so frequently

Relationships [ ]

Noé archiviste [ ].

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The Teacher raised Noé like his own grandchild after taking him in as a young boy. He gave Noé a happy and carefree childhood, reading with Noé and bringing him gifts. He also seems to have given Noé some level of combat training as a teenager. Noé in turn sees Teacher more as a father/ grandfather than as a vampire to be feared, curiously asking Ruthven if his Teacher is really such a strong vampire after Ruthven tells Noé about the Teacher’s power.

Despite all this, Teacher seems to see Noé as more of an object for investigation than as an individual.

Dominique de Sade [ ]

Dominique’s relationship with the Teacher is a positive one. The two aren’t shown interacting much, but Teacher is shown bringing his granddaughter presents during her visits.

This relationship, however, is only surface level. The Teacher seems to see Dominique as an aspect of his experiments on Louis, and likely would have let Louis kill her when he turned into a full cursebearer.

Louis de Sade [ ]

Louis was the Teacher’s grandson and experiment subject. The Teacher took Louis in as an infant, saving his life in the process, but performed a variety of experiments on his grandson, most likely making Louis into a cursebearer in the process.

The Teacher spent a good amount of time with Louis, raising him and interacting with him frequently, but their interactions seemed to have been emotionally detached and distant. At some point in Louis’s life the Teacher told him that he was both a cursebearer and Dominique’s twin sister, slated to die at birth. After this Louis began avoiding Teacher more often and their relationship deteriorated further.

August Ruthven [ ]

The Teacher despises Ruthven to the point of striking his name from every book in his castle. It’s suggested that they had some sort of interaction(s) in the past to fuel this hatred, but from what Ruthven tells Noé they don’t seem to know much about each other.

Vanitas of the Blue Moon [ ]

The Teacher has some kind of fascination towards Luna, not only because of his interest in the Books of Vanitas , but also because he says that Luna — whom he calls Blue — is "the most beautiful creature in this world". The Teacher is said to be the only other character whose eye is said to be the same vivid blue as them — aside from the Clan of the Blue Moon — although the connection between them is yet unknown.

Mikhail [ ]

Being presumed dead after the death of Vanitas of the Blue Moon, Mikhail was saved by the Teacher, whom he calls kind and his savior. The Teacher told him that there’s a way to bring the Vampire of the Blue Moon back to life, and, believing that his family will be able to be together again, Mikhail joined his side. Aside from putting Mikhail in danger, the Teacher seems to take good care of Mikhail, not only giving him a metal arm but also tending to his wounds post-fight.

  • “Listen well, mon chaton. You must never let anyone steal your ‘True Name.’ Your True Name is the formula that shapes your very being. In other words… it is your life itself—” [1]
  • “Mon chaton, I wish you to fly to Paris immediately. I hear it’s been discovered there. It really exists—the Book of Vanitas! Find it without fail… and see for yourself… with your own eyes… the true character of the Book of Vanitas—!” [1]
  • “I’m sure from now on… things will be much, much more fun.” [2]
  • “I don’t want you to do anything in particular. You’re free. Do as you please. I simply want to observe the process and result of whatever your well leads you to do.” [3]
  • “Engage with the tale of the people surrounding the Book of Vanitas. Once you’ve done that, how will you define the Book of Vanitas for yourself? That… is what I want to know.” [4]
  • “Well! That was magnificent. I thought perhaps I should stop you sooner… but I’m glad I didn’t. This was good. Yes… you’ve shown me something excellent.” [5]
  • “—The kingdom of dreams has fallen. Whether they’re as gentle as a cradle… or nightmares that eat away at you… in the end, dreams are only dreams. Inevitably, there will come a time when you must wake and face reality. When it does, let’s meet again, mes chatons.” [6]
  • “Curiously, simply changing what you say makes you feel as if your existence has undergone a significant change. Names… dredge up memories and revive them.” [7]
  • “You and I are both ‘observers.’ However, our disparate natures make it interesting. We can observe the same story, but form different interpretations.” [7]
  • “The color of yesterday’s sky. The brand of tea we’ll drink tomorrow. Vampires, humans, Dhams… anything will do. Let us talk… to pass the time. We’ll speak of the stories, the worlds, we’ve witnessed—” [7]
  • “Strict imitations are dull things. Fugues change flexibly, developing freely. They’re the most suitable accompaniment for the tragedy of Garnet. Don’t you agree?” [8]
  • “What I’m doing is thinking. I’m constantly… calculating… the route that will grant ‘our’ wish. For world peace.” [9]

Appearances [ ]

  • Mémoire 1: Vanitas — In the Event of Rusty Hopes* (First Appearance)
  • Mémoire 2: Noé — In the City of Flowers (Mentioned only)
  • Mémoire 4: Femme Fatale — Love*
  • Mémoire 5: Archiviste — Fangs That Reveal Blood (Mentioned only)
  • Mémoire 6: Altus — Other World (Mentioned only)
  • Mémoire 7: Bal Masqué — Night of Sneering Masks*
  • Mémoire 9: Réminiscence — Friends*
  • Mémoire 11: Deux Ombres — Point of Departure
  • Mémoire 12: Pause 𝄻 (Mentioned only)
  • Mémoire 13: Glissando — Glissando (Mentioned only)
  • Mémoire 15: Chasseur — Those Who Hunt Crimson*
  • Mémoire 19: Serment — Spell-bound*
  • Mémoire 20: Serment — Promise (Part One) (Mentioned only)
  • Mémoire 23: Au Pas Camarade — Pace*
  • Mémoire 24: Forêt d'argent — Chance Encounter (Mentioned only)
  • Mémoire 38: Naenia — She Who Harbors Death (Part One)
  • Mémoire 46: Un Autre — Scar*
  • Mémoire 54.5: La nuit sans lune — Dark Night (Part Two)
  • Mémoire 55: Après la pluie — His Wish (Part One)
  • Mémoire 55.5: Après la pluie — His Wish (Part Two)*
  • Mémoire 58: Observation — The Darkness in Between
  • Mémoire 59: Fuga — What the Organist Plays
  • Entracte: Couche — On Clothing (Mentioned only)
  • Mémoire 61: Jeu de paume — Court Tennis (Part One)
  • Mémoire 61.5: Jeu de paume — Court Tennis (Part Two) (Mentioned only)
  • Mémoire 62.5: Bourdonnement — Wingbeats of Scattered Thought (Part Two)
  • Mémoire 63: Quelqu'un — Someone*
  • Mémoire 1: Vanitas -In the Event of Rusty Hopes-*
  • Mémoire 2: Noé -In the City of Flowers- (Mentioned only)
  • Mémoire 3: Archiviste -Fangs That Lay Bare Blood- (Mentioned only)
  • Mémoire 4: Bal masqué -Night of Mocking Masks-*
  • Mémoire 5: Réminiscence -Friends-*
  • Mémoire 6: Salvatio -Questions-*
  • Mémoire 7: Femme fatale -Love- (Mentioned only)
  • Mémoire 12: Deux Ombres -Point of Departure-*
  • Mémoire 21: Un Autre -Scars-*
  • Mémoire 24: Après la pluie -His Wish-

(*) - Denotes that the character did not appear physically, but as a part of another character's memories.

  • The Comte de St. Germain is known as a historical figure who was an avid adventurer as well as a skilled philosopher, with interests in science, alchemy, and the arts. He used a variety of different names and titles, and made purposefully far-fetched claims of himself such as being 500 years old. He has managed to obscure his true identity so thoroughly that still his background is totally obscured and his real name remains unknown. [10]
  • It is implied he brought the recipe for tarte tatin to Altus , as mentioned by Luca . [11]
  • His Japanese voice actor previously provided the voice of Xerxes Break from Pandora Hearts .

References [ ]

  • ↑ 1.0 1.1 Mémoire 1: Vanitas
  • ↑ Mémoire 7: Bal Masqué
  • ↑ Mémoire 9: Réminiscence
  • ↑ Mémoire 11: Deux Ombres
  • ↑ Mémoire 54.5: La nuit sans lune (Part Two)
  • ↑ Mémoire 55: Après la pluie (Part One)
  • ↑ 7.0 7.1 7.2 Mémoire 58: Observation
  • ↑ Mémoire 59: Fuga
  • ↑ Mémoire 61: Jeu de paume (Part One)
  • ↑ Wikipedia: Count of St. Germain
  • ↑ Mémoire 12: Pause

Navigation [ ]

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  • Part of Series The Case Study Of Vanitas
  • Language German
  • Dimensions 4.92 x 0.55 x 7.09 inches
  • ISBN-10 3551765286
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  • Language ‏ : ‎ German
  • ISBN-10 ‏ : ‎ 3551765286
  • ISBN-13 ‏ : ‎ 978-3551765284
  • Item Weight ‏ : ‎ 6 ounces
  • Dimensions ‏ : ‎ 4.92 x 0.55 x 7.09 inches
  • Best Sellers Rank: #7,476,725 in Books ( See Top 100 in Books )

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  • Published: 17 April 2024

The economic commitment of climate change

  • Maximilian Kotz   ORCID: orcid.org/0000-0003-2564-5043 1 , 2 ,
  • Anders Levermann   ORCID: orcid.org/0000-0003-4432-4704 1 , 2 &
  • Leonie Wenz   ORCID: orcid.org/0000-0002-8500-1568 1 , 3  

Nature volume  628 ,  pages 551–557 ( 2024 ) Cite this article

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  • Environmental economics
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Global projections of macroeconomic climate-change damages typically consider impacts from average annual and national temperatures over long time horizons 1 , 2 , 3 , 4 , 5 , 6 . Here we use recent empirical findings from more than 1,600 regions worldwide over the past 40 years to project sub-national damages from temperature and precipitation, including daily variability and extremes 7 , 8 . Using an empirical approach that provides a robust lower bound on the persistence of impacts on economic growth, we find that the world economy is committed to an income reduction of 19% within the next 26 years independent of future emission choices (relative to a baseline without climate impacts, likely range of 11–29% accounting for physical climate and empirical uncertainty). These damages already outweigh the mitigation costs required to limit global warming to 2 °C by sixfold over this near-term time frame and thereafter diverge strongly dependent on emission choices. Committed damages arise predominantly through changes in average temperature, but accounting for further climatic components raises estimates by approximately 50% and leads to stronger regional heterogeneity. Committed losses are projected for all regions except those at very high latitudes, at which reductions in temperature variability bring benefits. The largest losses are committed at lower latitudes in regions with lower cumulative historical emissions and lower present-day income.

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Projections of the macroeconomic damage caused by future climate change are crucial to informing public and policy debates about adaptation, mitigation and climate justice. On the one hand, adaptation against climate impacts must be justified and planned on the basis of an understanding of their future magnitude and spatial distribution 9 . This is also of importance in the context of climate justice 10 , as well as to key societal actors, including governments, central banks and private businesses, which increasingly require the inclusion of climate risks in their macroeconomic forecasts to aid adaptive decision-making 11 , 12 . On the other hand, climate mitigation policy such as the Paris Climate Agreement is often evaluated by balancing the costs of its implementation against the benefits of avoiding projected physical damages. This evaluation occurs both formally through cost–benefit analyses 1 , 4 , 5 , 6 , as well as informally through public perception of mitigation and damage costs 13 .

Projections of future damages meet challenges when informing these debates, in particular the human biases relating to uncertainty and remoteness that are raised by long-term perspectives 14 . Here we aim to overcome such challenges by assessing the extent of economic damages from climate change to which the world is already committed by historical emissions and socio-economic inertia (the range of future emission scenarios that are considered socio-economically plausible 15 ). Such a focus on the near term limits the large uncertainties about diverging future emission trajectories, the resulting long-term climate response and the validity of applying historically observed climate–economic relations over long timescales during which socio-technical conditions may change considerably. As such, this focus aims to simplify the communication and maximize the credibility of projected economic damages from future climate change.

In projecting the future economic damages from climate change, we make use of recent advances in climate econometrics that provide evidence for impacts on sub-national economic growth from numerous components of the distribution of daily temperature and precipitation 3 , 7 , 8 . Using fixed-effects panel regression models to control for potential confounders, these studies exploit within-region variation in local temperature and precipitation in a panel of more than 1,600 regions worldwide, comprising climate and income data over the past 40 years, to identify the plausibly causal effects of changes in several climate variables on economic productivity 16 , 17 . Specifically, macroeconomic impacts have been identified from changing daily temperature variability, total annual precipitation, the annual number of wet days and extreme daily rainfall that occur in addition to those already identified from changing average temperature 2 , 3 , 18 . Moreover, regional heterogeneity in these effects based on the prevailing local climatic conditions has been found using interactions terms. The selection of these climate variables follows micro-level evidence for mechanisms related to the impacts of average temperatures on labour and agricultural productivity 2 , of temperature variability on agricultural productivity and health 7 , as well as of precipitation on agricultural productivity, labour outcomes and flood damages 8 (see Extended Data Table 1 for an overview, including more detailed references). References  7 , 8 contain a more detailed motivation for the use of these particular climate variables and provide extensive empirical tests about the robustness and nature of their effects on economic output, which are summarized in Methods . By accounting for these extra climatic variables at the sub-national level, we aim for a more comprehensive description of climate impacts with greater detail across both time and space.

Constraining the persistence of impacts

A key determinant and source of discrepancy in estimates of the magnitude of future climate damages is the extent to which the impact of a climate variable on economic growth rates persists. The two extreme cases in which these impacts persist indefinitely or only instantaneously are commonly referred to as growth or level effects 19 , 20 (see Methods section ‘Empirical model specification: fixed-effects distributed lag models’ for mathematical definitions). Recent work shows that future damages from climate change depend strongly on whether growth or level effects are assumed 20 . Following refs.  2 , 18 , we provide constraints on this persistence by using distributed lag models to test the significance of delayed effects separately for each climate variable. Notably, and in contrast to refs.  2 , 18 , we use climate variables in their first-differenced form following ref.  3 , implying a dependence of the growth rate on a change in climate variables. This choice means that a baseline specification without any lags constitutes a model prior of purely level effects, in which a permanent change in the climate has only an instantaneous effect on the growth rate 3 , 19 , 21 . By including lags, one can then test whether any effects may persist further. This is in contrast to the specification used by refs.  2 , 18 , in which climate variables are used without taking the first difference, implying a dependence of the growth rate on the level of climate variables. In this alternative case, the baseline specification without any lags constitutes a model prior of pure growth effects, in which a change in climate has an infinitely persistent effect on the growth rate. Consequently, including further lags in this alternative case tests whether the initial growth impact is recovered 18 , 19 , 21 . Both of these specifications suffer from the limiting possibility that, if too few lags are included, one might falsely accept the model prior. The limitations of including a very large number of lags, including loss of data and increasing statistical uncertainty with an increasing number of parameters, mean that such a possibility is likely. By choosing a specification in which the model prior is one of level effects, our approach is therefore conservative by design, avoiding assumptions of infinite persistence of climate impacts on growth and instead providing a lower bound on this persistence based on what is observable empirically (see Methods section ‘Empirical model specification: fixed-effects distributed lag models’ for further exposition of this framework). The conservative nature of such a choice is probably the reason that ref.  19 finds much greater consistency between the impacts projected by models that use the first difference of climate variables, as opposed to their levels.

We begin our empirical analysis of the persistence of climate impacts on growth using ten lags of the first-differenced climate variables in fixed-effects distributed lag models. We detect substantial effects on economic growth at time lags of up to approximately 8–10 years for the temperature terms and up to approximately 4 years for the precipitation terms (Extended Data Fig. 1 and Extended Data Table 2 ). Furthermore, evaluation by means of information criteria indicates that the inclusion of all five climate variables and the use of these numbers of lags provide a preferable trade-off between best-fitting the data and including further terms that could cause overfitting, in comparison with model specifications excluding climate variables or including more or fewer lags (Extended Data Fig. 3 , Supplementary Methods Section  1 and Supplementary Table 1 ). We therefore remove statistically insignificant terms at later lags (Supplementary Figs. 1 – 3 and Supplementary Tables 2 – 4 ). Further tests using Monte Carlo simulations demonstrate that the empirical models are robust to autocorrelation in the lagged climate variables (Supplementary Methods Section  2 and Supplementary Figs. 4 and 5 ), that information criteria provide an effective indicator for lag selection (Supplementary Methods Section  2 and Supplementary Fig. 6 ), that the results are robust to concerns of imperfect multicollinearity between climate variables and that including several climate variables is actually necessary to isolate their separate effects (Supplementary Methods Section  3 and Supplementary Fig. 7 ). We provide a further robustness check using a restricted distributed lag model to limit oscillations in the lagged parameter estimates that may result from autocorrelation, finding that it provides similar estimates of cumulative marginal effects to the unrestricted model (Supplementary Methods Section 4 and Supplementary Figs. 8 and 9 ). Finally, to explicitly account for any outstanding uncertainty arising from the precise choice of the number of lags, we include empirical models with marginally different numbers of lags in the error-sampling procedure of our projection of future damages. On the basis of the lag-selection procedure (the significance of lagged terms in Extended Data Fig. 1 and Extended Data Table 2 , as well as information criteria in Extended Data Fig. 3 ), we sample from models with eight to ten lags for temperature and four for precipitation (models shown in Supplementary Figs. 1 – 3 and Supplementary Tables 2 – 4 ). In summary, this empirical approach to constrain the persistence of climate impacts on economic growth rates is conservative by design in avoiding assumptions of infinite persistence, but nevertheless provides a lower bound on the extent of impact persistence that is robust to the numerous tests outlined above.

Committed damages until mid-century

We combine these empirical economic response functions (Supplementary Figs. 1 – 3 and Supplementary Tables 2 – 4 ) with an ensemble of 21 climate models (see Supplementary Table 5 ) from the Coupled Model Intercomparison Project Phase 6 (CMIP-6) 22 to project the macroeconomic damages from these components of physical climate change (see Methods for further details). Bias-adjusted climate models that provide a highly accurate reproduction of observed climatological patterns with limited uncertainty (Supplementary Table 6 ) are used to avoid introducing biases in the projections. Following a well-developed literature 2 , 3 , 19 , these projections do not aim to provide a prediction of future economic growth. Instead, they are a projection of the exogenous impact of future climate conditions on the economy relative to the baselines specified by socio-economic projections, based on the plausibly causal relationships inferred by the empirical models and assuming ceteris paribus. Other exogenous factors relevant for the prediction of economic output are purposefully assumed constant.

A Monte Carlo procedure that samples from climate model projections, empirical models with different numbers of lags and model parameter estimates (obtained by 1,000 block-bootstrap resamples of each of the regressions in Supplementary Figs. 1 – 3 and Supplementary Tables 2 – 4 ) is used to estimate the combined uncertainty from these sources. Given these uncertainty distributions, we find that projected global damages are statistically indistinguishable across the two most extreme emission scenarios until 2049 (at the 5% significance level; Fig. 1 ). As such, the climate damages occurring before this time constitute those to which the world is already committed owing to the combination of past emissions and the range of future emission scenarios that are considered socio-economically plausible 15 . These committed damages comprise a permanent income reduction of 19% on average globally (population-weighted average) in comparison with a baseline without climate-change impacts (with a likely range of 11–29%, following the likelihood classification adopted by the Intergovernmental Panel on Climate Change (IPCC); see caption of Fig. 1 ). Even though levels of income per capita generally still increase relative to those of today, this constitutes a permanent income reduction for most regions, including North America and Europe (each with median income reductions of approximately 11%) and with South Asia and Africa being the most strongly affected (each with median income reductions of approximately 22%; Fig. 1 ). Under a middle-of-the road scenario of future income development (SSP2, in which SSP stands for Shared Socio-economic Pathway), this corresponds to global annual damages in 2049 of 38 trillion in 2005 international dollars (likely range of 19–59 trillion 2005 international dollars). Compared with empirical specifications that assume pure growth or pure level effects, our preferred specification that provides a robust lower bound on the extent of climate impact persistence produces damages between these two extreme assumptions (Extended Data Fig. 3 ).

figure 1

Estimates of the projected reduction in income per capita from changes in all climate variables based on empirical models of climate impacts on economic output with a robust lower bound on their persistence (Extended Data Fig. 1 ) under a low-emission scenario compatible with the 2 °C warming target and a high-emission scenario (SSP2-RCP2.6 and SSP5-RCP8.5, respectively) are shown in purple and orange, respectively. Shading represents the 34% and 10% confidence intervals reflecting the likely and very likely ranges, respectively (following the likelihood classification adopted by the IPCC), having estimated uncertainty from a Monte Carlo procedure, which samples the uncertainty from the choice of physical climate models, empirical models with different numbers of lags and bootstrapped estimates of the regression parameters shown in Supplementary Figs. 1 – 3 . Vertical dashed lines show the time at which the climate damages of the two emission scenarios diverge at the 5% and 1% significance levels based on the distribution of differences between emission scenarios arising from the uncertainty sampling discussed above. Note that uncertainty in the difference of the two scenarios is smaller than the combined uncertainty of the two respective scenarios because samples of the uncertainty (climate model and empirical model choice, as well as model parameter bootstrap) are consistent across the two emission scenarios, hence the divergence of damages occurs while the uncertainty bounds of the two separate damage scenarios still overlap. Estimates of global mitigation costs from the three IAMs that provide results for the SSP2 baseline and SSP2-RCP2.6 scenario are shown in light green in the top panel, with the median of these estimates shown in bold.

Damages already outweigh mitigation costs

We compare the damages to which the world is committed over the next 25 years to estimates of the mitigation costs required to achieve the Paris Climate Agreement. Taking estimates of mitigation costs from the three integrated assessment models (IAMs) in the IPCC AR6 database 23 that provide results under comparable scenarios (SSP2 baseline and SSP2-RCP2.6, in which RCP stands for Representative Concentration Pathway), we find that the median committed climate damages are larger than the median mitigation costs in 2050 (six trillion in 2005 international dollars) by a factor of approximately six (note that estimates of mitigation costs are only provided every 10 years by the IAMs and so a comparison in 2049 is not possible). This comparison simply aims to compare the magnitude of future damages against mitigation costs, rather than to conduct a formal cost–benefit analysis of transitioning from one emission path to another. Formal cost–benefit analyses typically find that the net benefits of mitigation only emerge after 2050 (ref.  5 ), which may lead some to conclude that physical damages from climate change are simply not large enough to outweigh mitigation costs until the second half of the century. Our simple comparison of their magnitudes makes clear that damages are actually already considerably larger than mitigation costs and the delayed emergence of net mitigation benefits results primarily from the fact that damages across different emission paths are indistinguishable until mid-century (Fig. 1 ).

Although these near-term damages constitute those to which the world is already committed, we note that damage estimates diverge strongly across emission scenarios after 2049, conveying the clear benefits of mitigation from a purely economic point of view that have been emphasized in previous studies 4 , 24 . As well as the uncertainties assessed in Fig. 1 , these conclusions are robust to structural choices, such as the timescale with which changes in the moderating variables of the empirical models are estimated (Supplementary Figs. 10 and 11 ), as well as the order in which one accounts for the intertemporal and international components of currency comparison (Supplementary Fig. 12 ; see Methods for further details).

Damages from variability and extremes

Committed damages primarily arise through changes in average temperature (Fig. 2 ). This reflects the fact that projected changes in average temperature are larger than those in other climate variables when expressed as a function of their historical interannual variability (Extended Data Fig. 4 ). Because the historical variability is that on which the empirical models are estimated, larger projected changes in comparison with this variability probably lead to larger future impacts in a purely statistical sense. From a mechanistic perspective, one may plausibly interpret this result as implying that future changes in average temperature are the most unprecedented from the perspective of the historical fluctuations to which the economy is accustomed and therefore will cause the most damage. This insight may prove useful in terms of guiding adaptation measures to the sources of greatest damage.

figure 2

Estimates of the median projected reduction in sub-national income per capita across emission scenarios (SSP2-RCP2.6 and SSP2-RCP8.5) as well as climate model, empirical model and model parameter uncertainty in the year in which climate damages diverge at the 5% level (2049, as identified in Fig. 1 ). a , Impacts arising from all climate variables. b – f , Impacts arising separately from changes in annual mean temperature ( b ), daily temperature variability ( c ), total annual precipitation ( d ), the annual number of wet days (>1 mm) ( e ) and extreme daily rainfall ( f ) (see Methods for further definitions). Data on national administrative boundaries are obtained from the GADM database version 3.6 and are freely available for academic use ( https://gadm.org/ ).

Nevertheless, future damages based on empirical models that consider changes in annual average temperature only and exclude the other climate variables constitute income reductions of only 13% in 2049 (Extended Data Fig. 5a , likely range 5–21%). This suggests that accounting for the other components of the distribution of temperature and precipitation raises net damages by nearly 50%. This increase arises through the further damages that these climatic components cause, but also because their inclusion reveals a stronger negative economic response to average temperatures (Extended Data Fig. 5b ). The latter finding is consistent with our Monte Carlo simulations, which suggest that the magnitude of the effect of average temperature on economic growth is underestimated unless accounting for the impacts of other correlated climate variables (Supplementary Fig. 7 ).

In terms of the relative contributions of the different climatic components to overall damages, we find that accounting for daily temperature variability causes the largest increase in overall damages relative to empirical frameworks that only consider changes in annual average temperature (4.9 percentage points, likely range 2.4–8.7 percentage points, equivalent to approximately 10 trillion international dollars). Accounting for precipitation causes smaller increases in overall damages, which are—nevertheless—equivalent to approximately 1.2 trillion international dollars: 0.01 percentage points (−0.37–0.33 percentage points), 0.34 percentage points (0.07–0.90 percentage points) and 0.36 percentage points (0.13–0.65 percentage points) from total annual precipitation, the number of wet days and extreme daily precipitation, respectively. Moreover, climate models seem to underestimate future changes in temperature variability 25 and extreme precipitation 26 , 27 in response to anthropogenic forcing as compared with that observed historically, suggesting that the true impacts from these variables may be larger.

The distribution of committed damages

The spatial distribution of committed damages (Fig. 2a ) reflects a complex interplay between the patterns of future change in several climatic components and those of historical economic vulnerability to changes in those variables. Damages resulting from increasing annual mean temperature (Fig. 2b ) are negative almost everywhere globally, and larger at lower latitudes in regions in which temperatures are already higher and economic vulnerability to temperature increases is greatest (see the response heterogeneity to mean temperature embodied in Extended Data Fig. 1a ). This occurs despite the amplified warming projected at higher latitudes 28 , suggesting that regional heterogeneity in economic vulnerability to temperature changes outweighs heterogeneity in the magnitude of future warming (Supplementary Fig. 13a ). Economic damages owing to daily temperature variability (Fig. 2c ) exhibit a strong latitudinal polarisation, primarily reflecting the physical response of daily variability to greenhouse forcing in which increases in variability across lower latitudes (and Europe) contrast decreases at high latitudes 25 (Supplementary Fig. 13b ). These two temperature terms are the dominant determinants of the pattern of overall damages (Fig. 2a ), which exhibits a strong polarity with damages across most of the globe except at the highest northern latitudes. Future changes in total annual precipitation mainly bring economic benefits except in regions of drying, such as the Mediterranean and central South America (Fig. 2d and Supplementary Fig. 13c ), but these benefits are opposed by changes in the number of wet days, which produce damages with a similar pattern of opposite sign (Fig. 2e and Supplementary Fig. 13d ). By contrast, changes in extreme daily rainfall produce damages in all regions, reflecting the intensification of daily rainfall extremes over global land areas 29 , 30 (Fig. 2f and Supplementary Fig. 13e ).

The spatial distribution of committed damages implies considerable injustice along two dimensions: culpability for the historical emissions that have caused climate change and pre-existing levels of socio-economic welfare. Spearman’s rank correlations indicate that committed damages are significantly larger in countries with smaller historical cumulative emissions, as well as in regions with lower current income per capita (Fig. 3 ). This implies that those countries that will suffer the most from the damages already committed are those that are least responsible for climate change and which also have the least resources to adapt to it.

figure 3

Estimates of the median projected change in national income per capita across emission scenarios (RCP2.6 and RCP8.5) as well as climate model, empirical model and model parameter uncertainty in the year in which climate damages diverge at the 5% level (2049, as identified in Fig. 1 ) are plotted against cumulative national emissions per capita in 2020 (from the Global Carbon Project) and coloured by national income per capita in 2020 (from the World Bank) in a and vice versa in b . In each panel, the size of each scatter point is weighted by the national population in 2020 (from the World Bank). Inset numbers indicate the Spearman’s rank correlation ρ and P -values for a hypothesis test whose null hypothesis is of no correlation, as well as the Spearman’s rank correlation weighted by national population.

To further quantify this heterogeneity, we assess the difference in committed damages between the upper and lower quartiles of regions when ranked by present income levels and historical cumulative emissions (using a population weighting to both define the quartiles and estimate the group averages). On average, the quartile of countries with lower income are committed to an income loss that is 8.9 percentage points (or 61%) greater than the upper quartile (Extended Data Fig. 6 ), with a likely range of 3.8–14.7 percentage points across the uncertainty sampling of our damage projections (following the likelihood classification adopted by the IPCC). Similarly, the quartile of countries with lower historical cumulative emissions are committed to an income loss that is 6.9 percentage points (or 40%) greater than the upper quartile, with a likely range of 0.27–12 percentage points. These patterns reemphasize the prevalence of injustice in climate impacts 31 , 32 , 33 in the context of the damages to which the world is already committed by historical emissions and socio-economic inertia.

Contextualizing the magnitude of damages

The magnitude of projected economic damages exceeds previous literature estimates 2 , 3 , arising from several developments made on previous approaches. Our estimates are larger than those of ref.  2 (see first row of Extended Data Table 3 ), primarily because of the facts that sub-national estimates typically show a steeper temperature response (see also refs.  3 , 34 ) and that accounting for other climatic components raises damage estimates (Extended Data Fig. 5 ). However, we note that our empirical approach using first-differenced climate variables is conservative compared with that of ref.  2 in regard to the persistence of climate impacts on growth (see introduction and Methods section ‘Empirical model specification: fixed-effects distributed lag models’), an important determinant of the magnitude of long-term damages 19 , 21 . Using a similar empirical specification to ref.  2 , which assumes infinite persistence while maintaining the rest of our approach (sub-national data and further climate variables), produces considerably larger damages (purple curve of Extended Data Fig. 3 ). Compared with studies that do take the first difference of climate variables 3 , 35 , our estimates are also larger (see second and third rows of Extended Data Table 3 ). The inclusion of further climate variables (Extended Data Fig. 5 ) and a sufficient number of lags to more adequately capture the extent of impact persistence (Extended Data Figs. 1 and 2 ) are the main sources of this difference, as is the use of specifications that capture nonlinearities in the temperature response when compared with ref.  35 . In summary, our estimates develop on previous studies by incorporating the latest data and empirical insights 7 , 8 , as well as in providing a robust empirical lower bound on the persistence of impacts on economic growth, which constitutes a middle ground between the extremes of the growth-versus-levels debate 19 , 21 (Extended Data Fig. 3 ).

Compared with the fraction of variance explained by the empirical models historically (<5%), the projection of reductions in income of 19% may seem large. This arises owing to the fact that projected changes in climatic conditions are much larger than those that were experienced historically, particularly for changes in average temperature (Extended Data Fig. 4 ). As such, any assessment of future climate-change impacts necessarily requires an extrapolation outside the range of the historical data on which the empirical impact models were evaluated. Nevertheless, these models constitute the most state-of-the-art methods for inference of plausibly causal climate impacts based on observed data. Moreover, we take explicit steps to limit out-of-sample extrapolation by capping the moderating variables of the interaction terms at the 95th percentile of the historical distribution (see Methods ). This avoids extrapolating the marginal effects outside what was observed historically. Given the nonlinear response of economic output to annual mean temperature (Extended Data Fig. 1 and Extended Data Table 2 ), this is a conservative choice that limits the magnitude of damages that we project. Furthermore, back-of-the-envelope calculations indicate that the projected damages are consistent with the magnitude and patterns of historical economic development (see Supplementary Discussion Section  5 ).

Missing impacts and spatial spillovers

Despite assessing several climatic components from which economic impacts have recently been identified 3 , 7 , 8 , this assessment of aggregate climate damages should not be considered comprehensive. Important channels such as impacts from heatwaves 31 , sea-level rise 36 , tropical cyclones 37 and tipping points 38 , 39 , as well as non-market damages such as those to ecosystems 40 and human health 41 , are not considered in these estimates. Sea-level rise is unlikely to be feasibly incorporated into empirical assessments such as this because historical sea-level variability is mostly small. Non-market damages are inherently intractable within our estimates of impacts on aggregate monetary output and estimates of these impacts could arguably be considered as extra to those identified here. Recent empirical work suggests that accounting for these channels would probably raise estimates of these committed damages, with larger damages continuing to arise in the global south 31 , 36 , 37 , 38 , 39 , 40 , 41 , 42 .

Moreover, our main empirical analysis does not explicitly evaluate the potential for impacts in local regions to produce effects that ‘spill over’ into other regions. Such effects may further mitigate or amplify the impacts we estimate, for example, if companies relocate production from one affected region to another or if impacts propagate along supply chains. The current literature indicates that trade plays a substantial role in propagating spillover effects 43 , 44 , making their assessment at the sub-national level challenging without available data on sub-national trade dependencies. Studies accounting for only spatially adjacent neighbours indicate that negative impacts in one region induce further negative impacts in neighbouring regions 45 , 46 , 47 , 48 , suggesting that our projected damages are probably conservative by excluding these effects. In Supplementary Fig. 14 , we assess spillovers from neighbouring regions using a spatial-lag model. For simplicity, this analysis excludes temporal lags, focusing only on contemporaneous effects. The results show that accounting for spatial spillovers can amplify the overall magnitude, and also the heterogeneity, of impacts. Consistent with previous literature, this indicates that the overall magnitude (Fig. 1 ) and heterogeneity (Fig. 3 ) of damages that we project in our main specification may be conservative without explicitly accounting for spillovers. We note that further analysis that addresses both spatially and trade-connected spillovers, while also accounting for delayed impacts using temporal lags, would be necessary to adequately address this question fully. These approaches offer fruitful avenues for further research but are beyond the scope of this manuscript, which primarily aims to explore the impacts of different climate conditions and their persistence.

Policy implications

We find that the economic damages resulting from climate change until 2049 are those to which the world economy is already committed and that these greatly outweigh the costs required to mitigate emissions in line with the 2 °C target of the Paris Climate Agreement (Fig. 1 ). This assessment is complementary to formal analyses of the net costs and benefits associated with moving from one emission path to another, which typically find that net benefits of mitigation only emerge in the second half of the century 5 . Our simple comparison of the magnitude of damages and mitigation costs makes clear that this is primarily because damages are indistinguishable across emissions scenarios—that is, committed—until mid-century (Fig. 1 ) and that they are actually already much larger than mitigation costs. For simplicity, and owing to the availability of data, we compare damages to mitigation costs at the global level. Regional estimates of mitigation costs may shed further light on the national incentives for mitigation to which our results already hint, of relevance for international climate policy. Although these damages are committed from a mitigation perspective, adaptation may provide an opportunity to reduce them. Moreover, the strong divergence of damages after mid-century reemphasizes the clear benefits of mitigation from a purely economic perspective, as highlighted in previous studies 1 , 4 , 6 , 24 .

Historical climate data

Historical daily 2-m temperature and precipitation totals (in mm) are obtained for the period 1979–2019 from the W5E5 database. The W5E5 dataset comes from ERA-5, a state-of-the-art reanalysis of historical observations, but has been bias-adjusted by applying version 2.0 of the WATCH Forcing Data to ERA-5 reanalysis data and precipitation data from version 2.3 of the Global Precipitation Climatology Project to better reflect ground-based measurements 49 , 50 , 51 . We obtain these data on a 0.5° × 0.5° grid from the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) database. Notably, these historical data have been used to bias-adjust future climate projections from CMIP-6 (see the following section), ensuring consistency between the distribution of historical daily weather on which our empirical models were estimated and the climate projections used to estimate future damages. These data are publicly available from the ISIMIP database. See refs.  7 , 8 for robustness tests of the empirical models to the choice of climate data reanalysis products.

Future climate data

Daily 2-m temperature and precipitation totals (in mm) are taken from 21 climate models participating in CMIP-6 under a high (RCP8.5) and a low (RCP2.6) greenhouse gas emission scenario from 2015 to 2100. The data have been bias-adjusted and statistically downscaled to a common half-degree grid to reflect the historical distribution of daily temperature and precipitation of the W5E5 dataset using the trend-preserving method developed by the ISIMIP 50 , 52 . As such, the climate model data reproduce observed climatological patterns exceptionally well (Supplementary Table 5 ). Gridded data are publicly available from the ISIMIP database.

Historical economic data

Historical economic data come from the DOSE database of sub-national economic output 53 . We use a recent revision to the DOSE dataset that provides data across 83 countries, 1,660 sub-national regions with varying temporal coverage from 1960 to 2019. Sub-national units constitute the first administrative division below national, for example, states for the USA and provinces for China. Data come from measures of gross regional product per capita (GRPpc) or income per capita in local currencies, reflecting the values reported in national statistical agencies, yearbooks and, in some cases, academic literature. We follow previous literature 3 , 7 , 8 , 54 and assess real sub-national output per capita by first converting values from local currencies to US dollars to account for diverging national inflationary tendencies and then account for US inflation using a US deflator. Alternatively, one might first account for national inflation and then convert between currencies. Supplementary Fig. 12 demonstrates that our conclusions are consistent when accounting for price changes in the reversed order, although the magnitude of estimated damages varies. See the documentation of the DOSE dataset for further discussion of these choices. Conversions between currencies are conducted using exchange rates from the FRED database of the Federal Reserve Bank of St. Louis 55 and the national deflators from the World Bank 56 .

Future socio-economic data

Baseline gridded gross domestic product (GDP) and population data for the period 2015–2100 are taken from the middle-of-the-road scenario SSP2 (ref.  15 ). Population data have been downscaled to a half-degree grid by the ISIMIP following the methodologies of refs.  57 , 58 , which we then aggregate to the sub-national level of our economic data using the spatial aggregation procedure described below. Because current methodologies for downscaling the GDP of the SSPs use downscaled population to do so, per-capita estimates of GDP with a realistic distribution at the sub-national level are not readily available for the SSPs. We therefore use national-level GDP per capita (GDPpc) projections for all sub-national regions of a given country, assuming homogeneity within countries in terms of baseline GDPpc. Here we use projections that have been updated to account for the impact of the COVID-19 pandemic on the trajectory of future income, while remaining consistent with the long-term development of the SSPs 59 . The choice of baseline SSP alters the magnitude of projected climate damages in monetary terms, but when assessed in terms of percentage change from the baseline, the choice of socio-economic scenario is inconsequential. Gridded SSP population data and national-level GDPpc data are publicly available from the ISIMIP database. Sub-national estimates as used in this study are available in the code and data replication files.

Climate variables

Following recent literature 3 , 7 , 8 , we calculate an array of climate variables for which substantial impacts on macroeconomic output have been identified empirically, supported by further evidence at the micro level for plausible underlying mechanisms. See refs.  7 , 8 for an extensive motivation for the use of these particular climate variables and for detailed empirical tests on the nature and robustness of their effects on economic output. To summarize, these studies have found evidence for independent impacts on economic growth rates from annual average temperature, daily temperature variability, total annual precipitation, the annual number of wet days and extreme daily rainfall. Assessments of daily temperature variability were motivated by evidence of impacts on agricultural output and human health, as well as macroeconomic literature on the impacts of volatility on growth when manifest in different dimensions, such as government spending, exchange rates and even output itself 7 . Assessments of precipitation impacts were motivated by evidence of impacts on agricultural productivity, metropolitan labour outcomes and conflict, as well as damages caused by flash flooding 8 . See Extended Data Table 1 for detailed references to empirical studies of these physical mechanisms. Marked impacts of daily temperature variability, total annual precipitation, the number of wet days and extreme daily rainfall on macroeconomic output were identified robustly across different climate datasets, spatial aggregation schemes, specifications of regional time trends and error-clustering approaches. They were also found to be robust to the consideration of temperature extremes 7 , 8 . Furthermore, these climate variables were identified as having independent effects on economic output 7 , 8 , which we further explain here using Monte Carlo simulations to demonstrate the robustness of the results to concerns of imperfect multicollinearity between climate variables (Supplementary Methods Section  2 ), as well as by using information criteria (Supplementary Table 1 ) to demonstrate that including several lagged climate variables provides a preferable trade-off between optimally describing the data and limiting the possibility of overfitting.

We calculate these variables from the distribution of daily, d , temperature, T x , d , and precipitation, P x , d , at the grid-cell, x , level for both the historical and future climate data. As well as annual mean temperature, \({\bar{T}}_{x,y}\) , and annual total precipitation, P x , y , we calculate annual, y , measures of daily temperature variability, \({\widetilde{T}}_{x,y}\) :

the number of wet days, Pwd x , y :

and extreme daily rainfall:

in which T x , d , m , y is the grid-cell-specific daily temperature in month m and year y , \({\bar{T}}_{x,m,{y}}\) is the year and grid-cell-specific monthly, m , mean temperature, D m and D y the number of days in a given month m or year y , respectively, H the Heaviside step function, 1 mm the threshold used to define wet days and P 99.9 x is the 99.9th percentile of historical (1979–2019) daily precipitation at the grid-cell level. Units of the climate measures are degrees Celsius for annual mean temperature and daily temperature variability, millimetres for total annual precipitation and extreme daily precipitation, and simply the number of days for the annual number of wet days.

We also calculated weighted standard deviations of monthly rainfall totals as also used in ref.  8 but do not include them in our projections as we find that, when accounting for delayed effects, their effect becomes statistically indistinct and is better captured by changes in total annual rainfall.

Spatial aggregation

We aggregate grid-cell-level historical and future climate measures, as well as grid-cell-level future GDPpc and population, to the level of the first administrative unit below national level of the GADM database, using an area-weighting algorithm that estimates the portion of each grid cell falling within an administrative boundary. We use this as our baseline specification following previous findings that the effect of area or population weighting at the sub-national level is negligible 7 , 8 .

Empirical model specification: fixed-effects distributed lag models

Following a wide range of climate econometric literature 16 , 60 , we use panel regression models with a selection of fixed effects and time trends to isolate plausibly exogenous variation with which to maximize confidence in a causal interpretation of the effects of climate on economic growth rates. The use of region fixed effects, μ r , accounts for unobserved time-invariant differences between regions, such as prevailing climatic norms and growth rates owing to historical and geopolitical factors. The use of yearly fixed effects, η y , accounts for regionally invariant annual shocks to the global climate or economy such as the El Niño–Southern Oscillation or global recessions. In our baseline specification, we also include region-specific linear time trends, k r y , to exclude the possibility of spurious correlations resulting from common slow-moving trends in climate and growth.

The persistence of climate impacts on economic growth rates is a key determinant of the long-term magnitude of damages. Methods for inferring the extent of persistence in impacts on growth rates have typically used lagged climate variables to evaluate the presence of delayed effects or catch-up dynamics 2 , 18 . For example, consider starting from a model in which a climate condition, C r , y , (for example, annual mean temperature) affects the growth rate, Δlgrp r , y (the first difference of the logarithm of gross regional product) of region r in year y :

which we refer to as a ‘pure growth effects’ model in the main text. Typically, further lags are included,

and the cumulative effect of all lagged terms is evaluated to assess the extent to which climate impacts on growth rates persist. Following ref.  18 , in the case that,

the implication is that impacts on the growth rate persist up to NL years after the initial shock (possibly to a weaker or a stronger extent), whereas if

then the initial impact on the growth rate is recovered after NL years and the effect is only one on the level of output. However, we note that such approaches are limited by the fact that, when including an insufficient number of lags to detect a recovery of the growth rates, one may find equation ( 6 ) to be satisfied and incorrectly assume that a change in climatic conditions affects the growth rate indefinitely. In practice, given a limited record of historical data, including too few lags to confidently conclude in an infinitely persistent impact on the growth rate is likely, particularly over the long timescales over which future climate damages are often projected 2 , 24 . To avoid this issue, we instead begin our analysis with a model for which the level of output, lgrp r , y , depends on the level of a climate variable, C r , y :

Given the non-stationarity of the level of output, we follow the literature 19 and estimate such an equation in first-differenced form as,

which we refer to as a model of ‘pure level effects’ in the main text. This model constitutes a baseline specification in which a permanent change in the climate variable produces an instantaneous impact on the growth rate and a permanent effect only on the level of output. By including lagged variables in this specification,

we are able to test whether the impacts on the growth rate persist any further than instantaneously by evaluating whether α L  > 0 are statistically significantly different from zero. Even though this framework is also limited by the possibility of including too few lags, the choice of a baseline model specification in which impacts on the growth rate do not persist means that, in the case of including too few lags, the framework reverts to the baseline specification of level effects. As such, this framework is conservative with respect to the persistence of impacts and the magnitude of future damages. It naturally avoids assumptions of infinite persistence and we are able to interpret any persistence that we identify with equation ( 9 ) as a lower bound on the extent of climate impact persistence on growth rates. See the main text for further discussion of this specification choice, in particular about its conservative nature compared with previous literature estimates, such as refs.  2 , 18 .

We allow the response to climatic changes to vary across regions, using interactions of the climate variables with historical average (1979–2019) climatic conditions reflecting heterogenous effects identified in previous work 7 , 8 . Following this previous work, the moderating variables of these interaction terms constitute the historical average of either the variable itself or of the seasonal temperature difference, \({\hat{T}}_{r}\) , or annual mean temperature, \({\bar{T}}_{r}\) , in the case of daily temperature variability 7 and extreme daily rainfall, respectively 8 .

The resulting regression equation with N and M lagged variables, respectively, reads:

in which Δlgrp r , y is the annual, regional GRPpc growth rate, measured as the first difference of the logarithm of real GRPpc, following previous work 2 , 3 , 7 , 8 , 18 , 19 . Fixed-effects regressions were run using the fixest package in R (ref.  61 ).

Estimates of the coefficients of interest α i , L are shown in Extended Data Fig. 1 for N  =  M  = 10 lags and for our preferred choice of the number of lags in Supplementary Figs. 1 – 3 . In Extended Data Fig. 1 , errors are shown clustered at the regional level, but for the construction of damage projections, we block-bootstrap the regressions by region 1,000 times to provide a range of parameter estimates with which to sample the projection uncertainty (following refs.  2 , 31 ).

Spatial-lag model

In Supplementary Fig. 14 , we present the results from a spatial-lag model that explores the potential for climate impacts to ‘spill over’ into spatially neighbouring regions. We measure the distance between centroids of each pair of sub-national regions and construct spatial lags that take the average of the first-differenced climate variables and their interaction terms over neighbouring regions that are at distances of 0–500, 500–1,000, 1,000–1,500 and 1,500–2000 km (spatial lags, ‘SL’, 1 to 4). For simplicity, we then assess a spatial-lag model without temporal lags to assess spatial spillovers of contemporaneous climate impacts. This model takes the form:

in which SL indicates the spatial lag of each climate variable and interaction term. In Supplementary Fig. 14 , we plot the cumulative marginal effect of each climate variable at different baseline climate conditions by summing the coefficients for each climate variable and interaction term, for example, for average temperature impacts as:

These cumulative marginal effects can be regarded as the overall spatially dependent impact to an individual region given a one-unit shock to a climate variable in that region and all neighbouring regions at a given value of the moderating variable of the interaction term.

Constructing projections of economic damage from future climate change

We construct projections of future climate damages by applying the coefficients estimated in equation ( 10 ) and shown in Supplementary Tables 2 – 4 (when including only lags with statistically significant effects in specifications that limit overfitting; see Supplementary Methods Section  1 ) to projections of future climate change from the CMIP-6 models. Year-on-year changes in each primary climate variable of interest are calculated to reflect the year-to-year variations used in the empirical models. 30-year moving averages of the moderating variables of the interaction terms are calculated to reflect the long-term average of climatic conditions that were used for the moderating variables in the empirical models. By using moving averages in the projections, we account for the changing vulnerability to climate shocks based on the evolving long-term conditions (Supplementary Figs. 10 and 11 show that the results are robust to the precise choice of the window of this moving average). Although these climate variables are not differenced, the fact that the bias-adjusted climate models reproduce observed climatological patterns across regions for these moderating variables very accurately (Supplementary Table 6 ) with limited spread across models (<3%) precludes the possibility that any considerable bias or uncertainty is introduced by this methodological choice. However, we impose caps on these moderating variables at the 95th percentile at which they were observed in the historical data to prevent extrapolation of the marginal effects outside the range in which the regressions were estimated. This is a conservative choice that limits the magnitude of our damage projections.

Time series of primary climate variables and moderating climate variables are then combined with estimates of the empirical model parameters to evaluate the regression coefficients in equation ( 10 ), producing a time series of annual GRPpc growth-rate reductions for a given emission scenario, climate model and set of empirical model parameters. The resulting time series of growth-rate impacts reflects those occurring owing to future climate change. By contrast, a future scenario with no climate change would be one in which climate variables do not change (other than with random year-to-year fluctuations) and hence the time-averaged evaluation of equation ( 10 ) would be zero. Our approach therefore implicitly compares the future climate-change scenario to this no-climate-change baseline scenario.

The time series of growth-rate impacts owing to future climate change in region r and year y , δ r , y , are then added to the future baseline growth rates, π r , y (in log-diff form), obtained from the SSP2 scenario to yield trajectories of damaged GRPpc growth rates, ρ r , y . These trajectories are aggregated over time to estimate the future trajectory of GRPpc with future climate impacts:

in which GRPpc r , y =2020 is the initial log level of GRPpc. We begin damage estimates in 2020 to reflect the damages occurring since the end of the period for which we estimate the empirical models (1979–2019) and to match the timing of mitigation-cost estimates from most IAMs (see below).

For each emission scenario, this procedure is repeated 1,000 times while randomly sampling from the selection of climate models, the selection of empirical models with different numbers of lags (shown in Supplementary Figs. 1 – 3 and Supplementary Tables 2 – 4 ) and bootstrapped estimates of the regression parameters. The result is an ensemble of future GRPpc trajectories that reflect uncertainty from both physical climate change and the structural and sampling uncertainty of the empirical models.

Estimates of mitigation costs

We obtain IPCC estimates of the aggregate costs of emission mitigation from the AR6 Scenario Explorer and Database hosted by IIASA 23 . Specifically, we search the AR6 Scenarios Database World v1.1 for IAMs that provided estimates of global GDP and population under both a SSP2 baseline and a SSP2-RCP2.6 scenario to maintain consistency with the socio-economic and emission scenarios of the climate damage projections. We find five IAMs that provide data for these scenarios, namely, MESSAGE-GLOBIOM 1.0, REMIND-MAgPIE 1.5, AIM/GCE 2.0, GCAM 4.2 and WITCH-GLOBIOM 3.1. Of these five IAMs, we use the results only from the first three that passed the IPCC vetting procedure for reproducing historical emission and climate trajectories. We then estimate global mitigation costs as the percentage difference in global per capita GDP between the SSP2 baseline and the SSP2-RCP2.6 emission scenario. In the case of one of these IAMs, estimates of mitigation costs begin in 2020, whereas in the case of two others, mitigation costs begin in 2010. The mitigation cost estimates before 2020 in these two IAMs are mostly negligible, and our choice to begin comparison with damage estimates in 2020 is conservative with respect to the relative weight of climate damages compared with mitigation costs for these two IAMs.

Data availability

Data on economic production and ERA-5 climate data are publicly available at https://doi.org/10.5281/zenodo.4681306 (ref. 62 ) and https://www.ecmwf.int/en/forecasts/datasets/reanalysis-datasets/era5 , respectively. Data on mitigation costs are publicly available at https://data.ene.iiasa.ac.at/ar6/#/downloads . Processed climate and economic data, as well as all other necessary data for reproduction of the results, are available at the public repository https://doi.org/10.5281/zenodo.10562951  (ref. 63 ).

Code availability

All code necessary for reproduction of the results is available at the public repository https://doi.org/10.5281/zenodo.10562951  (ref. 63 ).

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Acknowledgements

We gratefully acknowledge financing from the Volkswagen Foundation and the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH on behalf of the Government of the Federal Republic of Germany and Federal Ministry for Economic Cooperation and Development (BMZ).

Open access funding provided by Potsdam-Institut für Klimafolgenforschung (PIK) e.V.

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Extended data figures and tables

Extended data fig. 1 constraining the persistence of historical climate impacts on economic growth rates..

The results of a panel-based fixed-effects distributed lag model for the effects of annual mean temperature ( a ), daily temperature variability ( b ), total annual precipitation ( c ), the number of wet days ( d ) and extreme daily precipitation ( e ) on sub-national economic growth rates. Point estimates show the effects of a 1 °C or one standard deviation increase (for temperature and precipitation variables, respectively) at the lower quartile, median and upper quartile of the relevant moderating variable (green, orange and purple, respectively) at different lagged periods after the initial shock (note that these are not cumulative effects). Climate variables are used in their first-differenced form (see main text for discussion) and the moderating climate variables are the annual mean temperature, seasonal temperature difference, total annual precipitation, number of wet days and annual mean temperature, respectively, in panels a – e (see Methods for further discussion). Error bars show the 95% confidence intervals having clustered standard errors by region. The within-region R 2 , Bayesian and Akaike information criteria for the model are shown at the top of the figure. This figure shows results with ten lags for each variable to demonstrate the observed levels of persistence, but our preferred specifications remove later lags based on the statistical significance of terms shown above and the information criteria shown in Extended Data Fig. 2 . The resulting models without later lags are shown in Supplementary Figs. 1 – 3 .

Extended Data Fig. 2 Incremental lag-selection procedure using information criteria and within-region R 2 .

Starting from a panel-based fixed-effects distributed lag model estimating the effects of climate on economic growth using the real historical data (as in equation ( 4 )) with ten lags for all climate variables (as shown in Extended Data Fig. 1 ), lags are incrementally removed for one climate variable at a time. The resulting Bayesian and Akaike information criteria are shown in a – e and f – j , respectively, and the within-region R 2 and number of observations in k – o and p – t , respectively. Different rows show the results when removing lags from different climate variables, ordered from top to bottom as annual mean temperature, daily temperature variability, total annual precipitation, the number of wet days and extreme annual precipitation. Information criteria show minima at approximately four lags for precipitation variables and ten to eight for temperature variables, indicating that including these numbers of lags does not lead to overfitting. See Supplementary Table 1 for an assessment using information criteria to determine whether including further climate variables causes overfitting.

Extended Data Fig. 3 Damages in our preferred specification that provides a robust lower bound on the persistence of climate impacts on economic growth versus damages in specifications of pure growth or pure level effects.

Estimates of future damages as shown in Fig. 1 but under the emission scenario RCP8.5 for three separate empirical specifications: in orange our preferred specification, which provides an empirical lower bound on the persistence of climate impacts on economic growth rates while avoiding assumptions of infinite persistence (see main text for further discussion); in purple a specification of ‘pure growth effects’ in which the first difference of climate variables is not taken and no lagged climate variables are included (the baseline specification of ref.  2 ); and in pink a specification of ‘pure level effects’ in which the first difference of climate variables is taken but no lagged terms are included.

Extended Data Fig. 4 Climate changes in different variables as a function of historical interannual variability.

Changes in each climate variable of interest from 1979–2019 to 2035–2065 under the high-emission scenario SSP5-RCP8.5, expressed as a percentage of the historical variability of each measure. Historical variability is estimated as the standard deviation of each detrended climate variable over the period 1979–2019 during which the empirical models were identified (detrending is appropriate because of the inclusion of region-specific linear time trends in the empirical models). See Supplementary Fig. 13 for changes expressed in standard units. Data on national administrative boundaries are obtained from the GADM database version 3.6 and are freely available for academic use ( https://gadm.org/ ).

Extended Data Fig. 5 Contribution of different climate variables to overall committed damages.

a , Climate damages in 2049 when using empirical models that account for all climate variables, changes in annual mean temperature only or changes in both annual mean temperature and one other climate variable (daily temperature variability, total annual precipitation, the number of wet days and extreme daily precipitation, respectively). b , The cumulative marginal effects of an increase in annual mean temperature of 1 °C, at different baseline temperatures, estimated from empirical models including all climate variables or annual mean temperature only. Estimates and uncertainty bars represent the median and 95% confidence intervals obtained from 1,000 block-bootstrap resamples from each of three different empirical models using eight, nine or ten lags of temperature terms.

Extended Data Fig. 6 The difference in committed damages between the upper and lower quartiles of countries when ranked by GDP and cumulative historical emissions.

Quartiles are defined using a population weighting, as are the average committed damages across each quartile group. The violin plots indicate the distribution of differences between quartiles across the two extreme emission scenarios (RCP2.6 and RCP8.5) and the uncertainty sampling procedure outlined in Methods , which accounts for uncertainty arising from the choice of lags in the empirical models, uncertainty in the empirical model parameter estimates, as well as the climate model projections. Bars indicate the median, as well as the 10th and 90th percentiles and upper and lower sixths of the distribution reflecting the very likely and likely ranges following the likelihood classification adopted by the IPCC.

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Kotz, M., Levermann, A. & Wenz, L. The economic commitment of climate change. Nature 628 , 551–557 (2024). https://doi.org/10.1038/s41586-024-07219-0

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the case study of vanitas german

This paper is in the following e-collection/theme issue:

Published on 24.4.2024 in Vol 26 (2024)

The Costs of Anonymization: Case Study Using Clinical Data

Authors of this article:

Author Orcid Image

Lisa Pilgram   1, 2 , MD ;   Thierry Meurers   3 , MSc ;   Bradley Malin   4 , PhD ;   Elke Schaeffner   5 , MSc, MD ;   Kai-Uwe Eckardt   2, 6 , MD ;   Fabian Prasser   3 , PhD ;   GCKD Investigators   7

1 Junior Digital Clinician Scientist Program, Biomedical Innovation Academy, Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany

2 Department of Nephrology and Medical Intensive Care, Charité—Universitätsmedizin Berlin, Berlin, Germany

3 Medical Informatics Group, Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany

4 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States

5 Institute of Public Health, Charité—Universitätsmedizin Berlin, Berlin, Germany

6 Department of Nephrology and Hypertension, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

7 See Acknowledgments, Erlangen, Germany

Corresponding Author:

  • Lisa Pilgram , MD
  • Junior Digital Clinician Scientist Program
  • Biomedical Innovation Academy
  • Berlin Institute of Health at Charité—Universitätsmedizin Berlin
  • Charitéplatz 1
  • Berlin , 10117
  • Phone: 49 30 450543049
  • Fax: 49 30 450 7 553 9
  • Email: [email protected]

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    Watch The Case Study of Vanitas (German Dub) A Chance Encounter, on Crunchyroll. Vanitas and Noé travel to Gévaudan in search of a creature known as the Beast, but things go sideways when they ...

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    Watch The Case Study of Vanitas (German Dub) His Wish, on Crunchyroll. Mikhail pleads with Vanitas to join him. ... The Case Study of Vanitas. 4.8 (28.1k) E24 - His Wish. Sub | Dub. Released on ...

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  4. Vanitas no Karte (The Case Study of Vanitas)

    Scorned by others of his kind for being born under a blue moon, the vampire Vanitas grew afraid and desolate. According to legend, he created a cursed grimoire known as the "Book of Vanitas," and it is said he would one day use it to bring retribution upon all vampires of the crimson moon. In 19th century Paris, Noé Archiviste is searching for the fabled Book of Vanitas. Whilst traveling ...

  5. The Case Study of Vanitas

    The Case Study of Vanitas (Japanese: ヴァニタスの 手記 ( カルテ ), Hepburn: Vanitasu no Karute) is a Japanese manga series written and illustrated by Jun Mochizuki.It has been serialized in Square Enix's shōnen manga magazine Monthly Gangan Joker since December 2015. In North America, the manga is published in English by Yen Press.. The Case Study of Vanitas is set in a ...

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  9. Vanitas (The Case Study of Vanitas)

    Vanitas (Japanese: ヴァニタス, Hepburn: Vanitasu) is the fictional protagonist and title character of the manga series The Case Study of Vanitas, which was written and illustrated by Jun Mochizuki.The character was named Vanitas of the Blue Moon, making him part of the Blue Moon clan with some vampire abilities.Vanitas possesses a grimoire called The Book of Vanitas (ヴァニタスの書 ...

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  11. List of The Case Study of Vanitas chapters

    The Case Study of Vanitas is a manga written and illustrated by Jun Mochizuki.Set in 19th century Paris and contains vampire and steampunk thematics. The story focuses on the young Vanitas who possesses the grimoire called The Book of Vanitas and uses it to heal cursed vampires. The vampire Noé Archiviste joins Vanitas in his quest to save cursed vampires.

  12. The Comte de Saint Germain is without a doubt a character I ...

    A subreddit dedicated to Vanitas no Carte (Vanitas no Karte, Vanitas no Shuki, The Case Study of Vanitas, ヴァニタスの手記(カルテ)). The manga is created by Jun Mochizuki and published in Square Enix's Gangan Joker monthly magazine. The anime is produced by studio Bones.

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    »Ich werde die Vampire retten!« Die »Bestie von Gévaudan«, die einst im 18. Jahrhundert Frankreich in Angst und Schrecken versetzt hat, ist im 19. Jahrhundert wiederaufgetaucht! Doch bevor Vanitas und Noé herausfinden können, ob die Bestie in Zusammenhang mit den Vampiren steht, stellen sich ihnen der Chasseur Astolpho und die Hexe des Höllenfeuers, Jeanne, in den Weg.

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    Jean-Jacques Chastel. voiced by J Michael Tatum and 1 other. Mikhail. voiced by Bryson Baugus and 1 other. Vampire of the Blue Moon. voiced by Marissa Lenti and 1 other. Dr. Moreau. voiced by Scott Gibbs and 1 other.

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    Buy The Case Study Of Vanitas 10: Vampir-Action im Steampunk-Setting (German Edition): ... (German Edition) Kindle Edition . German Edition by Jun Mochizuki (Author), Martin Bachernegg (Translator) Format: Kindle Edition. 4.9 4.9 out of 5 stars 72 ratings. Part of: The Case Study Of Vanitas .

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  20. The Case Study Of Vanitas 11: Vampir-Action im Steampunk-Setting

    The Case Study Of Vanitas 11: Vampir-Action im Steampunk-Setting (German Edition) Kindle Edition . German Edition by Jun Mochizuki (Author), Martin Bachernegg (Translator) Format: Kindle Edition. Part of: The Case Study Of Vanitas »Ich werde die Vampire retten!« Das ausgehende 19. Jahrhundert: Vampir Noé reist mit einem Luftschiff nach Paris ...

  21. The Case Study of Vanitas (German Dub)

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  23. The economic commitment of climate change

    A key determinant and source of discrepancy in estimates of the magnitude of future climate damages is the extent to which the impact of a climate variable on economic growth rates persists.

  24. The Costs of Anonymization: Case Study Using Clinical Data

    Charitéplatz 1. Berlin, 10117. Germany. Phone: 49 30 450543049. Fax: 49 30 450 7 553 9. Email: [email protected]. Background: Sharing data from clinical studies can accelerate scientific progress, improve transparency, and increase the potential for innovation and collaboration. However, privacy concerns remain a barrier to data sharing.

  25. The Case Study of Vanitas (German Dub) Promises

    Watch The Case Study of Vanitas (German Dub) Promises, on Crunchyroll. Dominique offers Jeanne advice. Jeanne surprises Vanitas with an invitation, and Dominique shadows them. Noé encounters Lord ...

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    Watch The Case Study of Vanitas (German Dub) Questions, on Crunchyroll. Vanitas comes to the rescue and helps Noé and company battle Charlatan's curse-bearers. Noé questions Vanitas's methods.