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Biotechnology articles from across Nature Portfolio

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

Affinity maturation of CRISPR-engineered B cell receptors in vivo

CRISPR–Cas12a was used to directly replace mouse antibody variable chain genes with human versions in primary B cells. The edited cells underwent affinity maturation in vivo, improving the potency of HIV-1 and SARS-CoV-2 neutralizing antibodies without loss of bioavailability. Affinity maturation of edited cells also enables new vaccine models and adaptive B cell therapies.

A retrotransposon for site-specific gene transfer

An engineered retrotransposon achieves targeted gene transfer into the human genome.

• Alison B. Hickman

Breaking up the StayGold dimer yields three photostable monomers

The exceptionally photostable green fluorescent protein StayGold has been monomerized in different laboratories, which has generated three unique monomeric variants that will enable new imaging applications.

• Joachim Goedhart
• Theodorus W. J. Gadella Jr

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Latest Research and Reviews

Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways

A novel magnetic anisotropic hydrogel (MAH) with magnetic and topographic anisotropy was designed by combining static magnetic field-induced magnetic nanomaterials and a hydrogel. The duel anisotropic hydrogel promotes osteogenic differentiation of BMSCs through upregulating SNHG5 and downstream SIRT6, which modulated the level of NOTCH1/2 by antagonizing DNMT1 protein stability.

• Shijia Tang

Lipids productivity of cyanobacterium Anabaena vaginicola in an internally illuminated photobioreactor using LED bar lights

• Hootan Goldoost
• Farzaneh Vahabzadeh
• Narges Fallah

Oncolytic mineralized bacteria as potent locally administered immunotherapeutics

Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.

• Chenya Wang
• Liping Zhong

Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteria

• Kudakwashe Nyambo
• Kudzanai Ian Tapfuma
• Vuyo Mavumengwana

A multicolor suite for deciphering population coding of calcium and cAMP in vivo

Improved green cAMP and red calcium sensors were developed to facilitate dual-color imaging in vivo. These sensors will allow studying the relationship between calcium and cAMP signaling.

• Tatsushi Yokoyama
• Satoshi Manita
• Masayuki Sakamoto

Artificial cells for in vivo biomedical applications through red blood cell biomimicry

Despite the enormous progress in the field of giant lipid vesicles, their use for in vivo biomedical applications is limited. Here, the authors discuss red blood cells as inspiration for enhancing those vesicles, investigating the required cellular features and the corresponding technical hurdles.

• Jorik Waeterschoot
• Willemien Gosselé
• Xavier Casadevall i Solvas

News and Comment

The future of at-home molecular testing

The COVID-19 pandemic showed what was possible for gene-based diagnostics. Now comes the true test – economics.

• Elie Dolgin

Comment on: current opinions on the management of prolonged ischemic priapism: does penoscrotal decompression outperform corporoglanular tunneling?

• Omer A. Raheem
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Found: a skilled, courageous postdoctoral fellow

To select the best postdoctoral fellows for their labs, principal investigators assess scientific qualifications and more.

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Making genome editing a success story in Africa

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Life Sciences Research Products Discounts

Our vision is to create a world where cutting-edge life sciences research products are accessible and affordable to all. Most importantly, enabling life science researchers to pursue groundbreaking discoveries without constraints.

Our mission is to democratize life sciences progress by providing affordable, high-quality life sciences research laboratory products discounts to researchers worldwide.

We offer an extensive range of products, stringent quality control processes, and continuous pursuit of affordability, Furthermore, we aim to empower life science researchers to accelerate discoveries, advance biological knowledge, and address global challenges.

Accessibility: We provide affordable life science products to scientists worldwide, ensuring that financial limitations do not hinder scientific progress.

Quality: We commit to delivering products of the highest quality, meeting rigorous standards and ensuring accurate and reliable results in life sciences experiments.

Innovation: We embrace innovation in both our products and workflows. Most importantly, constantly seeking ways to improve and optimize bio research laboratory products to meet the evolving needs of the scientific community.

Customer-First: We prioritize our customers’ needs, offering exceptional customer service, personalized support, and responsiveness. This ensures a positive experience throughout their bio research journey.

Ethics: We uphold the highest ethical standards in all aspects of our business, ensuring transparency, integrity. In addition, responsible practices in the development, production, and distribution of life sciences research products .

Sustainability: We commit to minimizing our environmental impact by implementing sustainable practices, reducing waste, promoting eco-friendly packaging. Furthermore, we support life science initiatives that contribute to a greener future.

Significant Importance of Affordable Bio Research Products

Life sciences research products play a vital role in laboratories, serving as essential tools for life science researchers in their quest to unravel the mysteries of life. Furthermore, these products encompass a wide range of items specifically designed to facilitate and enhance various research experiments and investigations.

One of the key components of these life science products is laboratory reagents. Specifically, these are substances used to cause specific chemical reactions, measure biomarkers, or detect the presence of certain molecules. Most importantly, reagents enable scientists to manipulate and analyze biological samples, aiding in the identification and understanding of fundamental biological processes.

In addition to reagents, laboratory scientists heavily rely on consumables and equipment tailored for life sciences research. Consumables include items like test tubes, pipettes, and microplates, which are used for sample preparation, storage, and analysis. Specialized equipment, such as centrifuges, spectrophotometers, and PCR machines, are essential for performing intricate procedures and obtaining precise measurements in the laboratory.

Life sciences research products also encompass advanced tools and technologies used for genetic analysis, such as DNA sequencing and gene expression profiling. Specifically, these cutting-edge technologies enable scientists to unravel the intricacies of the genome and investigate how genes function in various organisms. By utilizing these tools, researchers can gain invaluable insights into genetic diseases, evolutionary relationships, and the underlying mechanisms governing life itself.

Overall, affordable life science research products are indispensable for scientists striving to expand our knowledge of biology. By harnessing these products in their laboratories, researchers can unlock new discoveries, drive medical advancements, and contribute to our understanding of the intricate mechanisms that shape the living world.

Scaling Accessibility of Life Sciences Research Products

Imagine a world where scientific exploration knows no financial bounds.  A place made possible by initiatives like Cost Plus Bio. In the realm of life sciences research, gaining access to essential tools and products has historically posed challenges. High prices being the most formidable obstacle.

Imagine aspiring eighth graders, enthusiastic about the intricacies of biology, or dedicated scientists determined to decipher the complexities of genetic codes. What has often stood in their way? The soaring price tags associated with cutting-edge life sciences research products.

The Concept of Accessibility

This is where the concept of accessibility enters the scene. It’s about ensuring that the pursuit of knowledge isn’t restricted by financial limitations. Initiatives like Cost Plus Bio are reshaping the landscape by addressing these challenges head-on. Specifically, offering a solution that enables researchers, regardless of their budget constraints. Enabling researchers to embark on meaningful scientific journeys.

How is this transformation occurring? By streamlining operations, minimizing unnecessary costs, and fostering innovation in product delivery, companies like Cost Plus Bio are redefining the equation. The equation that once linked quality life science products with unattainable prices is being rewritten. As a result, researchers now have the means to unravel genetic mysteries, explore cellular landscapes, and contribute to the broader scientific tapestry without the financial shackles of the past.

Removing Life Sciences Research Products Economic Barriers

In the heart of this movement is the aspiration to cultivate a generation of thinkers, explorers, and problem solvers who aren’t bound by economic barriers. This isn’t just about leveling the playing field. Specifically, it’s about ensuring that passion and curiosity remain the driving forces behind scientific progress.

So, whether you’re a student taking your first steps into the world of biology, a university lab manager or a seasoned PhD researcher with years of experience, the essence remains the same – to make science accessible, inclusive, and impactful. Additionally, it’s about paving a path where costs don’t deter the pursuit of knowledge, and where unlocking the secrets of life is within reach for all who dare to dream.

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For over 48 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional benefits to clinicians.

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Our customers have come to expect full service from us including product technical support and clinical education, research and science resources, and practice development support and solutions, but don't take it from us- read testimonials from some of our loyal customers.

Biotics Research has proven to be an integral partner in my practice, contributing to practice revenues and patient health. Since switching to Biotics Research, I’ve seen a significant improvement in both. Any practice looking to incorporate the finest nutritional supplements should seriously consider Biotics Research…unsurpassed quality and clinical efficacy!

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From day one, I have been impressed with the quality of Biotics Research products. Now, 20 years later, I continue their use because my patients have benefited from the quality products provided by Biotics Research.

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Using Biotics Research has made a huge difference for both my patients and my practice. Most doctors prefer not to talk about the financial benefit of the supplement industry, but with the huge decline in patient reimbursement from insurance companies and a reduction in office visits due to escalating premiums and lack of insurance coverage, I take pride in generating significant revenue while providing my patients with the highest quality supplements in the industry.

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Biotics Education Blog

Niacin, NAFLD & Mortality

Results of a cohort study using NHANES (National Health and Nutrition Examination Survey, 2003-2018) data were recently published in JAMA Network Open...

Data supporting the use of apolipoproteins (APOs) in the assessment of chronic disease continues to mount, with a recent analysis published in the Ame...

A recently proposed stricter regulation of fine particulate matter (PM2.5) by EPA is a step toward significant reductions in morbidity and mortality, ...

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Sodium & bp.

Results of a crossover trial were recently published in JAMA Open Network, evaluating the effects of both a high and low-sodium diet on blood pressure...

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A study published recently in Cell Reports Medicine showed that a ketogenic diet is safe, feasible, and may be a beneficial intervention for patients ...

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A systematic review and meta-analysis recently published in the Journal of the Academy of Nutrition and Dietetics examined the effects of vitamin D su...

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Choose Biotics Research supplements today for products that pioneered the path of nutritional science to where it is today. For the purest, most efficacious supplements on the market, go with Biotics Research every time. We invite you to register for our FullScript Dispensary through Stephen Smith M.D., to place any Biotics Research product orders and much more…

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Biotics Research History

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing " The Best of Science and Nature. " We've focused on combining nature's principles with scientific ingenuity to create our Biotics Research supplements and magnify the nutritional benefits to clinicians and their patients. Biotics supplements are cost-effective, leading-edge products designed for enhanced performance. We've driven the advancement of our Biotics Research products by focusing our initiatives on research, natural effectiveness, unparalleled quality control and continuing innovation. Unlike other nutritional supplements manufactured using components such as food dyes and other unwanted ingredients, Biotics Research supplements are created with the importance of dissolution, assimilation and bioavailability in mind. Therefore, only the highest quality ingredients are used in all of our Biotics Research products – as they have been for over 40 years. We offer products formulated for testosterone support, liver detoxification, cardiovascular health and more. Even better, all Biotics supplements are gluten-free, and they always have been! Trying to figure out where to buy Biotics Research supplements? View the entire product line on Dr. Smith's FullScript Dispensary.

Why Choose Biotics Research Supplements?

The Biotics Research Corporation has always believed in the power of supplying doctors and their patients with the purest, most effective nutritional formulas available on the market. Over-the-counter (OTC) medications can be highly effective. Still, individuals with chronic medical conditions and the elderly carry the risk of adverse reactions when taking various forms of OTC drugs. Biotics Research supplements are the holistic intervention that can help those looking for an alternative to OTC drugs. Through innovation and consistent advancement of nutritional science, Biotics Research products have proven themselves ideal for improving overall lifestyle in these cases and pride themselves on helping individuals wean off traditional OTC drugs when necessary.

Biotics Research supplements are sourced only from raw materials from suppliers dedicated to transparency and sustainability. In nutritional science, it's essential to understand the impact a company can have on the environment – Biotics Research is committed to upholding the purity of the planet and its nutritional formulas. When you choose Biotics supplements, you're selecting nutritional formulas that contain only the purest and most efficacious ingredients.

Who Can Take Biotics Research Supplements?

Biotics Research products are safe and effective for both children and adults. However, you should always ensure you're purchasing a product suited to the user's specific needs. Shop Biotics Research full line of products for the whole family at Dr. Smith's FullScript Dispensary.

Biotics Research Supplements for Adults

Biotics Research products are safe for the advancement of health in all adults and older individuals. Depending on your specific needs, you'll be able to purchase any product in our online store as a holistic resource for your health.

Are Biotic Research Products Safe for Children?

While many know that supplements can be beneficial for adults, some may wonder if it's ok for children to consume them. In general, children won't need to take as many Biotic supplements as adults, as a balanced diet gets them the essential vitamins they need to be healthy. However, if you fear your child may be suffering from a vitamin deficiency, Biotics Research supplements are a healthy way to help your child. Vitamin D deficiency is the most common deficiency among children – a product like the Bio-D-Mulsion supplement can help them gain the essential nutrients they need. Biotics Research also has developed a line of supplements specifically for children, such as Children's ENT-Pro™ Lozenges to support otolaryngeal health in children. You can also find Biotics Research products like Aqueous Multi-Plus for those who can't reach total nutritional value through diet alone.

What Kind of Biotics Research Products Can I Purchase?

Biotics Research supplements are made from raw, organic materials – such as Biotics Researcher's very own biologically active vegetable cultures formulated for specific needs. Biotics Research offers an extensive range of products that can help your body's overall health. In our online store, you'll be able to find Biotics research products such as:

• Anxiety/Mood Support
• Immune Support
• Brain Health
• Kidney/Bladder Health
• Cardiovascular Health
• Sleep Support
• Liver Detoxification

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Bio-Ashwagandha

Biotics Research

Description

Ingredients, dosages and warnings.

Ashwagandha root (Withania somnifera) 

Microcrystalline cellulose, capsule shell (gelatin and water) and magnesium stearate.

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