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We believe in serving you, advancing health, and paving the way for great discoveries in biomedical research at the University of Michigan and beyond.

Cores are centralized facilities or labs which offer shared services, shared equipment, resources and expertise to biomedical researchers and investigators on a fee-for-service basis.

• Advanced Genomics
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The Store provides University of Michigan research investigators with easy, on-site procurement of enzymes, reagents, and kits used in molecular, cell biology, and some protein chemistry.

More than 700 different items from 13 vendors are stocked at five locations for immediate purchase.

The BRCF centralized access to research services, shared equipment, and the expertise of biomedical researchers/investigators to support research projects. Explore our Careers, FAQs, and Mission here.

Several of the Cores in the Biomedical Research Core Facilities offers products for sale to help you with your research projects. From enzyme kits and reagents to mouse models and gene panels.

The BRCF can help you discover technology, find experts, and advance your research every step of the way. Consult with the Cores or attend a training event to collaborate with top experts and take advantage of the latest technology in research.

Whether you need to drop off a sample of DNA or cells for imaging, obtain expert analysis, or store your samples, the BRCF are here to assist you.

Cutting-edge technology and dozens of instruments in the fields of Flow Cytometry, and Microscopy Image & Analysis are available through the BRCF, and self-service and technician-operated options are available.

Purchase Research Materials

Several of the Cores in the Biomedical Research Core Facilities offers products for sale to help you with your research projects. From enzyme kits and reagents to mouse models and gene panels. For more information, please visit:

• Advanced Genomics Core
• Transgenic Animal Model Core
• Vector Core

Consultation

The Biomedical Research Core Facilities (BRCF) can help you discover technology, find experts and advance your research every step of the way. Consult with any of our Cores to collaborate with top experts and take advantage of the latest technology in research. We help establish the scope and budget of your project, coordinate applications for funding, offer comprehensive training for investigators and more.

Many of our Cores offer their services to other academic and non-academic research institutions. Visit each Core’s specific website to learn more.

Prepare and Submit Your Samples & Data

Whether you need to drop off a sample of DNA or cells for imaging, the Biomedical Research Core Facilities are available to assist with your samples and data. Visit a specific core facility for more information.

Biomedical Research Core Facilities (BRCF), part of the University of Michigan Medical School Office of Research, are campus-wide laboratories that develop and provide state-of-the-art scientific resources to enable biomedical research. Our mission is that we believe in serving you, advancing health, and paving the way for great discoveries in biomedical research at the University of Michigan and beyond.

Due to the diversity of our work, many of our Cores have developed their own frequently asked questions (FAQs). Please visit each of our core websites to learn more about services and troubleshooting.

Because of the variety in services each Core provides, they all have a slightly different process to begin work with them. However, most project requests begin with a consultation. Check out the page of your core of interest to find out more, or view their “Contact Us” page to find out who to get in touch with.

Fill out our contact form and submit your question using “I have a project that may involve multiple cores.”

There are currently 11 cores under the BRCF umbrella, however many cores exist at the University of Michigan. To learn more about all of the cores located at U-M, please visit the Michigan Research Cores website.

MiCores is an operational software powered by Agilent Technologies and used by the BRCF to perform ordering, billing, and scheduling of scientific products and services. For more information about MiCores and how to register, visit the MiCores website .

There are many funding opportunities across the University and beyond. Highlighted below are some that are most applicable to the Biomedical Research Core Facilities. Please visit the UMMS Office of Research Funding Opportunities page for information about internal funding, external funding opportunities, bridging support, and more.

• Competition Space streamlines the process of finding and applying for, funding opportunities at the Medical School
• MICHR Funding: grant programs for basic, clinical, translational research and more available through the Michigan Institute for Clinical and Health Research (MICHR)
• Taubman Health Sciences Library Research Funding and Grants Guide

The Association of Biomolecular Resource Facilities (ABRF) has established recommended authorship guidelines that the Biomedical Research Core Facilities follow. Please see below for their recommended guidelines as implemented by the BRCF:

Why cite the contributions of a core?

It is important to document the use of each Biomedical Research Core Facility by investigators in publications. Doing so facilitates efforts to obtain funding for our Cores. Core facility personnel are valued scientists; when they make a substantial contribution to a publication, they deserve to be acknowledged like any other co-author. The existence of the BRCF relies on proper acknowledgment in publications and awards. Proper acknowledgment of the BRCF helps us to obtain support so that we may continue to provide services to the best of our abilities.

Please include the following information in the acknowledgments section of any publication resulting from services provided by or facilities used by any of the BRCF Cores:

• The name of the specific Biomedical Research Core Facility(ies) used in the scope of your research or project.
• Clearly, state how the author and core contributed to your research.
• If a center, department, grant or institution supported access to resources through funding or other means, please include that.

Statement Example

“In collaboration with this research, we acknowledge support from the University of Michigan Biomedical Research Core Facilities (Insert BRCF Core Name Here).”

If you have any questions about correctly attributing the Cores in a publication or award, please contact us.

For more information, please see the Authorship Guidelines established by the ABRF.

The BRCF administration office is located on the C-floor (C570) of Medical Science Research Building II (MSRB II). Each of our Cores is spread out across campus, including MSRB II, Biomedical Research Science Building (BSRB), Life Sciences Institute (LSI), Brehm, and North Campus Research Complex (NCRC).

How do I get to the MSRB II C-Floor?

The C-Floor can only be accessed by using the elevators in Medical Science Research Building II. Use the directions or map below to navigate to MSRB II.

Entering from 1150 W. Medical Center Dr. (MSRB II)

If you come through the main entrance at the circle drive, take the door to your left that says “MSRB II” and use those elevators to arrive at the C-Floor. You can also take the open staircase to the left of the entrance. View these directions on a map.

Entering from 1137 Catherine St. (Med Sci II)

If entering through the 4th floor of Medical Science Building II (Med Sci II) , head left from the entrance and follow the hallway straight down until it dead-ends at a stairwell. Once through that doorway, take the small flight of stairs to your left onto the 4th floor of MSRB I. From there, follow the hallway to the right until you reach the MSRB II elevators. View these directions on a map. Similarly, from the main entrance to the 3rd floor of Medical Science Building II (Med Sci II), head right down the long hallway until it dead-ends at a stairwell. Once through that doorway, take the small flight of stairs to your left onto the 3rd-floor MSRB I. From there, follow the hallway to the right until you reach the MSRB II elevators. View these directions on a map.

Entering from the Cancer Center of University Hospital

If entering from the Cancer Center parking structure, take the elevators to the 7th-floor skywalk and take a right at the first set of doors (this is the 3rd floor of Med Sci I). This will take you down a long hallway that opens up into Med Sci II. Take a right at the vending machines until you reach the stairwell. Once through that doorway, take the small flight of stairs to your left onto the 3rd floor of MSRB I. From there, follow the hallway to the right until you reach the MSRB II elevators. Follow these same directions if coming directly from the Cancer Center or UH. You must be on the 2nd floor of either building to connect to the 3rd floor of Med Sci I and II. View a more detailed map indicating directions from multiple sites at Michigan Medicine (note, this is a large file).

Subscribe today to receive the latest news, core updates, monthly newsletter, and more from the BRCF.

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Northwestern opens largest biomedical academic research building in u.s..

Feinberg School of Medicine has fastest-growing NIH funding in biomedical research

See a slideshow of photography of the Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, and   a gallery of photos from the June 17 dedication of the new building.

The Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center  – the largest new building solely dedicated to biomedical research at an American medical school* – officially opened June 17 at Northwestern University Feinberg School of Medicine.

Northwestern is the fastest-growing research enterprise among all U.S. medical schools – climbing from 39th to 15th in National Institutes of Health funding since 2002. The new center provides much-needed biomedical research space to continue Northwestern’s projected growth.

“The Simpson Querrey Biomedical Research Center is an inspired new home for discovery on Northwestern University’s Chicago medical campus,” said Eric G. Neilson, MD , vice president for medical affairs and Lewis Landsberg Dean of Northwestern University Feinberg School of Medicine. “Inside this modern new building, scientists will pioneer discoveries that will impact the practice of medicine and transform human health. Here, we will accelerate the pace of lifesaving medical science that fuels the local and national economy, near world-class campus partners and in a global city with unrivaled opportunities for biomedical commercialization and entrepreneurship.”

The new 12-story Perkins+Will-designed building, with striking curved-glass exteriors and light-filled laboratory neighborhoods, adds more than 625,000 square feet of research space to the Chicago academic medical campus. The building is designed for a future expansion that can more than double its size vertically, with up to 16 new floors in the second phase of construction.

The university already brings in more than $700 million in total sponsored research funding annually. The new facility will enable Northwestern to increase that by $150 million annually or $1.5 billion in the next 10 years with the additional space and investigators. It will also create 2,000 new high-paying, full-time jobs in the new space and is expected to generate an additional $390 million a year in economic activity in Chicago. In the building’s first phase, it created more than 2,500 construction jobs.

The Simpson Querrey Biomedical Research Center is named in honor of Northwestern Trustees Louis A. Simpson ’58 and Kimberly K. Querrey in recognition of their generous support that has advanced the University’s academic excellence and scientific discovery.

“The Simpson Querrey Biomedical Research Center represents one of the most important initiatives at Northwestern in recent years, and the fulfillment of promises the University made to the city of Chicago,” said Northwestern President Morton Schapiro, PhD . “It will help Northwestern’s research community to reach its fullest potential and to make unprecedented advances in improving life for countless millions.

“But while this center’s impact will be global, many of its benefits are intentionally local: It will serve as an economic engine within Chicago, working with nearby partners from education, business and government to create new opportunities for so many people who call this region home. The Northwestern community is immensely grateful to all who’ve helped make this moment possible, most notably Kimberly and Lou, whose generosity and dedication have been truly transformational for Northwestern.”

The building’s design is a direct response to the original 1925 campus master plan, which maximizes the use of limited urban land resources. Added greenery and open space at the street level along with an airy glass lobby create permeability and transparency in a dense urban neighborhood.

‘Collaborations will explode’

The medical school has principal investigators in cancer, cardiovascular diseases, neurosciences, epigenetics, nanotechnology and biomedicine, epithelial biology, infectious diseases and more, and some of those programs will be in the new building. Each floor in the new building can house 23 principal investigators and their teams.

Principal investigators, support staff and newly hired scientists began moving into the building in late April.

“Collaborations will explode on campus,” said Susan Quaggin, MD , director of the Feinberg Cardiovascular and Renal Research Institute. “I just know scientists will start talking about things that will lead to new directions and experiments, and bridge clinical and basic science.”

Quaggin, also chief of Nephrology and Hypertension in the Department of Medicine , said she is excited about her new proximity to potential collaborators, such as scientist Ali Shilatifard, PhD , chair of Biochemistry and Molecular Genetics and director of the Simpson Querrey Center for Epigenetics . This proximity will enable enhanced access to his bioinformatics teams, and “very hot” single-cell RNA sequencing technology, developed in his lab. This technology, unique to Northwestern, will unlock a deeper understanding of how glaucoma occurs and how to best develop new drugs, Quaggin said.

Close to identifying a lead therapeutic candidate for glaucoma, Quaggin says the larger lab space also will enable her to hire new scientists with stem cell, vascular and developmental biology expertise to advance her efforts to develop a bioengineered kidney and pancreas that grow blood vessels, which is “the holy grail,” she said.

Flexibility is critical

The lab plan on each floor is designed around the idea of flexible “research neighborhoods,” with the goal of creating a vibrant hub for scientists and their teams. Each floor also has deliberate interaction space in the center to promote cross talk between the three lab “neighborhoods” and promote collaboration.

“The building was designed with elegance and transparency in mind, welcoming the public at street level and prioritizing varied space types, natural light and extensive collaboration areas for researchers within,” said Ralph Johnson, design director of Perkins+Will.

Flexibility is critical. “Research groups grow based on new discoveries and new funding,” said Elizabeth McNally, MD, PhD , director of the Center for Genetic Medicine and Elizabeth J. Ward Professor of Genetic Medicine. “What you want is space that is much more open to expand and contract to follow where the science is going. That’s what the new Simpson Querrey Biomedical Research Center gives us.”

Space in the Simpson Querrey Biomedical Research Center will allow McNally to hire new scientists to advance work on her new treatment for muscular dystrophy, a group of diseases that cause progressive weakness and loss of muscle mass in children, mostly boys. McNally is currently ramping up production of a newly discovered “super glue” protein that can be delivered orally to help reseal and repair damaged muscles. Preclinical testing will begin soon to ensure patient safety for a clinical trial.

A connected campus

The new building brings physicians and scientists from the Feinberg School of Medicine, McCormick School of Engineering and Stanley Manne Children’s Research Institute together with top-ranked clinical affiliates Northwestern Memorial Hospital, Ann and Robert H. Lurie Children’s Hospital of Chicago and Shirley Ryan AbilityLab – all in one academic medical district.

The building includes floor-by-floor connections with the University’s Robert H. Lurie Biomedical Research Center as well as a new skybridge connection to the Searle Medical Research Building, enabling sensitive equipment and materials to travel long distances on campus with no exposure to Chicago’s climate.

The Stanley Manne Children’s Research Institute at the Ann & Robert H. Lurie Children’s Hospital of Chicago will occupy four floors of the new building, allowing investigators in pediatrics to share the same research space as Northwestern scientists across disciplines for the first time.

“We look forward to relocating our research facility just a short distance from Lurie Children’s and on the campus of our academic partners,” said Tom Shanley, MD , chair of Pediatrics at Feinberg and Lurie Children’s and president and chief research officer of the Stanley Manne Children’s Research Institute. “This building not only allows us to enhance our research capabilities across numerous scientific neighborhoods, but also more effectively leverage the proximity of our clinical and health service and policy research partners to identify greater translational opportunities to improve childhood health.”

The Stanley Manne Children’s Research Institute was named for investor, business executive and generous philanthropist Stanley Manne in 2014 in recognition of a transformative gift to sustain and enhance pediatric medical research at Lurie Children’s.

Additionally, the Simpson Querrey Biomedical Research Center will feature new public spaces, such as the Potocsnak Family Atrium, the 160-seat Simpson Querrey Auditorium, the Judd A. and Marjorie Weinberg Gallery, the Kabiller Student Commons and the Senyei Conference Center, with five conference rooms on the mezzanine level.

The building is on track to be LEED Gold Certified, signifying a strong commitment to sustainability and energy efficiency.

*Source: Association of American Medical Colleges, New Buildings, Research list.

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The Biomedical Research Core Facilities (BRCF) are part of the University of Michigan Medical School Office of Research. They enable cutting-edge research by helping researchers economically and efficiently take advantage of the latest technology and collaborate with top experts in the field.

They continually evaluate the technology and service needs of researchers, coordinate applications for grants to purchase equipment, and offer comprehensive training for investigators; many of the Cores offer their services to other research institutions and the private sector. The BRCF are among the top enablers in the Medical School's Strategic Research Initiative . They work together to facilitate the infrastructure improvements that benefit the entire research enterprise and leverage resources to support investigator-driven science. To learn more about recent strategic investments made into the Cores, visit the investments page.

Serving the entire University of Michigan research enterprise, the BRCF aims to provide our customers with economical, efficient services of the highest quality with the ultimate goal of positively impacting human health.

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Health Sciences Biomedical Research Facility, UCSD, California

In March 2014, the University of California, San Diego (UCSD), opened a health sciences biomedical research facility in La Jolla, California.

Project Type

Biomedical research facility

La Jolla, San Diego

Construction Started

ZGF Architects, KPFF Consulting Engineers, IBE Consulting Engineers, Integrated Engineering Consultants, Spurlock poirier, RFD, Burkett and Wong Engineers, Francis Krahe and Associates, Benson Industries, University Mechanical, Dynalectric Company, Best Interiors, ISEC Casework

General Contractor

McCarthy Building Companies

The facility accommodates new and expanded multi-departmental programmes, including bioinformatics, genomic medicine, gastrointestinal medicine, childhood diseases, pathology, immunology, inflammation, psychiatry, cardiology, neurosciences, infectious diseases and glycobiology.

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It was built with a $114.6m investment and is intended to foster communication and the exchange of ideas among researchers.

Details of the UCSD biomedical research facility

The biomedical research facility is built on a 3.3-acre site within the UCSD’s School of Medicine campus, with a 196,000ft² total floor space.

The facility includes five floors of laboratories and seven floors of office space. It includes a vivarium, core lab space and support mechanical, electrical and plumbing (MEP) systems, which are located in the basement.

The facility is equipped with complex wet bench laboratories, computational space, laboratory support, core facilities and conference spaces.

Design and features of the UCSD biomedical research facility

The health sciences research facility features computer-controlled exterior solar shading systems on its east, west and south facades.

The western facade features an articulated academic lawn and pedestrian-scaled arcade.

An exterior envelope includes a terracotta rain system, granite, coated aluminium panels, concrete and clear glass.

The main entrance of the building is located on the west, connecting to the pharmaceutical services building, while the secondary entrance is located on the north end.

The facility features open and light-filled interaction spaces on every floor, with movable seating.

It includes a large outdoor terrace on the second floor, which can be used for large gatherings, as well as a transparent glass elevator, a monumental staircase and multiple scales of gathering areas. The building includes operable windows.

Construction details and contractors for the project

Construction of the research facility began in April 2011 and the building was topped out in August 2012. It was opened in March 2014.

ZGF Architects provided the design for the health sciences biomedical research facility. McCarthy Building Companies was awarded the general construction contract.

KPFF Consulting Engineers was the structural engineer for the project, IBE Consulting Engineers was the mechanical and plumbing engineer and Integrated Engineering Consultants was the electrical engineer.

Spurlock Poirier served as the landscape architect and RFD was the laboratory planning consultant.

Civil engineering services were provided by Burkett and Wong Engineers, while lighting designs were provided by Francis Krahe and Associates.

The subcontractors involved were Benson Industries, University Mechanical, Dynalectric Company, Best Interiors and ISEC Casework.

Sustainability profile of the biomedical research facility

The research facility building was designed and constructed to achieve Leadership in Energy and Environmental Design ( LEED) Platinum certification from the US Green Building Council. The building was built using sustainable methods and innovative systems.

Sustainability features of the project include the extensive reuse of water for landscape irrigation and MEP systems to ensure optimum energy efficiency. It also includes optimised ventilation, reduced water use, integrated daylight and sustainable building materials.

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Pennington Biomedical Research Center, a campus of Louisiana State University, is a world-renowned leader at the forefront of medical discoveries related to obesity, diabetes, cardiovascular disease, cancer and dementia.  Our scientists conduct basic, clinical and population health research with the vision of leading the world in promoting metabolic health and eliminating metabolic disease through scientific discoveries that create solutions from cells to society.  

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Columbia University Begins Construction On New York City’s First All-Electric Biomedical Research Building

New building combines state-of-the-art medical research with a vision for a more sustainable future for science, share this page.

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Columbia University Vagelos College of Physicians and Surgeons (VP&S) will begin construction on New York City’s first all-electric university research building in May. The new biomedical research building in Washington Heights is designed by Kohn Pedersen Fox (KPF) and will house eight stories of laboratories and research facilities, collaboration corners, living walls, and community engagement spaces.

The new biomedical research building will become the center of Columbia’s efforts to gain new understanding of diseases and develop next-generation treatments for some of the most significant threats to human health, including neurodegenerative disease, autoimmune disease, metabolic disorders, heart disease, and cancer.

This will be the first university-owned research building in New York City that does not rely on fossil fuels and fully incorporates sustainability goals into all aspects of its design and operations. The new building will use significantly less energy than similar buildings of its kind and is expected to perform 30% more efficiently than the ASHRAE 90.1 2010 standard, an energy efficiency benchmark for commercial buildings in the United States.

Rendering of Columbia University Vagelos College of Physicians and Surgeons’ new biomedical research building (Credit: Kohn Pedersen Fox)

“We are so proud to be laying the groundwork for this innovative new research building at Columbia. To create a space that will advance biomedical science, bring us closer to our local community, and help our medical center reduce its carbon footprint all in one is truly remarkable,” says Katrina Armstrong, MD , d ean of the Faculties of Health Sciences and the Vagelos College of Physicians and Surgeons  and e xecutive vice president for Health and Biomedical Sciences, Columbia University. “ Our purpose as a university is to drive discovery, educate next-generation leaders, and create inclusive partnerships with our community. This new space will offer the best environment for our people to do all three.”

Credit: Kohn Pedersen Fox 

The building’s laboratory floors will house 32 principal investigators and their teams of research technicians, postdoctoral researchers, and graduate students. The building will feature unique collaboration corners between research spaces that will help facilitate spontaneous interactions and idea-sharing among scientists. Biophilic elements such as green walls of living plants and the extensive use of natural, renewable materials will help reduce work fatigue and provide health and environmental benefits. The new building is accessible to community partners, providing ground level space to support community health engagement and research education and dissemination activities.

Research laboratories typically consume five to 10 times more energy per square foot than an average office building, according to the Department of Energy. At a time when scientists are increasingly concerned about the environmental impact of their research, Columbia’s new biomedical research building will set a leading example of a more sustainable future for science. To limit energy consumption, research spaces will incorporate many sustainable design strategies including high-efficiency lab fume hoods, demand-based controls for lab equipment, and air-source electric heat pumps.

The new biomedical building will outperform emission limits set by New York City’s Local Law 97 and help advance Columbia University’s Plan 2030 climate goal of achieving campus-wide net-zero emissions by 2050.

Columbia’s new biomedical research building is the latest in a series of climate initiatives by Columbia University, which includes the establishment of the Climate School in 2020 and launch of a global program to incorporate climate change into medical education.

Biomedical Research & Innovation Center

Jefferson Lab established the Biomedical Research & Innovation Center (BRIC) as a central hub for transitioning state-of-the-art research and technology development from nuclear and particle physics to biological and health-related fields, including: novel cancer treatments, medical imaging, environmental, plant biology, and radiation detection and therapy. Our researchers partner with industry, academia and healthcare organizations to identify instrumentation needs that can enhance research and patient care, or fill technology gaps.

BRIC collaborates with private and public sector partners to develop new devices and systems based on our expert knowledge of particle accelerators and detectors. We engage with community organizations on data-driven research and advanced predictive analytics to facilitate better health outcomes. Several innovations from Jefferson Lab researchers are in use today for cancer treatment and diagnosis, among other applications. The BRIC also facilitates special events, colloquia, and workshops on various topics, including serving as host for the joint NIH/DOE series "Advancing Medical Care Through Discovery in the Physical Sciences.

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A 5-story research/laboratory facility on a 3.3-acre site on the Medical School campus at UCSD. It provides 196,000 SF of research and support space for Health Sciences needed to advance major interdisciplinary programs, including Medical Genomics. In addition it provides research space for new faculty in Pediatrics, Neurosciences, Reproductive Medicine and Surgery. BWE also provided design services for three crosswalks across Osler Lane adjacent to the building and planning and profiling of a duct bank, including existing utility crossings, to services this facility.

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Texas Biomedical Research Institute studies Alzheimers to Zika

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Texas Biomedical Research Institute is pioneering and sharing scientific breakthroughs to protect you, your families and our global community from the threat of infectious diseases. The Institute has an 80-year history of success that includes work on the first COVID-19 vaccine and therapies, the first Ebola treatment, the first Hepatitis-C therapy, and thousands of developmental discoveries. Texas Biomed helps create healthier communities with science that inspires new generations through STEM education programs, delivers jobs and economic impact in our community and heals through innovative research. Learn more about how you can #Stand4Science .

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Texas Biomedical Research Institute is dedicated to the advancement of human health through basic and translational research into the nature, causes, prevention and eradication of disease. Our scientific programs and research resources are focused in the following areas.

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An independent, not-for-profit biomedical research facility committed to improving human health by conducting basic-science research aimed at determining how disease develops at the molecular level. The institute, whose president is Nobel Laureate Herbert Hauptman, is home to the UB Department of Structural Biology.

A National Cancer Institute-designated comprehensive cancer center. For more than a century, Roswell Park’s physician-scientists have made fundamental contributions to reduce the cancer burden and helped set national standards for cancer care, research and education.

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Introduction to Biomedical Research Modalities

• Written by Steph Langel
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This module describes and differentiates basic, translational, and clinical research. Explore various research environments and approaches through faculty interviews and virtual lab tours. Learn how to get involved in research experiences and build your research competencies!

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UCSD Biomedical Research Facility

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The new, 196,000-square-foot Health Sciences Biomedical Research Facility at the University of California, San Diego is one of the most sustainable laboratories in the country. Located on a 3.3-acre site within the UCSD Health Sciences campus, it accommodates new and expanded multi-departmental programs, including bioinformatics, genomic medicine, gastrointestinal medicine, childhood diseases, pathology, immunology, inflammation, psychiatry, cardiology, neurosciences, infectious diseases, and glycobiology. The building is expected to achieve LEED Platinum status. 

The research building fits within the modern design context of the academic mall on the UCSD Health Sciences campus, with its exterior incorporating a combination of architectural concrete, curtain wall, painted aluminum metal panels, and terra cotta cladding. The facility encompasses five floors of wet bench laboratories, open lab space, and lab support space; plus seven stories of administrative office space, interaction spaces and conference rooms. 

The most notable design feature of the building is the dynamic, computer-controlled exterior solar shading system on the east, west and south facades, representing the most extensive use of this type of shading by any building in the UC system.  

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Eminent cancer physician-scientist joins Virginia Tech to lead research in Washington, D.C.

Christopher Hourigan will spearhead innovative cancer solutions at the Fralin Biomedical Research Institute Cancer Research Center in the nation's capital.

John Pastor

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A globally recognized physician-scientist who studies and treats blood cancer is joining Virginia Tech to lead cancer research in Washington, D.C., said Michael Friedlander, Virginia Tech’s vice president for health sciences and technology and executive director of the Fralin Biomedical Research Institute at VTC.

Christopher Hourigan , a senior investigator and chief of the Laboratory of Myeloid Malignancies at the National Institutes of Health, will join Virginia Tech as a professor with the institute and director of its Cancer Research Center in Washington, D.C.

“Dr. Hourigan exemplifies the prototype of a physician-scientist, integrating insights from his patient interactions directly into his fundamental and translational laboratory research,” Friedlander said. “We are extremely enthusiastic to have him join Virginia Tech and become a member of the Fralin Biomedical Research Institute team to take on this important new leadership role for our growing cancer research programs in Washington, D.C., and to further strengthen our collaborations with Carilion Clinic, Children’s National Hospital, and other health systems and universities.

The focus of the research effort, known as Fralin Biomedical Research Institute Cancer Research Center - D.C., is to bring basic, translational, clinical, and computational researchers together in the nation’s capital to focus on the shared aim of engineering cancer solutions. 

“Convening top talent like Dr. Hourigan and developing deep and diverse partnerships are key to solving our most complex global challenges,” said Virginia Tech President Tim Sands. “It’s exciting to see our vision for the university advancing across the commonwealth and in the greater Washington, D.C., metro area.” 

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“I also anticipate the innovations and insights that will emerge from Dr. Hourigan and the other Virginia Tech scientists in D.C. collaborating with the institute's cancer research teams in Roanoke as well as with our computer science and engineering colleagues at Virginia Tech’s new Innovation Campus in Alexandria,” Friedlander said.

Research will involve diverse, expert teams and national and international collaborations.

“We have the opportunity to build a new cancer research center from the ground up, focusing on getting talented and highly motivated teams working in innovative new ways to reduce the burden of suffering from cancer in the United States,” Hourigan said. “It's clear we're not doing well enough for people who are dealing with cancer, and this is our chance to come up with new ways to do better.”

The addition of Hourigan will accelerate the university’s initiatives in Washington, D.C. Newly renovated research facilities on the site of the former Walter Reed Army Medical Center on the Children’s National Research & Innovation Campus already house Fralin Biomedical Research Institute cancer research scientists Jia-Ray Yu and Kathleen Mulvaney , along with teams of researchers from the Center for Genetic Medicine Research and Rare Disease Institute of Children’s National Hospital.

Precise answers to hard questions

Hourigan’s research focuses on a high-risk form of blood cancer called acute myeloid leukemia, which annually affects about 20,000 Americans. He looks at reasons for why some people survive cancer while others end up dying, even though initially they seem to have had the same response to treatment.

“The person who's newly diagnosed with cancer and has gone through treatment will ask a reasonable question, ‘Well, what about me? I want to know what my actual likelihood of surviving is going to be and are you sure I don’t need more or different treatment?’” Hourigan said. “As an oncologist, those are often hard questions to answer. You have a lot of empathy with the person in front of you and wish we could give better, more personalized, answers. We're strongly focused on the idea that if we had better diagnostic tools to allow a precision medicine approach, we could give doctors and patients a better understanding of exactly where they are now and what’s the best thing for them to do next.”

In addition to his primary appointment with the institute, Hourigan will be a professor in the Department of Internal Medicine at the Virginia Tech Carilion School of Medicine .

Hourigan received his medical degree and research doctorates from Oxford University and completed residency and oncology fellowship training at Johns Hopkins University School of Medicine, where he was subsequently a practicing physician on the acute leukemia service and faculty member. He is board certified in hematology and medical oncology.

Prior to joining Virginia Tech, Hourigan was a senior investigator, co-director of the Myeloid Malignancies Program, and chief of the Laboratory of Myeloid Malignancies at the National Institutes of Health. 

He was awarded the Presidential Early Career Award for Scientists and Engineers, the National Institutes of Health Director’s Challenge Innovation Award, and was elected to Alpha Omega Alpha Medical Honor Society. He is a fellow of both the American College of Physicians and the Royal College of Physicians.

He looks forward to the task ahead. 

“Virginia Tech has some key strategic advantages,” Hourigan said. “It is nationally known for engineering and computational science, which are going to be increasingly important components of cancer research. I think there's also this sense of energy, innovation, engineering, and teams working across disciplines on hard problems here. And cancer is a hard problem.”

Ultimately, he wants to put cancer researchers out of business.

“I don't want there to be a need for cancer research anymore, whether that happens in my lifetime or the lifetimes of those individuals I train,” Hourigan said.  “The ultimate objective is not to have an industry of cancer research. Our focus has to be on the patient and on working hard to come up with real solutions to hard problems. It is only with research that we’ll be able to do better with cancer prevention, diagnosis, and treatment tomorrow than we currently can today. We need to have a sense of urgency and purpose because people are counting on us to come up with answers.”

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BIOMED - Biomedical Research Center / AND-RÉ

• Written by Alison Furuto
• Published on March 05, 2012

Representing the consolidation of high sustainability concerns, wise program organization criteria, and a strong iconographic language the Biomedical Research Center proposal by AND-RÉ associates a conventional and regular structural system. The pillars and beams are designed under an orthogonal metric of porches of standard sizing, thus allowing a rigorous organization of the interior – with one exterior covering skin covering made of metallic surface modules. More images and architects’ description after the break.

The high demands of the intricate Laboratories and Bioterium program, involved a rational organization resolution concluded in a system of maximum functionality. The form of the building is not a mere formal/plastic exercise, but an innovative reply before energy and environment necessities. The proposal not only responds to an high demand ambient requirements, but also reached a response of excellency, going beyond the initial requirements.

The volume is understood as a morphic mass, designed under a strategy of solar incidence control. The architecture is the first element to contribute for the success of the organism, answering to the environment commitments, diminishing the dependence in the mechanical systems of artificial environmental control. The system is based in a Morphologic Skin concept that involves the program, rationally distributed in the interior. Although the complex aspect of the form, the proposal appeals to objective construction solutions, executed without shallow forms or plastic artificiality.

Architects: AND-RÉ Location: Coimbra , Portugal Team: Adalgisa de Castro Lopes, Bruno André, Catarina Fernandes, Francisco Salgado Ré, Sara João, Sofia Mota Silva Engineering and Sustainability: AFA Consult Promoter: Coimbra University Area: 9500m2 Year: 2011

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Part 1. Overview Information

National Institutes of Health ( NIH )

C06 Research Facilities Construction Grant

• October 26, 2023 - Notice of Pre-Application Webinar for C06 Research Facilities Construction Grants PAR-23-306 and PAR-24-033. See Notice NOT-OD-24-019
• August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 .
• August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 .

See Section III. 3. Additional Information on Eligibility .

This Notice of Funding Opportunity (NOFO) invites applications from eligible academic and research institutions to apply for funding to modernize existing or construct new biomedical research facilities. Applications will be accepted from public and private nonprofit institutions of higher education as well as from non-profit research organizations. Applications from both research-intensive institutions and Institutions of Emerging Excellence (IEE) in biomedical research, both highly resourced and low-resourced institutions, from all geographic regions in the nation are strongly encouraged.

NIH recognizes the importance of all institutions of higher learning in contributing to the nation's research capacity. The goal of this NOFO is to modernize biomedical research infrastructure to strengthen biomedical research programs. Each project is expected to provide long-term improvements to the institutional research infrastructure. Intended projects are the construction or modernization of core facilities and the development of other shared research infrastructure serving an institution-wide research community with broad impact on biomedical research.

October 5, 2023

December 15, 2023

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

As described in the NIH Grants Policy Statement , an applicant must provide a copy of the application to the State Single Point of Contact (SPOC) no later than the time the application is submitted to NIH. SPOC comments must be submitted to NIH with the application, or the application must indicate the date on which the application was provided to the SPOC for review.

It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 2. Full Text of Announcement

Section i. notice of funding opportunity description.

This Notice of Funding Opportunity Announcement (NOFO) invites eligible institutions of higher education and research organizations to seek funding to modernize and improve existing shared-use research facilities (e.g., core laboratories, animal research facilities, or other collaborative research spaces), or to construct new biomedical research space that will be furnished with essential infrastructure and eligible integrated equipment (subject to the requirements described below under Funding Restrictions), or other necessary casework. The objective of this NOFO is to support the development of modern facilities that will enable and enhance the conduct of high impact, cutting-edge biomedical research with national or regional significance. Thus, any facility supported by this NOFO must serve a broad research community at local (within the applicant's own institution), regional (beyond the applicant's own institution), or national level.

NIH recognizes that modern physical infrastructure is necessary for the conduct of advanced, innovative research. As science progresses and new technologies become available, dedicated space is required to house specialized equipment and to carry out novel experimental protocols. Both Institutions of Emerging Excellence (IEE, as defined in 42 USC 283k(c)(2) ) and non-IEE institutions as well as highly resourced and low resourced institutions are encouraged to apply. Projects will vary and depend on the current institutional infrastructure and long-term institutional strategic plans. Focusing on the advancement of science through the modernization of physical space will be an essential and integral feature of all proposed projects. When completed, construction/modernization projects will have a significant impact by enabling innovative and new research opportunities and/or by raising the research capacities and capabilities to a new and higher level. An institution may request funds to modernize a core facility to create an environment required for research-driven specialized technological services. Likewise, funds may be requested to consolidate space for an institution-wide core which would provide streamlined workflows for contemporary multi-disciplinary investigations. Modernizing laboratory space used on a shared basis to meet the growing needs consistent with an institutional strategic vision for biomedical research is another example of a suitable request. A successful construction/modernization project will serve research teams and a broad range of research efforts. Laboratory space exclusively dedicated to individual Program Directors/Principal Investigators (PDs/PIs), or single research groups, is not supported under this NOFO.

Various factors are typically considered when developing or modernizing research infrastructure. For applications submitted to this NOFO, defined research needs will drive the requests for modern engineering solutions. As science progresses and new technologies become available, required dedicated space must comply with relevant technical specifications to provide a proper and well-controlled environment, to enable novel experimental approaches, and to house specialized equipment. It is encouraged that these new spaces adhere to the highest possible standards of green engineering designs and operations.

Modern physical infrastructure requires the implementation of advanced engineering designs. Some protocols may only be conducted in designated clean rooms, such as barrier facilities for pathogen-free research or space for synthesis of compounds meeting standards for human subject experiments. Certain equipment and/or research protocols require specially shielded rooms or rigorous control of environmental variables such as temperature or humidity. The shared space also needs to be adequately maintained to serve its desired function over many years. The formal structure of an institutional core typically offers effective oversight to ensure that the required engineering standards of a space it occupies are met and maintained over time. Also, such centralized facilities are organized to provide rigorous scientific support for the conduct of research.

NIH recognizes the importance of all institutions of higher learning and research organizations in contributing to the nation's research capacity. NIH intends to award at least 25% of the available funds to support projects from IEEs. These institutions play a special role in advancing biomedical research as they leverage their research abilities to address a problem, concern, or unmet health need. Often these institutions are located in a geographic area whose population includes a significant number of individuals with health status deficit, and the applicant provides health services to such individuals; or is located in a geographic area in which a deficit in health care technology, services , or research resources may adversely affect the health status of the population of the area in the future, and the applicant is carrying out activities with respect to protecting the health status of such population. As a part of their mission, IEEs must have plans and the ability to carry out the plans to conduct biomedical research or provide training to enhance the health of individuals from such population. These institutions often serve as centers for dissemination of health information, training development, and advancement of research. At times, low levels of research funding from NIH, other federal agencies, private foundations, and other sources, as well as a deficit in health care technology, services, or research resources such as a physical research infrastructure, may curtail the full potential of these efforts.

Many IEEs are located in designated geographic locations; however, geographical location, alone, is not sufficient to define an IEE. An institution in an Institutional Development Award ( IDeA )-eligible state may qualify as an IEE if the institution has deficient or inadequate physical infrastructure that deters it from achieving well-defined and well-focused research-related goals. These goals build on local capacity for research that encompasses various factors such as in-house scientific expertise, unique local resources, or special local populations and their health-related needs. Many institutions in non-IDeA-eligible states also meet these criteria and are equally qualified to apply as IEEs.

As IEEs often have low levels of federal and private funding for biomedical research, faculty at these institutions usually contribute a significant amount of their time to teaching either undergraduate or graduate curriculum courses, or both. Note, however, projects that would serve purely didactic activities are not appropriate under this NOFO.

IEE applicants should be striving to establish a particular research or research training capacity that serves the needs described above. Improvements in physical infrastructure are one element that can help meet these needs. An applicant should explain in what domain of biomedical research the institution is seeking to achieve excellence and how this proposed project will advance the effort. Ultimately, to be considered as an IEE for the purpose of this NOFO, an applicant institution must identify itself as an IEE and justify its status see the Project Narrative section for more information.

It is expected that all projects - both from research-intensive institutions and IEEs - will have long-term effects and will benefit broad biomedical research community at the applicant institution by providing a modern research environment that is accessible on a shared basis. It is also expected that projects awarded under this NOFO will have a transformative impact on research at the recipient institution.

Applications based entirely on regular maintenance, replacement of aging or failing equipment, and other routine work are not appropriate for this NOFO, and such applications will not be supported. Applications for upgrades of a space serving a single investigator are also inappropriate as are applications to support facilities for billable medical care, office space, or classrooms.

To appropriately conceive, develop, construct, and successfully complete the construction/modernization project, a PD/PI should possess knowledge of the relevant scientific field(s) to be served by the proposed facility, demonstrate leadership skills, and assemble a team with technical expertise related to all aspects of the project. The PD/PI does not need to be an NIH-funded investigator but should have the appropriate standing in the institutional administration and the research community to lead and oversee the project.

The project should be consistent with the following criteria and documentation requirements:

• The project is essential for biomedical research activities supported and the space involved will be used for these activities.
• The facility must be utilized for biomedical research purposes for which it was constructed or improved for at least 10 years beginning on the date of beneficial occupancy of the space.
• If the project is located in an existing building, the building must have a useful life consistent with program purposes, including the time to construct and complete the project plus 10 years of use following the occupancy of the research space; the building must be architecturally and structurally suitable for conversion to the type of research space required.
• If the space is rented, evidence must be provided that the terms of the lease and expected subsequent 10-year use of the facility are consistent with the proposed project. Specifically, a signed document from the building owner must be provided showing that the terms of the lease agreement and subsequent use of the facility will comply with the 10-year term of the Notice of Federal Interest (NFI) requirement following the occupancy of the facility. A statement of agreement by the owner of the space must be included. These documents will be verified if/when the application is considered for funding.
• If the project will affect a site listed (or eligible for inclusion) in the National Register of Historic Places, the requirements specified in "Preservation of Cultural and Historic Resources" must be followed.

PDs/PIs are strongly encouraged to contact the Scientific/Research Contact listed in Section VII. Agency Contacts to discuss their planned projects before submitting applications. Potential applicants are also encouraged to visit the C06 Frequently Asked Questions web page for additional guidance.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum award budget from Federal funds is $8,000,000 direct cost. Applications with a budget less than $3,000,000 direct cost will not be considered. Since the scope of different projects will vary, it is anticipated that the size of the awards will vary.

The total project period must not exceed five years. Funds will be provided in a single award with up to a 56-month budget and project period.

Architectural and engineering design fees are immediately available to applicants at the time of the Notice of Award (NoA); all other award funds are restricted until ORIP approves the design documents; upon approval, NIH will issue a revised NoA to release the restricted award funds. NIH grants policies are as described in the NIH Grants Policy Statement and will apply to the applications submitted and awards made from this NOFO.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Higher Education Institutions

• Public/State Controlled Institutions of Higher Education
• Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

• Hispanic-serving Institutions
• Historically Black Colleges and Universities (HBCUs)
• Tribally Controlled Colleges and Universities (TCCUs)
• Alaska Native and Native Hawaiian Serving Institutions
• Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

• Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

• System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
• NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
• Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
• eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
• Grants.gov Applicants must have an active SAM registration in order to complete the Grants.gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from diverse backgrounds, including underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities , NOT-OD-22-019 .

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

Multiple PDs/PIs are not allowed.

2. Cost Sharing

This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

Number of Applications

Only one application per institution (identified by NIH IPF number) is allowed.

NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application . This means that the NIH will not accept:

• A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
• A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
• An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications ).

Moreover, institutions with C06 awards funded under the Biomedical Research Facility Program (NOFOs PAR-21-139 , PAR-22-088 or PAR-23-045 ) are not eligible to apply to this NOFO, provided the awards are active on the receipt date for this NOFO. Thus, only one C06 Biomedical Research Facility active award per institution would be allowed at any given time.

Section IV. Application and Submission Information

1. Requesting an Application Package

The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. See the administrative office for instructions for plans to use an institutional system-to-system solution.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Letter of Intent

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

By the date listed in Part 1. Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information:

• Descriptive title of proposed activity
• Name(s), address(es), and telephone number(s) of the PD/PI
• Names of other key personnel
• Participating institution(s)
• Number and title of this funding opportunity

The letter of intent should be sent to:

Yong Chen, PhD Office of Research Infrastructure Programs (ORIP) Telephone: 301-594-1187 Email: [email protected]

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

The following exceptions or additional requirements apply:

• For this NOFO, there is no Research Strategy.
• Overview (use Specific Aims page): 1 page
• Scientific Justifications and Project Description sections: 12 pages in total

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this NOFO.

All instructions in the SF424 (R&R) Application Guide must be followed.

The following additional instructions apply:

Estimated Project Funding: Applicants must provide the 'Total Federal Funds Requested', 'Total Federal and Non-Federal Funds', and 'Estimated Program Income.

Is Application Subject to Review by State Executive Order 12372 Process: Applicants should indicate "yes" and provide the date the application was submitted to the State. Otherwise, the applicant should select "no".

Project Summary/Abstract: The Project Summary/Abstract should contain a succinct and accurate description of the proposed construction project and an explanation of the need for the facility. The application's broad, long-term objectives should be stated, concisely describing how the facility will enhance the infrastructure and biomedical research at the applicant institution.

NOTE: The Project Summary/Abstract must be no longer than 30 lines of text.

Project Narrative: In this section, using no more than two or three sentences, describe the project and the relevance of this project to public health. Be succinct and use plain language that can be understood by a general, lay audience. In addition, using this section to declare the IEE status of the applicant institution. If an IEE Status is claimed, briefly explain the justification, such as indicating the specific underrepresented or underserved populations that will benefit from the biomedical research supported by the proposed project.

Bibliography & References Cited: List only publications that are applicable to the construction proposal.

Facilities & Other Resources: Not Applicable. Do not include an attachment here.

Equipment: Not Applicable. Do not include an attachment here.

Other Attachments:

For this NOFO, the following 12 components are expected in the Other Attachments.

1) Overview (required) (File Name: Overview).

The Overview cannot exceed 1 page and must summarize the project, stating its goals, and outlining the proposed approaches to achieve them. Specifically, this section should include a description of the space affected by the project and any equipment which is requested in this application Tables 1 and 2 may be referenced to simplify the presentation. A short statement should also be included to summarize how the project will enhance institutional-wide research programs and benefit research groups. As a part of this statement, if applicable, an applicant that is an Institution of Emerging Excellence (IEE) must identify and briefly justify its status. In this section, as part of the justification, an applicant should state the long-term goals of improving a particular research or research training capacity or enhancing a research or research training area and how the proposed investments in the physical infrastructure will advance the institution to excellence in that domain.

2) Scientific Justification and Facility Development (required) (File Name: Scientific Justification and Facility Development)

This space is used for Scientific Justification and Development of the Facility. It is up to the PD/PI to allocate the 12 pages allowed for the project description to the sections: Scientific Justification and Development of the Facility. A successful application does not need to reach the page limitation; however, it must justify the request from a scientific perspective and describe technical design approaches with enough details to make clear the merits of the overall project. These merits include plans for long-term use of the space by many researchers.

The Scientific Justification section should focus on how the project will increase the institution-wide biomedical research capabilities and capacities. Defined biomedical research needs should drive the request and this section should make connections to the research community which would benefit from the project. To justify the need for the modernization of a core facility or an institutional laboratory, the PD/PI should describe the space and/or fixed equipment currently available to the institutional research community. The PD/PI should also identify present infrastructure deficiencies that impede biomedical research. The PD/PI should briefly describe the research needs of the community who will rely on the proposed facility.

In the case of an IEE institution , the PD/PI should outline ongoing efforts at the institution for the advancement of biomedical research and relate these efforts to the long-term growth plans at the institution. Plans to solve deficits in the available research infrastructure and funding should be a part of the justification of needs for the new infrastructure. This justification should be specific about the research area to be supported and address the relevant expertise and other available resources on which plans for the research expansion are built. Current NIH research funding is not an eligibility requirement but if available should be included in this project's justification, along with research funding from other sources, including other Federal agencies, private foundations, and the institution (e.g., endowments). Table 3 may be included, as applicable.

At an IEE, new infrastructure is critically needed to further the growth and development of the institution's research or research development and training. IEE applicants should be striving to establish a particular research or research training capacity or research or research training focus that serves the needs described above. Thus, as part of the justification for this project an IEE applicant should explain in what domain they are seeking to become excellent and how this project advances the institution to excellence in that domain.

In the case of research-intensive institutions , a presentation of how the conduct of selected active NIH-funded research projects would be advanced by the new or improved infrastructure, will strengthen the justification. Table 3 may be used to reference individual projects active, at the time of the application submission, and the specific infrastructure needs of the research program these projects are part of. It should be made clear that these needs won't expire when the listed grants end and there is an existing sufficiently strong research community at the institution which will be able to rely on the new infrastructure.

Centers and other resources which support a regional or nation-wide community of researchers should describe their role in enabling specific research activities and illustrate this point by giving examples of NIH-funded research projects which would be directly enhanced by the proposed infrastructure improvements. Here, Table 3 may be referenced. Long-term plans for support of infrastructure and research programs should be outlined to illustrate the institutional commitment for the scientific program.

For all applications, the presentation of this section should provide a bridge between the long-term institutional vision for biomedical research and the proposed infrastructure development. The narrative of this section should make it clear how the facility will be used by or provide services to many researchers.

This section should conclude with a paragraph about how the PD/PI will work with the project Key Personnel on overseeing the planning process and its execution. The team members' individual roles and their responsibilities at different stages of the project should establish their expected contribution towards the overall goal. It is also important for the PD/PI to describe how the team will be organized and demonstrate how its members will work together at different stages of the project. The PD/PI should document that the team as a group has expertise and skills necessary to design and construct the facility so that the scientific objectives are met.

The Development of the Facility section should present technical specifications, details of the architectural and engineering design, and the proposed construction processes. The PD/PI should provide enough details about implementation of the project, including technical challenges that will need to be overcome. This narrative should start with the location of the building in which the facility is to be housed (if a new structure is to be erected) or the location of the existing building (if a present facility is to be modernized) in relation to other buildings in the immediate area. In either case the narrative should also describe the location of the project in the building. The level of detail of the application's Line Drawings, data in Tables 1 and 2 and the narrative of this section must provide sufficient information for reviewers to determine the functionality of the overall design plans, and the safety and reliability of the proposed facility. The design specifications must adhere to the federal and industry standards and meet the requirements set by standard operating procedures described in the section Scientific Justification , as applicable. Schematic-level designs are not necessary at this stage, as long as the provided designs clearly answer design related questions.

In the narrative, all requested fixed equipment should be justified as being relevant to the function of the facility. Fixed equipment may include infrastructure equipment, such as HVAC units serving the facility and other large, fixed equipment that is built into the building structure such as plumbing and electrical systems. In addition to these very essential items for building operations, requests can be made for casework, fixed laboratory equipment or other equipment required to achieve full functionality of the facility as proposed. Also, the installation needs of all fixed equipment in the context of the engineering aspects of the project such as mechanical, electrical, and plumbing (MEP) specifications for their installation, should be presented - see data in Table 2, below.

The PD/PI should provide engineering and architectural criteria as relevant to the project, including:

• MEP specifications, such as hot and cold water, and steam requirements; number of air changes per hour, and any special ventilation requirements;
• fire protection requirements; building automation systems; security/surveillance;
• biohazard and radiation safety requirements; chemicals used;
• width of corridors and doors and surface finishes;
• quality of life issues (e.g., light levels, natural lighting, noise, vibration);
• functional relationships and zoning of the area.

All these criteria should be justified in the context of the specific function(s) of the requested facility, and a description of how they will be met should be provided. Construction design for the NIH-funded facilities shall conform to the latest edition of the NIH Design Requirements Manual (DRM) .

In summary, all requests must be justified in terms of both the scientific needs and the corresponding technical requirements for the facility. In particular, to address the rationale for the technical design, plans for the use of the facility must be clearly outlined. Attention must be paid to federal and industry biosafety standards and codes, so upon the completion of this project, the occupancy permit can be secured, and the facility can serve its research purpose.

Whenever practicable, the applicant should employ sustainable design practices and green technologies. Sustainability is the outcome of an integrated process of facility development and operation, incorporating a balance of life-cycle cost, environmental impact, and occupant health, safety, security, and productivity. The following primary elements of sustainable design should be discussed, as applicable:

• Optimization of energy use;
• Protection and conservation of indoor water (i.e., fixtures that reduce amount of water used; recycling of wastewater when appropriate) and outdoor water (i.e., natural site drainage and low impact storm water retention);
• Indoor environmental quality, including ventilation and thermal comfort, humidity control, day lighting;
• Reducing the environmental impact of materials by using low-emitting materials and minimizing the use of ozone depleting compounds, construction waste reuse and recycling, maximizing recycled and bio-based content.

If an award is made, for all improvements and repair projects that impact 40% or more of the overall floor area of a building, the applicant must obtain certification, during the design phase, from the U.S. Green Building Council's Leadership in Energy and Environmental Design (LEED) or the Green Building Initiative's Green Globes System Certification rating system.

3) Annotated satellite and/or map views of the envisioned construction site : illustrate the location of the construction and relationship with respect to adjacent buildings, areas, and roads (name the attachment: Annotated map views).

4) Line Drawings (required, name the attachment: Line drawings): Each line drawing must be formatted to fit on an 8.5" x 11" sheet of paper. (Do not submit "blueprints".) All floor plans must be legible, with the scale clearly indicated on each page. The floor plans must indicate the location of equipment and illustrate safety clearances and workspace. If applicable, submit drawings of the existing and proposed space. The drawings must indicate:

• functional layout of the entire area;
• size dimensions, function, and the net and gross square feet for each room;
• location of the proposed construction/renovation area in the existing building including building name/ address and the floor(s) affected) with affected/ renovated areas clearly marked;
• changes or additions to existing mechanical, electrical and plumbing systems; notes that annotate these changes may be made directly on the plan;
• functional layout of the proposed facility, showing the location of entries and exits, egress routes, clearances, and the location of fixed equipment.

Note, construction designs for NIH-funded facilities shall conform to the latest edition of the NIH Design Requirements Manual (DRM) . Although the line drawings do not count toward the page limits, do not include additional text.

5) Table 1 (required): list the size (dimensions) and square footage of each component (e.g., clean room, laboratory, closet etc.) that will be directly affected by the project. (name the attachment: Dimension Table)

6) Table 2 (required): list of requested fixed equipment. Table 2 should include information such as the manufacturer, model number, size, capacity, total cost, and location in the facility. Total cost of each item must be supported by vendor quotes in the Budget Justification and Vendor Quotes attachment (see below). (name the attachment: Equipment Table)

7) Table 3 (optional): list of active research grants which are directly related to the project. This table must have the following columns: (1) Funding Agency; (2) Grant Number; (3) PD/PI Name; (4) Annual Direct Costs for the current fiscal year; (5) Start and End Dates. Do not list more than 12 relevant grants. (name the attachment: Active grants)

8) Project timeline (required): To demonstrate how the project will be completed within the five-year budget and award period. Please include the major steps in the project. (name the attachment: Project timelines)

9) Budget Justification and Vendor Quotes (required, name the attachment: Budget Justification and Quotes): Justify and describe the application budget for the project. All vendor quotes should be attached here. In addition to supplying vendor quotes as applicable, the budget justification should include detailed breakdowns of the costs that comprise each of the budget categories:

• Administrative and legal expenses;
• Land, structures, rights-of-way, appraisals, etc.;
• Relocation expenses and payments;
• Architectural and engineering fees:
• Site preparation work;
• Demolition and removal;
• Construction;
• Project inspection fees;
• Contingencies.

10) Institutional Support Letter (required, name the attachment: Institutional Support Letter(s)). A letter from a high-ranking institutional official (e.g., Dean, Provost, President) indicating institutional support for the research activities to be conducted in the new facility and to document that it will be used as proposed. The letter must be co-signed by an institutional Signing Official. This letter should include plans to support such expenses as future operating and maintenance costs, staff salaries, and user training (if needed).

11) Certification of Title to Site (required, name the attachment: Certification of Title to Site): Applicants must include a legal opinion describing the interest the applicant institution has in the performance site. The legal opinion should describe any mortgages or other foreclosable liens on the property, including the principal amount of the mortgage (and rate of interest); the dates of the mortgage; the terms and conditions of repayment; the appraised value of the property; and any provisions designed to protect the Federal interest in the property. The facility must be utilized for biomedical research purposes for which it was approved for at least 10 years beginning on the date of beneficial occupancy of the space. Any lease agreement must cover a length of time sufficient for the usage requirement and be a minimum of 10 years in length from the completion of the facility.

12) Support Letters (optional): A maximum of seven optional support letters may be attached. Attach all the support letters in a single file (name the attachment: Support Letters).

The PD/PI must recruit Key Personnel with complementary scientific and technical skills. The PD/PI should be a PhD-level scientist who has a significant role at the applicant institution to ensure the success of the construction/modernization project, for example, a College Dean who oversees research space, Director of an Institute or Center, or a Scientific Director of a Core Facility. Also, an individual with technical proficiency in engineering or architectural matters related to the design and oversight of the technical aspect of the operation of the facilities must be identified for this application. This person, the construction Project Manager, will closely work with the PD/PI and an outside consulting firm on all technical aspects of the project, including planning, designing, constructing, completing, and commissioning of the facility. A project role for this person should be specified as "Other" or "Other Professional" and a biographical sketch with relevant information about their professional qualifications and expertise must be attached.

Depending on the scope of the project other Key Personnel, such as a Facility Manager, may be identified. The Facility Manager should provide appropriate expertise to assist with setting scientific requirements for the technical design and to make possible the immediate use of the completed facility. Often, this person would be a PhD-level scientist; for example, a DVM/VMD if an animal facility is requested or a scientist/core director if a specialized-used facility is planned.

The Budget Information for Construction Programs (SF424C) must be used to attach an overall application budget page for the total requested funds.

Applicants must provide the "Total Federal Funds Requested", "Total Federal and Non-Federal Funds", and "Estimated Program Income' on the SF424 (R&R) Cover form.

There are no indirect costs permitted under the C06 mechanism.

3. Unique Entity Identifier and System for Award Management (SAM)

See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov

4. Submission Dates and Times

Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications .

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

5. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

6. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .

Pre-award costs are allowable only as described in the NIH Grants Policy Statement .

The requested budget can support design, construction activity and purchase of fixed equipment and its installation costs. The total amount of these essential fixed equipment items, e.g., fume hoods, biosafety hoods, autoclaves, ice makers, etc, may not exceed 10% of the total federal request to NIH. This 10% does NOT include the HVAC, plumbing, electrical, etc. that are integral to obtaining a certificate of beneficial occupancy, but only research-related equipment as described above.

Allowable costs include:

• appraisals;
• bid advertising;
• inspection and commissioning fees;
• contingency fees (Allowable contingency fees are limited to 15 percent of the total allowable costs before bids are received and must be reduced to 10 percent after a construction contract has been awarded.);
• filing fees for recording of NFI.

Not-allowable costs include:

• bonus payments to contractors;
• consultant fees not related to actual construction;
• damage judgement suits;
• non-fixed equipment;
• scientific instruments (e.g., microscopes, scanners, spectrometers);
• FDA approval process following the completion of the construction project;
• fundraising expenses;
• interior and exterior decorating fees (e.g., purchase of artwork, sculpture, etc.)
• parking lot construction, exterior bike racks, electric car charging stations, and/or exterior landscaping

To protect the Federal interest in improved real property, grantees will be required to file an NFI in the Land Record Office of the jurisdiction where the facility will be located as required by 45 CFR 75.323 and the NIH GPS . The NFI is required when use and disposition conditions apply to the property as stated in the NoA. The time of its recordation shall be when construction begins. A copy of the recorded NFI must be provided to the Grants Management Office within 10 days following the date of recordation - see Section VII Agency Contacts Funds will be awarded in a single action using a five-year budget and project period.

If awarded, all funds will be restricted except for Project Design and Engineering Fees. NIH must approve the design documents before releasing the restricted funds. The awardee will be asked to submit the design documents for technical review. The purpose of the NIH design review is to ensure that applicable design standards are incorporated into the drawings and specifications so that the program requirements can be met. It is expected that the technical review process will be conducted in three stages for:

• Schematic Design Documents (SDDs) (15-35%),
• Development Design Documents (DDDs) (50-65%), and
• Construction Design Documents (CDDs) (95-100%).

Review at each stage may take 4-6 weeks. The applicant must submit SDDs within 4 months following the receipt of the Notice of Award (NoA), but considering the technical review timeline, the earliest possible submission of the design documents is encouraged following the receipt of the NoA. In general, most applicants require 16 months to complete the technical design phase, although this timeframe can be longer or shorter.

Note, changing scope of a construction project requires substantial redesigns, extra round of submissions of all three phases of design documents, and additional technical design reviews. Changing project scope inevitably increases the costs and shortens the available time for construction. As the C06 budget period cannot be extended, the institution must pay for any construction components completed after the budget period of the C06 award. It is unlikely to obtain an approval of a request for major changes of the scope of the construction project after the technical review process is completed and the revised NoA is issued.

The Environmental Analysis Form is not required at the time of the application submission. Instead, a Grants Management Specialist will request this information as part of the Just-in-Time process ( NOT-OD-10-120 ).

7. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with preparing the electronic application or for more information on the electronic submission process, visit the How to Apply - Application Guide . If applicants encounter a system issue that threatens the applicant's ability to complete the submission process on-time, the applicant must follow the Dealing with System Issues guidance . For assistance with application submission, contact the Application Submission Contacts in Section VII .

Important reminders:

All PDs/PIs must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization's profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete, non-compliant and/or nonresponsive will not be reviewed.

Applicants are required to follow the instructions for post-submission materials, as described in the policy .

Any instructions provided here are in addition to the instructions in the policy.

Section V. Application Review Information

1. Criteria

Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Reviewers will consider each of the review criteria below in the determination of scientific merit and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Does the applicant provide sufficient evidence of meritorious research program(s) that will benefit from completion of the project? How well are the component parts of the research program (that will be carried out in the facility) coordinated and managed? How will the proposed repair, renovation, or modernization activity facilitate the applicant institution's ability to conduct, expand, improve, or maintain biomedical or behavioral research?

Is there sufficient justification for improving this core facility? To what extent will the proposed change in the research environment facilitate the applicant institution's ability to conduct, expand, improve, or maintain biomedical or behavioral research? How will the proposed repair, renovation, or modernization activity increase efficiency in the use of energy, water, and/or materials to reduce adverse effects on the environment?

Specific to this NOFO, if applicable, are the long-term plans provided by an Institution of Emerging Excellence (IEE) for support and advancement of research meritorious? How are these plans related to the currently present research capacities at the IEE?

How effective is the facility manager likely to be, based on 1) the administrative approach to managing the facility, 2) the ability to interact with appropriate institutional officials to see that the ongoing needs of the facility are satisfied, and 3) the skills necessary to complete the project on time and within budget?

How effective is the PD/PI likely to be, based on 1) leadership qualities and experience, 2) institutional commitment and support, and 3) the appropriate scientific and fiscal administration skills necessary to complete this project on time and within budget? Does the applicant provide evidence of future commitment in maintaining this facility?

Specific to this NOFO, if applicable, how likely is the proposed infrastructure improvement at an IEE to expand research capacity addressing problems specific to the geographic areas or of special relevance to the underrepresented population in biomedical research or to individuals from groups of diverse backgrounds?

How likely is the proposed activity to benefit research at other institutions in the local geographic area, given the availability or absence of similar or related facilities? In which ways is the proposed activity likely to affect similar or related national facilities or benefit research nationwide?

How compelling are: 1) the identified need(s) in the research capabilities in the applicant organization and elsewhere that the proposed repair, renovation, or modernization activity is intended to address; 2) tangible benefits to the institutional research capability of the proposed activity; and 3) state-of-the-art research capabilities or efficiencies that would otherwise not be available?

Are requests for equipment justified and of direct benefit to the facility? Will the requested equipment remedy identified deficiencies or fill gaps in the animal facility?

Design Plan: How likely is the design plan to meet the identified need(s), based on: 1) proposed demolition areas and/or renovation areas, including associated room adjacencies, traffic patterns for the movement of people, animals, and materials (clean and dirty) through the facility, and relative location of needed ancillary areas (e.g., changing rooms for animal facilities); 2) total net and gross square feet of space to be renovated; 3) proposed timeline and sequence of construction; 4) potential problems, alternative strategies, and benchmarks for success presented; and 5) implement sustainable design principles? Engineering Criteria: How likely are the engineering systems to meet the identified need(s), based on: 1) the engineering criteria, including information about the mechanical, electrical, and plumbing systems, and utilities in the renovation; 2) descriptions of changes or additions to existing mechanical and electrical systems; and 3) the number of air changes per hour, electrical power, light levels, hot and cold water, and steam? Architectural Criteria: How likely are the architectural criteria and finishes to meet the identified need(s), based on: 1) the size dimensions, function, and net and gross square feet for each component; 2) architectural criteria such as the width of corridors and doors and surface finishes for the project; and 3) quality of life issues (e.g., natural lighting, noise, vibration)? Line Drawings: How likely are the line drawings to meet the identified need(s), based on: 1) the indicated function of the space; 2) the scale of the line drawings, and indication of adjacencies and operational relationships of equipment; 3) changes to be made to the space; and 4) location of major equipment, fume hoods, sinks, showers, and other major items indicated in the drawings?

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

Not Applicable

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).

Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

2. Review and Selection Process

Applications will be evaluated by (an) appropriate Scientific Review Group(s) , convened by The Center for Scientific Review , using the stated review criteria . Assignment to a Scientific Review Group will be shown in the eRA Commons.

As part of the scientific peer review, all applications:

• May undergo a selection process in which only those applications deemed to have the merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
• Will receive a written critique.

Appeals of initial peer review will not be accepted for applications submitted in response to this NOFO.

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this NOFO. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:

• Scientific and technical merit of the proposed project as determined by scientific peer review.
• Scientific merit of the research activities that will be carried out in the proposed facility
• Available funds under NIH extramural construction appropriation.
• Relevance of the project for which construction is proposed to the objectives and priorities of the particular program authorized by the Public Health Service Act
• Availability, by affiliation or other association, of other scientific or health personnel and facilities to the extent necessary to carry out effectively the program proposed for the facility, including the adequacy of an acceptable biohazard control and containment program when warranted
• The need for the facility and its total effects on similar or related facilities in the locale, and the need for appropriate geographic distribution of similar facilities
• The project design and cost effectiveness.

3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons . Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.

Information regarding the disposition of applications is available in the NIH Grants Policy Statement Section 2.4.4 Disposition of Applications .

Section VI. Award Administration Information

1. Award Notices

If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement .

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.

Awardees must comply with any funding restrictions described in Section IV.6. Funding Restrictions . Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.

2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities , including of note, but not limited to:

• Federal-wide Standard Terms and Conditions for Research Grants
• Prohibition on Certain Telecommunications and Video Surveillance Services or Equipment
• Acknowledgment of Federal Funding

If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.

Should the applicant organization successfully compete for an award, recipients of federal financial assistance (FFA) from HHS will be required to complete an HHS Assurance of Compliance form ( HHS Assurance of Compliance form (HHS 690) ) in which the recipient agrees, as a condition of receiving the grant, to administer programs in compliance with federal civil rights laws that prohibit discrimination on the basis of race, color, national origin, age, sex and disability, and agreeing to comply with federal conscience laws, where applicable. This includes ensuring that entities take meaningful steps to provide meaningful access to persons with limited English proficiency; and ensuring effective communication with persons with disabilities. Where applicable, Title XI and Section 1557 prohibit discrimination on the basis of sexual orientation, and gender identity, The HHS Office for Civil Rights provides guidance on complying with civil rights laws enforced by HHS. See https://www.hhs.gov/civil-rights/for-providers/provider-obligations/index.html and https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html .

HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator's scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.

• For guidance on meeting the legal obligation to take reasonable steps to ensure meaningful access to programs or activities by limited English proficient individuals see https://www.hhs.gov/civil-rights/for-individuals/special-topics/limited-english-proficiency/fact-sheet-guidance/index.html and https://www.lep.gov .
• For information on an institution's specific legal obligations for serving qualified individuals with disabilities, including providing program access, reasonable modifications, and to provide effective communication, see https://www.hhs.gov/civil-rights/for-individuals/disability/index.html .
• HHS funded health and education programs must be administered in an environment free of sexual harassment, see https://www.hhs.gov/civil-rights/for-individuals/sex-discrimination/index.html . For information about NIH's commitment to supporting a safe and respectful work environment, who to contact with questions or concerns, and what NIH's expectations are for institutions and the individuals supported on NIH-funded awards, please see https://grants.nih.gov/grants/policy/harassment.htm .
• For guidance on administering programs in compliance with applicable federal religious nondiscrimination laws and applicable federal conscience protection and associated anti-discrimination laws see https://www.hhs.gov/conscience/conscience-protections/index.html and https://www.hhs.gov/conscience/religious-freedom/index.html .

Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697.

In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant's integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 and 2 CFR Part 200.206 "Federal awarding agency review of risk posed by applicants." This provision will apply to all NIH grants and cooperative agreements except fellowships."

3. Data Management and Sharing

Note: The NIH Policy for Data Management and Sharing is effective for due dates on or after January 25, 2023.

Consistent with the NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the NIH Grants Policy Statement . Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.

Not Applicable for construction awards.

4. Reporting

Progress reports for multiyear funded awards are due annually on or before the anniversary of the budget/project period start date of award. The reporting period for multiyear funded award progress report is the calendar year preceding the anniversary date of the award. Information on the content of the progress report and instructions on how to submit the report are posted at http://grants.nih.gov/grants/policy/myf.htm .

A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement . Following completion and occupancy of the facility, recipients must certify on a yearly basis for 10 years that the facility is used to conduct biomedical research.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.

In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 Award Term and Conditions for Recipient Integrity and Performance Matters

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date , and post-submission issues)

Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact) Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources) Email: [email protected] (preferred method of contact) Telephone: 301-637-3015

Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace) Contact Center Telephone: 800-518-4726 Email: [email protected]

Jonathan Ivins, Ph.D. Center for Scientific Review (CSR) Email: [email protected]

Kenneth Holiness NHLBI ORIP Team Telephone: 301-480-6854 Email: [email protected]

Section VIII. Other Information

Recently issued trans-NIH policy notices may impact an applicant's application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts . All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284), 42 USC 283k, and under Federal Regulations 42 CFR Part 52b and 45 CFR Part 75.

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files .

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Founding Director of the Center for Biomedical Research and Innovation

Georgia Southern University

Academic Career & Executive Search is pleased to assist Georgia Southern University in its search for Founding Director of the Center for Biomedical Research and Innovation (CBRI).

For full consideration, please apply by May 17, 2024.

This is a remarkable time for an innovative and visionary leader to join Georgia Southern University in this pivotal role as the Founding Director of the proposed Center for Biomedical Research and Innovation (CBRI). In this role, the Director will shape and grow CBRI’s national and international research profile as they lead the Center’s scientists in research on the world’s most prevalent and serious health problems. In alignment with the University’s Research Excellence Strategic Plan , the successful candidate will forge meaningful partnerships aimed at fostering a culture of collaboration and multidisciplinary approaches to propel the Center toward high-impact biomedical research excellence.

Primarily housed on the Armstrong campus (Savannah), the Center will be the central point of engagement for research collaboration between the Medical College of Georgia (MCG) medical school, future dental school and biomedical researchers at Georgia Southern. The Director will be responsible for establishing policies, procedures and infrastructure for the CBRI and translating research to the public. With a strategic mission focused on advancing the understanding and treatment of human diseases and ailments through biomedical research, the Center Director will develop cluster areas that encourage collaboration and multi-PI research teams, encompassing various potential research focus areas:

• Cardiovascular
• Molecular Medicine
• Pharmacology
• Bioinformatics & Computational Biology
• Infectious Diseases
• Genomics & Genetics
• Biochemistry & Molecular Biology

This position reports to the Dean of the College of Science and Mathematics (COSM) and should possess a robust track record in research and leadership within a field relevant to the Center.

DUTIES AND RESPONSIBILITIES

• Provide a coherent vision for collaborative biomedical research through effective leadership that embraces the full range of disciplines represented by CBRI.
• Establish the research, policy, and human infrastructure for the effective management of the Center.
• Lead a nationally recognized externally funded research program in their own area of expertise while also fostering research and collaborations with other center faculty affiliates across a wide range of contemporary biomedical fields of study
• Develop CBRI's national and international profile.
• Develop mutually beneficial R&D partnerships with industry, government, and private partners.
• Foster and support high quality research and scholarly activities within CBRI by ensuring a stimulating, collegial, and well-managed environment.
• Attract, lead, retain and develop faculty and staff who will promote academic and research excellence within CBRI and will contribute to the successful development of CBRI, COSM, and the University.
• Manage resources effectively to ensure CBRI is self-sustainable after a period of 5 years.
• Engage a range of internal and external stakeholders to COSM and the University to collaboratively identify research opportunities and partnerships.

MINIMUM QUALIFICATIONS

• A terminal degree, Ph.D., M.D., or M.D./Ph.D. or other science or health-related terminal degrees (i.e., Pharm.D., D.V.M., D.D.S., D.M.D., D.P.H.).
• Extensive research experience working in an academic, industrial, or government research setting.
• At least 5-10 years of experience leading successful cross-disciplinary research teams, as evidenced nationally and, preferably, internationally.
• Experience, or at least the firm understanding, in the range of scientific disciplines and areas represented by CBRI's mission.
• Acute understanding of the priorities, operation, and strategies of securing externally funded grants and contracts to support research.
• Proven capacity to successfully mentor and develop early-career researchers.
• History of successful and effective staff management and professional development.
• Proven capacity to successfully train and develop early-career researchers.

PREFERRED QUALIFICATIONS

• PhD., M.D., or M.D./Ph.D.
• Strong academic record and eligibility for the rank of Professor in an appropriate academic department at Georgia Southern University.
• Extensive research experience at a research-intensive university.
• Successful and sustained record of achieving high levels of research-based funding as a Principal Investigator.
• Existing externally funded research in areas of science represented by CBRI and the desire to maintain funding while serving in the Director position.
• Experience developing and leading successful partnerships with any or all the following external partners: peer universities, healthcare organizations, corporations, governmental agencies, community-based organizations, and concerned individuals.
• A record of pursuing and supporting technology transfer and licensing, and economic development activities.

About the Institution

Georgia Southern University is an R2 public university in the state of Georgia and is the fifth-largest institution in the University System of Georgia. Serving over 26,000 students, Georgia Southern University’s 10 colleges, schools and departments offer 132 different degree programs at the bachelor’s, master’s and doctorate levels. These programs are offered on the University’s beautiful campuses in Statesboro, Savannah, Hinesville and through online instruction. Whether a recent high school graduate, a military-affiliated student or an adult learner seeking to advance a career, Georgia Southern has a place to call home for everyone, ranking nationally in the Top 100 degree producers for diverse students. Georgia Southern University ranks in the Top 10 Most Affordable Cities for Students in Georgia ( University Magazine 2023 ), and was named a “Military-Friendly” school for six years in a row and a Gold School for 2023-2024 by Viqtory Media . For additional recognitions, visit Points of Pride.

Since 1906, the University’s hallmark has been a culture of engagement that bridges theory with practice, extends the learning environment beyond the classroom and promotes student growth and life success. Central to the University’s mission is the faculty’s dedication to excellence in teaching and the development of a fertile learning environment exemplified by a free exchange of ideas, high academic expectations and individual responsibility for academic achievement. Faculty, staff, and students embrace core values of collaboration, academic excellence, discovery and innovation, integrity, openness and inclusion, and sustainability.

About the College

The College of Science and Mathematics (COSM) is one of 10 colleges that comprise Georgia Southern University. COSM strives for excellence and innovation in undergraduate and graduate research, teaching practice and service to our community. With an emphasis on high-impact and inclusive teaching strategies, our highly respected faculty foster learning in the classroom and beyond by promoting student engagement and offering innovative research opportunities to students.

The College offers undergraduate and graduate degree programs on the Armstrong (Savannah) and Statesboro campuses through the Departments of Biology, Biochemistry, Chemistry and Physics, , Mathematical Sciences, Military Science, The School of Earth, Environment, and Sustainability a as well as the Institute for Coastal Plain Science. In addition, the College offers the Associate of Science degree in the core curriculum (with science/math Area F concentration) and courses to meet the University’s general education requirements at the Liberty Campus in Hinesville.

The College boasts state-of-the-art teaching and research labs, including geospatial technology labs, an aquatics lab, microscopy suites, mass spectrometry suites and additional instrumentation necessary to support our faculty members’ diverse research interests and facilitate their numerous collaborations. The College recently created the COSM Core Research Laboratory (CCRL) to enhance our research capabilities. Additionally, the College houses animal care spaces, greenhouses, herbaria and an insectary where insects can be raised and studied. The College is also home to three large research collections (Herpetology, Entomology, and Botany). Our biochemistry and chemistry degrees are accredited by the American Chemical Society(ACS-certified) and the biochemistry degree is also certified by ASBMB.

Living in the Area

Visiting one of Georgia Southern University's campuses offers a unique opportunity to experience the diverse educational environments and vibrant communities that each location has to offer. The Statesboro Campus provides a traditional collegiate atmosphere with beautiful green spaces and state-of-the-art facilities. The Armstrong Campus in Savannah, located in the heart of the historic city, offers a dynamic urban setting, while the Hinesville Campus serves as a convenient option for military-affiliated students.

With a population of 150,000, Savannah is the oldest city in the state of Georgia, enjoying history and architecture dating back over 200 years. Savannah’s Spanish moss-draped buildings, thriving arts scene, warm summers and mild winters have drawn tens of thousands to the Hostess City and the wider metropolitan area over the last two decades. It is Georgia's fifth-largest city and the Savannah metropolitan area, Georgia's third largest, had a 2020 population of over 400,000.

Nestled on the salt marshes of coastal Georgia, the state’s oldest city continues to attract new residents with its low cost of living and historic charm. The cost of living in Savannah is 10% lower than the national average. However, what sets Savannah apart the most is the fact that housing in the area is 23% lower than the national average. Additionally, the Savannah metropolitan area has seen a population explosion in recent years, bolstered by Gulfstream Aerospace Corp.’s headquarters, and the new Hyundai Motors Metaplant located just outside of the growing city. The $5.5 billion manufacturing facility plans to employ 9,000+ workers creating an ideal environment for career growth and professional development.

For full consideration, please apply by May 17, 2024.   

To be viewed by the search firm, you must apply directly at: https://acesrch.applicantstack.com/x/detail/a21esjyw7il8

  Please apply through the application link and do not email applications.  

  Applications will be reviewed as they are received and should include a cover letter and curriculum vita. Ideally cover letters should not exceed two pages. All applications are treated confidentially.

  Inquiries, referrals, and nominations are also treated confidentially.

  Inquiries and questions : Please send to [email protected]

Nominations and referrals : Please send the nominees’ name, title, and contact information if available to [email protected].

Georgia Southern University provides equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, sexual orientation, gender identity or expression, national origin, religion, age, veteran status, political affiliation, or disability. Individuals in need of reasonable accommodations under the Americans with Disabilities Act to participate in the search process should notify Human Resources: (912) 478-6947.

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COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Programmer Analyst

• Biomedical Informatics
• Columbia University Medical Center
• Opening on: Apr 5 2024
• Job Type: Officer of Administration
• Bargaining Unit:
• Regular/Temporary: Regular
• End Date if Temporary:
• Hours Per Week: 35
• Standard Work Schedule: Monday - Friday
• Building: PH-20
• Salary Range: $140,000-$145,000

Position Summary

The Department of Biomedical Informatics (DBMI) at Columbia University has an opening for a Programmer Analyst.  Incumbent will work on the full pipeline for translation of research into deployed point-of-care applications for clinicians, such as patient record summarization systems, and mobile health tools for patients, such as self-tracking tools.  Incumbent will work under the supervision of Dr. Noemi Elhadad.

Responsibilities

• Design and implement code for backend and frontend of point of care and mobile tools for clinicians and patients.
• Prepare and administer datasets for experiments related to validation of such tools.
• Participate in meetings with researchers and other programmers.
• Other duties as assigned.

Minimum Qualifications

Requires a bachelor's degree or equivalent in computer science and experience, plus four years of related experience.

Preferred Qualifications

Master's degree in biomedical informatics, computer science, or equivalent field is a plus.

Other Requirements

• Must have experience in web development, cloud (Azure and AWS), use of relational and non-relational database, use of natural language processing and machine learning tools.
• Must be detail-oriented, self-motivated and require minimal direction.
• Must possess the ability to manage multiple, parallel activities and organize time and resources is a must.
• Excellent verbal and written communication skills are required.
• Experience in biomedical informatics is a plus.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.

Commitment to Diversity 

Columbia university is dedicated to increasing diversity in its workforce, its student body, and its educational programs. achieving continued academic excellence and creating a vibrant university community require nothing less. in fulfilling its mission to advance diversity at the university, columbia seeks to hire, retain, and promote exceptionally talented individuals from diverse backgrounds.  , share this job.

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Office of Neuroscience Research

Distinguished Lecture on Biomolecular Condensates and Mini Symposium: Ashutosh Chilkoti (Duke University), Dmitri Nusinow (Danforth Plant Science Center), Min Kyung Shinn (Pappu lab, WashU Biomedical Engineering)

Lecture Ashutosh Chilkoti: “Biomolecular Condensates from Synthetic Intrinsically Disordered Proteins: Tools for Biotechnology and Synthetic Biology”

Mini symposium talks Dmitri Nusinow: “The role of disorder in the assembly of photoreceptor condensates in plants” Min Kyung Shinn: “Nuclear speckle proteins form intrinsic and RNA-dependent microphases”

Hosted by the Center for Biomolecular Condensates

Join us for the final talk of the semester in the 2023-2024 Distinguished Lectures on Biomolecular Condensates Series sponsored by the Center for Biomolecular Condensates in the James McKelvey School of Engineering. Our distinguished speaker will be  Dr. Ashutosh Chilkoti , the Alan Kaganov Professor of Biomedical Engineeringfrom  Duke University . Dr. Chilkoti is a pioneer in the field of thermoresponsive phase transitions and the design of synthetic intrinsically disordered proteins that form condensates in different settings and have been deployed as devices and sensors in a variety of biotechnology and synthetic biology settings.  The talk,  scheduled for 4:15 PM on Thursday, April 11, 2024, will be presented in Whitaker Hall, Room 100, located on the east end of the Danforth campus. 

The title of Dr. Chilkoti’s talk will be Biomolecular Condensates from Synthetic Intrinsically Disordered Proteins: Tools for Biotechnology and Synthetic Biology . 

Dr. Chikoti’s lecture will be part of a mini symposium that will feature two 25-minute talks by members of the Center for Biomolecular Condensates. The first talk, between  3:00 PM and 3:30 PM,  will be given by  Dr. Dmitri Nusinow , Associate Member and PI in the Donald Danforth Plant Sciences Center.   His talk will be entitled:  The role of disorder in the assembly of photoreceptor condensates in plants . The second talk, between  3:35 PM and 4:05 PM  will be given by  Dr. Min Kyung Shinn , Postdoc in Biomedical Engineering.  Her talk will be entitled: Nuclear speckle proteins form intrinsic and RNA-dependent microphases . There will be a reception following the mini symposium and lecture by Dr. Young.

For inquiries contact Rohit Pappu .

Please RSVP by Monday, April 15, 2024

Aha sfrn semi-annual meeting, boston, may 13&14, 2024.

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