Depression, bipolar disorder, ADHD, schizophrenia and autism genetically linked
Genetic origins of schizophrenia
PPT
(PDF) New findings from schizophrenia gene study
Figure 1 from Clustering of metabolic comorbidity in schizophrenia: a genetic contribution
Perceptions of mental illness: Do biological explanations reduce stigma?
VIDEO
HY Genetics QOTD #31: Schizophrenia Inheritance Principles
Understanding Schizophrenia: Breaking Stigma and Finding Hope
How Does Biology Explain Schizophrenia?
Finding Genetic Variation in Soybean (Glycine max (L.) Merrill) Flowering Time by Simple Sequence
Decoding the genetic and physiological basis of schizophrenia
Schizophrenia: Genetics or Energy Dysfunction?
COMMENTS
Genetics of Schizophrenia: Overview of Methods, Findings and Limitations
Genetics of Schizophrenia: Overview of Methods, Findings and Limitations. Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia. However, the complexity of the object of inquiry makes it ...
Genomic findings in schizophrenia and their implications
There is a negative genetic correlation between common alleles associated with schizophrenia and those associated with cognitive ability (r g = −0.21) , which, given the similar SNP ...
Neurobiology of Schizophrenia: A Comprehensive Review
Schizophrenia is a debilitating disease that presents with both positive and negative symptoms affecting cognition and emotions. Extensive studies have analyzed the different factors that contribute to the disorder. There is evidence of significant genetic etiology involving multiple genes such as dystrobrevin binding protein 1 (DTNBP1) and ...
The genetic architecture of schizophrenia: review of large-scale
The genetic findings from CNV studies have also provided insight into the pathogenesis of schizophrenia. Here, we describe examples of two CNVs: 22q11.2 deletions and ARHGAP10 CNVs. The 22q11.2 ...
The schizophrenia genetics knowledgebase: a comprehensive ...
Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not ...
The Longtime Challenges—and New Progress—in Uncovering the Genetic
A GOAL OF genetics research in schizophrenia has been to identify specific genes that confer risk for schizophrenia and other genes that confer resistance. This is based on the vast experience in other branches of medicine that identification of disease risk or resilience genes helps inform the neurobiological basis of illness and guide the ...
Genetics of schizophrenia (Review)
Associated Data. A comprehensive review of the body of genetic studies on schizophrenia seems even more daunting than the battle a psychiatrist wages daily in the office with her archenemy of a thousand faces. The following article reunites some genetic, epigenetic and environmental factors of schizophrenia from revered and vast studies in a ...
Scientists Take Next Big Step in Understanding Genetics of
Published in the journal Cell Genomics, this research marks a big step forward in our understanding of the genetic basis of schizophrenia. "Our findings not only provide insights into the intricate regulatory landscape of genes, but also propose a groundbreaking approach to decoding the cumulative effect of genetic variants on gene regulation ...
Schizophrenia: genetic insights with clinical potential
Schizophrenia is a severe neuropsychiatric disorder that affects nearly 1% of the population and is characterized by a combination of psychotic symptoms and motivational and cognitive dysfunctions ...
Genetics of schizophrenia: Overview of methods, findings and limitations
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia. However, the complexity of the object of inquiry makes it almost impossible for non-specialists in genetics (e.g., many clinicians and researchers) to get a proper understanding and ...
Frontiers
Second, we reviewed the methods, samples, findings and limitations of previous genetic research on onset age in schizophrenia. Third, we discussed a potential conceptual framework for studying the genetic basis of onset age, as well as the concepts of susceptibility, modifier, and "mixed" genes.
Genetic origins of schizophrenia find common ground
In the first study, Trubetskoy et al. 2 identified hundreds of common genetic variants that each have a tiny influence on schizophrenia risk. By contrast, in the second, Singh et al. 3 discovered ...
Genetic insights into the neurodevelopmental origins of schizophrenia
This Review revisits the neurodevelopmental model of schizophrenia from a current genetics perspective, delineating the complex genetic basis of the disorder and highlighting gene expression and ...
Frontiers
1 Introduction. Chronic inflammation is hypothesized to be an underlying pathophysiological risk factor for the development of psychiatric disorders, including, anxiety (ANX), major depressive disorder (MDD) and schizophrenia (SCZ) (1, 2).There are several indications for an association between inflammation and increased susceptibility for the development of psychiatric disorders ().
Genetic research in schizophrenia: new tools and future perspectives
Genetically, schizophrenia is a complex disease whose pathogenesis is likely governed by a number of different risk factors. While substantial efforts have been made to identify the underlying susceptibility alleles over the past 2 decades, they have been of only limited success. Each year, the field is enriched with nearly 150 additional ...
Asparagine reduces the risk of schizophrenia: a bidirectional two
Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia.
The genetic relationships between brain structure and schizophrenia
We found that genetic covariation with brain structure was stronger for schizophrenia than for bipolar disorder, Alzheimer's disease or height, and pleiotropic genes were largely specific to ...
Genetic susceptibility to schizophrenia through neuroinflammatory
Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank ... in the analysis of whom 22427 (53.48%) were female and 25781 (46.52%) were male. 5148 individuals were excluded on the basis of incomplete optical coherence tomography data (for all phenotypes), 198 ...
Cortical gene expression architecture links healthy neurodevelopment to
Third, using data from the most recent GWASs of ASD 66, MDD 67 and schizophrenia 68, we found that genetic variants significantly associated with ASD were enriched in both C1 and C2 (but not in C3 ...
IMAGES
VIDEO
COMMENTS
Genetics of Schizophrenia: Overview of Methods, Findings and Limitations. Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia. However, the complexity of the object of inquiry makes it ...
There is a negative genetic correlation between common alleles associated with schizophrenia and those associated with cognitive ability (r g = −0.21) , which, given the similar SNP ...
Schizophrenia is a debilitating disease that presents with both positive and negative symptoms affecting cognition and emotions. Extensive studies have analyzed the different factors that contribute to the disorder. There is evidence of significant genetic etiology involving multiple genes such as dystrobrevin binding protein 1 (DTNBP1) and ...
The genetic findings from CNV studies have also provided insight into the pathogenesis of schizophrenia. Here, we describe examples of two CNVs: 22q11.2 deletions and ARHGAP10 CNVs. The 22q11.2 ...
Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not ...
A GOAL OF genetics research in schizophrenia has been to identify specific genes that confer risk for schizophrenia and other genes that confer resistance. This is based on the vast experience in other branches of medicine that identification of disease risk or resilience genes helps inform the neurobiological basis of illness and guide the ...
Associated Data. A comprehensive review of the body of genetic studies on schizophrenia seems even more daunting than the battle a psychiatrist wages daily in the office with her archenemy of a thousand faces. The following article reunites some genetic, epigenetic and environmental factors of schizophrenia from revered and vast studies in a ...
Published in the journal Cell Genomics, this research marks a big step forward in our understanding of the genetic basis of schizophrenia. "Our findings not only provide insights into the intricate regulatory landscape of genes, but also propose a groundbreaking approach to decoding the cumulative effect of genetic variants on gene regulation ...
Schizophrenia is a severe neuropsychiatric disorder that affects nearly 1% of the population and is characterized by a combination of psychotic symptoms and motivational and cognitive dysfunctions ...
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia. However, the complexity of the object of inquiry makes it almost impossible for non-specialists in genetics (e.g., many clinicians and researchers) to get a proper understanding and ...
Second, we reviewed the methods, samples, findings and limitations of previous genetic research on onset age in schizophrenia. Third, we discussed a potential conceptual framework for studying the genetic basis of onset age, as well as the concepts of susceptibility, modifier, and "mixed" genes.
In the first study, Trubetskoy et al. 2 identified hundreds of common genetic variants that each have a tiny influence on schizophrenia risk. By contrast, in the second, Singh et al. 3 discovered ...
This Review revisits the neurodevelopmental model of schizophrenia from a current genetics perspective, delineating the complex genetic basis of the disorder and highlighting gene expression and ...
1 Introduction. Chronic inflammation is hypothesized to be an underlying pathophysiological risk factor for the development of psychiatric disorders, including, anxiety (ANX), major depressive disorder (MDD) and schizophrenia (SCZ) (1, 2).There are several indications for an association between inflammation and increased susceptibility for the development of psychiatric disorders ().
Genetically, schizophrenia is a complex disease whose pathogenesis is likely governed by a number of different risk factors. While substantial efforts have been made to identify the underlying susceptibility alleles over the past 2 decades, they have been of only limited success. Each year, the field is enriched with nearly 150 additional ...
Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia.
We found that genetic covariation with brain structure was stronger for schizophrenia than for bipolar disorder, Alzheimer's disease or height, and pleiotropic genes were largely specific to ...
Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank ... in the analysis of whom 22427 (53.48%) were female and 25781 (46.52%) were male. 5148 individuals were excluded on the basis of incomplete optical coherence tomography data (for all phenotypes), 198 ...
Third, using data from the most recent GWASs of ASD 66, MDD 67 and schizophrenia 68, we found that genetic variants significantly associated with ASD were enriched in both C1 and C2 (but not in C3 ...