thesis drugs reddit

We’re independently supported by our readers and we may earn a commission when you buy through our links.

What are you looking for?

Search ideas for you, thesis nootropics review.

Sheridan Grant

Content Specialist

Sheridan is a writer from Hamilton, Ontario. She has a passion for writing about what she loves and learning new things along the way. Her topics of expertise include skincare and beauty, home decor, and DIYing.

Table of Contents

About Thesis Nootropics

Hands up if you guzzle five coffees a day to stay awake, have tried all the supplements in the book desperate to improve your headspace, and aren’t interested in prescribed medications. Designed to increase focus , Thesis nootropics might be for you. 

Thesis offers a customized blend of ingredients designed to optimize your cognitive function , with personalized details that tackle your specific needs. Nootropics boost brain performance in the same way a stimulant would, without the common negative effects. 

A study published in the Journal of Alzheimer’s Disease found that nootropics may help improve cognitive function in people with Alzheimer’s disease.

Interested in finding out more about the brand and how it works? Leaf through our Thesis Nootropics review. We’ll be your guide through the company and the process, as well as details on the treatments, highlights from customer reviews, answers to important FAQs, and more, to help you decide if it’s worth the try.

Pros and Cons

• Multiple cognitive benefits: Thesis Nootropics offers a variety of blends that cater to multiple aspects of cognitive function.
• Long-term effects: On top of short term benefits for daily life, Thesis nootropics ingredients are designed to impact the brain in the long-term.
• Personalized recommendations: Thesis Nootropics makes personalized recommendations based on your goals and unique brain chemistry.
• Potential side effects: The most common side effects to watch out for when you start taking Thesis Nootropics include heartburn, headaches, confusion, dizziness, loss of appetite, and digestive issues.
• Need to stop taking if issues arise: If you experience a headache or an upset stomach that won’t go away while taking their nootropics, Thesis recommends that you stop taking them.

What is Thesis Nootropics?

Nootropics are nutrient compounds and substances that are known to improve brain performance , such as caffeine and creatine. They help with issues that affect motivation, creativity, mood, memory, focus, and cognitive processing.

Nootropics are the ideal addition to an already healthy lifestyle that consists of exercise, proper nutrition, and enjoyable activities.  Thesis nootropics are carefully formulated to target specific needs, ranging from energy to creativity. The brand focuses on safety, ensuring that all supplements adhere to FDA guidelines and go through multiple clinical trials. 

How Thesis Nootropics Works

With all that being said, you may be wondering how Thesis provides users with an option that is specific to their needs. Fortunately, the process is simple and hassle free. Here’s how it works:

• Take the Thesis nootropics quiz
• Answer questions about your basic information
• Receive personalized recommendations 
• Get your starter kit for $120 , or $79 monthly when you subscribe 

After that, you’ll select one formula to take each week, taking one day off in between each different option. You’ll also track your results in the daily journal over the month to see how they affect your daily life. 

From there, it operates as a subscription service. Users will be able to optimize their next shipment by telling the brand which formulas worked best.

If you don’t like any of the blends in your box, let the company know and they’ll switch it for something that’s a better fit for your lifestyle, genetics, and goals.

Thesis Nootropics Ingredients

Thesis Nootropics is a brand that offers personalized nootropics designed to enhance cognitive function and overall brain health. Their blends contain a variety of ingredients that are carefully chosen for their cognitive-boosting properties. Here are some of the key ingredients in Thesis Nootropics:

• Cognizin (Citicoline) : Cognizin is a type of choline that is known for its ability to enhance cognitive function, including memory and focus.
• L-Theanine : L-Theanine is an amino acid that is found in green tea, and is known for its ability to promote relaxation and reduce stress and anxiety.
• Lion’s Mane Mushroom : Lion’s Mane Mushroom is a type of medicinal mushroom that is believed to have cognitive-boosting properties, including improved memory and focus.
• Rhodiola Rosea : Rhodiola Rosea is an adaptogenic herb that is known for its ability to reduce stress and fatigue, and improve mental clarity and cognitive function.
• Ashwagandha : Ashwagandha is an adaptogenic herb that is known for its ability to reduce stress and anxiety, and improve memory and cognitive function.
• Phosphatidylserine : Phosphatidylserine is a type of phospholipid that is found in high concentrations in the brain, and is believed to support cognitive function, including memory and focus³
• Alpha-GPC : Alpha-GPC is a type of choline that is known for its ability to enhance cognitive function, including memory and focus.
• TAU (uridine): TAU is a blend of uridine, choline, and DHA, which is believed to support brain health and cognitive function.
• Artichoke extract : Artichoke extract is believed to enhance cognitive function by increasing levels of acetylcholine, a neurotransmitter that is important for memory and learning.
• Dynamine : Dynamine is a type of alkaloid that is believed to enhance cognitive function by increasing levels of dopamine, a neurotransmitter that is important for mood and motivation.

Overall, the ingredients in Thesis Nootropics are carefully chosen for their cognitive-boosting properties, and are designed to work together to enhance overall brain health and cognitive function.

Thesis Nootropics Health Benefits

Thesis Nootropics is a brand that offers personalized nootropics designed to enhance cognitive function and overall brain health. Their blends contain a variety of ingredients that are carefully chosen for their cognitive-boosting properties, and offer numerous health benefits. Here are some of the health benefits of Thesis Nootropics:

• Increased cognitive energy : One of the key benefits of Thesis Nootropics is increased cognitive energy, which can help improve productivity, mental alertness, and motivation, as it contains cognizin .
• Enhanced mental clarity : Another benefit of Thesis Nootropics is enhanced mental clarity,given from Lion’s Mane Mushroom which can help reduce brain fog and improve focus.
• Improved memory and learning abilities : Thesis Nootropics contains ingredients that are believed to improve memory and learning abilities, like Phosphatidylserine , which can help users retain information more effectively.
• Elevated mood : Thesis Nootropics may help elevate mood and reduce symptoms of anxiety and depression, thanks to ingredients like L-Theanine and Ashwagandha .
• Lowered stress levels : The adaptogenic herbs in Thesis Nootropics, such as Rhodiola Rosea and Ashwagandha , are known for their ability to lower stress levels and promote relaxation.
• Boosted focus : Thesis Nootropics contains ingredients like Alpha-GPC and Artichoke extract , which are believed to boost focus and concentration.

While Thesis Nootropics offers numerous health benefits, it’s important to note that the long-term effects of nootropics are not yet fully understood and more research is needed.

3 Thesis Nootropics Bestsellers

Thesis energy review.

If you’re constantly struggling to keep up with the demands of your busy life, it might be time to try a natural energy booster like Thesis Energy. This powerful nootropic blend is specifically designed to increase energy, overcome fatigue, and build mental stamina.

Thesis Energy is caffeine-free, making it a great option for those who are sensitive to caffeine or looking for a natural alternative to traditional energy drinks. The Energy formulation is designed to help improve focus and mental clarity, increase cognitive energy, and reduce fatigue. Whether you’re facing a busy day at work, recovering after a night of poor sleep, or gearing up for an intense workout, Thesis Energy can help you power through.

Each ingredient in Thesis Energy is carefully chosen for its energy-boosting properties. The specific ingredients can vary depending on your needs, but they work together to help increase energy, improve mental clarity, and reduce fatigue.

To get the most out of Thesis Energy, take it every morning on an empty stomach. You can also take it again after lunch if you need an extra boost. It’s designed to help you tackle busy, hectic days, recover from poor sleep, and power through intense workouts.

If you’re tired of relying on coffee and energy drinks to get through the day, it might be time to give Thesis Energy a try. Check availability and start boosting your energy naturally today!

Thesis Creativity

If you’re someone who struggles with creativity or finds yourself feeling stuck in your creative endeavors, Thesis Creativity may be worth considering. This nootropic supplement is designed to help spark inspiration, enhance verbal fluency, and boost confidence in your own great ideas.

So what’s in Thesis Creativity? The ingredients may vary depending on your specific needs, but these ingredients work together to support stress management, memory function, mood regulation, and energy production.

By supporting stress management, memory function, and mood regulation, Thesis Creativity can help free up mental space for more creative thinking. Additionally, the caffeine and L-theanine combo can provide a boost of energy and focus without the jitters and crash that can come with caffeine alone.

To get the most out of Thesis Creativity, it is recommended to take it every morning on an empty stomach and again after lunch if you need an extra boost. This nootropic blend is particularly helpful for brainstorming and creative thinking, writing and creative projects, and public speaking and social situations.

As with any nootropic supplement, it’s important to note that the long-term effects of Thesis Creativity are not yet fully understood and more research is needed. It’s always a good idea to speak with a healthcare professional before adding any new supplements to your routine.

In summary, if you’re looking for a little extra help in the creativity department, Thesis Creativity may be a valuable addition to your nootropic lineup. Its unique blend of ingredients can help support mental clarity, mood regulation, and energy production, making it a valuable tool for any creative individual.

Thesis Logic

If you’ve been having trouble with your memory lately, such as forgetting what you had for lunch yesterday or struggling to recall common words, then Thesis Logic may be just what you need. This formula is designed to help enhance your processing speed, boost your memory, and deepen your thinking.

Thesis Logic is caffeine-free, making it a great option for those who are sensitive to caffeine. The formula is ideal for use during deep, focused work, complex problem-solving, research projects, and completing tedious tasks.

Taking Thesis Logic is easy – simply take it every morning on an empty stomach, and take it again after lunch if you need an extra boost. By incorporating Thesis Logic into your daily routine, you may notice improvements in your cognitive function and overall mental performance.

Who Is Thesis Nootropics For? 

Thesis nootropics are designed for a number of different specific needs, including anyone who wants to focus better, have more energy, and maintain mental clarity. All in all, the products are specifically formulated to improve day to day life and target your specific needs .

Thesis Nootropics Side Effects

While Thesis nootropics are designed to enhance cognitive performance and provide a range of benefits, it’s important to be aware of the potential side effects that can occur. As with any supplement, individual reactions can vary, and some people may experience side effects while others may not.

Some of the potential side effects of Thesis nootropics include:

• Insomnia : Some nootropics contain caffeine or other stimulants that can disrupt sleep patterns and lead to difficulty falling asleep or staying asleep.
• Blurry vision : Certain nootropics, such as those containing alpha GPC, have been linked to temporary blurry vision.
• High blood pressure : Stimulant-based nootropics can increase blood pressure, which can be dangerous for people with hypertension or other heart conditions.
• Fast heart rate : Similarly, stimulants can also increase heart rate, leading to palpitations or a rapid pulse.
• Circulation problem s: Certain nootropics, such as vinpocetine, can affect blood flow and circulation, leading to issues like dizziness, nausea, or headaches.
• Addiction : Some nootropics, such as those containing racetams, have been associated with the potential for addiction or dependence if used long-term.

It’s important to remember that not all nootropics will produce these side effects, and the severity of any reactions will depend on individual factors such as dosage, duration of use, and underlying health conditions. However, it’s always wise to discuss any potential risks with a healthcare professional before starting any new supplement regimen.

Additionally, it’s important to follow dosage instructions carefully and not to exceed recommended amounts, as this can increase the risk of side effects. By being mindful of potential risks and using nootropics responsibly, users can reap the benefits of these supplements without experiencing adverse effects.

Thesis Nootropics Reviews: What Do Customers Think?

At this point in our Thesis nootropics review, it’s time to turn to what customers are saying. So, we sourced testimonials from the brand’s website, Reddit, and ZenMasterWellness. And spoiler alert, the Thesis nootropics reviews we came across have nothing but good things to say.

On takethesis.com , the brand earns 4.4/5 stars out of 7,956 reviews. One patron describes their particular blend as the perfect alternative to prescription meds :

“ I have been off stimulants for months now and these formulas are far superior. My husband and daughter both noticed the change and said I have been more productive, focused, less anxious, and more “thinking outside the box”. I have tried for years to get off stims and nothing would work .”

On Reddit, many reviewers share similar sentiments about how effective the products are. One buyer shares that they tried tons of different nootropics on the market, and Thesis stands out amongst the crowd . 

On ZenMasterWellness, one reviewer states that their blend provided the exact results they were looking for :

“ They offer notable improvements to how well I’m able to focus, stay on task, and grind when it’s time to grind. In practice, this usually looks like a clearer mind and an improved ability to just… chill. With the Clarity and Creativity blends, in particular, I just feel leveled out .”

Backed by clinical trials and real customer experiences, Thesis stands out in the world of nootropics and supplements. The personalized selections prove effective, while the quality ingredients live up to expectations. 

Is Thesis Nootropics Legit?

If you’re wondering if this brand offers products that are too good to be true, this Thesis nootropics review is here to say that it is the real deal .

The brand is backed by numerous clinical trials, which highlight how 86% of customers reported improvements in a wide range of cognitive challenges, while 89% noticed an improvement in their ability to reduce stress and maintain energy.

Is Thesis Nootropics Worth It?

Thesis is an appealing choice in the world of nootropics because it provides a completely customized selection based on your needs and goals. Plus, the ingredients are potent and ensure the best effects—and you only end up paying for the benefits you actually need.

With that in mind, this Thesis nootropics review deems the brand worth the try.

Alternatives

Here are some alternatives to Thesis Nootropics that you might find interesting:

• Mind Lab Pro – This nootropic supplement is designed to improve cognitive function and mental performance. It contains 11 ingredients that work together to enhance memory, focus, and overall brain health.
• Thorne Supplements : If you’re looking for high-quality, science-based supplements, Thorne is a great choice. Their products are designed with the latest research in mind and are rigorously tested for quality and purity. Some of their popular offerings include multivitamins, protein powders, and omega-3 supplements.
• WeAreFeel Supplements : WeAreFeel is a supplement brand that offers a variety of products designed to support different aspects of your health. Their supplements are vegan-friendly and free from artificial colors, flavors, and preservatives. Some of their popular offerings include multivitamins, probiotics, and omega-3 supplements.
• Neuro Gum : If you’re looking for a quick and easy way to boost your focus and energy levels, Neuro Gum is a great option. This gum is infused with caffeine and other natural ingredients that can help improve mental clarity and alertness. Plus, it’s sugar-free and comes in a variety of delicious flavors.
• Neuriva Plus : Neuriva Plus is a brain supplement that’s designed to improve memory, focus, and cognitive performance. It contains a blend of natural ingredients, including coffee fruit extract and phosphatidylserine, that have been shown to support brain health. If you’re looking for a natural way to boost your cognitive function, Neuriva Plus is worth considering.

Thesis Nootropics Promotions & Discounts 

There aren’t currently any Thesis promos or discounts available. That being said, if you subscribe for recurring shipments of your recommended products, you’ll save $40 monthly .

Where to Buy Thesis Nootropics

At the time of this Thesis nootropics review, the products are exclusively available on the brand’s website, takethesis.com .

Is Thesis Nootropics vegan?  

Thesis nootropics are made with only vegan ingredients . That being said, while the brand has taken precautions to protect against cross contamination, the products are not certified vegan.

Is Thesis Nootropics gluten-free? 

On top of being vegan, Thesis products are made without gluten, eggs, or nuts . Again, while the brand strives to protect users against cross contamination, the products are not certified gluten free. 

What is Thesis Nootropics’ Shipping Policy?

If you’re anxiously awaiting your order from this Thesis nootropics review, you’ll be happy to hear that the company offers speedy shipping, sending orders out within 1 business day. After that, packages should arrive within only 1-3 business days . Costs are calculated at checkout.

At this time, Thesis is not able to offer international shipping. This Thesis nootropics review recommends following the brand on social media and signing up for the newsletter to stay up to date with shipping policies. 

What is Thesis Nootropics’ Return Policy?

If you find that your Thesis formula isn’t working out, the company requests that you contact them to make changes and adjustments to ensure you are able to receive the proper help.

If you would still like to make a return, follow these simple steps for a refund:

• Submit your refund request
• Ship the items back within 30 days of the original delivery
• Send an email with your tracking number to the brand
• Return any remaining product in their original packaging to: 

Thesis Returns 902 Broadway

6th Floor New York, NY 

Once your return has been received, a refund will be processed and email confirmation will be sent. It’s also important to note that the brand can only refund one month’s supply per customer and return shipping is the customer’s responsibility. 

How to Contact Thesis Nootropics

We hope you enjoyed this Thesis nootropics review! If you have any further questions about the brand or its products, you can contact them using the following methods:

• Call 1 (646) 647-3599
• Email [email protected]

902 Broadway Floor 6 New York, NY 10010

If you’re looking for other ways to boost your productivity via supplements, check out these other brands we’ve reviewed:

Thorne Supplements Review

WeAreFeel Supplements Review

Neuro Gum Review

Neuriva Plus Review

Our team is dedicated to finding and telling you more about the web’s best products. If you purchase through our links, we may receive a commission. Our editorial team is independent.

Ask the community or leave a comment

Customer reviews, leave a review, ask the community or leave a comment cancel reply.

Your email address will not be published. Required fields are marked *

This field is required

This field is required Please use a valid email

Save my name, email, and website in this browser for the next time I comment.

You may also be interested in

Save More On Brillia for Adults 3-Month Supply

• Account Sign In or Create
• - Subscriptions
• - Referrals

Thesis Nootropics vs Adderall: How They Work, Side Effects & Choosing if One is Right for You

When it comes to addressing common symptoms of ADHD, from inattention to hyperactivity , one of the most popular forms of treatments is the stimulant medication Adderall® . Like other stimulants, Adderall works by targeting brain chemicals like dopamine and norepinephrine to reduce symptoms of ADHD. It is available by prescription only. 

A newer type of stimulant that is available without a prescription is Thesis nootropics , which contains ingredients like functional mushrooms, choline, vitamins, and adaptogens to enhance cognitive function. Though they are not recommended to treat any health condition, including ADHD, many people do use them to manage symptoms like inattention and hyperactivity to avoid the side effects associated with prescription stimulants like Adderall.

But do they work? This is what we’ll explore in the following article: which product is better for ADHD, the side effects of each, and alternative medications to consider.

ADHD Medication Overview

ADHD is a neurodevelopmental disorder that affects a person’s ability to focus, control impulses, and regulate their emotions. Medications are often a key component of ADHD treatment and there are several different types. They include:

• Stimulant Medications : Stimulant medications work by increasing the levels of certain neurotransmitters like dopamine and norepinephrine in the brain to improve attention and impulsive control. Examples include Adderall, Ritalin® , Concerta®, and Vvvanse® . These are the most commonly prescribed ADHD medications and are sometimes taken as needed.
• Non-Stimulant Medications : Though stimulants are the most common drugs for ADHD, in some cases, a doctor will prescribe non-stimulant ADHD meds if a patient doesn’t respond to stimulants or if side effects are too intense. Non-stimulant meds also target brain chemicals to control symptoms of ADHD, but these drugs tend to work slower than stimulants and are typically dosed for daily use. Examples include Strattera®, Intuniv®, and Kapvay®. 
• Other Medications : In some cases, doctors may prescribe antidepressants, such as Wellbutrin®, tricyclic antidepressants, or serotonin-norepinephrine reuptake inhibitors (SNRIs) like Effexor® if the patient doesn’t respond to stimulants or non-stimulants. Alternatively, some individuals consider taking non-prescription homeopathic medications like Brillia to avoid the side effects associated with prescription drugs or to avoid having to increase the dosage of current prescription drugs. Brillia is designed to reduce symptoms associated with ADHD and anxiety without harsh, synthetic chemicals or harmful side effects, making it a suitable choice for those with co-occuring conditions.  

Thesis Nootropics vs Adderall: Which is Better for ADHD?

Though nootropics like Thesis are sometimes referred to as “smart drugs” because of their ability to boost focus and cognitive function, they may not be as potent as prescription stimulant drugs like Adderall in reducing symptoms of ADHD. There are some distinct differences between their mechanisms of action, their safety profiles, and the research surrounding each.

The active ingredients in Thesis nootropics, which include functional mushrooms, vitamins, and herbal extracts are generally safe and gentle on the body, which could be appealing to those who have not responded well to prescription drugs like Adderall, which contains the chemical amphetamine. However, nutritional supplements like Thesis are not regulated by the FDA in the same way as prescription drugs, so questions remain surrounding their safety and efficacy. 

How Thesis Nootropics Work to Boost Cognitive Function

According to the manufacturers of Thesis , the ingredients in their formulas work across “multiple brain pathways,” to support brain energy, optimize neurotransmitter status, improve cerebral circulation, and enhance neuroprotection. 1 Like many other supplements, Thesis is not intended to target the source of symptoms; rather the nutrients in their different blends can help the general function of the brain and improve overall well-being. This is different from medications, which target specific chemical imbalances in the brain to stop the instigation of symptoms altogether. Some of the research-backed nutrients include:

• Lion’s mane mushroom : May increase levels of brain derived neurotrophic factor (BDNF) to improve clarity and focus 2
• Vitamin B12 : May improve attention and mood 3
• Bacopa monnieri : May improve memory 4
• Tyrosine : May increase dopamine synthesis 5  
• L-Phenylalanine : May reduce depressive symptoms 6
• Panax ginseng : May improve executive function (when combined with omega-3s) 7

What to Know About Adderall

First approved in 1996 , Adderall is a prescription drug consisting of  amphetamine and dextroamphetamine, which are central nervous system stimulants that bind to dopamine and norepinephrine receptors in the brain. 8 This binding effect increases the levels of these neurotransmitters, which is thought to improve concentration and alertness while reducing hyperactivity and impulsivity.

Though Adderall and other stimulant medications are highly effective for many and typically a first-line treatment, this medication is associated with a number of side effects, including headache, upset stomach, and decreased appetite — which is one of the reasons many try to avoid using them to see if more gentle options can give the level of support that is adequate. Adderall is also notorious for being misused and abused by high school and college students due its reputation as a study aid and euphoria inducer. 

Side Effects of Both

Though the side effects of Thesis nootropics are generally milder than those associated with Adderall, they should still be considered. Explore the side effects of both products below.

Thesis Nootropics Side Effects

Numerous Thesis reviewers have expressed satisfaction with the product, reporting no adverse effects. While some blends include caffeine, which can cause jitteriness or interfere with sleep, users have the option to exclude it. On the flip side, some reviewers have mentioned experiencing side effects such as nausea and insomnia 9 .

Thesis is also not suitable for children. 

Adderall Side Effects 

Adderall, like other stimulants, is known to cause a number of side effects in users. These side effects may go away on their own or you can work with your doctor to adjust your dosage or switch to another medication. 

Side effects of Adderall include:

• Upset stomach
• Loss of appetite
• Weight loss
• Mood changes
• Nervousness
• Fast heart rate

Which Product is More Effective?

When it comes to Thesis vs Adderall for ADHD, reviews are mixed. Adderall seems to outshine Thesis in terms of efficacy, but it does come with a higher risk of more serious side effects. 

Here is a sampling of the reviews of Thesis on TikTok and Reddit:

• Worked for a few hours, then downhill : TikTok user mikerapadas said: “Motivation [blend] provided me a real feeling of drive. I could feel myself being pulled towards my task and I felt little hints of extra optimism. But…it lasted only a few hours. After that came the negatives: mainly, I just felt less well overall; my temper was slightly more sensitive, and I could feel myself getting annoyed a lot more easily.” 10
• More focused, but poor sleep : Reddit user jamie_choo wrote: “Not sure if it's just a placebo effect but I do feel more focused throughout the day. However, I've been losing sleep in the last couple of days since my mind is way more active at night than usual.” 11

Reviews on Adderall are also mixed, but lean toward the positive when it comes to efficacy alone. Adderall has an average rating of 7.2 out of 10 from a total of 372 reviews On Drugs.com. Sixty-four percent of reviewers reported a positive experience, while 20 percent reported a negative experience . 12   Negative reviews of Adderall have more to do with the side effects than efficacy, with remarks that the medication caused rapid heart rate, stomach pains, anxiety , insomnia, hallucinations, and suicidal ideation . 13  

Alternative ADHD Medications

If you’re looking for something safe and impactful to reduce ADHD symptoms, there are other options beyond nootropic supplements and prescription ADHD medication .

Brillia is one alternative option to consider. Free from harsh, synthetic chemicals and harmful side effects, Brillia is a clinically-proven non-prescription homeopathic medication that contains targeted antibodies to the S100B protein, a crucial regulator of various brain processes, both intracellular and extracellular. By modulating the activity of this protein, Brillia can effectively manage symptoms of ADHD and anxiety without causing side effects like drowsiness, nausea, decreased appetite, dependency, nor does it mask the personality in any way. 

It's worth noting that Brillia does not disrupt blood chemistry, a common feature of stimulant medications like Adderall. In balancing the S100B protein Brillia also helps to normalize the levels of monoamines, including dopamine, norepinephrine, and serotonin, in different brain regions, mirroring the neurotransmitter targets of drugs like Adderall.

In contrast to dietary supplements like Thesis, Brillia adheres to rigorous FDA standards and regulations, encompassing quality, claims, and labeling. The product's active and inactive ingredients must undergo thorough review, and supporting evidence for its claims is required for sale in the United States. Backed by clinical evidence supporting its safety and efficacy, Brillia can be safely used by children as young as five and adults , without the need for an official diagnosis or medical supervision.

Brillia is also incredibly versatile. You can use the medication as an alternative to prescription medication or in conjunction with prescription medication to address lingering symptoms like anxiety (a common side effect of Adderall and other stimulant medications). Some users take Brillia with their prescription medication to avoid having to increase the dosage of their current meds, which also increases the likelihood of side effects. 

If you choose to transition to Brillia from a prescription medication, we ask that you do so under the guidance of your doctor to ensure this path is right for you. 

How to Choose Which One is Right for You

There is no single way to treat ADHD and what may work for you may not work as well for another person. Weighing the pros and cons of each option available is the best way to make an informed decision regarding your own care. At Brillia, we recommend starting with healthy lifestyle changes , including following a nutritious diet , getting enough sleep , controlling your screen time , and practicing mindfulness techniques regularly. These are all powerful factors that can make an impactful improvement in your symptoms and potentially help you avoid medications and supplements altogether.

If you need more support and choose to try Brillia , we ask that you find the dose that best meets your needs and remain consistent with your dosage while the product builds up in your system. Brillia is a gentle and cumulative product, and your body relies on a steady trickle of the active ingredient to get the best results. Most users see a result in 3-4 weeks, but it may take longer. If you need help finding the right dose, our Customer Care team is always available to offer guidance to ensure you experience the best results with Brillia. You’ll also have access to a wide community of Brillia users who can share tips and resources on how to make the most of your Brillia journey. 

To explore other options on managing symptoms of ADHD with or without prescription medication, visit the Brillia(nce) Resource Center and learn how a holistic approach can help you develop the tools you need to control your symptoms long-term.

References: 1 https://takethesis.com/pages/science, 2 https://pubmed.ncbi.nlm.nih.gov/31118969/, 3 https://www.mdpi.com/2072-6643/14/7/1494, 4 https://pubmed.ncbi.nlm.nih.gov/20590480/, 5 https://pubmed.ncbi.nlm.nih.gov/30853567/, 6 https://pubmed.ncbi.nlm.nih.gov/380577/, 7 https://pubmed.ncbi.nlm.nih.gov/32847461/, 8 https://www.psycom.net/adderall-amphetamine, 9 https://www.reddit.com/r/Nootropics/comments/ru37qm/thesis_nootropics_review/, 10 https://www.tiktok.com/@mikerapadas/video/7251691048630603050, 11 https://www.reddit.com/r/Nootropics/comments/ru37qm/thesis_nootropics_review/, 12 https://www.drugs.com/comments/amphetamine-dextroamphetamine/adderall-for-attention-deficit-disorder.html, 13 https://www.drugs.com/comments/amphetamine-dextroamphetamine/adderall-xr-for-attention-deficit-disorder.html

How To Stay Motivated & Productive Working From Home

Working remotely can be convenient, until you get distracted by the TV. Find out how to stay focused from home when trying to get your work done.

How To Motivate Your Child To Do Their Homework

Help motivate your child with ADHD to get started on their homework, maintain focus, and complete their tasks for academic success.

5 Activities To Do This Spring To Help With Your Child's Anxiety

Spring is a time of fresh starts, and there’s no better time than the present to come up with fresh ways to help your child manage their anxiety more effectively.

• Choosing a selection results in a full page refresh.
• Opens in a new window.

Thesis Nootropics Review 2024: Honest Thoughts + Am I Still Buying?

• Last updated: March 19, 2024

About Dr. Steve Kim, MD

Physician Advisor

After using Thesis nootropics for more than a year, for me, the higher price point is definitely worth it for the cognitive benefits I’ve experienced. Specifically, I’ve noticed that I am not feeling overwhelmed as often as I was prior, and I am able to focus and complete tasks with more ease.

Thesis Overview

• Price:  $119 for one-time purchase or $79 with subscription
• Helps With:  Cognitive function, including motivation, memory, focus, and more
• Side Effects:  Headache, stomachache, and more
• Safety: Made with ingredients that are Generally Recognized As Safe (GRAS) by the FDA or have passed Phase III clinical trials
• Dietary Information:  Vegan, and made without gluten, eggs, and nuts

Thesis offers a variety of  nootropics, also called “smart drugs,” which are medicinal substances that improve cognitive function, specifically memory, thinking, and learning. While some prescription nootropics are FDA-approved, Thesis is not regulated by the FDA and is available over-the-counter (OTC). However, their ingredients are third-party tested and they only use ingredients that are either Generally Recognized As Safe (GRAS) by the FDA or have passed through Phase III clinical trials. 

I’ve been taking Thesis for over a year now, about six times a week, and I’ve noticed some significant improvements in terms of how often I feel overwhelmed, as well as my ability to focus and stay on task. While I know Thesis won’t work well for everyone, these nootropics agree well with me and I’ll continue using them to help boost my productivity, focus, and more. 

In this article, I’ll delve into my experience using Thesis nootropics, as well as discuss their potential benefits, side effects, and more.

• Custom blends
• Personal coaching / support by nootropic experts
• No proprietary blends (AKA no hidden ingredients!)
• Caffeinated or noncaffeinated formulas
• Effective ingredients
• No free trials
• Relatively high monthly cost

My Experience Taking Thesis Nootropics

I’ve been loving Thesis since I started using their products, specifically the Clarity, Creativity, Logic, and Energy blends, over a year ago. While there’s no nootropic that’ll offer you the same potency you’d get from Adderall, or other prescription stimulant medications, I’ve found Thesis to work surprisingly well for my needs.

When using them 6 times a week, they have offered notable improvements in how well I’m able to focus and stay on task. In practice, this usually looks like a clearer mind and an improved ability to maintain a relaxed state of mind while completing various tasks. As someone who feels overwhelmed fairly often, this is a welcomed change of pace.

With their Clarity and Creativity blends, in particular, I just feel leveled out. I’m able to sit down and work, without feeling like I’m just hopped up on too much caffeine, a feeling that really makes me uncomfortable. 

In the world of nootropics, where certain products don’t seem noticeable whatsoever, it cannot be overstated just how awesome my experience with Thesis has been.

Benefits of Thesis

As a customer, you’ll have the opportunity to speak with their coaches at any time. I have reached out on a few occasions, just to talk about the fascinating world of nootropics. In particular, I have had amazing conversations with one of their neurologists, Cindy. It truly is nice to speak with other individuals who are as fascinated with the science behind nootropics as I am.

Another aspect of Thesis that I really respect is that they clearly publish not only which ingredients they include, but also the exact amounts of each ingredient. This matters because it allows consumers to actually cross-check the research behind the ingredients/dosages, an unfortunate rarity in the supplement space.

•  6 custom blends, each with unique effects that may work well for many individuals
• Personal coaching/support from nootropic experts
• No proprietary blends (hidden ingredients)
• Caffeinated or non-caffeinated formulas
• Effective ingredients that are backed by science and are third-party tested
• Available OTC
• Not FDA-approved
• Relatively high monthly price, which may not work for everyone

How Does Thesis Work?

You’ll start by filling out a questionnaire on their website, which should only take a few minutes. Once you’re done with the survey, Thesis’ algorithm will run through its millions of data points to predict which of their blends may work best for you. 

Once you place your order, either as a one-time purchase or as a subscription, you’ll be shipped your blends.

Per the instructions, you’ll begin taking your blends and note how you feel in the included daily journal. This will help your track whether your blends are the right fit for your needs or if they need to be adjusted. You’ll also be able to speak with one of their coaches at any time for additional support. 

Related reading: Stasis Supplement Review – Our Research, Testing, and Impressions

Thesis vs. Alternatives

 We’ve created this comparison table to pit Thesis up against Onnit and Mind Lab Pro , two other popular nootropic brands.

Thesis Nootropics Side Effects

The ingredients in Thesis may lead to side effects in some individuals, including: 

• Stomachache
• Signs of an allergic reaction

If you experience any prolonged discomfort, stop taking Thesis and reach out to your healthcare provider. Seek urgent medical care if you experience serious symptoms of an allergic reaction.

The Verdict: Are Thesis Nootropics Worth It?

Thesis offers a complete toolkit of nootropics that are tailored to your needs, in addition to ongoing expert support. Unlike other nootropics, which may include unnecessary or hidden ingredients, Thesis only offers what you need with their six unique blends that focus on supporting logic, energy, creativity, clarity, motivation, and confidence. Once you find the blend or blends that work for you, you can opt into a subscription and save on costs. 

While the monthly cost may be on the higher side, the ability to select only the blends you need, instead of opting for a nootropic that may include ingredients that are unnecessary for your particular needs, is definitely a major benefit of opting for this provider over others.

Keep in mind that Thesis will not feel as potent as prescription stimulant medication and that certain blends may lead to side effects, like gastrointestinal problems or headaches, in some. It’s always best to speak with your healthcare provider prior to trying Thesis to ensure that it is safe for you to do so.

Thesis will not be as potent as Adderall, a prescription medication. However,  Thesis , a type of nootropic or “smart drug,” may work well for some individuals in boosting cognitive function, focus, and more. 

Some nootropics can be used every day. However, it’s best to follow the specific’s products instructions, as well as speak to your healthcare provider about safe use.

Thesis  may be safe for some individuals to use. According to the company, they only use ingredients that are either classified as Generally Recognized As Safe (GRAS) by the FDA or that havve passed through Phase III clinical trials. However, it’s always best to speak with your healthcare provider prior to trying Thesis to ensure that it is safe for you to use.

Thesis does not offer free samples, however, they do offer a no-questions-asked refund. 

Thesis offer caffeinated and caffeine-free formulas.

Cheapest At-Home Ketamine Treatment: Where to Get the Most Affordable Online Care

Talkiatry ADHD Review: Our Experience With Online Psychiatry Care

Best Cognitive Therapy Apps (for iOS + Android)

Innerwell Review: How It Compares to Other At-Home Ketamine Treatments

Shimmer Care Review 2024: Our Experience With ADHD Coaching

Inflow App Review: How 14 Days of Using Inflow Helped Recenter Me

Online Pharmacies

Hims Review

Keeps Review

Keeps vs Hims

BlueChew Review

Rugiet Review

Hims ED Review

Online Therapy

BetterHelp Review

BetterHelp vs Talkspace

General Health Tests

Best DNA Health Test

Best Microbiome Test

Viome Review

Best At-Home Herpes Test

STDcheck Review

Hair and Hair Loss

Best Hair Loss Treatment for Men

Best Laser Cap for Hair Loss

Kiierr Laser Cap Review

Relationships & Sexual Health

Best STD Dating Websites

Best Herpes Dating Websites

Best Erectile Dysfunction Treatment

Best Delay Spray

Best Prostate Massager

BlueChew Free Trial

Nutrition Guide

Found Weight Loss Review

BlueChew Promo Code

Best CBD for Arthritis

Best Incontinence Underwear for Women

Best Incontinence Underwear for Men

Fitness and Weight

Best Amino Acid Supplements

Best Muscle Building Stack

Vital Reds Review

Total Restore Review

Best NMN Supplement

Best NAC Supplement

Best NAD Supplement

Best Berberine Supplement

Mood and Energy

Best Nootropics

Best Saffron Supplement

Sexual Health

Best Testosterone Booster

Best Male Enhancement Pills

Best Volume Pills

Skeletal System

Muscular System

Cardiovascular System

Digestive System

Nervous System

Respiratory System

Urinary System

Integumentary System

Thesis Nootropics Review

Thesis has a range of targeted nootropics you can combine to optimize your results. our team will help you decide which ones are right for you..

Daniel is a senior editor and writer at Innerbody Research. After receiving his bachelor’s degree in writing, he attended post-graduate studies at George Mason University and pursued a career in nutritional science.

Dr. Segar is a cardiology fellow at the Texas Heart Institute and a member of Innerbody Research's Medical Review Board.

In this Review

Nootropics in general offer the potential to improve cognitive abilities and regulate mood without the need for a prescription. And while more research is necessary, current data suggests that they consist of ingredients that are generally safe and effective for healthy adults. 35 However, Thesis isn’t the only provider of high-quality nootropics, nor do they offer especially low prices. In this review, we'll compare and contrast Thesis’ six formulas and see how they stack up against a growing field of competitors.

Our Findings

Despite the somewhat high price, we recommend Thesis to anyone looking for a nootropic subscription that can be tailored to their specific needs. The formulas from Thesis provide tangible benefits with minimal ingredients, and each formula is available with or without caffeine. Thesis also offers stellar customer service and delivers their product in individually packed doses you can take just about anywhere.

• You can feel most results within an hour
• Products are third-party-tested for purity
• All options available without stimulants
• Outstanding phone support
• Subscriptions include complimentary wellness coaching
• Free shipping on all orders
• Use code INNERBODY for 10% off your first order
• Somewhat more expensive than competitors
• Up to four large pills per dose

GREAT PICKS FROM THESIS

Special Offer: Take 10% OFF with code INNERBODY

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles. As nootropics have become more important players in the supplements landscape, we’ve taken a serious look at the key players to see which ones are worthwhile.

Thesis exists in a class of nootropics that combines multiple nootropic ingredients to achieve specific goals. We’ve spent hundreds of hours researching and testing various nootropics, including both individual ingredients and combinations like Thesis offers. In researching Thesis and their competitors, our team has read more than 100 clinical studies examining the efficacy and safety of nootropic ingredients, and we’ve combined all of that knowledge with our experiences to create this review.

If you're curious about our team's experience using Thesis nootropics and wondering how the products will arrive at your door, we made this handy, 5-minute video summarizing those details:

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

How we evaluated Thesis

To evaluate Thesis, we examined the extensive research available on each ingredient the company uses and compared them to a growing marketplace of nootropics, many of which our testing team has tried over the past few years. Specifically, we assessed how effectively Thesis' formulas work, as well as their safety, cost, and the convenience of acquiring and taking them.

Ultimately, we found Thesis to be one of the more reliable companies in terms of product quality and customer care, even if they are among the more expensive nootropic brands. For any nootropic, you’re looking to create a noticeable effect in brain performance, and altering anything to do with that sensitive chemistry likely warrants a fair investment. The bargain bin is not typically where you want to shop for mind-enhancing substances.

We’ll get into a more direct comparison between Thesis and their competitors a little later, and you’ll see that the balance between their price and overall value is quite reasonable. For now, let’s look at each criterion in more detail.

Effectiveness

Nootropic companies have a plethora of ingredients at their fingertips when they formulate their products. Some companies take a modern approach, focusing on the latest research into established Western medicines. Others look to the past, where ancient Chinese and Ayurvedic practices employed various botanicals to achieve cognitive effects. The best companies combine these approaches, using potentially beneficial ingredients that science supports.

Thesis takes this combined approach, employing just under three dozen ingredients from amino acids to ancient herbs across their six products. The company scores highly in effectiveness thanks to the ingredients they choose and the doses they offer for each, making it likely that you can notice their combined effects.

Individual results will vary due to everything from sleep patterns to diet, but most people should find benefits in at least one of Thesis' six formulas. Caffeinated formulas generally have more pronounced effects than stimulant-free versions, but the value of Thesis offering every formula with or without stimulants cannot be overstated.

One minor knock against Thesis is that, unlike some of their competitors, Thesis does not have a nootropic blend designed for improved sleep. Better sleep supports cognition and mood, so some companies offer formulas designed specifically for sleep promotion with ingredients like melatonin. That said, some of Thesis’ formulas contain lion’s mane or Zembrin (a branded form of Sceletium tortuosum that’s been shown to reduce anxiety and promote sleep). 2 3 And the amount of Zembrin used in Thesis’ Creativity and Confidence blends is the exact same amount used in these successful studies — 25mg.

Good nootropics are, unfortunately, a bit expensive. You can find less expensive options than Thesis, but their $79 monthly rate is right in the middle of what the market demands. You could also argue that the ingredient quality, customization options, and overall efficacy Thesis offers make it a superior value to many less expensive alternatives. Still, the price remains a sticking point for some.

Let's compare the monthly and per-dose costs with some of Thesis' closest competition. The prices below reflect subscription savings where available.

Three of the seven competitors included in the chart above are more expensive than Thesis, and another three are no more than $15 less expensive, revealing their generally average cost. Focus Factor — consistently our top budget pick among nootropics — costs much less than others in the field and includes many ingredients with associated clinical research. The downside is that increasing the number of ingredients (even when they seem to work) increases the odds of an adverse reaction.

TruBrain is the only company that truly compares to Thesis from a quality and variety standpoint. Other companies offer only one or two formulas, whereas Thesis and TruBrain each offer several more targeted products. TruBrain allows you to spend just $69 on your first jar when you subscribe — $10 less than Thesis — but that price shoots up to $119 every month after that, making Thesis the superior value.

When we consider the safety of any supplement, we look at available research into individual ingredients and compare those dosages with what the supplement offers. Whenever possible, we also test the product ourselves to observe its effects on us. Additionally, we look for safety standards in manufacturing that can provide added peace of mind, like third-party testing and compliance with the FDA’s Good Manufacturing Practices (GMP).

Thesis manufactures their products in GMP-compliant facilities and has third-party testing performed to assess the purity of each ingredient and formula. And the clinical research involving the lion's share of their ingredients reveals minimal risk profiles with few to no adverse effects reported. That said, ashwagandha isn’t safe for pregnant or breastfeeding individuals, and it can stimulate thyroid activity, so anyone with thyroid concerns (hyper- or hypothyroidism) or on medication to regulate thyroid function should be careful. 36 37

Thesis also limits their formulas to a handful of ingredients, which reduces the likelihood that any one of them would cause an adverse reaction. This is pretty typical of nootropics in Thesis’ class, but less expensive nootropics might try to convince you of their value by stuffing a single blend with several dozen components. That might increase the chances you feel some positive effect, but the side effect risk goes up by the same token.

Convenience

Our convenience rating considers various aspects of a user's experience. It usually starts with the quality of a product's website design and whether or not its pages are easy to navigate. We also consider the presence of subscription systems that make reordering easier and money-back guarantees that protect your investment. A company's customer service is another vital aspect of convenience, especially if you need questions answered. The quality of an FAQ section, the availability of representatives via chat or phone call, and the responsiveness to email inquiries all play a part here.

Our convenience rating is also informed by the steps required to actually take the product. Nootropics often consist of large capsules, and doses can contain anywhere from 1-7 capsules, which is awful for anyone with difficulty taking pills. Smaller capsules, fewer capsules per dose, and simple dosing schedules are ideal. Thesis’ capsule count varies per formula, ranging from 2-4 mid-size capsules you can take 30 minutes before you might want or need their effects.

To summarize some important aspects of nootropic company convenience, let's look at which companies have large capsule counts, good money-back guarantees, and subscription systems.

Thesis also provides a service that few other companies offer: free consultations with in-house nootropic coaches. These experts can help you figure out the best time to take specific Thesis formulas and guide your experience so you can tell whether or not they're working for you. Follow-up consultations are also free as long as you subscribe to the product.

What are nootropics?

Nootropic is a term most people use to refer to any non-prescription supplement that can boost brainpower. 4 The technical definition is a little more nuanced — encompassing prescription medications like Ritalin and Adderall — but the supplement industry has largely co-opted it to categorize the new class of non-prescription products. The word loosely translates from its Greek origins to mean mind-changing, and the majority of ingredients in a given nootropic seek to alter the brain’s cognitive abilities, as well as its governance of mood and energy.

Most nootropic supplements contain botanical ingredients, vitamins, minerals, and amino acids that boast at least some clinical research connecting them with improvements in any of the following:

Compared to their prescription cousins, nootropic supplements aren't particularly strong. Still, limited clinical research indicates a tangible benefit to taking them.

What is Thesis?

Thesis is a supplement company with a focus on nootropics. Their founders each had experiences growing up with what would today be considered learning disabilities, and they credit nootropics for changing their lives. They make six distinct nootropic formulas, each with a specific ingredient profile.

Thesis differentiates themselves from their competitors in several critical ways:

• They offer a starter kit containing a personalized combination of four blends.
• You have the option to remove caffeine by request from any formula.
• They provide some of the best phone support we've ever experienced.
• Their targeted formulas conform to changing needs.

By providing you with a mix of formulas, Thesis gives you the ability to enhance the aspects of your cognitive and emotional life that need it the most on any given day. Maybe you know you have low energy levels on Mondays and Wednesdays, so you can take the Energy formula on those days. Maybe you want to devote your weekends to artistic pursuits. You can use the Creativity blend for that. Or you might find that one of their six blends works well for you in any situation. In that case, you can adjust your order to receive only that formula.

Thesis' customer service — particularly over the phone — is outstanding. While many customers might find chat support more convenient, our testers rarely waited more than a minute to speak to someone, and Thesis employs phone operators who are extraordinarily knowledgeable about the product and nootropics in general. Their email support is fine, and their chat support often redirects to an email inquiry. But that phone support is some of the best our testing team has experienced.

Is Thesis safe?

Most of the ingredients that Thesis uses in their nootropics exhibit minimal side effects in clinical research, so there’s a good chance that Thesis' various formulas will be safe for most people. But Thesis has nearly three dozen ingredients in their catalog, and not all of them will be safe for all users, including those who are pregnant or breastfeeding. Of course, the most important thing you can do is talk to your doctor before taking Thesis.

The most common side effects to watch out for when you start taking Thesis nootropics include:

• Loss of appetite
• Digestive issues

Thesis advises discontinuing their nootropics if you experience persistent headaches or an upset stomach.

Some Thesis products may present contraindications with certain prescription medicines. For example, ashwagandha has been shown to normalize thyroid hormone levels in people with hypothyroidism. 5 This has led some to believe that it could conversely cause thyrotoxicity in people with hyperthyroidism, though it’s worth noting that the study in question employed double the highest ashwagandha dose you’ll find in Thesis nootropics — the study used 600mg, and the ashwagandha dose in Thesis’ Creativity is 300mg.

Still, this should make abundantly clear the case for speaking with your doctor prior to taking Thesis. This is especially true considering the lack of research into the specific ingredient combinations you’ll find in Thesis products. There is also very little research looking into the risks of combining nootropic supplements with prescription stimulants such as Ritalin, Adderall, or Vyvanse.

Some side effects, such as jitteriness, can be attributed to the caffeine in Thesis formulas. The fact that you can elect to remove caffeine from any formula expands the company’s reach to anyone with caffeine sensitivities and those who really don’t want to give up their morning cup of coffee. If you want caffeine in your Thesis formula, we recommend trying it without having had any coffee first, so you can see how it affects you.

Insider Tip: If you’re not sure whether to get your formula with or without caffeine, we recommend getting it with caffeine. Thesis isolates the included caffeine in a single capsule separate from other ingredients. Caffeinated formulas cost the same as uncaffeinated ones, and you can always elect not to take the caffeine capsule (the smallest capsule in any formula, containing a white powder).

What are the ingredients in Thesis?

Thesis uses an impressive set of ingredients, many of which have been part of respectable clinical research. Not all of the effects they hope these ingredients provide have been proven with sufficient statistical significance or over multiple studies in different populations, but what we do know strongly suggests efficacy.

Here's a look at several Thesis ingredients that have encouraging research behind them:

Several studies on mice show that dihydrohonokiol-B (DHH-B) has potent anxiolytic effects. 6 That means it may be able to help combat anxiety. However, we can’t say this for sure since there haven’t been any studies conducted on humans yet, so any potential benefits are speculative at this time. 25 Converting the successful dose used in mice (1mg) to the equivalent human amount (4.86 mg) is about half the amount used in Thesis’ Confidence (10mg). 6

In numerous studies, ashwagandha has been shown to reduce stress and anxiety. 32 Thesis uses a branded KSM-66 ashwagandha, which has a high standardized count of withanolides — the component of ashwagandha responsible for its positive effects. 33 This ensures both efficacy and consistency from doses that align with those used in successful studies.

While every formula is different, you'll notice that each contains caffeine and L-theanine. The nootropic properties of caffeine are well established. 19 L-theanine — a non-stimulant derived from green tea — has been shown to smooth out the jittery effects of caffeine. You can easily have caffeine removed from any Thesis formula for no extra cost, which is unique in the nootropic market. The L-theanine will remain, as it has its own set of cognitive benefits in addition to its ability to tame caffeine. 20

Saffron offers multiple benefits, including increased levels of dopamine and glutamate, that are dose-dependent. Human studies have also shown positive effects on depression symptoms. Thesis’ Confidence uses 28mg, which is 2mg less than what was used in many of the studies on saffron’s antidepressant effects. However, one study did find success with as little as 15mg. 7

A review of more than 120 scientific articles looking into the cognitive effects of phosphatidylserine concluded that it “safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells.” The study goes on to say that it “supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate.” 34

Derived from a South African plant, Zembrin appears to provide cognitive and anti-anxiety effects as demonstrated in clinical studies on human participants that used the same 25mg dose found in Thesis Creativity and Confidence. 8

Synapsa is a patented form of Bacopa extract, a traditional Ayurvedic memory enhancer. Studies on humans resulted in statistically significant improvements in cognitive tests. The study used 150mg twice daily (300mg total), which is only 20mg less than the 320mg used in Thesis’ Logic. 9

7,8 DHF is a small molecular TrkB agonist that can easily cross the blood-brain barrier. It can increase brain-derived neurotrophic factor (BDNF), a protein that improves neuroplasticity, learning, and memory. BDNF deficiencies are connected to numerous cognitive ailments as well. However, no human studies have been conducted. 26 In mice, 7,8 DHF appears to enhance spatial memory. When converting the effective dose for mice to humans, Thesis’ Clarity offers roughly 6mg more (about 24mg compared to Thesis’ 30mg). 27

Choline is a precursor to acetylcholine, a powerful neurotransmitter in the peripheral, autonomic, and enteric nervous systems. 10 One study on older adult human participants found that taking 187-399mg per day of choline reduced the risk of low cognitive functioning by nearly 50% compared to an intake under 187mg per day. 28 The CDP choline content in Thesis’ Energy is 300mg.

A 2010 clinical study on 485 older adult (over 55 years old) subjects found that 900mg per day of DHA improved memory and learning in those with age-related cognitive decline. 11 And another study in healthy adults 18-90 years old found that 580mg per day helped improve memory. 29 Unfortunately, the amounts used in many studies to improve cognitive function are quite a bit more than the 200mg (which is DHA and L-lysine combined) found in Thesis’ Logic.

Like choline, Alpha-GPC acts as an effective acetylcholine precursor. Studies also show that supplementation with Alpha-GPC can stave off exercise-induced reductions in choline levels. The effective amount used in the mentioned study is 200mg, which is less than half of what you’ll find in Thesis’ Clarity (500mg). 12

In addition to being an effective treatment for neuropathic pain, agmatine appears to have potent effects as an antidepressant. A five-year safety case report study concluded that there are no long-term side effect risks. Thesis’ Creativity only contains 250mg, which is well below the amount tolerated by study participants (2.67g per day). 13

Research into epicatechin indicates that it can enhance cerebral blood flow, delivering more oxygen to the brain to ensure it operates at its highest efficiency. The most effective dose for cognitive benefits appears to be over 50mg per day, and Thesis’ Clarity contains 278mg. 14

Lion's mane has been shown to increase nerve growth factor and promote neurite outgrowth of specific neural cells. It's a safe and reliable neurotrophic, but studies have debunked claims of neuroprotective properties. 15 A very small study of only 41 participants found that 1.8g of Lion’s mane may reduce stress and improve cognitive performance. 30 Thesis’ Clarity contains 500mg of Lion’s mane.

Hyperphenylalaninemia, a severe deficiency in phenylalanine, results in reduced dopamine, serotonin, and noradrenaline levels in the brain. 16 It can also alter cerebral myelin and protein synthesis. Supplementing with phenylalanine may provide neuroprotective benefits.

In a 2020 study, phenylalanine was a large component in a mix of seven amino acids that appeared to improve cognitive, psychological, and social functioning in middle-aged and older adults. Effective doses ranged from 0.85g to 1.7g of phenylalanine. A serving of Thesis’ Motivation contains 500mg, a bit under half of the average amount. 31

Examining the six formulas

Thesis has six nootropic formulas in their lineup (even though you can only choose up to four of them per box). Several other nootropic companies like TruBrain and BrainMD boast targeted lineups, as well, but Thesis is the Goldilocks of the bunch. Where BrainMD’s hyper-specific formulas rely on perhaps too few ingredients to make them worthwhile, many of TruBrain’s complex blends lack real specificity. With Thesis, you get targeted effects from numerous ingredients in moderately complex and reasonably priced combinations.

Each Thesis formula has a blend of ingredients that addresses specific needs. Their names give you a pretty big clue as to what the company intends each to do, but a closer look at their ingredients will help you understand how they achieve this.

Their formulas are:

Interestingly, the company thinks of its formulas as working well in pairs. You don't have to utilize them as such, but it's helpful to know how they view their most effective combinations. The following list details their purported combined benefits.

Enhances focus, eliminates brain fog, and lets thoughts flow naturally

Gets you going, keeps you going, and never crashes

Sparks new ideas, inspires extroversion, and revels in openness

You'll usually only take one formula at a time, but these pairs may act synergistically for specific personality types or cognitive needs.

Note that your first shipment of Thesis will contain six individually packed doses for four of these six formulas. Thesis chooses these formulas for you based on the results of an intake questionnaire, but you can make adjustments to that shipment on the customer dashboard before the shipment leaves their warehouse.

Let's take a closer look at each formula as they would appear with caffeine included.

Thesis Clarity

Thesis Clarity relies on 7,8 DHF (dihydroxyflavone), Alpha GPC (glycerylphosphorylcholine), epicatechin, and lion's mane to increase blood flow to the brain and stimulate the production of acetylcholine, a powerful neurotransmitter associated with learning, memory, and attention. It's particularly adept at cutting through brain fog.

Here's a look at Clarity's full ingredients list:

• Alpha GPC: 500mg
• Lion's Mane Mushroom: 500mg
• Camellia sinensis tea leaf: 278mg
• Dihydroxyflavone: 30mg
• Caffeine: 100mg
• L-Theanine: 200mg

One dose of Clarity consists of four capsules for the caffeinated formula and three capsules for the stimulant-free formula.

Thesis Logic

Thesis Logic contains triacetyluridine (TAU), which caters to the health of the entire central nervous system. It also uses phosphatidylserine to help facilitate communication between and protection of brain cells. 17

This is Logic’s complete ingredients list:

• Ginkgo Biloba: 160mg
• Theobromine: 100mg
• Phosphatidylserine: 400mg
• High DHA Algae: 200mg
• Triacetyluridine: 30mg
• Bacopa Monnieri: 320mg

One dose of Logic consists of four capsules for the caffeinated formula and three capsules for the stimulant-free formula.

Thesis Energy

Thesis Energy uses cysteine and tyrosine alongside caffeine to deliver a steady energy supply. It also includes TeaCrine, a branded form of theacrine, which partners with caffeine to affect adenosine signaling and prevent fatigue.

Here’s a full list of Energy’s ingredients:

• Citicoline: 300mg
• Mango leaf: 300mg
• Theacrine: 100mg
• N-Acetyl cysteine: 500mg
• Indian trumpet tree: 100mg
• N-Acetyl L-tyrosine: 300mg

One dose of Energy consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Motivation

Blood flow and cellular function are at the core of Thesis Motivation . It employs artichoke extract, forskolin, and B12 to achieve these goals, with a healthy dose of phenylalanine for added focus and motivation.

Here's Motivation's full ingredients list:

• L-Phenylalanine: 500mg
• Methylliberine: 100mg
• Vitamin B12: 1000mcg
• Forskolin: 250mg
• Artichoke: 450mg

One dose of Motivation consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Creativity

Thesis Creativity aims to realign you with your inspiration by removing barriers caused by stress, anxiety, and depression. It contains ingredients with powerful anxiolytic properties and 5-HT reuptake inhibition.

Here's a look at Creativity’s ingredients list:

• Alpha GPC: 150mg
• Agmatine sulfate: 250mg
• Panax ginseng: 200mg
• Ashwagandha root: 300mg
• Sceletium tortuosum : 25mg

One dose of Creativity consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Confidence

Confidence is designed to work hand-in-hand with Creativity, using saffron and DHH-B from magnolia bark to increase dopamine levels and decrease anxiety. One fascinating ingredient in this formula is sage extract, which one 2021 study showed can help with various memory tasks, including name and face recognition. 18 It’s worth noting, though, that this study employed a 600mg dose compared to Thesis’ 333mg dose.

Here is Confidence's complete ingredients list:

• Saffron: 28mg
• Magnesium bisglycinate: 500mg
• Sage: 333mg
• Magnolia Bark: 10mg
• Ashwagandha leaf & root: 120mg

One dose of Confidence consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Our Thesis testing results

Our testing team has tried every Thesis formula (with and without caffeine) to determine their short- and long-term efficacy, at least at an anecdotal level. Here’s a quick summary of our experiences:

Clarity provided our testers with a combined sense of focus and mental ease, though we mostly found that it worked best from its second day forward. The very first dose is mildly effective, but it served us better as a loading dose. We had no crash from either caffeinated or uncaffeinated formulas.

Our testers found that Logic provided a similar experience as Clarity, increasing focus and mental acuity, but the caffeinated formula caused a crash in two of our testers. By excluding the caffeine, that crash can be avoided, though that comes at the expense of some efficacy.

We were very curious about how this formula would perform without the caffeine. Our testers had a noticeable increase in energy without jitteriness about one hour after taking Energy. The caffeinated version caused the worst crash of all the formulas, but we were pleased to find that the formula without caffeine still provided noticeable energy increases without a crash.

Our testers are generally a pretty motivated bunch, so we might not have been the best group to evaluate this particular formula. The testers who felt an uptick in a sense of motivation described it more like a feeling of being able to follow through on tasks with less distraction and completion anxiety.

Creativity, like Clarity, seemed to work better for our testers on its second and third days than on its first. Testers generally described a sensation similar to Motivation but without the feeling of being “on rails,” as one tester put it. It seems to allow for more curiosity and exploration, though not necessarily as much follow-through.

This is Thesis’ newest formula, so fewer of our testers have tried it. Among those who have, one tester with a mild case of social anxiety described feeling a bit more relaxed among groups of people. Testers preferred this formula without caffeine.

Thesis pricing, shipping, and returns

Thesis keeps their price structure decidedly simple. This is refreshing, considering the range of nootropics they offer. You don't have to worry about one formula costing you more than another. However, Thesis doesn't make a non-subscription approach economically feasible.

Every Thesis shipment — including the starter pack — consists of four small boxes, each containing six doses of a single formula. That’s 24 doses/month.

Here's how it works:

• Any one-time purchase of a one-month supply, including the starter kit, costs $119.
• When you subscribe, that monthly cost is only $79.
• You can take an extra 10% off your first order with the coupon code INNERBODY

Subscriptions require an account with Thesis, which gives you access to a well-designed customer dashboard. This is where you can easily make formula adjustments, alter your shipping schedule, or cancel your subscription entirely.

Shipping from Thesis is free in the U.S., and the company offers a 30-day money-back guarantee. In our testing experience, we attempted a return on a second shipment into the subscription. While it isn’t the company’s policy to do so, they refunded our money and let us keep the product. This is similar to some other “Keep it” guarantees we’ve seen from competitors, and we appreciated it.

Getting started with Thesis Nootropics

Thesis' website is easy to navigate, but it is inconvenient that you must complete the signup questionnaire before accessing formula-specific pages. There are ways around this — like direct searching or just knowing the formula URLs — but we think reviewing formulas should be a little easier when you first get to the site. And you won’t be able to place an order for anything until you complete the questionnaire.

The user interface for managing your subscription is exceptionally intuitive. You can quickly adjust your formula combinations, specifying whether or not you want specific formulas to contain caffeine.

Setting up a subscription with Thesis is a straightforward process. Here are the basic steps:

• Take the Thesis quiz . This will create a starter kit specific to your results. (You can also build a box from scratch if you know which formulas you want to try.)
• Order your starter kit. We recommend going with the kit Thesis creates after your quiz, but if you change your mind, you can use the customer portal after placing your order to make any changes to the formula combination before it ships.
• Set up a coaching consultation. This is an optional step, but we recommend it and encourage you to have your first consultation before your kit arrives.
• Take your nootropics as needed. Most people can experience some of Thesis nootropics' benefits within a few hours of ingestion. Some ingredients and formulas may take a few days to produce results.
• Refine your order. As you near the end of your first month, you can head over to the Thesis website and customize your next order to include the formula or formulas you like most.
• Set up follow-up consultations as needed. These will help you refine your future orders and maximize your results.

When you subscribe to the starter kit, you will continue receiving that kit every month until you customize your order. Thesis divides their boxes into four six-dose supplies, and you can mix and match those supplies to suit your needs. For example, you could boost energy on the weekdays and creativity on the weekends by getting a one-month supply with 18 servings of Energy in three packages and six servings of Creativity in a single package.

Personalized insights and coaching

When you take the quiz on the Thesis website, you'll get personalized insights comparing your results to other quiz-takers and a data set developed from nearly 500 scientific studies. The parameters in your results cover don’t completely line up with their formulas, but they include:

These results inform the system to make recommendations for your starter kit. After you order, you can set up a consultation with a Thesis coach. These consultations are free, and you can have as many follow-up sessions as you like. Other companies have apps or online resources like blogs or courses to help you on your nootropic journey, but Thesis’ personalized coaching offers a unique approach and execution.

Consultation calls last around 15 minutes, though some of our testers had their sessions go longer as their coaches' schedules allowed. We received best practices information about taking nootropics that covered dose timing, formula application, and more. Some of our testers also received diet and exercise advice that coincided with their formulas.

Alternatives to Thesis

There are generally two tiers of products in the nootropics landscape. The lower tier consists of products that cost between $20 and $40. Many of these nootropics contain proprietary blends that obscure the exact quantities of ingredients, presumably so companies can use more of the least expensive components. Some companies in this tier disclose their ingredient quantities but may not source them from the highest quality suppliers or perform third-party testing of any kind.

Top brands in this tier include:

• Onnit Alpha BRAIN
• Moon Juice Brain Dust
• Focus Factor

The second tier — where you'll find Thesis — consists of more expensive nootropics that spell their contents out clearly, use high-quality ingredients, and often perform third-party testing to ensure safety and potency. Top brands in this tier include:

• Qualia Mind

Hunter Focus

We have a comprehensive breakdown of our top nootropics , but here's a concise breakdown of Thesis' most comparable competition.

TruBrain offers one of the widest varieties of nootropics of any company — one of the few catalogs that rivals the variety Thesis offers. They also have some novel and beneficial delivery methods for their nootropic ingredients. Those include energy bars and liquid shots that are outstanding for anyone with difficulty swallowing pills.

TruBrain offers their nootropics in a targeted fashion, not unlike what you get from Thesis. They formerly offered their targeted blends in shot form only, but now you can get any of these targeted blends in capsule or liquid shot form. The shots come in small 1oz pouches that make them easy to take anywhere.

TruBrain's targeted blends include:

This is TruBrain's original blend. It contains seven nootropics, including Noopept, a branded form of N-phenylacetyl-L-prolylglycine ethyl ester. This blend is caffeine-free.

The Strong blend is identical to the Medium formulation in contents and doses, but it also contains 100mg of caffeine.

The Extra Strong formula builds on the Strong blend by adding 150mg of adrafinil (2-(diphenylmethyl)sulfinyl-N-hydroxyacetamide). 21 This wakefulness-promoting substance may also help with weight loss and athletic performance.

TruBrain's Sleep formula contains just four nootropic ingredients: GABA, melatonin, 5-HTP, and a blend that TruBrain calls "functional oils."

Mellow is identical to the medium strength formula, but it adds the functional oil combination used in Sleep.

This formula contains Lion's mane, a mushroom that may promote neural growth , though human studies are necessary to determine if this is true. 22 Its other nootropic ingredients are rhodiola, guayusa, and rosehips.

A 30-day supply of TruBrain nootropic shots costs $89. That's $10 more than the subscription cost for a one-month supply of Thesis. Some of their shots contain caffeine, and others don't. If it already contains caffeine, there's no way to alter a TruBrain formula to be stimulant-free.

The first month of TruBrain capsules costs a bit less, coming in at $69. After your first month, however, the price goes up to $119. That makes Thesis the better value, but if you want the best possible nootropics for sleep support, it might be worth the extra money to check out TruBrain.

Qualia Mind is a brand under the Neurohacker Collective, a company that offers several products to address things like sleep quality, skin health, and vision. They have three nootropics available:

• Qualia Mind Caffeine-Free
• Qualia Mind Focus

Their original blend is comprehensive, consisting of nearly 30 ingredients in high doses. That means it's liable to provide you with noticeable effects. It also means you might not know which of those effects are coming from which ingredients, and some of the less beneficial components in your body may also have side effects you'd rather avoid.

The caffeine-free version is identical to the original formula but leaves the caffeine out. Qualia Focus is a more streamlined offering with only seven nootropic ingredients, including caffeine, L-theanine, and L-ornithine. 23

Initial shipments from Qualia Mind are significantly discounted, but after the first month, the price makes theirs one of the most expensive nootropics we've tested. For example, the first month of a subscription to Qualia Mind costs just $39. After that, it costs $139/month. And a one-time purchase is $159.

One inconvenient aspect of Qualia Mind is that a single dose consists of seven capsules, which can get tiresome even for people who don't have trouble swallowing pills. On the bright side, Qualia's 100-day money-back guarantee allows you to try it for a little over three months to determine if you can handle that kind of daily dosing.

Hunter Focus is one of three supplements in the Hunter stack alongside the company's Test and Burn supplements. The stack is intended for male use — Test is a testosterone supplement — but Focus and Burn are suitable for men and women.

Like Qualia Mind, Focus has a long list of ingredients in generous doses. In fact, one serving of Hunter Focus is like taking all six of Thesis' formulas at once. That said, the serving itself is difficult to swallow, as it consists of six large pills.

Another knock on Hunter is that they don't offer a subscription system. That means you can't get an extra discount, and you must remember to reorder when you're running low (theoretically, a nootropic like this should boost your memory). There's also no money-back guarantee to speak of, only a return policy with a relatively short window that only applies to unopened products.

One bottle of Hunter Focus costs $90, and shipping is $8.95 unless you buy more than one bottle at a time. The company will throw a fourth in for free if you buy three bottles at once. That's the only way to get any savings through Hunter.

Individual nootropic components

Many companies offer combinations of nootropic ingredients to perform specific brain-related tasks or even provide globally positive cognitive benefits. However, the scientific research behind most of these ingredients almost always includes just one rather than a combination. Some people prefer to try one at a time to minimize the potential for side effects and determine if one particular ingredient works for them. A few companies offer single-ingredient nootropic supplements for this specific purpose.

Our favorite company dealing in individual nootropic components is Nootropics Depot. They offer a wide variety of single-ingredient supplements and a few targeted blends. The prices are generally fair, with an average range running from $16-$70. A 30-day money-back guarantee covers every purchase, and you get free shipping on orders over $50.

Nootropics FAQ

.css-1ygl3x{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;width:100%;outline:2px solid transparent;outline-offset:2px;transition-property:var(--chakra-transition-property-common);transition-duration:var(--chakra-transition-duration-normal);font-size:1rem;-webkit-padding-start:var(--chakra-space-4);padding-inline-start:var(--chakra-space-4);-webkit-padding-end:var(--chakra-space-4);padding-inline-end:var(--chakra-space-4);padding-top:var(--chakra-space-2);padding-bottom:var(--chakra-space-2);}.css-1ygl3x:focus,.css-1ygl3x[data-focus]{box-shadow:var(--chakra-shadows-outline);}.css-1ygl3x:hover,.css-1ygl3x[data-hover]{background:var(--chakra-colors-blackalpha-50);}.css-1ygl3x[disabled],.css-1ygl3x[aria-disabled=true],.css-1ygl3x[data-disabled]{opacity:0.4;cursor:not-allowed;} .css-1eziwv{-webkit-flex:1;-ms-flex:1;flex:1;text-align:left;} how do nootropics affect the brain .css-1eok0x8{width:1em;height:1em;display:inline-block;line-height:1em;-webkit-flex-shrink:0;-ms-flex-negative:0;flex-shrink:0;color:#e22c3e;opacity:1;-webkit-transition:-webkit-transform 0.2s;transition:transform 0.2s;transform-origin:center;font-size:1.25em;vertical-align:middle;}.

Specific nootropics affect different parts of the brain in their own ways. Some — like caffeine — reduce fatigue by blocking adenosine receptors, while others act to protect neural connections that are already present while possibly contributing to new neural growth. 24 Some also mitigate depression and anxiety, which frees up the brain to perform at its best.

Are nootropics safe?

The safety of a nootropic depends on the specific ingredients involved. Many are perfectly safe in the doses commonly employed by nootropic companies, but some can cause reactions like increased heart rate, gastrointestinal discomfort, headache, and even tremors. The smartest thing to do is to talk to your doctor before introducing any new supplement to your regimen.

Do nootropics really work?

Many nootropic supplements are noticeably effective — caffeine is a great example. Efficacy varies depending on the specific component or combination. Fortunately, a lot of companies offer money-back guarantees, so you can try their products to see if they work for you without much financial risk.

Will nootropics make me smarter?

Nootropics won't necessarily make you smarter, but many can increase your alertness, improve short-term recall, and promote neural growth and protection. That creates a great environment for learning if you apply yourself while using nootropics, and many ingredients can help you with the motivation it takes to do so.

How do you pronounce nootropics?

The 'noo' in nootropics comes from the Greek nous , which philosophers use to mean mind or intelligence. The 'tropic' in nootropic comes from the Greek tropikos , which relates to turning or changing. So, nootropic roughly translates to mind-changing. You pronounce the 'noo' like 'new' and the 'tropic' with a long O sound, like 'toe pick.'

Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Mayo Clinic. (2022). Memory lapses: Normal aging or something more? Mayo Clinic Press.

Reay, J., Wetherell, M. A., Morton, E., Lillis, J., & Badmaev, V. (2020). Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers . Human Psychopharmacology: Clinical and Experimental, 35 (6), 1-7.

Chiu, S., Gericke, N., Farina-Woodbury, M., Badmaev, V., Raheb, H., Terpstra, K., Antongiorgi, J., Bureau, Y., Cernovsky, Z., Hou, J., Sanchez, V., Williams, M., Copen, J., Husni, M., & Goble, L. (2014). Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia . Evidence-Based Complementary and Alternative Medicine , 2014, 682014.

Suliman, N. A., Mat Taib, C. N., Mohd Moklas, M. A., Adenan, M. I., Hidayat Baharuldin, M. T., & Basir, R. (2016). Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic . Evidence-Based Complementary and Alternative Medicine: ECAM, 2016.

Sharma, A. K., Basu, I., & Singh, S. (2018). Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial . Journal of Alternative and Complementary Medicine, 24 (3), 243–248.

Kuribara, H., Kishi, E., & Maruyama, Y. (2010). Does Dihydrohonokiol, a Potent Anxiolytic Compound, Result in the Development of Benzodiazepine-like Side Effects? Journal of Pharmacy and Pharmacology, 52 (8), 1017-1022.

Siddiqui, M. J., M. Saleh, M. S., B. Binti Basharuddin, S. N., Binti Zamri, S. H., Najib, M., Ibrahim, C., Noor, M., Binti Mazha, H. N., Hassan, N. M., & Khatib, A. (2018). Saffron (Crocus sativus L.): As an Antidepressant . Journal of Pharmacy & Bioallied Sciences, 10 (4), 173-180.

Terburg, D., Syal, S., Rosenberger, L. A., Heany, S., Phillips, N., Gericke, N., Stein, D. J., & Van Honk, J. (2013). Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus . Neuropsychopharmacology, 38 (13), 2708-2716.

Kumar, N., Abichandani, L. G., Thawani, V., Gharpure, K. J., Naidu, U. R., & Ramana, G. V. (2015). Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial . Evidence-based Complementary and Alternative Medicine: eCAM, 2016 .

Colucci, L., Bosco, M., Ziello, A. R., Rea, R., Amenta, F., & Fasanaro, A. M. (2012). Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: A review . Journal of Experimental Pharmacology, 4 , 163-172.

Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., Salem, N., Jr, Stedman, M., & MIDAS Investigators (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline . Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 6 (6), 456–464.

Parker, A. G., Byars, A., Purpura, M., & Jäger, R. (2015). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility . Journal of the International Society of Sports Nutrition, 12 (Suppl 1), P41.

Gilad, G. M., & Gilad, V. H. (2014). Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report . Journal of Medicinal Food, 17 (11), 1256–1259.

Haskell-Ramsay, C. F., Schmitt, J., & Actis-Goretta, L. (2018). The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow . Nutrients, 10 (8).

Lai, P. L., Naidu, M., Sabaratnam, V., Wong, K. H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia . International Journal of Medicinal Mushrooms, 15 (6), 539–554.

Ashe, K., Kelso, W., Farrand, S., Panetta, J., Fazio, T., De Jong, G., & Walterfang, M. (2019). Psychiatric and Cognitive Aspects of Phenylketonuria: The Limitations of Diet and Promise of New Treatments . Frontiers in Psychiatry, 10 , 434708.

Dobolyi, A., Juhász, G., Kovács, Z., & Kardos, J. (2011). Uridine function in the central nervous system . Current Topics in Medicinal Chemistry, 11 (8), 1058–1067.

Wightman, E. L., Jackson, P. A., Spittlehouse, B., Heffernan, T., Guillemet, D., & Kennedy, D. O. (2021). The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans . Nutrients, 13 (1), 218.

Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015). Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug? Current Neuropharmacology, 13 (1), 71-88.

Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial . Nutrients, 11 (10), 2362.

Lowe, D.W., Dobson, E., Jewett, A.G., Whisler, E.E. (2021). Adrafinil: Psychostimulant and Purported Nootropic? The American Journal of Psychiatry Residents’ Journal, 17 (1).

Sabaratnam, V., Kah-Hui, W., Naidu, M., & David, P. R. (2013). Neuronal Health – Can Culinary and Medicinal Mushrooms Help? Journal of Traditional and Complementary Medicine, 3 (1), 62-68.

Miyake, M., Kirisako, T., Kokubo, T., Miura, Y., Morishita, K., Okamura, H., & Tsuda, A. (2014). Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers . Nutrition Journal, 13 , 53.

P., E., Rábano, A., Cafini, F., & Ávila, J. (2019). Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease . Nature Medicine, 25 (4), 554-560.

Rauf, A., Olatunde, A., Imran, M., Alhumaydhi, F. A., Aljohani, A. S., Khan, S. A., Uddin, M. S., Mitra, S., Emran, T. B., Khayrullin, M., Rebezov, M., Kamal, M. A., & Shariati, M. A. (2021). Honokiol: A review of its pharmacological potential and therapeutic insights . Phytomedicine, 90 , 153647.

Yang, S., & Zhu, G. (2022). 7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development . Current Neuropharmacology, 20 (8), 1479-1497.

Lazari, A., Tisca, C., Tachrount, M., B., A., Miller, K. L., & Lerch, J. P. (2023). 7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice . Frontiers in Systems Neuroscience, 17 , 1134594.

Liu, L., Qiao, S., Zhuang, L., Xu, S., Chen, L., Lai, Q., & Wang, W. (2021). Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States . Behavioural Neurology, 2021 .

Li, J., R. Pora, B. L., Dong, K., & Hasjim, J. (2021). Health benefits of docosahexaenoic acid and its bioavailability: A review . Food Science & Nutrition, 9 (9), 5229-5243.

Docherty, S., Doughty, F. L., & Smith, E. F. (2023). The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study . Nutrients, 15 (22).

Suzuki, H., Yamashiro, D., Ogawa, S., Kobayashi, M., Cho, D., Iizuka, A., Takada, M., Isokawa, M., Nagao, K., & Fujiwara, Y. (2020). Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial . Frontiers in Nutrition, 7 , 586166.

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults . Indian Journal of Psychological Medicine, 34 (3), 255-262.

Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009). Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine . Molecules, 14 (7), 2373-2393.

Glade, M. J., & Smith, K. (2015). Phosphatidylserine and the human brain . Nutrition (Burbank, Los Angeles County, Calif.), 31 (6), 781–786.

Malík, M., & Tlustoš, P. (2022). Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs . Nutrients, 14 (16).

National Center for Complementary and Integrative Health. (2023). Ashwagandha . NIH.

Kamal, H. I., Patel, K., Brdak, A., Heffernan, J., & Ahmad, N. (2022). Ashwagandha as a Unique Cause of Thyrotoxicosis Presenting With Supraventricular Tachycardia . Cureus, 14 (3).

No spam! Your privacy is important to us.

Copyright © Innerbody Research 1997 - 2024. All Rights Reserved.

Innerbody Research does not provide medical advice, diagnosis, or treatment. You must consult your own medical professional.

What Is Thesis?

How does it work, thesis nootropics benefits, thesis blend breakdown, thesis energy benefits, clarity benefits, motivation benefits, logic benefits, creativity benefits, side effects, who should take it, who shouldn't take it, where can you buy it, other user reviews, how does thesis compare to other supplements, our verdict on thesis nootropics.

• Supplements >
• Nootropics >
• ThesIs Nootropics Review

Thesis Nootropics Review (2024) Is It Worth The Hype?

As a fitness coach, I've seen the impact of high-quality nootropic supplements on motivation and concentration during workouts.

Teaming up with my dietitian and 12 clients, we documented the significant cognitive benefits and general effects of Thesis over a period of four weeks.

Does it genuinely fulfill its promise of enhancing your mental performance and focus?

Before trying out the supplement, keep reading and find out if it's right for your mental wellness needs.

Thesis is a stack of supplements that aims to improve cognitive function, mental stamina, mood, and overall mental energy levels.

Thesis nootropics' energy formula claims to boost energy levels while catering to individuals following a certified gluten-free diet, promoting positive habits and supporting nerve health.

What's particularly interesting about purchasing this stack is the Thesis algorithm.

It’s a set of questions that assess your personal needs to create a bespoke starter kit.

More on this shortly.

As a result, you get a recommendation from a couple of their products to provide personalized blends for nootropics.

Let’s learn more about how Thesis supplements work with your brain health.

Thesis Nootropics

The Thesis experience begins with a questionnaire to assess your needs and goals, like improved physical and mental energy.

Based on your responses, the algorithm will recommend different Thesis blends to help you achieve your goals.

After going through the quiz, you get a recommended Thesis starter kit.

The five different products Thesis then recommends claim to work similarly to smart drugs by boosting your cognitive function and mood.

But unlike prescription medications, Thesis uses natural ingredients like vitamins, amino acids, minerals, and herbs.

“Nootropics, a greek word meaning 'Towards the Mind', are compounds that are both (1) neurologically active and (2) directly or indirectly enhance cognitive potential via increased capabilities (ie. reflexes), state of well-being, or learning potential.” - Kamal Patel, MPH, MBA at Examine.com

Once you are a Thesis customer, you can also set up a meeting with a Thesis coach to review your stack and the effects you are looking for and experiencing.

But does that make Thesis legit?

Let’s see what our detailed clinical research reveals.

The first thing that we got our testing team to do is to go through a full week of keeping an hourly journal to self-evaluate their mood, concentration, and cognitive function.

Then we put them through three weeks of taking their Thesis recommended stack and got them all to keep their hourly journaling going.

The first thing we noted was that the energy blend and creativity formula seemed to give our clients a good boost in brain performance.

And the folks that took the motivation blend a few hours before heading to the gym also found they were more focused on their workouts.

However, the majority of our test group highlighted that the effects seemed to wear off after about 4–5 hours.

We also noted that the logic formula didn’t provide a huge benefit, which could be down to a lack of a proven formula.

We also found that the Thesis nootropics cost can mount up if you want to stack a few of them.

• Allows you to combine different product formulas for personal goals
• Provides support from coaches to help you refine your stack
• Positive impacts on mood and concentration levels
• Some of the ingredients are not supported by reliable clinical trials
• You may need to swallow quite a few capsules, depending on your particular blend

Thesis Nootropics offers a unique blend of ingredients that target thesis energy, thesis creativity, cellular function, and even skin health, making it a notable contender in the supplement industry.

For this part of the Thesis supplements review, I got my dietitian to help out and analyze the Thesis formula for each of the products.

We also tested the effects with 12 clients to see whether the marketing hype lives up to expectations.

Let's have a more detailed look at the features and benefits of each blend.

The idea behind Thesis Energy is to help people clear brain fog and feel more mentally energized.

To verify this, we paid close attention to the journal entries our testing team made in the afternoons. This is typically when people feel a slump.

What we found was that folks who took this supplement after lunch gained some mental clarity.

But it seems like the effect wears off after about four hours, so you don’t gain an all-day effect like with other nootropics.

Key Ingredients:

• Choline: According to PubMed, this mineral may boost memory function and verbal fluency [ 1 ].
• L-Theanine: A controlled trial posted in Nutritional Neurosciences suggests that this amino acid can work well with caffeine to increase alertness without causing jitters [ 2 ].
• Caffeine: This stimulant can boost alertness, but you can get this from a morning coffee, so I’m not overly impressed that it’s added here [ 3 ].

Thesis Clarity is another product that aims to improve neural communication and allow you to think more clearly and effectively.

Thesis Nootropics' clarity formula provides an extra boost of cognitive performance, targeting stress response reduction and improving sleep quality, all while delivering a healthy dose for enhanced mental clarity and improved ability.

We did note in our testing review that there seems to be an improvement in mental function for several hours after taking it.

But this also seemed to happen more with those testers who took the clarity and energy formula.

• 7,8-DHF: Studies have shown that Dihydroxyflavone can cross the blood-brain barrier and act as a neuroprotective ingredient [ 4 ].
• Alpha GPC: This is an ingredient that has been shown to protect against neurological decline [ 5 ].
• Lion’s Mane: This mushroom is common in nootropics and has been shown to improve mental performance and creativity [ 6 ].

A large part of improving mental health comes down to how focused and motivated you are with daily tasks. Our clients who tested the Thesis Motivation noted that it seemed to help them remain more motivated during workouts.

But this doesn’t seem to happen if you take it in the morning and go to the gym later in the day. So you’d need to get your timing right.

• L-Phenylalanine: Research has shown that this ingredient can help with signs of depression and improve overall mood [ 7 ].
• Dynamine: Also known as Methylliberine, studies have highlighted that it can impact your mental well-being when combined with caffeine [ 8 ].
• Forskolin: The interesting thing about this herbal ingredient is that it can improve blood flow to the brain for better focus and motivation [ 9 ].

For this product, we looked at what our clients noted in their journals when they were at work or studying. While they did find a boost in focus, none of them noted that it helped improve verbal fluency or problem-solving skills.

• Ginkgo Biloba: This is a common ingredient in traditional medicine, but modern clinical trials have shown that it can help brain health through improved blood flow and anti-inflammatory properties [ 10 ].
• Ashwagandha: This herb can have a direct impact on stress and memory, allowing you to think clearly and effectively [ 11 ].
• Saffron: It’s the most expensive herb in the world, and studies have linked it to improved stress, mood, and cognitive capacity [ 12 ].

A few of our clients tried the creativity blends, but this is one of the products where most of them didn’t report any significant improvements.

Combinations with other products above did positively impact mood and stress, but we couldn’t find any comments where our clients highlighted that they felt more creative in their work or any other creatively demanding context.

• Agmatine: This amino acid doesn’t just boost cognitive performance but may also help to protect brain cells against oxidative stress [ 13 ].
• Zembrin: Research has shown that this herb can impact both stress and anxiety, but there’s no specific evidence that it can help with creativity [ 14 ].
• Ginseng: This is a common ingredient in diet supplements as it can improve blood sugar levels, but that wouldn’t directly influence creativity [ 15 ].

We also asked all of our clients to provide any feedback they had on side effects related to the nootropic blends.

Overall, the majority of people found that it didn't cause any major issues.

We only noted that one person had a bit of a rash, which could have been a result of an allergic reaction to one of the ingredients.

We also found that it’s best not to take these capsules on an empty stomach. Ideally, take them within 20 minutes of eating a meal to avoid stomach upset.

Based on my personal experience, people who want to achieve a moderate boost in brain function may want to take nootropic supplements.

You would need to experiment with the timing as these capsules don’t provide effects for the entire day. But after about a week, you should be in a position to spread out the capsules for maximum effect.

You can also contact a coach directly for advice on timing. It's especially important when you have no prior experience in taking these supplements. However, a good starting point is to take the minimum and adjust from there.

Based on our own experience, people with high blood pressure or neurological diseases shouldn’t take Thesis natural nootropics to enhance cognitive function.

In such cases, it’s best to have a doctor review your detailed medical history and the nootropic ingredients for any potential side effects.

Our testing team didn’t note any improvements whatsoever, and when we specifically asked them after the trial, none of them said they saw a noticeable difference.

You can buy Thesis Nootropics directly from the company website.

We generally recommend avoiding third-party retailers to ensure that you always get the real product, so this is a positive highlight.

We placed two orders, and the package arrived within four days, which is about average for nootropic supplement companies.

One thing to point out on the Thesis supplements shipping policy is that currently, the company doesn’t offer international shipping.

We also had a look for other nootropic reviews online to see what users were saying.

“It gave me more energy. I have struggled with low energy and I felt like my old self again. I could get up & get things done.” - Laurie C., taketheseis.com

“After 1 month of using Energy, Creativity, Clarity and Logic pack, I do not note any difference in mindset. I opted for the non-caffeinated blends as I am not a big caffeine person to begin with so a caffeinated blend might show some improvement.” - Beefnug, Reddit

“I have been continuously nauseated every day using thesis packets. I have given it a week and a half and cannot handle the negative side effects. Disappointed.” - AdGroundbreaking5162, Reddit

Our Thesis scientific research suggests that it doesn’t compare well to our testing of three other products for improving cognitive function.

First of all, we looked at the results we have for Mind Lab Pro .

The one thing that stands out the most is that it seems to be effective for many more hours than Thesis, so the timing doesn’t become an issue.

The second one we compared is Onnit Alpha Brain . This nootropic supplement seems to provide a lot more focus and motivation, especially while you’re at the gym.

Compared to Gorilla Mind Smooth , Thesis doesn’t have the same effect on boosting energy and reducing stress.

Related Articles:

• Avantera Elevate Review
• Best Nootropics For Men
• Best Nootropics For Women

Is It Safe To Take Thesis Nootropics Every Day?

Yes, it is safe to take Thesis Nootropics every day. We found Thesis to be generally easy to process, but you need to look out for allergies to any of the ingredients. A good way to do this is to ask your physician for advice since they will know whether these ingredients are good for your health.

Does Thesis Nootropics Contain Banned Ingredients?

No, Thesis Nootropics doesn’t contain any banned ingredients. All of the ingredients are based on minerals, amino acids, and herbs that won’t cause a positive drug test result.

Based on our feedback from a nutritionist and the test results with 12 clients, we don't recommend Thesis.

Not only do its effects wear off after a few hours, which makes timing your intake a problem, but it also burns a hole in your pocket for just a stack of three or four products.

Instead, I highly recommend one of the best nootropic brands we have tested so far: Mind Lab Pro .

Our results show that its effects last for most of the day and provide great clarity, energy, focus, and concentration, making it a favorite among clients of all age groups.

We Recommend This Instead

Mind Lab Pro

• Great combination of herbs and amino acids that work as a cognitive enhancer
• Added B vitamins to support red blood cell production and boosted energy levels
• Great feedback from users that it can help with relieving anxiety
• Get the BEST PRICE until the end of April
• The capsules are not the smallest ones to swallow

About The Author

James Cunningham is an author and dietary supplement connoisseur with a solid academic foundation, holding a BSc in Sport & Exercise Science from the University of Hertfordshire. Specializing in Performance Psychology, his expertise is backed by both rigorous study and practical experience.

As an author, James is committed to guiding his readers towards optimal health and performance, providing actionable insights and strategies through his writings.

You May Also Like

Write a Reply or Comment Cancel reply

Your email address will not be published. Required fields are marked *

Rating 5 star 4 star 3 star 2 star 1 star

Thesis Nootropics Helped Me Ditch My 3-Coffee-A-Day Habit

Here's what to know about the personalized supplement brand.

As someone who pours herself a tall glass of iced coffee three times a day — and sometimes even more, oops — I figured it wouldn’t hurt to look into other ways to boost my energy and focus. Of course, I also try to get enough sleep, water, and exercise, too. But I was also down to try a few supplements from Thesis, a nootropics company that aims to make you feel more productive with its plant-based blends.

If you’re not familiar, nootropics are similar to adaptogens in that they’re a class of functional plants that are buzzy in the wellness world. But nootropics — which include ingredients like ashwagandha , L-theanine , choline , and functional mushrooms — are more focused on activating different parts of your brain to support motivation, mood, memory, and cognitive processing . That’s why they’re sometimes called smart drugs or cognitive enhancers — and thus have a different role to play than everyday vitamins.

At Thesis, you’re hooked up with a kit of personalized vitamins , adaptogens , and nootropics that are meant to help support you in accomplishing your goals and feeling more energized and productive. I tried them out for a month and I have some thoughts. Here’s what it was like to try Thesis, in case you’re also a coffee fiend who could use a little more focus and energy.

• Price: $79/monthly subscription
• Best for: Energy, focus
• My rating: 4/5
• What we like: Personalized supplements, supportive coaches
• What we don't like: Can seem pricey, you have to be ready for some trial and error

What Is Thesis?

To get started, you’ll first take a quiz on the Thesis website that asks you about how you feel on a day-to-day basis, how much coffee you drink, what your energy levels are like, and how much you sleep (among other lifestyle questions) so that it can determine the best supplements for you. It’ll then send you a starter kit with six different supplement blends targeted for each issue you might be experiencing. From there, it’s up to you to decide which ones you want to continue using. It works like a process of elimination — you experiment by taking each supplement for six days to see whether or not it feels effective.

The Thesis line features eight different supplement blends: Creativity, Focus, Motivation, Clarity, Energy, Motivation, Confidence, and Logic. Though the brand notes it would love to formulate one pill that works for everyone, brain chemistry is so complex, so it decided it’s better to take the long route and have customers try multiple supplements in order to find the best fit for their noggin. That’s why Thesis also puts you in contact with a wellness coach, so you can chat and ask questions with an expert along the way.

How Do Nootropics Work?

Nootropics are meant to allow your brain to do its thing, only faster and with more efficiency. So, instead of slogging away at your desk with brain fog , you might notice that you feel perkier, extra organized, and more on-point than you normally do as you continue taking the supplements.

Some of the blends contain the nootropic acetylcholine , which is a neurotransmitter from the essential nutrient choline known for memory, learning, and healthy brain function . There are also plenty of amino acids, vitamins, and plant-based adaptogens in each packet to fight off fatigue and stress while protecting your brain from toxins so it’s easier to take in info — and actually remember what you learned. Other staple nootropics include ginkgo biloba , certain kinds of mushrooms, and caffeine, each of which plays a unique function in your cognitive function.

My Experience

When I took the Thesis quiz , I said that I wanted to improve my energy, focus, and mood. A few days later, I received my starter kit, which contained Clarity , Confidence , Motivation , and Logic all laid out in cute little boxes. You’re supposed to pick one — each box contains six sachets full of pills — and take a packet a day for six days. I was immediately drawn to Clarity, a supplement combo that’s supposed to help with high-pressure situations, concentration, and tasks that require focus and attention. It has Lion’s Mane extract (a mushroom), caffeine, L-theanine , and a few other ingredients meant to support a calm, focused flow. The idea is to take the supplements in the morning so they kick in before you start your day, and most of the effects are said to last from four to six hours.

I’d been taking Clarity for a few days when I had a phone call with Cindy Yan , a Thesis wellness coach and nootropics expert. We chatted about my usual routine, how I’d been feeling, and any questions I had about the process. When I said I felt a slight uptick in focus, but nothing too dramatic, Yan told me the first couple days are called the “loading phase” which is when the nutrients work their way into your body. If you don’t feel anything after that point, it’s a sign the supplement isn’t necessary or right for your neurochemistry. If you do like how you feel, it’s a keeper.

As we chatted about my routine, Yan realized I’d benefit from Creativity, an ashwagandha-based supplement meant for brainstorming and public speaking, so that I could feel like a rockstar at work. I also told her that I tend to crave a nap around 3 p.m., so she suggested the Energy supplement made with choline and mango leaf extract , which you can take every day or on extra-busy days, before a workout , or whenever you want to feel alert.

Talking to a coach as I tested the supplements was a true perk. While the quiz got me started with some great options, having access to Yan helped me hone in on what I truly needed.

Yan suggested I log how I felt every day as I took each supplement so I could keep track of any noticeable differences. A week in, I looked at the scribbles in my notebook and noticed that I did seem more productive during the six days I took Clarity. I wasn’t launching rockets to the moon, but I was getting through my emails and typing away like a woman on fire.

The next supplement on my agenda was Energy, a blend meant for busy days, intense workouts, and staying alert thanks to its mango leaf, theacrine , caffeine, and n-acetyl cysteine — and this is the one that gave me the most benefit. Yan was right on the money. She said I could take it in the morning and/or right after lunch to nip my afternoon slump in the bud, and it truly worked — no fourth mid-day coffee for me.

The more I took Energy, the less I felt like I needed to unhinge my jaw and dump as much cold brew into my face as possible. I found myself drinking a sensible cup or two in the morning, and that was that. Thesis says you can feel the effects of the supplements in as little as 30 minutes or it can take up to five days for all the benefits to sink in as your body and brain adjust. For me, though, Energy kicked in pretty quickly.

The Bottom Line

Typically, Thesis users land on two or three supplements for their regimen. After the month-long trial phase, you can order just the ones you want and forget about the rest. Personally, I’m sold on Energy and can see myself hanging onto Clarity, too.

Thesis seems to have figured things out in the nootropic supplement realm. While the boxes seem pricey, it isn’t so bad when you think about buying each supplement on your own individually — and the fact that you get a wellness coach, too.

TL;DR: I’d recommend it for anyone who feels fatigued, unproductive, or unfocused, or for folks who rely on caffeine to get through the day, like me. You might just find that there’s a better way.

Studies referenced:

Baba, Y. (2021). Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. doi: 10.1089/jmf.2020.4803. Epub 2021 Mar 22.

Coqueiro, AY. (2019). Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients. doi: 10.3390/nu11040863.

Gelabert-Rebato, M. (2019). A Single Dose of The Mango Leaf Extract Zynamite ® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients. 2019 Oct 28;11(11):2592. doi: 10.3390/nu11112592.

Lai, PL. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. doi: 10.1615/intjmedmushr.v15.i6.30.

Malík, M, Tlustoš P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients. 2022 Aug 17;14(16):3367. doi: 10.3390/nu14163367. PMID: 36014874; PMCID: PMC9415189.

Mokhtari, V. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell J. doi: 10.22074/cellj.2016.4872.

Penry, JT. (2008). Choline: an important micronutrient for maximal endurance-exercise performance? Int J Sport Nutr Exerc Metab. doi: 10.1123/ijsnem.18.2.191.

Sam, C. (2022). Physiology, Acetylcholine. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32491757.

Silberstein, R. B. (2010). Examining Brain-Cognition Effects of Ginkgo Biloba Extract: Brain Activation in the Left Temporal and Left Prefrontal Cortex in an Object Working Memory Task. Evidence-based Complementary and Alternative Medicine : ECAM , 2011 . https://doi.org/10.1155/2011/164139

Suliman, NA. (2016). Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evid Based Complement Alternat Med. doi: 10.1155/2016/4391375.

Todorova, V. (2021). Plant Adaptogens-History and Future Perspectives. Nutrients. doi: 10.3390/nu13082861.

Wiedeman, AM. (2018). Dietary Choline Intake: Current State of Knowledge Across the Life Cycle. Nutrients. doi: 10.3390/nu10101513.

Thesis Nootropic Review - Do Personalized Nootropics Work? I Found Out.

O dds are if you hadn’t heard about nootropics before the early 2010s, you’ve heard about them now. Nootropics burst onto the scene around that time, and they’ve been trending ever since. Why? Well, with bold claims of making you feel more focused, calmer, and even smarter , it’s no wonder that these unique supplements have been catching people’s attention. Especially after the toll of the pandemic on all of our mental wellbeing…

If you’re dealing with brain fog, fatigue, and poor productivity, nootropics probably sound enticing. But, finding natural, effective, no-nonsense nootropics in today’s crowded wellness market can seem like a steep order. 

That’s where Thesis comes in. Takethesis.com is an online brand that’s been a leader in personalized nootropics for years. With all-natural supplement blends that they claim are rooted in science, Thesis promises to bring a new meaning to the term “smart drugs”. 

But as someone who’s always reserved a healthy level of skepticism around the efficacy of supplements in general, I decided to try Thesis nootropics firsthand to see what the hype was all about. In this review, I’ll share my experience with Thesis, including my honest reaction after taking their formulas for greater focus, confidence, logic, and more.

Curious if Thesis can introduce you to the valuable world of nootropics, without the BS? Keep reading to learn what’s inside Thesis ‘ supplements and whether or not their nootropic blends had any effect on my brain.

What are nootropics?

Any natural or synthetic substance that can positively affect cognition, focus, memory, and other mental faculties, and sometimes your mood, is considered a nootropic.

Prescription stimulants like Adderall for ADHD are included as well. And while prescription drugs work for many, they typically exhibit a high instance of unwanted side effects. Natural remedies that boost mental performance, including organic supplements and dietary changes, are generally more sustainable over the long term. In fact, many ADHD patients first discover nootropics after seeking healthier alternatives to Adderall and other pharmaceuticals.

Read our full comparison of nootropics vs Adderall for more details on the key differences.

Source: Thesis

How long have nootropics been around?

The use of nootropics first became widespread in the 70s, when  Piracetam first became widely known as a treatment for motion sickness, then later was found to boost cognitive performance. This spurred more of an effort toward discovering and developing more nootropics . It’s since become a thriving market, especially after the global pandemic wreaked havoc on mental health and left many with persistent brain fog. Today, the internet is awash with countless brain-boosting products available to consumers without prescription, and most don’t have FDA approval or much clinical data to support their claims.

While we love having options, the wide range of (unproven) nootropic supplements available today makes it hard to know which could work for you. There are dozens of brands, each offering various different nootropic blends, all claiming to be the best in class. Should you really be expected to try them all?

Thesis is on a mission to solve this conundrum. The company emerged to not only offer great quality and transparency around their blends, but also to recognize patients’ need for personalized recommendations from experts.

Let’s dive in to see what nootropics Thesis offers, and how the support they offer differs from typical supplement companies.

What are Thesis nootropics?

Thesis (rebranded from FindMyFormula.com) is a longstanding nootropics company with an impressive customer base of over 500,000 users. Having been in the space for years, Thesis has developed a comprehensive data set of nootropics research that dwarfs those of their competitors. I found this data-driven pitch compelling, and thus decided that I’d give Thesis a shot as my first foray into the world of nootropics in general.

1. How Thesis works

To get started, complete Thesis’ online questionnaire . They only ask for basic info – you don’t have to share specific lab tests or detailed medical history. Next, the Thesis algorithm will process your answers to recommend one or more nootropic blends best suited to your needs, which will be shipped to your house within 1-3 business days. 

Thesis recommends you sample their nootropic blends for a month before selecting ones that you believe work the best for you. Of course, you don’t have to stick with just one – and many Thesis customers opt to continue taking two or more blends for varied nootropic benefits as desired. Customer’s purchase data then funnels back to bolster Thesis’s algorithm, further strengthening the reliability of its recommendation engine. Pretty cool, I must admit.

2. What makes Thesis unique

Thesis’ personalized nootropic recommendation algorithm, paired with the ability to try out four unique nootropic blends before selecting your go-to formula, is what defines the Thesis process. They spare you from the difficult, time-intensive testing of individual nootropics on your own, which could easily take months (and cost a serious amount of $). By first paring down your options to the supplements that are most likely to work for you, Thesis takes the legwork out of trying nootropics. 

Plus, when you become a Thesis customer, you’ll also get access to a nootropics expert. This coach is available for consultation at any time to help you optimize your nootropics routine so that you get the most out of these specialized supplements. This includes keeping track of your progress, as well as answering any and all questions you may have about the science supporting each ingredient.

What’s inside Thesis’s unique nootropic blends?

At this point, you’re probably wondering what nootropic blends Thesis has to offer, and what secret sauce ingredients lie within. Thesis currently has six different formulations, each designed to target specific needs:

After filling out Thesis’ online questionnaire, I was recommended all but their Creativity blend . Below, I’ll outline the key nootropic ingredients inside each, as well as review my own personal experience in experimenting with them for the first time.

Energy formula Ingedients

Thesis’ Energy formula is designed to boost energy, fight fatigue, and improve mental stamina. Its ingredients include:

• Choline, for learning and memory
• NAC, for detoxification
• NALT, to support nerve cell communication
• Sabroxy®, for a dopamine boost and heightened memory
• TeaCrine®, for improved motivation, energy, and cognitive function
• Zynamite®, for mental and physical energy
• Caffeine, for energy and alertness
• L-Theanine, for an improved stress response

Review of Thesis energy – did it work for me?

Keep in mind that the power of placebo is well documented, as is the tremendous bias in self-reporting of any kind. These two factors, in combination with the day-to-day choppiness of life in general, make it hard to objectively determine how well supplements of any kind work for a given individual, much less the general population at large. 

That said, putting those caveats aside for sec, I took Thesis’ energy blend for 6 days straight, and I definitely felt more ALERT. The results were noticeable and fairly instant – I felt more alive and energetic within the first hour of taking the four recommended pills , and the feeling generally continued late into the afternoon. 

Fearful that my morning cup of coffee might overshadow or confound the nootropic’s effects, my routine was to take Thesis’ energy formula first thing in the morning with just a glass of water. It could just be the pill’s healthy dose of caffeine (or again, perhaps just placebo?), but regardless, I no longer craved coffee. Thesis’ Energy nootropics jolted me to full attention and kept my energy high for hours. If you’re looking for a caffeine replacement, or perhaps just an extra boost after a night of poor sleep, I definitely recommend Thesis’ blend for higher energy. Here’s what they pills look like up close:

The one downside? I ended up trying Thesis Energy with coffee one morning and felt pretty jittery. Of course, caffeine (and nootropics!) affect everyone differently, so if you’re eager to give these a shot, try them with and without your normal dose of coffee or tea to see how you feel. For me, I only needed one, not both, but it’s worth testing to find out what works for you!

Clarity formula ingredients

Do you find yourself often feeling foggy or forgetful? If so, Thesis’s Clarity formula may be worth a try. Formulated for increased focus and attention span, the Clarity nootropics are designed to help you more easily enter a flow state. 

What ingredients are inside Thesis’ Clarity? Their unique formula contains:

• 7,8-DHF, for neural communication, neurogenesis, and neuroprotection
• Alpha GPC, for memory, neurogenesis, and neuroprotection
• Epicatechin, for improved mood, blood flow, and neuroprotection
• Lion’s Mane, for improved memory consolidation and neuroprotection
• L-Theanine, for a better response to stress

Review of Thesis clarity – my personal experience

In my next phase of experimentation with Thesis nootropics, I decided to sample the Clarity blend for 6 days straight. Note that these six days did not overlap with days I took other nootropics, as I wanted to document my reaction to their blends independently, rather than seeing how I felt taking all of them together at once.

Although the benefits of Thesis’ Clarity blend were admittedly less immediate and noticeable than those I experienced with their Energy blend, I can honestly report that on the days I took Clarity, I found it easy to maintain a state of mental flow for longer . I generally don’t struggle to enter flow and engage deeply with my work, and this remained true while taking Thesis Clarity. What was different for me, however, was the duration of my flow, and I did my best to document these benefits closely through journaling.

To try and make my process as scientific as possible, at lunch each day I recorded how long I was able to stay focused that AM, and then again at dinner, noting how long I had been able to focus in that afternoon. Upon comparing my notes from the week I took Clarity vs the week I didn’t take anything at all, some clear benefits emerged. Overall, I was able to stay in a state of flow for ~35% longer with Thesis Clarity , although I’d be careful not to assume similar results too broadly for a couple of key reasons.

For one, placebo could very much be to blame given that I wanted to be more focused, and thus that desire alone could be to blame for my positive results. There’s also a small sample bias. Having only taken Clarity for one week, my self-reported data is a long way from “scientific significance”. 

That said, nootropics and supplements are all about how you feel, and the end conclusion remains the same: I felt focused for longer when taking Thesis’ recommended blend for Clarity. If you find yourself being overly fidgety, forgetful, or disengaged at work, I recommend you give Thesis Clarity a shot.

Motivation formula ingredients

The Motivation formula is intended to boost willpower and productivity while reducing procrastination. This formula from Thesis includes the following nootropic ingredients:

• Artichoke extract, for stress management and circulation
• Dynamine®, for crash-free energy and a mood boost
• Forskolin, for improved cognitive function
• L-Phenylalanine, for mood, attention, and motivation
• B12, for energy and nerve wellness
• Theanine, for an improved stress response

Review of Thesis Motivation – does it actually work?

Although I consider myself highly motivated, we all have days when we feel kind of “meh”. Rather than sampling Thesis’ Motivation nootropic every day for six days in a row, as I had with other blends, I instead opted to only experiment with them on days I woke up feeling noticeably uninspired. Interestingly, but perhaps not so surprisingly, these mostly fell on Mondays, although I felt less inclined to face my responsibilities on other days as well.

So, on these days of lower motivation when I took Thesis’ recommended Motivation nootropics, how did they make me feel? Honestly, I’m not sure. When reviewing my journal entries, I don’t notice any strong signs that the Thesis’ Motivation nootropics helped me significantly. It’s possible they acted in more subtle or slower ways because, by the afternoon, my notes indicate that I always felt fully engaged and motivated with whatever I was doing. But I must admit, I felt no sudden rush of motivation or anything super perceptible about Thesis’ nootropics for Motivation.

This may be because I didn’t adequately measure my personal motivation level while journaling. It could also be that on cherry-picking days I felt less motivated and heavily on biased my experience. For instance, I wonder if my results would have been more pronounced if I took Motivation consistently every day? Ultimately, I should probably test Thesis’ Motivation blend more before drawing any hard conclusions. And again, it’s worth noting that everyone’s body is quite different. While I don’t struggle with day-to-day motivation, others clearly do, and thus might see more noticeable results than I did.

Creativity formula ingedients

Thesis’s Creativity formula is designed to spark inspiration, improve verbal fluency, and provide a boost of confidence. It contains:

• Agmatine, for stress management
• Alpha GPC, support for memory, neuroprotection, and neurogenesis
• Ginseng, for learning and memory
• Ashwagandha, to promote calm in stressful settings
• Zembrin®, for mood regulation and blood flow to the brain
• Caffeine, for energy

My review of thesis creativity

Unfortunately, Thesis didn’t recommend this formula to me, so I can’t comment on its efficacy. That said, it’s one of Thesis’ most popular formulations, and thus seems to work for thousands of happy customers. I’ll update this section when I have a chance to try it first-hand.

Confidence formula ingredients

Confidence is the newest nootropic blend from Thesis. It contains ingredients to target stress and insecurities while fostering a sense of self-assurance. The idea behind the Confidence blend is that it will help users to feel more sure of themselves and stay in the present.

The Confidence nootropic ingredients include:

• Magnesium L-threonate

Ashwagandha

Review of thesis confidence – does it work.

Even the most self-assured among us crave more confidence. That’s because it’s attractive and infectious. As Thesis’ newest nootropic blend, Confidence is recommended for “high-pressure situations” when you want to “expand your comfort zone”, so I decided to reserve mine for situations in which I was meeting new people, which often, for me, means anticipatory social anxiety.

Recording how I felt two hours before leaving to meet new folks (both for business and pleasure), and then comparing that to my notes from just one hour before each meeting, a clear pattern emerged. In all cases, I reported feeling more relaxed and ready for new encounters after taking Thesis nootropics .

Absent any supplements whatsoever, my typical levels of social anxiety generally increase steadily up until the moment I see people. Generally, I turn to meditation to try to remedy that in the short term. However, that didn’t appear to be the case the 6 times I sampled Thesis’ confidence formula, although it’s unclear why. Perhaps it’s a placebo effect. But in any event, I was encouraged to keep trying Thesis Confidence nootropics before performative moments of all kinds.

Do Thesis nootropics really work?

I didn’t expect any nootropics to have a significant perceptible impact on my mood or cognition, yet 3 of the 4 blends that I tried brought real benefits. In case you missed it, I chronicled my experience trying various nootropic blends from Thesis above. Overall, I have to say I was pretty impressed with their results. 

For me, Thesis’ Energy and Confidence blends worked the best. Clarity also helped me maintain flow for longer during the workday, but I didn’t notice any strong effects from their Motivation supplements. Of course, I don’t know for sure that the nootropics are directly responsible for the benefits I perceived after trialing each variety 6 times. It could have just been placebo effect or some other internal bias altering my perception of reality. But honestly, does it really matter? The effects were very positive, and for the most part, perceptible, too. That’s a win-win!

That said, everyone responds differently to nutrients, which explains why you should maintain a healthy dose of skepticism about how well nootropic blends might work for you. How can something as simple as an herb really make you feel happier, more focused, and more productive? You won’t know unless you try them for yourself and pay close attention to how you feel.

Since my initial exploration, several members of my team have tried Thesis nootropics as well. While we all agree that you likely won’t feel as stark of a mental difference from all natural nootropics as you would with synthetic prescription drugs, but we all experienced a noticeable, positive effect on mood, memory, energy, and focus. This corroborating evidence – albeit self-reported – reassured me that perhaps my experience wasn’t all placebo after all.

What’s it like to talk to a Thesis nootropic coach?

After trying Thesis supplements, I was eager to chat with their team of expert nootropic coaches to discuss my experience. Naturally, I wanted to know if what I felt was “normal”, as well as how to further optimize the benefits I felt by making adjustments. I know there are lots of telehealth platforms on the market and having a coach with the knowledge of something that I knew less about made me much more comfortable.

I was able to schedule a call within just a few days and chatted with someone named Cindy with a degree in neurobiology. She was able to explain how the various nootropics I had tried likely contributed to my experience and offered a few recommendations around what to try next given my individual results.

Ultimately, I not only enjoyed the conversation but felt like I had clear next steps. It was reassuring to know I could get advice again at any time in the future. This is an amazingly personal feature that makes Thesis stand out against other nootropic brands.

What active ingredients does Thesis include in their compounds?

Each ingredient included in Thesis’s formulations is backed by science, which you can find right on their website. There are ways to test for any deficiencies  that you might have, which can also help you decide which supplements would benefit you. Here’s an overview:

Synapsa® (Bacopa monnieri plant)

Bacopa has been shown to boost memory recall and be neuroprotective. 

TAU (uridine)

The body uses uridine to create choline (a cognitive enhancer), construct nerve cell membranes, and help prevent neuron damage. 

7,8-DHF (dihydroxyflavone)

Studies indicate that 7,8-DHF can help protect against brain damage and neurological decline. 

Choline supports nerve health, cerebral metabolism, and the function of neurotransmitters. It also has been shown to have neuroprotective benefits, preserving the health of your brain. 

When it’s taken regularly, DHA has been shown to boost memory and reaction time. 

Ashwagandha root helps regulate the body’s response to cortisol, the “ stress hormone”. 

The active components of GS15-4 Panax Ginseng have been found to boost memory formation and learning. 

NALT (N-Acetyl-L-Tyrosine)

NALT can increase alertness, energy, and cognitive function . 

Artichoke extract

Artichoke extract is rich in antioxidants that can boost your overall bodily function and offer protection against stress and toxins. 

NAC boosts levels of glutathione, which can reduce oxidative stress and help naturally detoxify the body. 

Methylcobalamin, a form of vitamin B12, is used in Thesis supplements to improve nerve health and energy levels. 

Lion’s Mane mushrooms

Lion’s Mane mushrooms can enhance your mood and quality of sleep while reducing stress levels.

There are a total of 28 ingredients found in Thesis nootropic blends . Others not listed above include alpha GPC, Zembrin®, phosphatidylserine, forskolin, Sabroxy®, TeaCrine®, agmatine, epicatechin, alpha GPC, Dynamine®, L-theanine, Zynamite®, L-Phenylalanine, theobromine, ginkgo Biloba, and caffeine. 

How much do Thesis nootropics cost?

For a one-time purchase, Thesis costs $119 for a one-month supply . This isn’t the most economical way to try their nootropics, though. Instead, we’d recommend signing up for a subscription , which costs $79 for a one-month supply, and will force you to properly test Thesis over a longer period for more credible results.

Thesis offers a 30-day money-back guarantee, which eliminates the risk of trying them out. If you’re not sold after a month, you can simply get your investment back – no questions asked. 

Thesis alternatives: How does Thesis compare to other nootropic brands?

Of course, Thesis is far from the only nootropic company in town. How does it stack up vs alternatives? Take a look for yourself:

Thesis Nootropic reviews: What are customers saying?

Before diving into nootropics with Thesis, we knew that you’d want to read what other customers are praising or complaining about in their reviews. Here’s what we found online:

Source: Facebook

Source: Reddit

The verdict: Are Thesis nootropics legit?

Armed with all of the information, including my own personal journey trying their nootropics for the first time, and a comparison of Thesis vs other popular alternatives… should you give Thesis a shot?

While Thesis is pricier than its competitors, we believe that their personalized approach is ultimately worth it for the value. For one, Thesis offers you access to an expert nootropics coach, who can seriously enhance your experience with the supplements and guide you on your journey to optimal mental performance.

Additionally, Thesis has done the heavy lifting of finding legitimate ingredients that are backed by reputable science and are more transparent with their ingredients and dosage than other brands. If we’re comparing to taking it upon yourself to test out individual nootropics on your own, Thesis will save you a ton of time.

Plus, the company’s unique blends pair ingredients that complement each other, and you won’t find these formulations anywhere else. They are custom formulas based on your individual needs, and you can try them for 30 days risk-free thanks to their money-back guarantee.

When push comes to shove, we’d recommend Thesis to anyone who’s interested in testing nootropics for the first time and doesn’t know where to start, as well as more experienced wellness enthusiasts looking to make nootropics a regular part of their self-care routine. For greater focus, energy, motivation, and a major mood boost, nootropics from Thesis worked for me, and with thousands of happy customers, it’s reasonable to assume their blends can work wonders for anyone willing to experiment under the guidance of one of their coaches. Of course, you’ll never know unless you try it out for yourself. Just don’t forget to use our promo code FINVSFIN for 10% off at checkout.

Remember to always consult with your doctor before starting a new supplement to ensure it’s right for you.

Have you tried out nootropics? Let us know about your experience and result in the comments below!

Frequently Asked Questions (FAQ)

For a one-time purchase, Thesis costs $119 for a  one-month supply . This isn’t the most economical way to try their nootropics, though. Instead, we’d recommend signing up for a  subscription , which costs $79 for a one-month supply, and will force you to properly test Thesis over a longer period for more credible results.

Discover more innovative mental health startups

Plushcare anxiety review: is it legit for therapy online.

Home › Mental Health › Plushcare Anxiety Review Rating: 4.5 / 5 ★★★★★ 4.5/5 Telehealth platforms, like PlushCare, allow you to prioritize your mental health in a more convenient and affordable way. With PlushCare’s online platform, you won’t have to rearrange your schedule, worry about transportation, or leave home to connect with a therapist or doctor, even if you may need a prescription. You can arrange an appointment when it’s convenient for you, including same-day bookings.  Let’s review Plushcare’s approach, pricing, and alternatives for fast, convenient anxiety and depression treatment online. PlushCare Anxiety Pros + Cons ProsIntegration of medication and therapy –

Klarity Anxiety Review – Pros, Cons, Alternatives, & More

Affecting over 40 million American adults each year, anxiety is one of the most common mental health conditions. Regardless of the type of anxiety condition, they are all highly treatable, with many individuals experiencing symptom reduction or relief with appropriate treatment.   Finding treatment, booking an appointment, and traveling to an office for support may feel overwhelming and exhausting, making online mental health platforms, like Klarity, incredibly useful. The platform connects you with practitioners all over the country who aim to provide you with the best telepsychiatry treatment possible.     In this review, we explore what Klarity is, including its

Circle Medical ADHD Review – Is It Legit For ADHD Meds Online?

ADHD can interfere with your quality of life and disrupt your work schedule. We know how busy life can get, and sometimes, it may feel impossible to make the time to see an in-person care provider. Plus, the steps to find appropriate support may feel overwhelming. The good news? You can get an ADHD diagnosis and treatment all online, thanks to telemedicine. Circle Medical is a primary care practice that offers online appointments and care, including ADHD assessments and treatment. We review Circle Medical in-depth – specifically their ADHD treatment (although they can treat many other conditions, online or in

How to Get Prescribed Adderall Online

Difficulty focusing, impulsivity, disorganization, trouble planning ahead…we all have scattered thoughts and trouble motivating ourselves from time to time, but if you’re distracted too regularly to the point where your ability to perform daily life is impacted, you may very well have ADHD. Check out this in-depth roadmap of how to get prescription meds for Adderall online.

TruBrain Sleep Review – Is It the Best Nootropic Drink for Better Sleep?

Nootropics, or “smart drugs,” are substances that may boost cognitive function, including learning and focus. However, some nootropics also aim to enhance sleep.    TruBrain’s Sleep Drinks are a fast-acting formula that support deep, restorative sleep, according to the company.   Learn more about this 1 ounce sleep shot, including its ingredients, how it compares to other sleep nootropics, and its potential benefits.     TruBrain Pros and Cons   Pros Cons Non-groggy: Optimizes sleep and may help you feel clear-headed in the morning Easy: No prep involved; simply enjoy ~30mins before getting ready for bed Convenient: The individual ingredients

Stasis Review – Can It Really Eliminate the Negative Effects of Stimulants?

Stimulants, like Adderall, may be incredibly useful for some people in managing symptoms associated with ADHD. Unfortunately, they may also come with side effects, such as decreased sleep and appetite, as well as increased heart rate and blood pressure. A severe side effect called neurotoxicity, which describes changes to the nervous system’s typical activity after exposure to a toxic substance, is also possible.    Some supplements, such as Stasis daily supplements, are aiming to combat these side effects by replenishing certain nutrients that stimulants may deplete from your body temporarily. When taken correctly and under the guidance of your healthcare

• Illuminate Health
• Certification Program
• Editorial Guidelines
• Return Policy
• Terms of Service
• Privacy Policy

Thesis Review: Are Personalized Nootropics Legit?

Calloway Cook Calloway Cook is the President of Illuminate Labs and has reviewed over 1,000 clinical trials. See full bio . , Author | Taylor Graber MD Taylor Graber is a Medical Doctor (MD) and a practicing anaesthesiologist. He's also an entrepreneur who runs a health and wellness startup. See full bio . , Medical Reviewer Last updated: Nov 05, 2023

Calloway Cook Calloway Cook is the President of Illuminate Labs and has reviewed over 1,000 clinical trials. See full bio . , Author

Taylor Graber MD Taylor Graber is a Medical Doctor (MD) and a practicing anaesthesiologist. He's also an entrepreneur who runs a health and wellness startup. See full bio . , Medical Reviewer Last updated: Nov 05, 2023

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

Illuminate Labs has a team of medical experts including doctors and Registered Dietitians who are assigned to review the accuracy of health claims and medical research summaries based on the relevancy of their expertise to the article topic.

The focus of our articles is to share our opinion on the potential efficacy and safety of health trends and products.

T hesis is a wellness brand that sells personalized nootropics. The brand sells supplements with unique names like “Creativity” and “Motivation,” and claims that their individualized products are “based on your unique brain chemistry.”

But is there legitimate research backing personalized nootropics or is this just a marketing spin? Why does the brand ask for so much personal data? Are their supplements well-formulated? And how do real users rate and describe the effects of Thesis?

In this article we’ll answer all of these questions and more as we share our concerns about the marketing practices and health claims of Thesis.

We’ll also analyze the ingredients in one of their formulations based on medical research to give our take on whether or not it's likely to be effective. We’ll share real, unsponsored user reviews of Thesis nootropics including some from individuals with ADHD.

Is the “Personalized” Approach Fake?

The branding around Thesis is of “personalized nootropic formulas,” however this may be entirely untrue.

We submitted test answers into the health intake form of their site, along with a fake email, and after submitting all of this information we were brought to their “Starter Kit” landing page which is accessible at this link .

If you access the above link in a new window, the products suggested are the exact same, which suggests that Thesis is really collecting sensitive customer health data based on the guise of “personalized” supplements, while providing no additional value, which is a highly questionable marketing approach in our opinion.

The concept of “personalized nootropics” doesn’t even make sense, because the manufacturer would have to literally formulate and package them when a customer placed an order, unique to each customer’s order which is highly unlikely. It would make no business sense for a company to formulate millions of unique products and would be logistically impossible.

It appears that Thesis simply recommends some of their supplements to consumers based on their needs, which is not a “personalized nootropic formula,” it’s a personalized recommendation which literally any brand could offer.

This leads us to our second concern about this brand.

Rather than simply selling supplements, they require users to complete a questionnaire which asks a number of sensitive health questions. 

As shown above, the brand requires users to answer questions about their gender identity and their alcoholic intake in their health quiz. What does this have anything to do with nootropics, and why would any user share this data with a random supplement startup?

We would recommend avoiding this brand based on these marketing and data collection practices alone, but in the next section we’ll analyze the formulation of one of their products.

Ingredient Analysis

Thesis’ “Motivation Formula” contains five active ingredients: l-phenylalanine, Dynamine, vitamin B12, forskolin and artichoke extract.

L-phenylalanine is an amino acid that Thesis describes as supporting mood, attention and motivation, however these claims are uncited and we can’t find any medical evidence supporting them. 

Most of the clinical research we found on this ingredient involves obesity, with this clinical trial finding that l-phenylalanine may increase the sense of fullness and decrease calories consumed in overweight individuals, but only at a dose 20x that in Thesis’ supplement.

Dynamine is a trademarked form of methylliberine, which is a chemical compound that can be isolated from coffee beans and tea. Thesis claims that this compound “supports alertness” but this claim is uncited and we can’t find any medical evidence supporting it.

The manufacturer of this ingredient is a company called Compound Solutions, and the company even states on their website that this ingredient is “typically used in combination with caffeine and TeaCrine,” because all three of the clinical trials that the manufacturer cites on their website use Dynamine in combination with either caffeine or TeaCrine.

However, there is no caffeine or TeaCrine in Thesis Motivation.

Vitamin B12 is often included in nootropic formulations, but we’re unsure why. As we referenced in our review of another nootropic supplement called Noocube which also contains this ingredient, we can’t identify any medical evidence that vitamin B12 improves cognitive function in healthy adults without a vitamin B12 deficiency.

Forskolin was shown in an animal study to reduce memory loss, but the lowest dose used was equivalent to over 200% of the human-equivalent dose in Thesis. We can’t identify any clinical trials with human trial participants proving this compound to be an effective nootropic.

Artichoke extract is the final active ingredient, and Thesis claims that this ingredient “supports blood flow and promotes stress management.” These claims are uncited and we’re unclear on why this ingredient would be included in a nootropic formula, as even the stated health claims do not reference an explicit improvement in cognitive function.

Thesis fails to publish inactive ingredients for Motivation, which is an important consumer safety concern.

Overall we do not consider Thesis Motivation likely to be effective for improving cognitive function or productivity as we are unable to identify a single active ingredient that we would consider effective at the given dose, based on a review of clinical studies.

We do not recommend this supplement or brand, and consider this product to be one of the worst nootropic formulations that we’ve reviewed on Illuminate Health. Most nootropic supplements we review at least contain one effectively-dosed active ingredient.

We Tried Thesis Ourselves

One of our product testers named Matt Donnelly tested Thesis. Here's his experience:

I spent the month trying out the starter pack, which included CLARITY, MOTIVATION, LOGIC, and MOTIVATION.

Of the four, the only one that seemed to have any positive effect was LOGIC. It's good for “Research projects” and “Complex problem-solving” according to the packaging.

I was hoping for good results because I had been sidetracked from creative projects. It seemed like this one may have contributed to more focus overall and focused attention.

On some days I got very tired a few hours after taking the capsules, and needed to lie down in the afternoon.

There are three or four pills in each packet. It seemed to me like a lot to consume on a daily basis, and the pills are large so they could be challenging to swallow.

Overall, I would rate Thesis 3/10 and I wouldn't purchase this product again.

Real, Unsponsored User Review of Thesis

A YouTube creator named “LUKAS YAN” reviewed Thesis nootropics and shared his thoughts on whether or not the supplements improved his physical and mental energy:

Will Thesis Nootropics Cause Side Effects?

Thesis Nootropics do not appear to have been studied in any clinical trials, so it’s impossible to say for certain whether or not they’re likely to cause side effects. However, we can make an educated guess based on their formulations.

Most of the active ingredients in Thesis supplements appear to be safe and well-studied. We don’t have access to the full set of the brand’s supplements because instead of transparently posting all product pages they rely on the “individualized” marketing.

Our concern in regard to side effects is that the brand fails to clearly publish inactive ingredient information, and some inactive ingredients can cause side effects.

We hope that in the future Thesis publishes inactive ingredients in the same section where active ingredients are published for each supplement they sell. This is important for consumer safety.

Our Clean Nootropic Picks

There are compounds which have been shown in medical studies to be effective for cognitive enhancement and memory support.

MCT oil  is a food supplement derived from coconut oil that  improved memory recall by 20% in adults   in a 2022   meta-study .

Bulletproof MCT Oil   is our top MCT oil pick, because its only ingredient is MCT oil derived from coconuts and it has zero additives. It currently retails for   under $16 .

Ginkgo biloba extract  is arguably the most well-studied nootropic supplement apart from caffeine.

A  medical review  published in the  Psychopharmacology  journal  found that ginkgo biloba supplementation improved attention and cognitive performance in healthy, young adults.

Illuminate Labs Ginkgo Biloba Extract   is our supplement which is third-party tested to ensure purity and label accuracy, and retails for   only $15   at a subscription price.

Panax ginseng extract  is another well-studied nootropic supplement. A 2013  clinical trial  found that  ginseng extract caused " overwhelmingly positive effects on neurocognitive function across different cognitive domains."

Illuminate Labs Panax Ginseng Extract   is our supplement which is third-party tested to ensure purity and label accuracy, and retails for   only $15   at a subscription price.

Is Thesis Effective for ADHD?

We don’t recommend using Thesis supplements to treat any specific health condition. There are several TikTok reviews from users with ADHD who tried Thesis supplements.

A TikTok user named “BrigidMarie TV” reviewed the brand here:

@brigid_marietv ADHD med challenge with thesis nootropics has ended. #nootropics #adhd #executivedysfuntion ♬ How`s Your Day - aAp Vision

A TikTok user named “BadKitty” had a less favorable review:

@badkitty7777 #thesisreview #thesis #adhd #anxiety #mentalhealth #scathingreview #trash ♬ original sound - BadKitty

We disagree with the way Thesis markets their products, and we recommend that consumers avoid giving sensitive health data to dietary supplement startups unnecessarily.

The one Thesis supplement that we analyzed based on its active ingredients, called Motivation, was underwhelming. We were unable to identify any effectively-dosed ingredients based on a review of medical research, and the brand fails to clearly publish inactive ingredient information or cite the health claims made about their ingredients.

We do not recommend Thesis supplements although we don’t consider it likely that the supplements will cause side effects.

Some TikTok users with ADHD who tried Thesis supplements had relatively negative feedback.

Mind Lab Pro Review: The Most Well-Studied Nootropic?

• nootropics.

Noobru Review: Can it Boost Focus?

Is Coffee Bad For You? Four Surprising Research Findings

• nutrition.

Is Core Water Good for You? Our Concern Explained

• hydration.

Simple Weight Loss Review: Does the App Work?

• weight loss.

Zepbound Review: The New & Improved Ozempic?

Supergut Review: Is "Nature's Ozempic" Real?

• gut health.

Best Earl Grey Tea 2024: Which Brand is Healthiest?

• tea.

Best Creatine Gummies 2024: Which Brands Actually Work?

• exercise.

Is Tru Fru Healthy? An Ingredient Analysis

• nutrition.

Is Oikos Triple Zero Unhealthy? An RD Answers

Olly Combat Cravings Review: Best Weight Loss Capsules?

Hello Mood Review: Is THCa Dangerous?

• cannabis.

Dermaclara Review: Does Silicone Reduce Wrinkles?

• anti-aging.

Skinesa Review: Can Probiotics Improve Skin?

• probiotics.

Physician's Choice Review: Is the #1 Probiotic Actually Healthy?

Olly Probiotic Review: Overpriced and Underdosed?

Blueprint Review: Are Bryan Johnson's Supplements Unhealthy?

• longevity.

Simpler Hair Color Review: Does Hair Cream Work?

• hair dye.

RoC Vitamin C Serum Review: Can it Brighten Skin?

• skincare.

Is Coffee Creamer Bad for You? An Ingredient Analysis

• coffee.

Is Coffee mate Bad for You? An Ingredient Analysis

Best Mouthwash for Bad Breath: Our 2024 Top Picks

• dental health.

Is Chobani Healthy? A Dietitian Answers

Six Star Creatine Review: Improved Power During Workouts?

Beef Tallow Moisturizer: TikTok Scam or Naturally Hydrating?

Olay Super Serum Review: Are 5-in-1 Benefits Possible?

Jublia Review: Does Prescription Antifungal Cream Work?

• athlete's foot.

Is Cantu Bad For Your Hair? An Ingredient Analysis

• hair.

Truvani Review: Healthiest Protein Brand?

• protein.

Can “Enhanced” Olive Oil Improve Health?

Isopure Review: Best Keto Protein Brand?

Füm Review: Is Inhaling Essential Oil Dangerous?

• public health.

Are Cheez-Its Healthy? An Ingredient Analysis

Best Tea for Congestion: Three Research-Backed Options

Is Bai Good for You? A Dietitian's Review

Wrinkles Schminkles Review: Can Face Patches Reduce Wrinkles?

VouPre Review: Is $1,000 Skincare Worth It?

Life Cykel Review: Best Mushroom Tincture Brand?

• herbal supplements.

Is Fiji Water Good for You? A Research Analysis

Is BioSilk Good For Your Hair? An Ingredient Analysis

Six Star Whey Protein Review: Is "Immune Support" Protein Legit?

Is AriZona Green Tea Good for You? A Dietitian Answers

Are Popcorners Healthy? An Ingredient Analysis

Is Aussie Good for Your Hair? An Ingredient Analysis

Field of Greens Review: Are Organic Greens Healthier?

• green powder.

Is Herbal Essences Good for Hair? A Dermatologist Answers

Are Uncrustables Healthy? An Ingredient Review

Best Female Libido Supplements: What's Proven to Work?

• sex drive.

Best Yerba Mate: Our Two Healthiest Picks

Is Tajín Bad For You? A Dietitian Answers

Illuminate labs is a proud member of.

• choosing a selection results in a full page refresh

The Best Nootropics Supplements Personalized to Your Brain?

Updated: 01/25/2024

Affiliate Disclosure: This post contains affiliate links , which means Outliyr LLC gets a small commission if you buy (at no cost to you). Thanks for your support!

Your brain is a primary difference between winning a Nobel prize and living a life of mediocrity.

How well it functions isn’t solely a matter of genetics.

Neuroscience research, and overwhelming anecdotal experience, show that we can dramatically upgrade our:

• Mental clarity
• Productivity
• Access to the flow state
• Information processing speed

Welcome to the world of “neurohacking”. Using special ingredients and lifestyle practices to optimize the brains and increase our overall quality of life.

But there’s one glaring issue…

Companies making the best brain-boosting supplements recognize this and customize their formulas to your unique lifestyle.

One such nootropic experience is a “newcomer” (you’ll learn why this isn’t exactly true) called Thesis. You take a short brain assessment, they send you a starter kit, and their complimentary coach helps you hone the perfect brain supplements — customized to you!

This post will thoroughly review of TakeThesis, how it compares to other nootropics companies, and whether this is the last brain supplement you’ll need.

In a hurry?

Use the exclusive Thesis code URBAN to save 10%

Quick & Dirty Intro to Nootropics

These are different from the off-label use of prescription pharmaceuticals like Adderall.

Essentially, nootropics are a special class of ingredients that satisfy ALL the following criteria:

• Safe and non-toxic
• Enhance learning and memory
• Protect against injury
• Boost natural cognitive ability (memory, logic, creativity, focus, etc)

There’s something that makes them even better…

Nootropics upgrade your baseline performance even after you stop taking them . They cause long-term changes to brain structure and function. Almost like training you how to operate at a higher level and forming positive habits.

At the same time, the good ones provide a quick and noticeable pick-me-up. You don’t wonder if they’re working.

The right formulas help you reach your full potential faster and more effectively.

What is Take Thesis Nootropics?

Thesis is the masterpiece of expert brain supplement formulators Dan Freed and Adam Greenfield. This duo began researching nootropics out of personal need. Both struggled with poor cognitive performance. They learned how to balance brain chemistry to maximize performance.

Now they’re sharing their discoveries with the world.

After great success with their original product, Find My Formula (which I reviewed here), they revamped their formulations and process.

While each of us has unique neurochemistries, after working with enough people, they began to spot patterns in which ingredients, the forms of those ingredients, and doses work best. Over the span of years, they’ve amassed a huge dataset:

• 30,000+ users
• 550,000 recommendations made
• 127 ingredients tested

Resulting in 86% of users reporting higher energy levels, better mood, more reliable memory, and greater motivation.

Unsurprisingly, Thesis has garnered a stellar 96% customer satisfaction.

The company also has soul. By donating a portion of each sale to both the Covenant House and The Multidisciplinary Association for Psychedelic Studies (MAPS), they’re evolving the future of brain enhancement and also making it more accessible to the world.

Thesis Nootropics Ingredients

When evaluating any nootropic, you must consider how they source and test ingredients.

The sad truth is that most of the products on the market are WORSE than useless. Contaminated with heavy metals, mycotoxins, pathogens, even adulterated with banned (dangerous) substances.

Thesis puts each ingredient through a rigorous, multi-step ethical, medical, and legal evaluation. Before acquiring and testing the ingredients for safety and purity, every ingredient must be supported as safe and effective by clinical trials.

This team keeps up with the ever-changing regulations.

Since the days of Find My Formula, a lot has changed. Each of their blends has undergone a major overhaul.

One of the common gripes with naturals is that you don’t feel anything.

How Thesis Works

Thesis isn’t your run-of-the-mill supplement company.

They’ve streamlined a process resulting in 86 percent of users finding their neurochemically tuned formulations in less than one month.

This is how to best use Thesis:

• Assess your unique brain
• Establish your baseline
• Begin your Starter Kit
• Notice what works for you and what doesn’t
• Tweak and optimize with complimentary coaching

Your Thesis journey begins with a short survey to understand your basic lifestyle, how your brain functions, and your goals for using nootropics. The entire “quiz” takes just a few minutes. When you finish, their AI finds your “digital twin” to determine which formulations are most likely to work for you.

A few days later, you’ll receive the Thesis Starter Kit in the mail, with the four separate blends best matched to your brain.

I suggest jotting down the way you feel, your challenges, and goals. That way you’ll have something to reference after several weeks of testing. Bonus points for including audio/video in your log.

You’ll follow the directions, testing each product for six days in a row. Then take a break over the weekend, allowing your body to reset. Though you don’t need two days off, I notice better effects when I give my body the extra rest day.

If you’re sensitive, I suggest taking these capsules first thing in the morning.

At any point, you can schedule a call with one of the resident Thesis Nootropics Experts. They’ll help coach you to ensuring the best possible experience and tweak your kit as necessary. Definitely take advantage of the experts, as they’re a key bonus of Thesis !

By the end of the month, you’ll have discovered your favorite blends and the ones that you don’t like. It’s perfectly normal to not like some of them, and your future orders will only include the products you love most.

The Thesis Nootropic Blends for Every Goal

Note that I’ve written about five blends below, but your Starter Kit will only contain four. Once you’ve gone through the Starter Kit, you’ve demoed the blends.

Hopefully, you’ve discovered the ones that work great for you.

For every subsequent order, you get four slots to customize however you prefer. My favorite combo is:

• (2) Clarity

But if I really loved a particular blend, for example, I could just do:

• (4) Creativity

You can request any of the formulations in either of two versions: caffeinated or caffeine-free.

Don’t pay much attention to the names of each. They’re merely general suggestions of the most often reported benefits. It’s entirely possible that you’ll get more clarity from Creativity, or better logical reasoning from Energy.

Let’s examine each of the different blends.

Thesis Energy

I reach for Energy when I get less than 7 hours of sleep, or when I need extra energy to crush a workout and power through a long Monday. It’s also useful for travel days, or when I know I’ll wind up in energy-depleting situations. Others use it to reinforce new healthy habits.

Thesis Energy blend ingredients include:

• Zynamite® – 300mg
• TeaCrine® – 100mg
• Sabroxy® – 100mg
• CDP Choline – 300mg
• N-Acetyl-L-Tyrosine – 300mg
• N-Acetyl Cysteine – 500mg
• Optional: Caffeine – 100mg
• Optional: L-Theanine – 200mg

Sabroxy is an ancient Ayurvedic extract that comes from the bark of the Indian trumpet tree. Research suggests it enhances memory, focus, immunomodulation, mood, and even skin health.

From previous experience, I know that I respond well to Zynamite and TeaCrine. The former is an extract of mango leaf, and the latter is a molecular cousin of caffeine that comes from a tea plant, is non-habit forming, and with fewer side effects. Both noticeably increase energy, as expected. As a bonus, I find that these two also lift my mood.

Compared to the previous Energy formula, this iteration is smoother and more refined. Each sachet contains three capsules, and I start feeling effects 15 minutes after swallowing them.

I’ve been a big fan of all the Energy blends I’ve tested so far. It’s constantly ranked in my top 2 favorites due to the pronounced effects. It feels like a more full-body caffeine without the jitters or crash.

Thesis Clarity

As the package insert describes, Clarity supports a calm, focused flow and is great for optimal performance during high-stakes days. Good for presentations, content creation, and non-stimulating concentration.

I’ve found this description to be spot on. The formula has undergone a complete overhaul, featuring two ingredients I haven’t found in other nootropics.

Thesis Clarity blend ingredients include:

• 7,8 Dihydroxyflavone – 30mg
• Camellia Sinesis Extract – 250mg
• Alpha GPC – 250mg
• Epicatechin – 250mg
• Lion’s Mane 8:1 Extract – 500mg

7, 8 Dihydroxyflavone is a man-made flavonoid that can penetrate the blood-brain barrier and mimic the effects of BDNF (dubbed “MiracleGro for the brain”). Camellia Sinesis is the ingredient that earned tea’s reputation as a health drink. It’s a potent source of the relaxing compound l-Theanine. Epicatechin also comes from tea, and it promotes optimal blood flow, mood, and neuroprotection.

A dose of Clarity takes three capsules, and I couldn’t pinpoint the exact time I started feeling it. The effects became more pronounced after approximately one hour.

Don’t expect a huge boost in energy or racing thoughts from this one. Once I released that expectation, I noticed that I felt clear, calm yet alert, steady, and mentally sharp . All without overstimulation. I flowed through my work, easily focusing on each task through completion.

To my surprise, Clarity went from among my least favorite Find My Formula blends, to my Thesis top pick.

I’m confident that this is one of the only nootropics that I can take in the afternoon (or even evening) and still sleep great.

Thesis Creativity

Creativity helps you generate new ideas, think abstractly, and finally bring your dream projects to fruition. It works by quieting overthinking and helping integrate both hemispheres of the brain.

The stack of powerful adaptogenic herbs also makes it an excellent choice for stressful situations, or to relax in social events.

You can rest assured that it contains some of the most researched and scientifically proven herbs on the planet. Ashwagandha and Panax Ginseng are staples in Ayurvedic (Indian) and Traditional Chinese Medicine. Thousands of studies back their use.

Thesis Creativity blend ingredients include:

• KSM-66 Ashwagandha – 300mg
• GS15-4 Panax Ginseng – 200mg
• Zembrin® – 25mg
• Agmatine Sulfate – 250mg
• Alpha GPC – 150mg

The Thesis formulators did a great job here, handpicking the strongest, cleanest, and most bioavailable forms of each ingredient.

Zembrin is one I hadn’t heard of, but am impressed by what I’ve learned. It’s a plant extract known to boost mood, improve workout focus, alleviate nervousness, and enhance complex problem-solving.

Approximately 45 minutes after my three-capsule dose, I noticed myself feeling slightly less reactive to urgent emails and other daily stressors. I could also more easily discern wisdom from my intuition. Each time I followed my instinct, I made the right choice.

I do already regularly take Ashwagandha and Ginseng in my own supplement regimen (which I stopped for this experiment), so it’s likely that my reaction is milder than most.

Thesis Logic

The name summarizes it well. Logic supports rational thinking. Making a popular choice among lawyers, bankers, programmers, scientists, academics, and those looking to boost their analytical abilities.

Though I didn’t get it selected for my Starter Kit, I reached out to their customer service to have it swapped in. As a Data Scientist, I knew that this would fit me well.

I was right. My first experience with the original Find My Formula Logic blend quickly took silver (only behind their original Energy). It hit the sweet spot between energetic stimulation and effortless focus. I went from spec sheet to finished product 35 percent faster than normal.

Thesis Logic blend ingredients include:

• Triacetyluridine – 30mg
• Vegan Omega-3 Lysine complex (EPA + DHA) – 200mg
• Phosphatidylserine – 200mg
• Theobromine – 100mg
• Gingko Biloba – 160mg
• Synapsa® (Bacopa monnieri extract) – 320mg

As its name suggests, Triacetyluridine is a more potent version of the nootropic uridine. It’s known to improve learning, memory, energy, mood, and reduce neuroinflammation.

Theobromine is a mild stimulant related to caffeine naturally occurring in cacao. It increases blood flow, and improves focus.

Those interested in memory enhancement may know Bacopa — one of the greatest ancient memory-enhancing herbs. Gingko is another notable natural herb, known to improve alertness, concentration, focus, and memory.

Phosphatidylserine comes from sunflowers. It gently alleviates stress without drowsiness, improves memory, and increases alertness.

Indeed, the Logic formulation improves working memory, offsets stress, and accelerates learning. On days I reluctantly approached tedious work, the two capsule dose of Logic took the edge off within about 20 minutes.

I’m still experimenting with the latest Logic blend, but so far it stacks up with the original. The new Logic feels slightly weaker, but I greatly prefer the new ingredients.

Thesis Motivation

Motivation comes in a lime-green sachet. It’s Thesis’ take on the classic and original CILTEP nootropic stack.

Motivation bills itself as best for:

• Crushing your TODO list
• Building healthy habits
• Increasing discipline and drive

It’s one of the blends that’s most polarizing. You either love it, or you hate it.

I’ve tested this exact formulation produced by several different companies (including NaturalStacks and Find My Formula), and I’ve had bad experiences every single time.

The predominant effect I notice is a headache (which I never get). I also feel slightly spacey. This time I came prepared and used Semax to pull me out of my CILTEP fog.

But just as many people rave about their Motivation.

Thesis Motivation blend ingredients include:

• Forskolin – 250mg
• Methylcobalamin – 1000mcg
• Dynamine – 100mg
• L-Phenylalanine – 500mg
• Artichoke Extract – 450mg

It’s safe to say that after two days of use, you’ll know which Motivation camp you fall into.

Thesis Confidence

Confidence is a newer Thesis blend that came out in mid-2022 after heavy internal research and development. I’ve been using it for the last few weeks and it’s certainly one of my favorites. Perhaps my top non-stimulating Thesis Formula.

Typical use cases for Confidence include:

• Important situations
• Doing uncomfortable or new things
• Times of leadership
• Stopping overwhelm

My experience with Thesis Confidence has been overwhelmingly positive. Within about 30 minutes, I felt a smooth and definite mood boost. The day seemed to flow easily. I didn’t feel jitters or nervousness before overwise stressful no-agenda meetings.

This one is great for social situations. I’m noticing that I feel more comfortable and bold as a newbie Bachata dancer.

Although it’s not very stimulating, I noticed a slight rush kind of like the effect of finishing a good workout. Increased blood flow and slight flushing paired with relaxation (but certainly not any sedation).

Thesis Confidence blend ingredients include:

• Saffron extract (affron®) – 28mg
• Ashwagandha extract (Shoden®) – 120mg
• Sage extract – 333mg
• Magnesium threonate – 50mg
• Magnolia bark extract (DHH-B) – 10mg

This is an excellent formula. I love the synergy between the ingredients. Plus, many of these (like Saffron) are expensive and commonly faked in supplements. By using the patented versions, we’re assuredly getting the real thing.

How to Use Thesis

When the shipment finally arrives in the mail, you might feel overwhelmed.

Here’s what to expect…

Inside the large box, you’ll find four smaller boxes. Each box contains five sachets. Monday through Saturday mornings, you take one full sachet (2-3 capsules).

I suggest you take notes beforehand on what you wish to get out of the experience. Some popular examples include:

• Spending less time distracted on social media
• Output at your main job
• Progress toward hobbies, projects, or other work
• Starting a new skill, language, or health habit
• Finish work faster

Then, at the end of each day, spend 15-seconds jotting down notes in the provided instruction manual. Trust me, this makes a huge difference. After completing week four, you’ll probably forget which blends you loved, the effects they had, and which ones didn’t work for you.

Some of the ingredients last slightly longer in your system, so I take the entire weekend off to allow my neurochemistry to reset. This also ensures you get the most bang for your buck.

After repeating this process for all four boxes, you’ll have discovered your favorite blends. A Thesis coach can help you customize future orders so you’ll only receive the ones you want!

Tips to Get the Most Out of Thesis Nootropics

Nootropics aren’t cheap.

You can skip this entire section, but these tips will help ensure that you get the most out of your experience.

Caffeine-free . If you’re new to nootropics, start with the non-caffeinated versions. I drink coffee most days. Sometimes two cups. But I always get my nootropics caffeine-free. For several reasons. First, nootropics potentiate caffeine. One coffee can feel like 3. If you’re not used to the combo, going caff-free gives you more control. Caff-free also means that I can take nootropics later in the day. Also, the health benefits of coffee don’t come from caffeine but from the polyphenols, flavonoids, and other phytochemicals. Plus, I just like the taste of coffee.

If you like this kind of thing, join my FREE nootropics mini-course where you’ll learn:

• How professionals choose products
• Tips to feel stronger effects and get more out of your supplements
• Money-saving hacks
• Natural cognitive enhancement technologies
• Latest neuroscience-backed strategies to upgrade your brain

Fill out the info below to get started…

Request received. Your invitation should arrive in your inbox within about 5 minutes.

Thesis Nootropics Questions & Answers

Should i take thesis with caffeine.

I recommend taking Thesis without caffeine to start. Caffeine greatly increases the effects of certain nootropics. For some, this can be too much and lead to panic, headaches, and unease. You can always add coffee and more easily control your caffeine dosage later.

What’s the difference between Thesis and Find My Formula nootropics?

Thesis is the latest generation of Find My Formula nootropics. They’ve refined, upgraded, and revamped every single one of their formulas according to the latest neuroscience research. Find My Formula products are no longer available.

Which Thesis blend is best?

Your ideal Thesis stack depends on your neurochemistry, lifestyle, and goals. People either love or hate their Motivation blend. My favorites (in order) are Clarity, Energy, and then Logic.

How much do Thesis nootropics cost?

Thesis offers two different buying options: one-time, and subscription. One-time purchases cost $119.00 and subscriptions cost $79.00 per month. Use code URBAN and save an extra 15 percent! Thesis backs all purchases with a full 30-day no-questions-asked money-back guarantee.

Thesis Nootropics Review: Boosting Your Brain With Precision Formulas

Ignore those that say you’re stuck with a less-than-optimal brain.

According to the latest neuroscience (and countless personal examples), that’s demonstrably false.

That is if you use the right products.

The most popular nootropics today are:

I’m constantly trying the latest nootropic formulas.

I take most of them for a month and see little benefit.

Thesis is one exception, featuring an impressive array of the highest-quality forms of well-researched ingredients. Drawing from their millions of data points, they’ve come up with unique formulas that give you both a quick boost and long-term benefits .

So that one day, should you choose, you can completely stop supplementing and continue enjoying all the fruits of an upgraded brain.

I personally prefer their Clarity, Energy, and Logic. Each serves a role specific to the type of day I have ahead.

Since the original Find My Formula blends, I’m impressed with their improvements. They’ve moved away from some of the man-made ingredients and embraced natural (but effective) bioharmonizing compounds.

As of January 2022, Thesis has amassed a 4.5+ star rating on 7,411 ratings.

Try it yourself with the exclusive Outliyr discount:

Thesis nootropics code URBAN saves you 10%

To the long-term Formula users — what do you think of the update? Have you enjoyed the new Thesis blends?

Let’s have a discussion in the comments below!

Post Tags: Brain & Cognition , Lifestyle , Nootropics , Review , Supplements

12 thoughts on “The Best Nootropics Supplements Personalized to Your Brain?”

Unfortunately, I can not use any of the samples sent by Thesis. Each packet contained the caffeine equal to a cup of coffee.

What a bummer!

I’m not sure how you do with caffeine, but it also includes l-theanine which is a natural amino acid that really smoothes out the negative effects of caffeine (I won’t use any form of caffeine without it). You might want to reach out to their team about this, but last I heard, one of the pills in each sachet is exclusively caffeine/theanine. I’ve received a few caffeinated boxes, and just threw away the smallest white caffeine/theanine pill.

Or you can reach out to them and they will likely make it right.

Hey, I had the same issue. Fortunately, the caffeine portion comes in its own separate capsule (the white capsule in each packet), so you can choose to leave it out!

Correct. It’s the smaller white one if there are multiple white capsules.

I’ll be honest. I think this is a scam, like snake oil.

Hi Andrew. Not sure what you mean. Have you ever used nootropics? Or botanicals/herbals? What makes you think this is a scam?

This is my first time visiting the website although I’m no stranger to nootropics. I don’t remember where or how I discovered acetyl choline—AGP?—but it was a game changer for me. I’d been taking phosphatidylserine for memory enhancement for at least 2 decades, L-Tyrosine to boost dopamine, PEA, for the same reason. All on my own initiative, as a result of my own independent research. What disturbs me about Thesis is: 1). I suffer from a congenital disease for which there is no cure—Lipedema—and this is allegedly at the root of the fatigue which has blighted my entire life and which I have been attempting to overcome for most of it. The disease afflicts about 10% of women and as one doctor blithely informed me, “you;d be better off with cancer. At least there’s a chance you might recover.” As a result of the quiz I took, Thesis informed me I was in the bottom 4% of applicants and never investigated further. Well, Hello. 2). Quiz had questions about exercise but nothing about diet or meditation, Since I follow functional and integrative Medicine, these gaps disappointed me. I still haven’t made up my mind about becoming a member, but I am grateful to Andrew Huberman for drawing my attention to this range of products.

Hi Jacqueline, sorry about the super slow response here! Glad you’ve found things that work for you. That’s strange. When I took the quiz, they didn’t show percentiles. I agree, diet and meditation are essential. Impossible to overlook really, especially when we’re discussing nutraceuticals. I’ll let them know when I talk to them next.

Update on “the ingredients are not evenly distributed throughout the pills.” I spoke to a Thesis rep this week, and after a detailed conversation regarding the caffeine pills (the small white pill in each caffeine line of products), she clarified that the other pills (not the 100mg of caffeine + 200 mg of L-Theanine small white pill) have the remaining blend evenly distributed between the pills.

Loved your article, how you spelt it out, and agree strongly with the feelings on Clarity being “clear, calm yet alert, steady, and mentally sharp. All without overstimulation.”

Good correction! The caffeine/theanine pill is easy enough to spot.

Thanks for the feedback. Which are your favorite(s)?

Nick, this is an awesome intro to nootropics and Thesis, thank you for breaking this down! I was a Formula customer for years and my favorite blends were Clarity and Creativity. With the new Thesis formulations Energy has been added into my routine! I feel like I have tools at my disposal for any occasion… Creativity is great for social situations or other experiences that would otherwise leave me mentally fatigued, Clarity is great when I have a ton I want to accomplish without interruption, Energy is great when I haven’t had great sleep or need to do more physical stuff. I don’t use it every day, but it’s there when I need a lift. Great read, thanks for the knowledge!

Thanks! How often do you use Thesis? Do you combine it with anything else?

Leave a Comment Cancel reply

Nick Urban  is the Founder of Outliyr, an expert Biohacker with 12+ years of experience, a Data Scientist, a Certified CHEK Practitioner, Host of the Mind Body Peak Performance Podcast, and a High-Performance Coach. Click  here  to read how Nick went from struggling pre-diabetic, to collegiate rugby national champion. To send Nick a message, visit his  Contact Page .

Diet & Nutrition

Ingredients and compounds

Mind & Cognition

Movement & Fitness

Tools & Gears & Services

Common Tags

• Alternative Medicine
• Alternatives
• Ancestral Health
• Bioelectric
• Biohacking Cities
• Bioharmonizing
• Blood Sugar
• Blood Testing
• Brain & Cognition
• Cardiovascular Health
• Digital Drugs
• Digital Product
• Electrical & Quantum
• Electrolytes
• Environment
• Essential Oils
• Extreme Temperatures
• Food Intolerances & Allergies
• Foundational Health
• Functional & Holistic Health
• Grocery Shopping
• Holidays & Vacation
• Inflammation
• Mitochondria
• Nervous System
• Oral Health
• Performance
• Product Roundup
• Quantification
• Recommendations
• Recovery & Resilience
• Relationships
• Routines & Rituals
• Spirituality
• Strength & Muscle
• Supplements
• Toxins & Toxicants
• Trace Minerals
• Vitamins & Minerals
• Weight Loss

Who is Nick Urban

Every year I spend over 1,000 hours reading, discovering, testing, and analyzing strategies

Nick Urban is the Founder of Outliyr, an expert Biohacker of 10+ years, Data Scientist, Certified CHEK Practitioner, Host of the Mind Body Peak Performance Podcast , and a High-Performance Coach. Click here to read how Nick went from struggling pre-diabetic, to collegiate rugby national champion. If you want to send Nick a quick message, then visit his Contact Page .

Zoom with Nick Urban

BiOptimizers Breakthroughs

An entire catalog of best-in-class formulas produced by the world's highest-rated supplement brand. As mentioned in my full BiOptimizers review , I use their products daily. Code URBAN saves 10%

Sens.ai NeuroFitness Training

Like building your ideal body in the gym, we can also train our minds to work better and more efficiently. I use this 5-in-1 system daily. Read my review and use code URBAN to save 5%

Nootopia Brain Breakthrough

Instantly unlock your brain's full potential with powerful elixirs customized to your unique neurochemistry. Read my review and use code URBAN to save 10%

Coaching Login

Biohacker's Shop

Mind Body Peak Podcast

Urban Supplement Stack

Biohacking Resources

1500 E Riverside Dr, Austin TX

530-426-2319

©2024 Outliyr LLC

Privacy Policy | Terms Of Service | Editorial Policy | Disclaimers

Thesis Nootropics Review

Nootropics fan and expert James Dixon examines this personalized supplement in our Thesis Nootropics review. Find out how he rates it after testing it below…

Last Updated:

May 4, 2023

Written by James Dixon – fact checked by Jason M & the editorial team

James Dixon is one of the key players in the SOMA Analytics’ team. He is a personal trainer and is educated to Masters level in Philosophy. He is a published author and is a keen advocate of high quality nootropic supplements.

This article complies with the SOMA Analytics editorial policy. Full details of which can be found here

SOMA Analytics is supported by our readers. We may earn a commission when you purchase through links on this page. Our content is checked for factual accuracy by our editorial team and is written by expert nutritionalists.

Nootropic supplements – so called ‘smart drugs’ – are all the rage. They represent a rapidly expanding corner of the supplement market and have had genuinely life altering effects on many, many users – myself included.

They’re not actually ‘drugs’ as you would think of them. This isn’t medication we’re talking about, here. Rather, these supplements are compounds of natural ingredients designed to work together to boost your cognitive health and brain function.

A good nootropic should help you feel smarter… which is a bold claim. There is something to it, however. They should aid your focus, learning skills, memory, and creativity. They should reduce brain fog, anxiety, and lethargy, replacing them with clarity, calm, and plenty of low-key energy.

If you struggle with any of these symptoms, there is a good chance that you could do with a good nootropic, which is exactly what we’re looking at today. Though perhaps not the best of the best, Thesis Nootropics offer a range of products that are all intelligently crafted and, to a degree, fairly personalized.

And when I say they aren’t the best of the best, this doesn’t mean much. The nootropic market is crowded. There are a couple of standout items out there – NooCube springs to mind, here. Playing second fiddle to these is still a large accomplishment. Let’s dive in and take a full look as I dig in to this Thesis Nootropics review.

Quick Verdict: Thesis Nootropics

Can’t wait to read the whole article? Thesis Nootropics have a great range of different nootropics aimed at different needs. They also have an excellent nutritional coaching system to support you.

However, the reality is that most people won’t really gain from this additional 5% and products such as NooCube offer greater value for money with similar nootropic benefits.

Introducing Thesis Nootropics

As above, Thesis Nootropics are smart drugs. They offer high quality nootropics that are designed to help with various aspects of your cognitive health and function. Their products all contain top shelf ingredients all proven to help your brain to work optimally.

They also do something a bit different. Where most nootropics – and most other supplements, for that matter – offer you the same over the counter pills as they would offer anyone else, Thesis bring personalized supplements to bear. Through their online store, you can fully personalize your nootropic options to make the most of your own specific needs and circumstances.

It’s really quite clever.

They started out as FindMyFormula.com before rebranding a few years back. So, although ‘Thesis Nootropics’ may seem like a newcomer to the market, they have actually been around for a long time. They bring this pedigree to the fore with this product.

With a customer base of over half a million users, they have proven themselves and then some. The data they hold from their research into nootropics is peerless – I can’t think of anyone with better. And they use it well, crafting and re-crafting their formulae with proper, diligent science and data in mind.

The personalization process is actually quite straightforward too – at least, it is for the customer, which is always nice.

You start off by going to their website and taking their questionnaire. Don’t worry, it’s not all that comprehensive, asking for only basic information. There is no need to take any lab tests or divulge your medical history. However, it’s enough for them to make a match for the nootropic blends that will best suit your needs.

Optimize Your Mental Agility

Claim access to the full potential of your brain

with these optimum nootropic stacks and

exclusive discounts …

There are two ways to read this, of course. Either, it’s a non-invasive way to tailor your supplements, or it’s not a deep enough dive, so how well tailored can they really be? I felt a little let down, here. When I came in being promised ‘personalized supplements’ I had higher hopes. Instead, it’s just sort of asking what you want and pointing you in the right direction.

It’s nice, it’s just not quite as revolutionary as the literature and branding suggest.

The next phase is good, though. They’ll send your shipment out to arrive with 1-3 business days. However, they ask you to treat this as a sample; they invite you to try out a few different blends of theirs before picking it. This data is fed back to their algorithm, further enhancing their future prescriptive capabilities.

Again, you can read this cynically or not. Either it’s a great way to search out what works best for you, or it’s doing their job for you and getting you to buy plenty of their products in the process… if their original diagnostics are that good, why do you then need to cycle through their catalogue?

Except that they allow you to try up to four before committing to a longer term formula. Pair this with that original questionnaire and, cynicism on hold, you have an excellent and innovative product. It helps you to refine your own choices without having to do the legwork, which can often take months, a lot of money, and a fair amount of trial and error.

The final part is my favorite part. This dispels much of my lingering cynicism. As a Thesis customer, you are assigned a nootropics expert, a sort of coach and pharmacist in one. You can consult with them virtually at any time. They can help you to further refine your nootropics regime, optimizing what can be optimized, tracking your progress and wellbeing, and generally educate you by ably answering any questions you might have.

I love this. It takes Thesis to the next level – it’s less a supplement and more a course focussed on wellbeing.

It’s not cheap, I’ll warn you now. A starter kit will go over a hundred dollars. A prescription will run to a monthly bill of around eighty. This is roughly twice what you would pay for something like NooCube or Mind Lab Pro , supplements I consider to be the best of the best. It’s around four times what you could pay for a lower end, yet workable, nootropic.

You’re presented with a choice, then: pay extra for the support and tailoring, or pay a far more reasonable amount for something that will still do the job incredibly well.

Why Choose Thesis Nootropics?

The benefits of Thesis Nootropics are fairly straightforward.

Firstly, Thesis shares the same benefits as any other good quality nootropic supplement. They offer several blends (more on this below), which between them can improve your cognitive function from pretty much every angle. You can boost your cognitive energy, improve your clarity, improve your memory and learning abilities, clear brain fog, improve your mood, reduce your stress levels, and boost your ability to focus, among other things.

This is all good. It’s what you’re looking for in a nootropic in the first place.

But, of course, the benefits go beyond this. The two main things you get from Thesis, that set it apart and above most of its competition, are really very special.

Firstly, of course, you get the personalization mentioned above. This can be fantastic. Or it can be a little superfluous. If you try something like NooCube, you will probably find it working for you. It may not be 100% scientifically optimal, but it will be 95% there for most of us.

However, if others haven’t worked for you, personalization may be a very good idea. You can really zero in on the aspects of your own cognitive health and function that you feel need improving. Also, if you want to get that final 5% (figures not accurate, of course) and don’t mind parting with a little extra cash, Thesis can be well worth it. You will be as cognitively optimal as modern nootropic research can make you, which is no small thing.

Then there is the access to their experts. Again, this can be superfluous. How much do most of us really need to know about nootropics above and beyond what you can read in any good review or rundown? Just learn the basics, throw back a couple of NooCube capsules, and get on with your life.

But, again, it can be wonderful. This is where the extra price begins to seem really quite minimal.

Our Preferred Alternative To Thesis

Although we found Thesis Nootropics to include high quality ingredients, the personalization for most people is not required and adds a lot of expense to an already pricey supplement.

We prefer NooCube, the nootropic taken by our tester and writer – thanks to its high quality formula, high impact results and value for money cost.

Thesis Nootropic Ingredients

Thesis Nootropics offer several different blends, relatively personalized towards the individual, focussed entirely on aiding different facets of cognition and brain health. Given these differences, it’s no surprise that each blend contains a different list of ingredients – though there are of course some commonalities between them.

The energy blend is one of their most popular. The formula is made to boost your energy levels whilst fighting fatigue and improving your mental stamina. It makes use of choline, which is known for aiding memory and learning. It also uses bot NAC and NALT, which aid detoxification and nerve cell communication, respectively.

It also includes some of their own ingredients, notably Sabroxy®, for increased dopamine output and a memory boost, TeaCrine®, for improved energy levels alongside motivation and cognitive function, and Zynamite®, purely for physical and mental energy.

It also includes some more standard energy inducing nootropic ingredients, notably caffeine, for energy, and l-theanine, to improve your stress response.

Next up, we have Thesis’ Clarity, which goes off book on the ingredients list. However, it still contains plenty of the ingredients I would expect to see in any good nootropic. You get 7,8-DHF and Alpha GPC, which both aid neural communication, neurogenesis, and neuro-protection. Epicatechin and Lion’s Mane also both provide neuro-protection, whilst also improving mood, memory, blood flow to the brain, and memory consolidation.

It also contains caffeine and l-theanine, making it good for stress response and energy levels.

Motivation is a bit of a funny one, as motivation is inherently a hard metric to either properly define or measure. However, in this context, motivation means a boost to willpower and productivity, and help in warding off procrastination.

It manages this with a good ingredients list. Artichoke extract kicks things off, improving circulation and helping with stress response (and management). Then there is Dynamine®, for a mood boost and plenty of long-lasting energy, without the kind of crash associated with caffeine.

Forskolin and l-phenylalanine work together to improve cognition function, mood, and attention. All of this should inspire greater motivation. It gives you a good dose of vitamin B12, too, for improved energy and to look after your nerve. It rounds out with caffeine and theanine.

Again, the Creativity formula is an odd one – can one scientifically boost creativity? Well, Thesis give it a good shot. It’s designed to improve verbal fluency and confidence, which should result in greater inspiration and the will to follow through with it.

The Creativity formula contains agmatine, ashwagandha and l-theanine, all of which help with managing stress levels and anxiety. It also contains Alpha GPC, which is great for memory, neuro-protection, and neurogenesis, and Zembrin®, which improves mood regulation and increase the flow of blood to the brain.

You also get a good caffeine hit with Thesis’ Creativity blend.

Finally, we have Thesis’ latest blend, Confidence. As you may well imagine, this leads to a boost in confidence!

Confidence’s ingredients all target stress, especially stress responses to insecurities, whilst promoting a feeling of self-assurance. These include magnesium, ashwagandha, saffron, sage, and DHH-B, all of which combine hopefully make you feel more confident in your own skin.

How to Use Thesis Nootropics

Nootropics are amongst the easier supplements to live with. There are no special timings or anything like that to hit, and the portions are all very manageable. Thesis Nootropics fit this pattern nicely. For all of their different lines, simply take them in the morning, ideally when you first get up, on an empty stomach with a decent glass of water.

If you need a bit of an extra boost during the day (particularly if you’re going for the energy blend), feel free to take a second dose at lunchtime to see you through until the evening. This will ensure clarity and energy all day long.

Using Thesis Nootropics

I was quite sceptical of nootropics when I first heard about them in the early 2010s. They sounded too good to be true – over the counter supplements made from all-natural ingredients that can boost your brain health and cognitive function? No way.

Many are too good to be true. Plenty of nootropics out there don’t do anything above and beyond giving you a brief energy kick, and this is usually down to their caffeine content. You’d be better off having a cup of coffee or cheap caffeine supplement.

Thesis Nootropics are not too good to be true. They are good – very good, in fact – and highly workable. I’m not entirely sold on them. I find them to be a bit gimmicky. They shouldn’t be gimmicky, of course – tailoring to your users and offering coaching is no gimmick. However, it’s just a little shallow to be truly tailored – they are simply giving you a selection of stacks, which many supplement stores offer (CrazyBulk, for instance).

And the coaching is perhaps a little superfluous for most people.

But the supplements themselves are good. They are well developed, well made, high quality, and will absolutely elicit the effects they claim in many, many people.

I got on well with them. I took their Energy blend first, which is always my priority (I’m always juggling seven or eight different projects at any time, so an energy boost will always be welcome!) It did what it said it would. I found my focus improving and my energy lasting me through the day. I usually drink a lot of coffee, which tends to give me spikes and crashes. The spike wasn’t as high with the Energy blend, but nor was there any kind of crash.

I also tried Clarity, as I take a couple of prescription medications that can lead to a touch of brain fog. It cut through my brain fog well, lending me a great deal of clear sighted cognitive energy. There was no coming round in the morning, no chugging espressos just to form a coherent sentence. Or, at least, I came round quicker and reduced my espresso intake.

I also wanted to know a bit about Thesis’ coaches, or whatever they call themselves. I got in touch and was chatting to a woman with a highly relevant, impressive array of academic credentials just a few days later. She explained how the components in the blends I was trying worked and interplayed, and pointed me in the direction of a couple more that I might to try.

The advice was kind of handy, though it wasn’t anything I would struggle to find out just from perusing their website. The information was interesting to a health and supplements nerd, but that was it. I can’t imagine it being in any way helpful. I can’t even imagine it being interesting to most people.

It’s not a good use of money (and you will be spending a lot of money on Thesis). The supplement is strong – the blends I tried were strong. But none of them gave me the kinds of results I have experienced whilst taking cheaper, better nootropics, namely NooCube – this is what I personally tend to take on an ongoing basis.

There is no harm in trying Thesis. They offer a one-month money-back guarantee, so you can get that hefty price tag (generally around $119) back again if you’re not satisfied. But I think you will be satisfied. Thesis is a satisfying product. It’s just not the best, and the best happens to be an awful lot cheaper.

Do also bear in mind that nootropics can cause side effects – Thesis’ blends are no exception. They can lead to blurred vision, high blood pressure, an accelerated pulse, circulation problems, and insomnia, though severe or long lasting cases are rare.

Pros and Cons

Thesis nootropics pros.

• Personalized for optimal benefits
• Comes with access to their experts
• High quality ingredients
• Highly reputable company
• Different blends for different uses/needs
• Ability to try out different blends before committing
• Easy to take

Thesis Nootropics Cons

• The personalization is a little shallow
• It’s very pricey (about twice as costly as other leading nootropics)

Our Thesis Video Review

Are Thesis Nootropics’ products vegan? 

All of Thesis Nootropics’ products are indeed suitable for vegans. All ingredients are free from animal products. However, they do note the possibility of cross contamination, so the product is not certified vegan.

Are Thesis Nootropics’ products gluten free?

Thesis Nootropics’ blends are all free from gluten, eggs, and nuts, as well as being dairy free. However, once more, they note the possibility of cross contamination. Their lines haven’t therefore been certified gluten free.

What is Thesis Nootropics’ shipping policy?

Thesis Nootropics have a fairly fast delivery service. They promise to dispatch all orders within one business day, with the packages being delivered between 1-3 business days after that. They do not offer international shipping, however, and they calculate costs at checkout, so do beware price hikes.

Thesis Nootropics are good. In fact, they are very good. The personalized aspect, whilst admittedly a little shallow, is still very welcome. I like it a lot. As a bit of a supplements nerd, I also love the idea of being able to chat to an expert at any time – this really is a nice touch.

However, I can’t help but feel that it’s all a little superfluous. Most people know their own needs. A quick Google search will show you what nootropics will be best for you. If in doubt, go for a cover-all nootropic. I keep mentioning NooCube with good reason – it should do pretty much everything that all of Thesis’ blends do.

Then there is the price. You’re paying a lot for a good product with plenty of customer care involved. However, as above, the customer care is largely excessive. If you really want it – and I can see plenty of people wanting it, with good reason – then by all means fork out extra. However, it’s just a little much for most people.

For a month’s supply (at non-subscription prices), you can buy around three months’ worth of NooCube. For this, you’ll be getting just about the best nootropic on the market with no extra legwork – just simply take it each morning, save some money, and get on with your life with your cognitive health in near perfect shape.

Verdict: Thesis Nootropics

Thesis Nootropics have a great range of different nootropics aimed at different needs. They also have an excellent nutritional coaching system to support you.

The reality is that most people won’t really gain from this additional 5% and alternative products such as NooCube offer far greater value for money with similar (if not better) nootropic benefits.

This article was written by: James Dixon – SOMA Analytics PT, Nutritionalist & Published Author

James Dixon is one of the key players in the SOMA Analytics’ team. He is a personal trainer and is educated to Masters level. He is a published author and is a keen advocate of high quality nootropic supplements. James enjoys helping others to reach their peak both physically and mentally and believes that expressing his knowledge through his writing is an effective way to positively impact the wellbeing of others on a larger scale.

• Anxiety Disorder
• Bipolar Disorder
• Schizophrenia
• Adjustment Disorder
• Agoraphobia
• Antisocial Personality Disorder
• Borderline Personality Disorder
• Childhood ADHD
• Dissociative Identity Disorder
• Narcissistic Personality Disorder
• Oppositional Defiant Disorder
• Panic Attack
• Postpartum Depression
• Schizoaffective Disorder
• Seasonal Affective Disorder
• Sex Addiction
• Social Anxiety
• Specific Phobias
• Teenage Depression
• Black Mental Health
• Emotional Health
• Sex & Relationships
• Understanding Therapy
• Workplace Mental Health
• My Life with OCD
• Caregivers Chronicles
• Empathy at Work
• Sex, Love & All of the Above
• Parent Central
• Mindful Moment
• Mental Health News
• Live Town Hall: Mental Health in Focus
• Inside Mental Health
• Inside Schizophrenia
• Inside Bipolar
• ADHD Symptoms Quiz
• Anxiety Symptoms Quiz
• Autism Quiz: Family & Friends
• Autism Symptoms Quiz
• Bipolar Disorder Quiz
• Borderline Personality Test
• Childhood ADHD Quiz
• Depression Symptoms Quiz
• Eating Disorder Quiz
• Narcissim Symptoms Test
• OCD Symptoms Quiz
• Psychopathy Test
• PTSD Symptoms Quiz
• Schizophrenia Quiz
• Attachment Style Quiz
• Career Test
• Do I Need Therapy Quiz?
• Domestic Violence Screening Quiz
• Emotional Type Quiz
• Loneliness Quiz
• Parenting Style Quiz
• Personality Test
• Relationship Quiz
• Stress Test
• What's Your Sleep Like?
• Find Support
• Suicide Prevention
• Drugs & Medications
• Find a Therapist

Can Nootropics Help with ADHD?

Nootropics are often recommended as a way to manage ADHD symptoms. This article explores how they work to help you learn if they might be right for you.

If you’ve met one person with ADHD, you’ve met one person with ADHD. It’s a complex condition and individuals experience it differently. This can make it challenging for health professionals to manage it adequately.

Nootropics are drugs that improve your mental performance. They include ADHD drugs like Ritalin and Adderall, plus substances like caffeine and nicotine.

ADHD stands for attention deficit hyperactivity disorder. It’s also known as attention-deficit disorder (ADD). Those with the condition may feel like they:

• are unable to focus
• miss small details
• rush through tasks
• procrastinate
• avoid tough projects that take mental effort

These are just a few of the many varying symptoms sometimes associated with ADHD.

Of course, it’s natural to want to try anything and everything to better handle your daily activities. Still, it’s important to remain cautious and curious about any possible treatments to ensure your health and safety.

When managing ADHD, health professionals look for options that improve attention, working memory, and overall mental performance. One way they may accomplish this is by prescribing nootropics.

What are nootropics?

Nootropics are substances meant to improve mental performance. You can find them in prescription medications and dietary supplements.

Nootropic drugs

The Food and Drug Administration (FDA) has approved prescription nootropic drugs to treat certain conditions, including ADHD. The FDA has deemed them safe for use under the supervision of your doctor.

Prescription nootropic drugs include:

• modafinil: treats daytime sleepiness to keep you alert
• methylphenidate (Ritalin): stimulant approved to treat ADHD and a sleep disorder called narcolepsy
• amphetamines: the active ingredient in certain medications, such as Adderall . They increase dopamine and norepinephrine to improve alertness

In the United States, you can also buy nootropic stimulants over-the-counter and without a prescription. For example, a product named NoDoz (a caffeine pill) helps some individuals with ADHD stay alert and is available without a doctor’s order.

Even though the FDA approves these drugs, it’s important to take them with caution and chat with your healthcare professional before starting.

Nootropic supplements

Some nootropic supplements for ADHD are marketed as being “natural” or “herbal.”

You can find natural nootropics in certain foods, herbs, and plants marketed to improve brain health and ability to think (cognitive functioning).

Below are some natural nootropics and what recent research says about their use for ADHD:

• Caffeine. Children and teens with ADHD consume more caffeine than their peers during later times of the day because it may improve attention and alertness.
• Ginkgo Biloba. The extract from ginkgo leaves may improve ADHD symptoms and causes fewer side effects than medications like methylphenidate, but is also less effective.
• Nicotine. Young people with ADHD are 2–3 times more likely to smoke or vape nicotine products, possibly as a way to self-medicate.

The packaging and marketing of some nootropics claim to improve brain health and enhance mental performance in those with ADHD and ADD. However, according to the FDA , dietary supplements cannot claim to treat or prevent a medical condition.

Plus, even though these compounds are natural, it’s important to proceed with caution.

The FDA doesn’t need to approve dietary supplements, so some of these products may not be safe. Therefore, it’s best to speak with your doctor about any ADHD nootropics that spark your interest as a possible treatment.

How can nootropics help with ADHD symptoms?

Whether a nootropic is created in a lab or occurs naturally, they have similar methods of action.

Nootropics can boost blood circulation to the brain increases, meaning it receives more oxygen and nutrients. One of these nutrients is glucose.

Glucose is essential for energy generation. Your brain and nervous system cells rely on this energy to send messages, enabling you to better focus your attention and face challenges.

Ultimately, this means that nootropics may:

• increase brain activity
• enhance thinking
• improve memory
• boost adaption skills

What is the best nootropic for ADHD?

Based on research on their effectiveness and safety, the best nootropics for ADHD management include:

• methylphenidate (Ritalin)
• dextroamphetamine sulfate ( Dexedrine )

Ginkgo Biloba

Regardless of what piques your interest, it’s important to speak with your doctor before taking any of these, no matter if they’re natural or in drug form.

Methylphenidate (Ritalin)

Methylphenidate, also known by the brand name Ritalin, is often the first-line drug treatment for children with ADHD. Studies show that it’s highly effective, even after long-term use.

If you take the drug as directed, the risk of dependence is low. However, higher or extra doses may increase the risk, so speak with your doctor before changing how much you take.

Having trouble sleeping or feeling overly nervous are common side effects of methylphenidate. If you experience this, consult your healthcare professional to potentially explore alternative drugs or dosages.

Dextroamphetamine sulfate (Dexedrine)

Another stimulant, dextroamphetamine sulfate, decreases your impulsiveness while increasing your attention.

Some people develop a tolerance after long-term use, so after taking Dexedrine for a while, your doctor may ask you to stop taking it to monitor your symptoms. You may then need to switch to a different nootropic.

This natural supplement promotes blood flow to your brain to improve memory. Although it’s less effective than prescription medications, it may improve ADHD symptoms.

However, you should use it with caution since it’s speculated to increase the risk of bleeding.

When you take in caffeine, you might expect:

• increased attention
• improved learning
• improved memory

Caffeine accomplishes this without causing unwanted side effects associated with some prescription medications.

A 2020 study on U.S. soldiers reported that using caffeine appeared to reduce ADHD symptoms and may have improved cognitive performance.

Nootropics vs. other ADHD treatment methods

The goal of effective ADHD treatment is to address and improve all aspects of your functioning. Medication alone likely can’t do this.

Other steps to take include:

• patient and family education
• support groups

Stimulants help around 70% of those with ADHD. Some people use nootropics alongside other methods.

A stimulant that works for one person won’t necessarily work for you. That’s why it’s best to work with your doctor who can help you identify which treatment or treatments work best for you — even if it takes a little trial and error.

It can help to speak with your healthcare professional if you aren’t seeing benefits while on your current medication.

Effective ADHD management generally includes prescription medication therapy. In addition, nootropics are often prescribed to help manage symptoms.

You can find nootropics in prescription, over-the-counter, and supplement forms.

Whichever option you’re interested in, it’s important to discuss it with your doctor before trying it. They can help monitor the effectiveness of any drug or supplement and make adjustments as needed.

Although nootropics are sometimes referred to as “brain boosters” since they’re believed to improve memory, thinking, and focus, they may not be enough to treat your ADHD.

It’s also worth exploring ADHD management tools , podcasts , and other options to help you live a fulfilling life with ADHD.

Last medically reviewed on October 27, 2022

14 sources collapsed

• Amsterdam J, et al. (2017). Causal factors of increased smoking in ADHD: A systematic review. https://www.tandfonline.com/doi/full/10.1080/10826084.2017.1334066
• Attention deficit-hyperactivity disorder. (2022). https://www.ninds.nih.gov/health-information/disorders/attention-deficit-hyperactivity-disorder?search-term=Dexedrine
• Bloch M, et al. (2015). Nutritional supplements for the treatment of attention-deficit hyperactivity disorder. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170184/
• Cipollone G, et al. (2020). Exploring the role of caffeine use in adult-ADHD symptom severity of US army soldiers. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700297/
• Cusic C, et al. (2020). Caffeine use and associations with sleep in adolescents with and without ADHD. https://academic.oup.com/jpepsy/article/45/6/643/5835378?login=true
• Dietary supplement products & ingredients. (2022). https://www.fda.gov/food/dietary-supplements/dietary-supplement-products-ingredients
• Greenblatt K, et al. (2022). Modafinil. https://www.ncbi.nlm.nih.gov/books/NBK531476/
• Magnus W, et al. (2022). Attention deficit hyperactivity disorder. https://www.ncbi.nlm.nih.gov/books/NBK441838/
• Matthljessen AF, et al. (2019). Continued benefits of methylphenidate in ADHD after 2 years in clinical practice: A randomized placebo-controlled discontinuation study. https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2019.18111296
• Nootropics: Drugs vs. dietary supplements for brain health. (2022). https://www.opss.org/article/nootropics-drugs-vs-dietary-supplements-brain-health
• Suliman N, et al. (2016). Establishing natural nootropics: Recent molecular enhancement influenced by natural nootropic. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021479/
• Vazquez J, et al. (2022). Effects of caffeine consumption on attention deficit hyperactivity disorder (ADHD) treatment: A systematic review of animal studies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875377/
• Verghese C, et al. (2022). Methylphenidate. https://www.ncbi.nlm.nih.gov/books/NBK482451/
• Verlaet A, et al. (2018). Rationale for dietary antioxidant treatment for ADHD. https://www.mdpi.com/2072-6643/10/4/405/htm

Read this next

You might wonder if you're "too old" to have ADHD. In fact, symptoms of adult ADHD might sometimes be confused with other conditions. Here's what you…

Managing impulsivity can be challenging for an adult living with ADHD. Impulse control is possible, though, and these 5 techniques will help you take…

Lack of focus is a telltale symptom of ADHD, but there are ways to help you sustain attention, even during boring tasks.

Borderline personality disorder (BPD) and ADHD share similar symptoms and can occur together. Treatment options are available to reduce your symptoms…

If you live with ADHD, it's still possible to join the military. Understanding the qualification guidelines can help you get support during…

ADHD affects millions of people worldwide annually. If you have ADHD, you aren’t alone. Many people are living with ADHD and can receive treatment.

If you have ADHD challenges with organization, focusing, or staying on task, you may be living with ADHD inattentive type. But treatment can help you…

Why is ADD/ADHD a controversial diagnosis and what can you do about it? Inside Mental Health podcast delves deep. Listen Now!

Neurofeedback is a noninvasive therapy that may reduce symptoms of ADHD. We look at how it works and its effectiveness.

Drivers living with ADHD can improve their driving skills by practicing safe driving tips, such as avoiding cell phone use and trying to drive a stick…

• Ingredients

blends tailored to your unique needs.

Your Personalized Blends

(  8,205 REVIEWS )

Subscribe & Save $40 Skip or Cancel Anytime.

Subscribe & Save $40

• Save $40 every month
• Pause or cancel anytime
• Free 1:1 coaching

One Time Purchase

SHIPS WITHIN 1 BUSINESS DAY

Clarity caffeine-free

KEY FOCUS AREAS

• Maintain focus
• Support attention
• Enter flow state

KEY INGREDIENT

Alpha-GPC has been shown to support healthy cognitive function and physical performance.

ALL INGREDIENTS:

• ALPHA GPC (500mg)
• LION'S MANE MUSHROOM (500mg)
• CAMELLIA SINENSIS TEA LEAF (278mg)
• DIHYDROXYFLAVONE (30mg)
• CAFFEINE (100mg)
• L-THEANINE (200mg)

Creativity caffeine-free

• Spark inspiration
• Support verbal fluency
• Maintain confidence

KSM-66 Ashwagandha has been shown to significantly reduce stress and anxiety.

• ALPHA GPC (150mg)
• AGMATINE SULFATE (250mg)
• PANAX GINSENG (200mg)
• ASHWAGANDHA ROOT (300mg)
• SCELETIUM TORTUOSUM (25mg)

Logic caffeine-free

• Support memory
• Promote deep thinking
• Maintain processing speed

Synapsa has been shown to significantly improve working memory.

• GINKGO BILOBA (160mg)
• THEOBROMINE (100mg)
• PHOSPHATIDYLSERINE (400mg)
• HIGH DHA ALGAE (200mg)
• URIDINE MONOPHOSPHATE (30mg)
• BACOPA MONNIERI (320mg)

Energy caffeine-free

• Promote Energy
• Fight Fatigue
• Build Mental Stamina

Teacrine has been shown to increase energy, motivation, and concentration.

• CITICOLINE (300mg)
• MANGO LEAF (300mg)
• THEACRINE (100mg)
• N-ACETYL CYSTEINE (500mg)
• INDIAN TRUMPET TREE (100mg)
• N-ACETYL L-TYROSINE (300mg)

Motivation caffeine-free

• Maintain willpower
• Manage procrastination
• Manage stress

CDT (Dynamine) has been shown to help with cognitive control and reaction time during mentally demanding tasks.

• L-PHENYLALANINE (500mg)
• METHYLLIBERINE (100mg)
• VITAMIN B12 (1000mcg)
• FORSKOLIN (250mg)
• ARTICHOKE (450mg)

Confidence caffeine-free

• Encourages Calm State
• Support Mental Flexibility
• Promotes Positive Outlook

Zembrin has been shown to improve in mood and disposition.

• SAFFRON (28mg)
• MAGNESIUM BISGLYCINATE (500mg)
• SAGE (333mg)
• MAGNOLIA BARK (10mg)
• ASHWAGANDHA LEAF & ROOT (120mg)

Baseline Assessment

Our algorithm was built by data scientists and has over 14,861,970 data points total. It matches you with formulas that are specifically aligned with your unique neurological make up, and identifies areas for improvement so you can reach your desired goals.

RajatDev's Personalized Insights

The personalized recommendations delivered by our platform are supported by evidence of 472 independent scientific studies.

After following our recommendations, XXX of our customers have reported improvements in a wide range of cognitive challenges.

Your overall score is higher than XXX of other customers who completed their initial questionnaire.

XXX of our customers with results similar to yours noticed an improvement in their ability to reduce stress and maintain energy within 7 days of using Thesis’ unique formulas.

How does the starter kit work?

Try a blend each week.

Choose one formula weekly, track its impact on your day.

TRACK HOW YOU FEEL

Track the impact of the remaining 3 formulas for the rest of the month.

OPTIMIZE YOUR STACK

We'll check in mid-month to see what's working, and our coaches will help you optimize your stack.

Trusted by experts

Dr. gabrielle lyon.

Functional Medicine & Nutritional Sciences

“I work with CEOs, celebrities, and other top performers in my practice. Thesis is what I recommend and take personally for focus and cognition. I even used it to help me nail my first TedX talk.”

Gabrielle’s blends

Professional Basketball Player & Mental Health Advocate

“With a busy life on and off the court, Thesis gives me energy and focus to get through the longest days and keep me sharp.”

Kevin's blends

Ultra-endurance Athlete & Nutrition Advocate

"Thesis has provided a substantial benefit to my ability to focus. Creativity works best for me — I take it 30 mins before a podcast or writing and it helps get me into the zone."

RICH’s blends

(  8905 Reviews )

Mon Apr 01 2024

I’m going to be honest with you, I was skeptical but I started a new job so I thought maybe it could help.Within a half hour of the first time taking it I saw immediate results.I’m more alert and focused than I’ve been in years.I’m so happy I found Thesis as it has been life changing for me so far.

I absolutely love this stuff, seriously. I’ve tried just about every nootropic in addition to making formulas for myself but nothing comes close to Thesis. I’m actually shocked at how well it works. I work anywhere from 10-14 hours seven days a week and I can feel myself and being more motivated, even after 14 hours, I’ll be a customer for life and I recommend your products to my people.

I have been off stimulants for months now and these formulas are far superior. My husband and daughter both noticed the change and said I have been more productive, focused, less anxious, and more "thinking outside the box". I have tried for years to get off stims and nothing would work. Thank you for making such an amazing product.

I love Thesis! I have used it for 5 months plus. And it has been a game changer for me. I’m a single mom and run 2 businesses. I was struggling before I found Thesis. Now I’m able to get through any day like a rockstar.

You guys have been a lifesaver for me. I’m not sure how I could have done this past year without some help and you really were there for me. Great experiences and awesome customer service!

Showing 1 to 5 of 7955 results

Frequently Asked Questions

Our Starter Kit is designed so that you can try multiple formulations to identify which blends work best with your unique brain chemistry.

Each week you will sample one of your recommended blends, and record how you respond.

Things to note would include increased productivity, decreased procrastination, enhanced focus and any changes in your routine.

At the end of the first month, you should have a good idea as to which blends work most effectively for you. These will be the blends you will continue with in your next month. If you've chosen our subscription option, we will send an email 3 days before your next shipment is sent. You can customize your upcoming box directly through the account portal and book a 1 on 1 consultation with a Wellness Coach .

Depending on your genetics and experience with nootropics, the effects can be felt in as little as 30 minutes after taking each blend.

Thesis has the most impact when taken on an empty stomach, just after waking from a normal night of rest.

Some people may need a few days of consecutive use to feel the effects of the nutrients.

We offer the most advanced cognitive performance system available, which enables you to find the exact compliment for your specific brain chemistry and desired areas of focus

Our innovative Starter Kit allows you to experience multiple formulations and determine which blends work best. Our process is complex because we’ve found that our systematic trial yields the best results in the shortest amount of time.

If we could formulate one pill that would work for everyone, we would. However, because the human brain is deeply complex, that is not possible.

You will receive four distinct Thesis blends totaling a four week supply, an instructional booklet, and access to our team of wellness coaches to help you set and achieve your goals.

You will also receive email messages with additional instructions to make the most of this exploratory month.

Choose up to 4 blends below that best match your goals. You can make changes to these selections in the future, based on what works best for you. GET STARTED

Thesis is shipped from our headquarters in New York City, via First Class Mail through the USPS, and takes about 2-5 business days to arrive within the continental US. Orders will be shipped same-day whenever possible.

If you are in need of priority shipping, email us ([email protected]) as soon as your order is placed, and we will upgrade it for you!

Pure and effective ingredients

Potent active ingredients.

Quality counts when supplementing, and only the active ingredients in a blend make an impact.

Clinically Studied Ingredients

We only use nutrients that have been proven to deliver desired effects in clinical trials.

All ingredients in each batch are tested with a third party lab to ensure optimal potency and purity.

30-Day Money Back Guarantee

Try risk-free for 30 days. 9 out of 10 people find at least one blend that works for them, but if you're one of the unlucky ones, we'll get you a full refund. No questions asked.

Based on our 1,000,000+ data points, we have recommended these formulas for you. Your starter kit will contain each of these four blends.

• + Maintain focus
• + Support attention
• + Enter flow state
• + Spark inspiration
• + Support verbal fluency
• + Maintain confidence
• + Support memory
• + Promote deep thinking
• + Maintain processing speed
• + Promote Energy
• + Fight Fatigue
• + Build Mental Stamina
• + Maintain willpower
• + Manage procrastination
• + Manage stress
• + Encourages Calm State
• + Support Mental Flexibility
• + Promotes Positive Outlook

WANT TO BUILD YOUR OWN BOX?

Get Free Shipping + 33% OFF .

Demand for weight-loss drug Zepbound is so strong that Eli Lilly is warning patients may leave pharmacies empty-handed 

Eli Lilly & Co.  said that some patients may have trouble getting its new weight loss drug Zepbound as complaints of backorders and delays mount across the US.

“Due to the unprecedented demand for these medicines, some patients may experience difficulty when trying to fill their prescription at their pharmacy,” a Lilly spokesperson said.

The  US Food and Drug Administration  doesn’t currently consider the obesity shot in shortage and Lilly said it “continues to manufacture and ship all doses of Zepbound.”

Rite Aid Corp.  and Amazon Pharmacy said that the drug was in short supply, and multiple pharmacists across the US told Bloomberg News that some or all of the doses of the drug were on backorder.

On the website of Amazon Pharmacy, which has a  partnership  with Lilly, four doses of Zepbound are listed as unavailable. An Amazon spokesperson confirmed there is a “nationwide shortage” of some weight-loss medications, including Zepbound.

A Rite Aid spokesperson told Bloomberg News the demand for the obesity shot has “created some sporadic supply constraints.”

Other large pharmacy chains, including  CVS Health Corp. ,  Walgreens Boots Alliance Inc. , and  Walmart Inc.  did not respond to requests for comment on their Zepbound supply.

Pharmacists say they’re having difficulty ordering the drugs from major wholesalers. On Mar. 25, wholesaler  McKesson Corp. ’s ordering system displayed to one pharmacist that all doses of Zepbound were on a supplier backorder, with the next release of drugs expected in early or mid-April, according to records reviewed by Bloomberg News. Full recovery of supply was “TBD,” the notice said.

Cardinal Health Inc. , another distributor, was also reporting a manufacturer backorder for some doses of Zepbound and limiting shipments to pharmacies, said Richard Glotzer, owner and pharmacist at Drug Mart of Millwood in Westchester County. A CVS pharmacy technician in Ohio, who asked not to be identified, provided the same information.

McKesson and Cardinal did not respond to requests for comment.

— With assistance from Jemima Denham

Latest in Health

• 0 minutes ago

Judge slashes Bayer’s $1.5 billion Roundup verdict by more than 60% after Supreme Court decision on limiting punishments

The horrors of TMJ: Chronic pain, metal jaws, and futile treatments

ALS drug will be pulled from US market after study showed patients didn’t benefit

Match Group CEO: Dating apps are the best place to find love, no matter what you see on TikTok

America’s largest egg producer kills 1.6 million chickens, halts production in Texas after finding bird flu

Virtual colonoscopy lets you skip the scope. Here’s what to know about the colorectal cancer screening Mark Cuban says saves time and money

Most popular.

California’s new $20-an-hour fast food minimum wage is so good that schools are worried they can’t compete for cafeteria workers

MacKenzie Scott’s game-changing philanthropy still mystifies nonprofits: ‘Her gifts are super generous, but unfortunately, they don’t provide long term sustainability’

Nearly a quarter of baby boomer and late Gen X men are ‘unretiring’ or planning to because they can’t afford to kick up their feet in the current climate

Sam Bankman-Fried’s mom tried to explain her son to the judge: ‘He has never felt happiness or pleasure in his life and does not think he is capable of feeling it’

Donald Trump’s plans to build a pickleball court on his Irish golf resort held up over concerns about its impact on a protected snail

The new retirement is no retirement: Baby boomers are keeping jobs well into their sixties and seventies because they ’like going to work’

An Ozempic baby boom? Some GLP-1 users report unexpected pregnancies.

Across social media, women who have used Ozempic or similar medications for diabetes or weight loss are reporting an unexpected side effect — surprise pregnancies.

The Facebook group “I got pregnant on Ozempic,” has more than 500 members. Numerous posts on Reddit and TikTok discuss unplanned pregnancies while on Ozempic and similar drugs which can spur significant weight loss by curbing appetite and slowing the digestive process. The drugs are known as “Glucagon-like peptide 1” or GLP-1 drugs.

The reports of an Ozempic baby boom are anecdotal, and it’s not known how widespread the phenomenon is. Experts say significant weight loss can affect fertility. Others speculate that the GLP-1 drugs could interfere with the absorption of oral contraceptives, causing birth control failures.

“I got pregnant on a GLP-1,” posted Deb Oliviara, 32, on her @Dkalsolive TikTok account, which has 36,000 followers. She had noted in another video that she’d previously suffered two miscarriages and a stillbirth.

Oliviara, who lives in Michigan, said in a direct message that she had been using Ozempic for three months before getting pregnant. “I was three weeks along when I found out,” Oliviara said. “I am now 3 months pregnant, and baby is doing amazing.”

“My little Mounjaro baby is almost 6 months old after trying for over 10 years with PCOS!” another woman commented on the post, referring to polycystic ovary syndrome , a hormonal health condition that is a leading cause of infertility.

Paige Burnham, 29, who lives in Louisville, had lost about 80 pounds while using Ozempic, also known as semaglutide, for Type 2 diabetes when she began feeling nauseous on a trip to Disney World. She assumed the symptom was due to the drug. “My most typical Ozempic side effect was nausea,” she said.

But she learned the symptom was actually morning sickness due to pregnancy — a surprise since she and her partner had tried for four years to conceive. She stopped taking Ozempic and gave birth to a healthy baby boy, Creed, in March 2023.

A lack of research on pregnancy and GLP-1 drugs

Little is known about the effects of Ozempic and similar drugs on women who want to get pregnant or who become pregnant while taking the drugs because they were specifically excluded from early clinical trials of the drug.

A spokesman for Novo Nordisk, which makes Ozempic and Wegovy, said the company is collecting data to evaluate the safety of becoming pregnant while using Wegovy, the version of semaglutide approved for weight loss.

“Pregnancy or intention to become pregnant were exclusion criteria in our trials with semaglutide in both obesity and type 2 diabetes,” the company said in a statement.

Get Well+Being tips straight to your inbox

Eli Lilly, maker of the GLP-1 drugs Mounjaro and Zepbound, did not respond to requests for comment.

The biggest concern among women who become pregnant using a GLP-1 is whether the drug poses a risk to the fetus. While women like Burnham and Oliviara have posted reassuring stories of delivering healthy babies, doctors say it’s important to use backup birth control and stop the drug immediately if you become pregnant.

A Novo Nordisk spokesman said in a statement that there isn’t enough available data to know if the drug poses a risk for birth defects, miscarriage or other adverse events related to pregnancy. Based on animal reproduction studies for Wegovy, the company said there “may be potential risks to the fetus from exposure to semaglutide during pregnancy.”

The company recommends stopping Wegovy at least two months before a planned pregnancy.

According to Ozempic’s prescribing information , pregnant rats administered Ozempic showed fetal structural abnormalities, fetal growth problems and embryonic mortality. In rabbits and cynomolgus monkeys, there were early pregnancy losses or structural abnormalities as well as marked maternal body weight loss.

Controlling diabetes is important for a healthy pregnancy, and experts say patients taking Ozempic for diabetes should discuss the risks and benefits with their doctor.

Why drugs like Ozempic might affect pregnancy risk

While it’s unclear whether women taking a GLP-1 have a higher risk of unplanned pregnancies, doctors say there are a few explanations why some women are getting pregnant while using the drugs.

Weight loss can have an effect on ovulation and fertility, said Lora Shahine , a reproductive endocrinologist with a fertility practice in Seattle and Bellevue, Wash.

“I think that with weight loss and balancing of hormones and improved insulin resistance, the hormonal access clicks back in, and all of a sudden they start ovulating again — they might not have been ovulating for years,” said Shahine, who is also an associate clinical professor at the University of Washington.

Stephanie Fein , an internist in Los Angeles who specializes in helping women lose weight for their fertility, said that losing just 5 to 10 percent of body weight can help someone conceive. “No one knows exactly the reason,” she said. “Fat is hormonally active. We know it has effects on estrogen, and it will impact ovulation and possibly egg development.”

The drugs also may interfere with oral contraceptives in some patients, doctors say. The GLP-1 drugs help people lose weight by slowing gastric emptying, curbing hunger and leaving people feel full sooner. It may be that the GLP-1 drugs also affect the absorption of oral contraceptives, said William Dietz, physician and chair of the STOP Obesity Alliance at the Milken Institute School of Public Health at George Washington University. “This may mean that birth control medications are metabolized or ineffective,” he said.

Dietz said most experts recommend discontinuing GLP-1 medications when pregnancy is detected. “I don’t think we know the impact of these drugs on fetal development,” he added.

Shahine recommends that women using oral contraceptives who are taking a GLP-1 drug use a second form of birth control. The drugs also aren’t recommended for mothers who are breastfeeding. Animal studies have shown semaglutide is present in the milk of lactating rats treated with the drug.

After Burnham stopped breastfeeding, she resumed taking Ozempic. Because of her past struggles with infertility, she doesn’t want to take birth control, although she said she is concerned about getting pregnant too soon. “I’m not ready yet,” she said.

Amy Klein is the author of “The Trying Game: Get Through Fertility Treatment and Get Pregnant without Losing Your Mind.”

Read more from Well+Being

Well+Being shares news and advice for living well every day. Sign up for our newsletter to get tips directly in your inbox.

Are you taking your meds wrong ? Many patients make these common mistakes.

Centenarians give their advice about everything.

The wall sit is a simple exercise that can lower your blood pressure.

Tart cherries — more specifically, tart cherry juice — may help with inflammation and pain.

Do you self-sabotage ? Here’s how to stop.

You can now get Ozempic at Costco — but don't expect big savings

• Costco is now selling the weight loss drug Ozempic through a partnership with health startup Sesame.
• Members can pay $179 for a prescription and appointment as part of a three-month package.
• Still, that doesn't cover the cost of the GLP-1 drug, which has gained popularity but can be costly.

Silver bullion and sushi aren't the only new additions to Costco's product selection this year. Now, you can get a prescription for the weight loss drug Ozempic through the retailer, too.

Costco has started offering the prescriptions through a partnership with healthcare startup Sesame, CNN reported on Tuesday. For $179, members can get a prescription for the GLP-1 weight loss drug plus a meeting with a doctor or specialist. Members who get the drug are also able to message a doctor with questions or issues as they continue to use Ozempic.

One thing the program — which lasts three months and is renewable — does not include is the actual cost of Ozempic, which can run up to $1,600 a month without insurance, CNN reported. Getting insurance to cover the drugs is still tough for non-diabetic users, and some employers are worried that the costs could strain their finances.

Related stories

Costco did not immediately respond to requests for comment from Business Insider. Sesame Chief Marketing Officer Michael DiLorenzo told BI that the company has seen the number of participants in the startup's weight loss service increase by 50 times since it unveiled the option with Costco on Tuesday.

DiLorenzo said that Sesame is "focused on making sure that the products we have in-market now with Costco — weight loss, primary care, and mental health — are delivering the exceptional experience and results that Costco Members expect of everything they get from Costco."

Ozempic, Wegovy, and other GLP-1 drugs have gained popularity among people trying to lose weight over the last few years. First intended as a treatment for type 2 diabetes, the drug uses semaglutide, an ingredient that can moderate blood sugar. It can also reduce appetite, which is why it has gained traction for non-diabetic patients trying to shed pounds.

Sales of the drugs have been so great that they likely helped Denmark avoid a recession since the country is home to Ozempic- and Wegovy-maker Novo Nordisk.

Costco started working with Sesame last fall to offer basic health services, such as virtual check-ups. GLP-1 drugs weren't initially part of the partnership, according to Sesame cofounder and president Michael Botta.

But approximately one in five requests that Sesame got through the Costco program was about weight loss, so Sesame developed the offering to cater to those customers.

"We realized pretty quickly, just by looking at what people were curious about, that there was a clear unmet need here," he told CNN.

Watch: Ozempic explained: how a miracle diabetes drug became the center of a weight loss craze

• Main content

More From Forbes

Medicare plans may now provide limited coverage for obesity drug wegovy.

• Share to Facebook
• Share to Twitter
• Share to Linkedin

Wegovy is a self-injectable prescription weight loss medicine, which is now also indicated for ... [+] certain people with severe cardiovascular risk factors. (Photo by: Michael Siluk/UCG/Universal Images Group via Getty Images)

The weight loss drug Wegovy secured a supplemental cardiovascular indication from the Food and Drug Administration last month. This allows for limited access to the drug for certain Medicare beneficiaries who fulfill weight and major cardiovascular risk criteria.

Currently, Medicare is prohibited by law from covering medications for obesity. Congress is unlikely to lift the prohibition any time soon. And merely 20% of state Medicaid agencies permit coverage of weight loss drugs.

However, because a cardiovascular indication to prevent heart attacks or strokes was added last month to an already approved obesity drug, Wegovy (semaglutide), this paves the way for coverage by health plans operating in the Medicare Part D (outpatient) program. These plans may now cover Wegovy for patients who are overweight or obese and have preexisting (severe) cardiovascular disease.

Furthermore, going forward Medicaid plans will be obligated to place Wegovy on their lists of drugs which they reimburse. But state Medicaid agencies and managed care plans can still require patients to undergo step edits before they can obtain Wegovy for the cardiovascular indication. This means they may have to try cheaper alternatives before being able to access the product.

Medicare plans don’t have to include Wegovy on formulary as it does not fall under one of the six protected drug classes in which all medicines must be reimbursed. Therefore it’s likely plans will make similarly cautious decisions about coverage to the ones being made in the commercial sector where less than 50% of insurers cover Wegovy.

Best Short-Term Health Insurance Companies Of 2022

Best health insurance companies of 2022.

Also, the numbers of beneficiaries eligible for coverage will be limited, even when plans decide to reimburse, as the narrowly defined sub-population with the cardiovascular indication isn’t representative of the typical Medicare beneficiary who is overweight or obese. The FDA based its decision to add the indication to Wegovy’s label on SELECT trial data . Clinical trial participants were overweight or obese and at severe risk for subsequent major cardiovascular events. For example, more than two-thirds had a previous heart attack, one-fourth a prior stroke and 82% have coronary heart disease. Accordingly, when plans cover the product, it’s very likely they will institute prior authorization protocols as well as other utilization management tools.

Restrictions are also probable because the absolute risk reduction of 1.5% of significant cardiovascular events among SELECT trial participants was relatively small. Namely, during the SELECT trial, major adverse cardiac events occurred in 6.5% of patients on Wegovy and 8% of those on placebo. This translates into a number needed to treat of 67 to avoid one severe cardiovascular event, which may not be considered a particularly good value proposition from an insurer’s perspective. So even for the sub-population at severe risk, taking Wegovy will not necessarily lead to cost savings . What’s more, the data didn’t show Wegovy decreased the risk of cardiovascular death by a statistically significant margin .

Moreover, what may concern payers is that many patients don’t stay on their obesity medications, which then leads to weight rebound once they come off. A recently published peer-reviewed study shows that only 40% of obese patients taking semaglutide-based products were persistent at one year. And another released real-world analysis demonstrated considerably lower persistence of 28% at the end of one year.

Adding a cardiovascular indication will allow access by at-risk Medicare beneficiaries to the weight loss drug Wegovy. But it’s expected that Medicare plans that decide to pay for Wegovy will implement a set of stringent coverage restrictions.

• Editorial Standards
• Reprints & Permissions

We've detected unusual activity from your computer network

To continue, please click the box below to let us know you're not a robot.

Why did this happen?

Please make sure your browser supports JavaScript and cookies and that you are not blocking them from loading. For more information you can review our Terms of Service and Cookie Policy .

For inquiries related to this message please contact our support team and provide the reference ID below.

Lilly's weight-loss drug Zepbound to face supply crunch through April-end, US FDA says

• Eli Lilly and Co Follow
• Novo Nordisk A/S Follow
• U.S. Food and Drug Administration Follow

Keep up with the latest medical breakthroughs and healthcare trends with the Reuters Health Rounds newsletter. Sign up here.

Reporting by Christy Santhosh and Sriparna Roy in Bengaluru; Editing by Shilpi Majumdar

Our Standards: The Thomson Reuters Trust Principles. , opens new tab

Royal Bank of Canada fires CFO over undisclosed relationship

Royal Bank of Canada on Friday said it appointed Katherine Gibson as interim Chief Financial Officer, effective immediately, following the departure of Nadine Ahn.