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Department of Biochemistry and Molecular Biology Theses and Dissertations

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This collection contains theses and dissertations submitted by graduate students under the Department of Biochemistry and Molecular Biology for either a Master of Science degree or a Doctor of Philosophy degree.

Recent Submissions

OPTIMIZED ISOLATION AND QUANTIFICATION OF IN VIVO DISTRIBUTION OF EXOSOMES FOR POTENTIAL TARGETED THERANOSTIC APPLICATION

THE ROLE OF GPR109A IN REGULATION OF RETINAL ANGIOGENESIS AND BLOOD-RETINAL BARRIER AS A POTENTIAL THERAPEUTIC TARGET IN DIABETIC RETINOPATHY

A Molecular Basis of Chemoresistance in Bladder Cancer

Osteopontin as a novel immune checkpoint, gene regulation by the putative campylobacter jejuni diguanylate cyclase cbrr, glycosaminoglycans, chondroitinase, and molecular subtypes in bladder cancer.

HLA-G DIMER PROLONGS KIDNEY ALLOGRAFT SURVIVAL BY INHIBITING CD8+T CELL ACTIVATION AND GRANZYME B EXPRESSION

Investigating the Role of the Hdac3 Co-Repressor Complex in Glucocorticoid Signaling-Mediated Bone Marrow Lipid Storage with Age

CHOLINESTERASE INHIBITOR TOXICITY: MECHANISTIC STUDIES AND THERAPEUTIC STRATEGIES FOCUSED ON AXONAL TRANSPORT

Primary Tumor-Induced Immunity Is Suppressed By Surgery-Induced Inflammation In The Presence Of Residual Tumor Cells

DISCOVERY AND VALIDATION OF A NOVEL NEUTROPHIL ACTIVATION MARKER ASSOCIATED WITH OBESITY

Role of arginase in obesity-induced visceral adipose tissue dysregulation and endothelial dysfunction.

DNA METHYLATION AS A KEY PLAYER IN INFLAMMATION-MEDIATED COLON TUMORIGENESIS

The c-MYC oncogene deregulates global DNA methylation and hydroxymethylation to control genome-wide gene expression for tumor maintenance in leukemia/lymphoma

The Role of GPR109A in NAD+ Metabolism in Aging RPE

Immune regulation of tumor cell plasticity: A promising molecular target in breast cancer metastasis

THE TUMOR SECRETORY FACTOR ZAG PROMOTES WHITE ADIPOSE TISSUE BROWNING AND ENERGY WASTING IN CACHEXIA

Canonical wnt signaling in antigen presenting cells regulates microbiota-induced inflammation and immune cell homeostasis in the colon.

CXCR2 EXPRESSING TUMOR CELLS DRIVE VASCULAR MIMICRY IN ANTI-ANGIOGENIC THERAPY RESISTANT GLIOBLASTOMA

MECHANISM OF 12/15 LIPOXYGENASE-INDUCED RETINAL MICROVASCULAR DYSFUNCTION IN DIABETIC RETINOPATHY

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Chemistry & Biochemistry Theses & Dissertations

Theses and dissertations published by graduate students in the Department of Chemistry and Biochemistry, College of Sciences, Old Dominion University, since Fall 2016 are available in this collection. Backfiles of all dissertations (and some theses) have also been added.

In late Fall 2023 or Spring 2024, all theses will be digitized and available here. In the meantime, consult the Library Catalog to find older items in print.

Theses/Dissertations from 2023 2023

Dissertation: Structural Insights into the cl-Par-4 Protein: Ionic Requirements, Conformational Transitions, and Interaction With Cisplatin , Krishna Kumar Raut

Thesis: Synthesis and Characterization of Cobalt(III) Complexes and a Vanadium(IV) Complex with Flavonoids as Ligands , Ethan Schroeder

Thesis: Molecular Evidence for the Export of Terrigenous Organic Matter to the North Gulf of Mexico by Solid-State 13 C NMR and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Humic Acids , Sarah Ann Ware

Theses/Dissertations from 2022 2022

Dissertation: Investigating the Biorisk of Genetically Engineered Thermosynechococcus Elongatus BP1 , Cherrelle Leah Barnes

Dissertation: Implications of Metal Coordination in Damage and Recognition of Nucleic Acids and Lipid Bilayers , Ana Dreab

Dissertation: Clostridioides Difficile Biofilm and Spore Production in Response to Antibiotics and Immune Stress , Adenrele M. Oludiran

Dissertation: Design, Synthesis and Characterization of Triazole Based Glycoconjugates and 4,6-Acetal Protected D-Glucosamine Derivatives as Low Molecular Weight Gelators , Pooja Sharma

Theses/Dissertations from 2021 2021

Dissertation: Design, Synthesis and Characterization of Carbohydrate Based Macrocycles, Photo Responsive Derivatives, and Glycoconjugates Based Low Molecular Weight Gelators , Surya Bahadur Adhikari

Dissertation: Computational and Experimental Investigation into the Determinants of Protein Structure, Folding, and Stability in the β-Grasp Superfamily , John T. Bedford II

Dissertation: Synthesis and Characterization of 4,6-protected Glucosamine Derivatives and Branched Glycoconjugates , Jonathan Bietsch

Dissertation: Biophysical Characterization of the Par-4 Tumor Suppressor: Evidence of Structure Outside the Coiled Coil Domain and Interactions with Platinum Chemotherapeutics , Andrea Megan Clark

Dissertation: Computational Analysis of Type 3 Iodothyronine Deiodinase: Potential Inhibitors, Substrate Binding, and Dimer Structure , Eric Scott Marsan

Dissertation: The Development of Novel Carbohydrate-Based Gelators and Their Applications as Advanced Soft Materials , Joedian Morris

Dissertation: Genetically Engineered Thermosynechococcus Elongatus BP1: Assessment of Potential Biorisks and Biofuel Production , Thu Ho Anh Nguyen-Jones

Dissertation: Evaluating the Role of the Stringent Response Mechanism in Clostridioides difficile Survival and Pathogenesis , Astha Pokhrel

Dissertation: Mechanisms of Stress Survival in Gram Positive Bacterial Pathogens , Asia Poudel

Dissertation: Improvement of Biochar Through Ozonization and Biosafety of Genetically Engineered Cyanobacteria , Oumar Sacko

Thesis: Evaluation of Horizontal Gene Transfer Between Genetically Engineered Cyanobacteria and Gram-Negative Bacteria , Andriana Chrysovalanti Zourou

Theses/Dissertations from 2020 2020

Dissertation: Synthesis, Characterization, and Kinetics Studies of New Cobalt Complexes for the Production of H 2 in Acidic Media , Michael John Celestine

Dissertation: Structural Characterization of Organic Matter in Oil Shales Using Multiple Nuclear Magnetic Resonance Spectroscopic Techniques , Wenying Chu

Dissertation: Advances in the Understanding of Sourcing and Fate of Pyrogenic Organic Matter in the Environment , Aleksandar Ivaylov Goranov

Dissertation: Synthesis, Characterization, Spectroscopic, and Mesomorphic Studies of New Schiff Base Ligands and Titanium, Cobalt, Nickel and Copper Metal Centers , Raj K. Gurung

Thesis: Network Approaches to Elucidate the Determinants of Protein Topology and Stability , Zeinab Haratipour

Dissertation: Lignin: A Likely Precursor of a Significant Fraction of Humic Substances Via Oxidative Transformations , Seyyedhadi Khatami

Dissertation: Synthesis and Characterization of Carbohydrate Based Molecular Gelators and Macrocycles Through Cycloaddition Reactions , Dan Wang

Theses/Dissertations from 2019 2019

Dissertation: Synthesis, Characterization, and Drug Delivery Applications of Carbohydrate Based Low Molecular Weight Gelators , Kristen Elizabeth Bashaw

Thesis: A Dual Nanostructured Approach to SERS Amenable to Large-Scale Production , Kory Brian Castro

Theses/Dissertations from 2018 2018

Dissertation: Synthesis and Characterization of Glycolipids, Glycoclusters and Glycomacrocycles , Anji Chen

Dissertation: Development and Evaluation of Post-Production Oxygenation Techniques for the Augmentation of Biochar , Matthew David Huff

Thesis: Characterizing the Activity of Antimicrobial Peptides Against the Pathogenic Bacterium Clostridium Difficile in an Anaerobic Environment , Adenrele Mojeed Oludiran

Dissertation: Computational Investigation of Energetic Materials: Influence of Intramolecular and Intermolecular Interactions on Sensitivity , Ashley Lauren Shoaf

Dissertation: Study of ABC Membrane Transporters in Single Live Cells , Preeyaporn Songkiatisak

Thesis: The Effect of Soxhlet Extraction and Synthesis Temperature on Properties of Polyaniline , Samuel Watson Stahl

Dissertation: Structure of the Picornavirus Replication Platform: A Potential Drug Target for Inhibiting Virus Replication , Meghan Suzanne Warden

Theses/Dissertations from 2017 2017

Dissertation: Observations of Greenhouse Gas Isotopologues with ACE-FTS and WACCM , Eric Michael Buzan

Dissertation: Alicyclic and Aromatic Carboxylic Acids in Soil Organic Matter: An Investigation of Potential Origin and Association with Plutonium Using Advanced Analytical Techniques , Nicole DiDonato

Thesis: Characterization of 3-Ester and 3-Carbamate Derivatives of N-Acetyl-D-Glucosamine and Their Use in Controlled Drug Delivery , Consuelo Garcia

Dissertation: Synthesis, Characterization and Application of Sugar-Based Low Molecular Weight Gelators , Ifeanyi Simeon Okafor

Dissertation: Lignin Contribution to the Global Carbon Pool: Investigating the Abiotic Modification of Lignin by Reactive Oxygen Species , Derek Charles Waggoner

Theses/Dissertations from 2016 2016

Thesis: Synthesis and Mechanistic Investigations of Transition Metal Complexes and Ligands for Chemotherapeutic Applications , Jimmie Lee Bullock Jr.

Dissertation: Design of Drug Nano-Carriers for Study of Multidrug Resistance in Single Live Cells , Pavan Kumar Cherukuri

Dissertation: Synthesis, Morphological Control, Dispersion Stabilization and In Situ Self-Assembly of Noble Metal Nanostructures Using Multidentate Resorcinarene Surfactants , Sangbum Han

Thesis: Discoloration of a Green Pigment in Tintoretto’s Allegorical Figure of Spring and Analysis of the Chemical Properties and Stability of Copper Resinate , Sarah Wells Conner Horn

Dissertation: Low-Temperature Artificial Maturation Studies of Type II and Type III Kerogens: Implications for Biogenic Gas Production , Albert Willy Nguena Kamga

Dissertation: Bioenergetics: Experimental Demonstration of Excess Protons and Related Features , Haitham A. Saeed

Dissertation: Possible Sources and Impacts of Biochar Water Extractable Organic Compounds on Aquatic Microorganisms , Cameron Russell Smith

Theses/Dissertations from 2015 2015

Thesis: Synthesis, Characterisation, Electrochemical, and Spectroscopic Studies of Cobaloximes: Unique Clues of Cobalt(I) Species in Various Solvents , Michael John Celestine

Dissertation: Computational Investigation of Pernicious Compounds: Arsenic and High Energy Density Materials and Their relevant Mechanisms , Lenora Kathleen Harper

Dissertation: Artificial Maturation Studies of Polymethylenic Plant Biopolymers: Investigating the Chemical Alterations from Plant Material to Coal , Blaine Elizabeth Hartman

Dissertation: Investigation of the Potential for Algaenan to Produce Hydrocarbon Based Fuels From Algae by Hydrous Pyrolysis , Wassim Adel Obeid

Dissertation: Exploring the Effect of Climate Change on Biological Systems , Nardos Sori

Dissertation: Study of Photochemical Formation of Hydroxyl Radical in Natural Waters , Luni Sun

Dissertation: Source-Specific Molecular Signatures for Light-Absorbing Organic Aerosols , Amanda Susan Willoughby

Theses/Dissertations from 2014 2014

Dissertation: Spectroscopic Characterization of Dissolved Organic Matter: Insights Into the Linkage Between Sources and Chemical Composition , Xiaoyan Cao

Dissertation: Molecular Characterization and Photochemical Transformation of Dissolved Organic Matter From Land to Ocean , Hongmei Chen

Dissertation: Density Functional Theory Modeling of It-Stacking and Electrophilic Donor-Acceptor Interactions with Application to Therapeutic Targeting of Zinc-Finger Proteins , Patricia Beall Lutz

Dissertation: Synthesis and Characterization of Sugar Based Low Molecular Weight Gelators and the Preparation of Chiral Sulfinamides , Hari Prasad Reddy Mangunuru

Dissertation: Advances in Understanding the Molecular Composition of Dissolved Organic Matter and Its Reactivity in the Environment , Rajaa Mesfioui

Theses/Dissertations from 2013 2013

Dissertation: Novel Algorithms and Instrumentation for Vibrational Spectroscopic Methods of Analysis , Mohamed F. Abdelkader

Thesis: Molecular Characteristics of the Water Soluable Organic Matter in Size Resolved Aerosols Collected Over the North Atlantic Ocean , Sarah Catherine Gurganus

Theses/Dissertations from 2012 2012

Dissertation: Spectroscopic Characterization of Dissolved Organic Matter: Insights into Composition, Photochemical Transformation and Carbon Cycling , John Robert Helms

Thesis: Multidentate Resorcinarene Surfactants for the Phase Transfer of Metal Nanoparticles and Nanodiamonds: Applications in Catalysis and Diamond Film Growth , Vara Prasad Sheela

Thesis: Identification of Persistent Long Range Interactions in G A 95 and G B 95 Through Thermal Unfolding Simulations , Milen Redai Tesfamariam

Theses/Dissertations from 2011 2011

Dissertation: Computational Investigation of the Bioactive Selenium Compounds Ebselen and Selenious Acid , Sonia Antony

Dissertation: Bioinformatics, Thermodynamics and Kinetics Analysis of an All Alpha Helical Protein with a Gree-Key Topology , Hai Li

Thesis: Insights into Chemical Structure Changes of Kerogen from Bituminous Coal in Response to Dike Intrusions Investigated by Advanced Solid-State 13 C NMR , Yuan Li

Dissertation: The Nature, Origin and Preservation of Amide Organic Nitrogen in Organic Matter , Georgina Anne McKee

Theses/Dissertations from 2010 2010

Thesis: Comparison of Ice Core Dissolved Organic Matter from a Greenland Ice Core by Nanospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry , Joshua Jeremiah Shiloh Marsh

Thesis: Molecular Characterization of The Soluble Fraction of Atmospheric Particulate Matter Obtained by Chemical Oxidation With Nitric Acid , Amanda Susan Priest

Dissertation: Conformational Change and Topological Stability of Proteins , Jeffrey Andrew Tibbitt

Theses/Dissertations from 2009 2009

Dissertation: The Use of Fourier Transform (FT) Surface-Enhanced Raman Scattering for Biochemical Analysis , Robert Butler Jeffers

Thesis: Solvent Dependent Morphologies in Thiol-ene Photopolymerization: A Facile Route to Synthesis of Resorcinarene Nanocapsules , Zaharoula Marie Kalaitzis

Thesis: Development of Chemometric Models and Calibration Transfer for Rapid Diesel and Jet Fuel Analysis Using Near Infrared Spectroscopy , Christopher Matthew Larkin

Dissertation: Export of Terrestrial Dissolved Organic Matter Along a River to Ocean Transect of the Lower Chesapeake Bay Investigated by Advanced Analytical Techniques , Rachel Leigh Sleighter

Theses/Dissertations from 2008 2008

Thesis: The Regulation of Endothelial and Neuronal Nitric Oxide Synthase Expression in the Preglomerular Vessels by the Increase in Intracellular Calcium Concentration , Stephanie Thomas Montgomery

Theses/Dissertations from 2006 2006

Thesis: Development of Single Nanoparticle Optical Assays for Imaging Single Living Cells , William John Brownlow

Thesis: Spectral Shape as an Indicator of Molecular Weight in Chromophoric Dissolved Organic Matter , John Robert Helms

Thesis: Biochemical Profiling of Gout Patients , Tamera Fayre Schlitt

Theses/Dissertations from 2005 2005

Thesis: Development and Application of a GG-IRMS Reductive Pyrolysis Reactor Interface for the δ 34 S Determination of Sulfur in Individual Organic Compounds , N. Deborah Hewlett

Thesis: Natural and Synthetic Viniferins Associated with the Grapevine Disease Young Vine Decline , David Michael McGinnis

Theses/Dissertations from 2004 2004

Thesis: Bacterial Degradation of Disinfection By-Products in Drinking Water , Laura Inga Fauntleroy

Theses/Dissertations from 2003 2003

Thesis: Real-Time Study of Multidrug Resistance Mechanism in Pseudomonas Aeruginosa Using Nanoparticle Optics and Single Live Cell Imaging , Sophia Vasou Kyriacou

Thesis: Synthesis and Biological Evaluation of Novel Capacitative Calcium Entry Blockers , Thadigiri Celina Mala

Theses/Dissertations from 2002 2002

Thesis: Production of a Monoclonal Antibody Against Benzo[α]Pyrene Diol Epoxide DNA Adducts , Brian Peden Austin

Thesis: Styrene Monomer Solubility in Artificial and Natural Seawaters of the Lower Chesapeake Bay , Eric Joseph Miller

Theses/Dissertations from 2001 2001

Thesis: Positive Regulation of PKA on Human Gonadotropin-Releasing Hormone (hGnRH) Gene Expression in Human Placental JEG-3 Cells , Zhaoyang Wen

Theses/Dissertations from 2000 2000

Thesis: Copper Complexation and Speciation in the Western South and Equatorial Atlantic Ocean , John A. Consolvo

Thesis: Cytotoxic T Cell Response to Influenza Vaccination in Older Adults , Caroline R. Letter

Thesis: Induction of Apoptosis in Human Prostate Cancer Cells by Resveratrol , Gary Zulfikar Morris

Thesis: Fourier Transform Raman Spectroscopy for Process Control in the Petroleum Industry , Kent Lawson Wise

Theses/Dissertations from 1999 1999

Thesis: Zinc Speculation and Ligand Fluxes in Chesapeake Bay and Elizabeth River Pore Waters , Duncan Glover Byers

Thesis: Generation of Human chorionic gonadotropin Beta Subunit Specific Monoclonal Antibody Using a Synthetic Peptide , Zhe Huang

Thesis: A Study on the Effects of the N-Terminal Amino Acid Sequence on the Activation of Human T-Cell Leukemia Virus Type 1 Protease , Hidayah Muhammad Kendall

Thesis: Humic Substances as Interferences in the Analysis of Nitrite in Water , Stephanie Ann Tebault

Theses/Dissertations from 1998 1998

Thesis: Explosive Vapor Generation and Sampling in Conjunction with Ion Mobility Spectrometry , Saeed H. Almeer

Thesis: Determination of the N-Terminal Amino Acid Residues on Polypeptides in Secondary Wastewaters , Edward L. Creecy

Thesis: Developmental and Hormonal Regulation of the Expression of Cytosolic Phospholipase A 2 Protein Levels in Baboon Placenta , Kathleen Elizabeth Dunstan

Thesis: Development of Fluorescent Techniques in the Kinetic Characterization of Reverse Transcriptase , Kevin Kevin Howerton

Thesis: Chemical Modification of CVD Diamond Electrodes , Robert Matthew Johnson

Theses/Dissertations from 1997 1997

Thesis: Evaluation of Solid Phase Extraction Followed by Supercritical Fluid Elution of Semi-Volatile Organic Compounds in Toxicity Characteristic Leachates , William Edward Corl III

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School of Biochemistry

• Faculty of Life Sciences
• Website http://www.bris.ac.uk/biochemistry/

United Kingdom

Student theses

• 1 - 50 out of 139 results
• Title (descending)

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3d printing enzyme mediated interpenetrating-network biohybrid materials with shape changing properties.

Supervisor: Perriman, A. W. (Supervisor) & Anderson, J. L. R. (Supervisor)

Student thesis : Doctoral Thesis › Doctor of Philosophy (PhD)

A Baculoviral ‘Swag Bag’ Protein and DNA Delivery Toolkit for CRISPR-based Editing of Human Genomes

Supervisor: Berger, I. (Supervisor) & Dillingham, M. (Supervisor)

A biophysical investigation into the self-assembly of α-helix - polyproline II helix oligomers

Supervisor: Race, P. R. (Supervisor) & Woolfson, D. N. (Supervisor)

A characterisation of mononuclear phagocyte dynamics in the healthy and regenerating zebrafish heart

Supervisor: Richardson, B. (Supervisor) & Martin, P. B. (Supervisor)

ADDomer: synthetic multiepitope virus-like particle platform for next-generation vaccines and high-affinity binders

Supervisor: Berger, I. (Supervisor), Mulholland, A. (Supervisor) & Berger-Schaffitzel, C. (Supervisor)

A framework for the investigation of heme homeostasis through genetically encoded heme sensors

Supervisor: Raven, E. (Supervisor) & Anderson, R. (Supervisor)

Ago2/DDX6-Dependent miRNA Activity in Neuronal Plasticity

Supervisor: Hanley, J. (Supervisor) & Henley, J. (Supervisor)

Student thesis : Master's Thesis › Master of Science by Research (MScR)

An Alternative Approach to Combat Antimicrobial Resistant Infections of Medical Implants and Devices

Supervisor: Nobbs, A. (Supervisor), Su, B. (Supervisor) & Verkade, P. (Supervisor)

An investigation of the activation of µ opioid receptors by fentanyls using in silico and in vitro approaches

Supervisor: Kelly, E. P. (Supervisor) & Sessions, R. B. (Supervisor)

Antibiotics from the Abyss - Establishing the Bristol Sponge Microbiome Collection as an Antibiotic Discovery Pipeline

Supervisor: Willis, C. (Supervisor), Race, P. (Supervisor) & Essex-Lopresti, A. (External person) (Supervisor)

A Promiscuous and Catalytically Proficient De Novo Carbene Transferase

Supervisor: Anderson, R. (Supervisor) & Seddon, A. (Supervisor)

Assembly and characterisation of Diels-Alderase polymer conjugates for industrial biocatalysis

Supervisor: Burston, S. (Supervisor) & Race, P. (Supervisor)

Assembly and functionalisation of membraneless organelles from de novo designed proteins

Supervisor: Woolfson, D. (Supervisor) & Savery, N. (Supervisor)

Baculoviral Nanosystems for DNA Delivery and Energy Sensing

Supervisor: Berger, I. (Supervisor) & Collinson, I. (Supervisor)

Biocrystals: Growth, Synthesis and Materials

Supervisor: Patil, A. (Supervisor) & Anderson, R. (Supervisor)

Changes in Dendritic and Synaptic Function During Early Postnatal Development of the Mouse Barrel Cortex

Supervisor: Ashby, M. C. (Supervisor)

Characterisation of Ataxia Telangiectasia Mutated in RPE-1 cells and its role in cellular sensitivity to hypo-osmotic stress

Supervisor: Mellor, H. H. (Supervisor) & Wood, W. J. (Supervisor)

Characterisation of Channelrhodopsin-2 in a neuronal culture model

Supervisor: Henley, J. M. (Supervisor) & Randall, A. D. (Supervisor)

Characterisation of the atypical calpain family of C elegans

Characterisation of the hells and irc5 subfamily of chromatin remodellers.

Supervisor: Dillingham, M. (Supervisor) & Chambers, A. (Supervisor)

Characterisation of two short QT syndrome potassium channel mutations

Supervisor: Hancox, J. (Supervisor) & Dempsey, C. (Supervisor)

Characterising Red Cell-Derived Vesicles in Sickle Cell Disease and Investigating Potential to Induce Tolerance to Human Red Cell Antigens

Supervisor: Blair, A. (Supervisor) & Anstee, D. J. (Supervisor)

Computational design, construction, and characterisation of artificial peroxidases

Supervisor: Anderson, R. (Supervisor) & Mulholland, A. (Supervisor)

Computational Design and Structural Characterization of de novo Heme Maquettes

Supervisor: Anderson, J. L. R. (Supervisor) & Mulholland, A. J. (Supervisor)

Computation Design of Bioenergetic Membrane Proteins

Supervisor: Curnow, P. (Supervisor) & Anderson, R. (Supervisor)

Conformational Control of Modular Proteins

Supervisor: Parmeggiani, F. (Supervisor) & Anderson, R. (Supervisor)

CRISPR-Cas9 gene editing in an immortalized erythroid cell line for production of engineered red blood cells

Supervisor: Spear, A. (Supervisor), Toye, A. (Supervisor) & Frayne, J. (Supervisor)

Crystallographic studies of NAD'+- dependent L- and D- 2-hydroxyacid dehydrogenases.

Supervisor: Brady, R. L. (Supervisor)

De novo designed phospho-switchable protein-protein interaction domains for synthetic biology applications

Supervisor: Woolfson, D. N. (Supervisor) & Savery, N. J. (Supervisor)

De novo designed protein-protein interaction domains for synthetic biology applications in cells

De novo design of photoactivatable electron transfer proteins.

Supervisor: Van der Kamp, M. (Supervisor) & Anderson, R. (Supervisor)

Development and validation of synthetically engineered microbial consortia

Supervisor: Di Bernardo, M. (Supervisor), Savery, N. (Supervisor) & Marucci, L. (Supervisor)

Development of Novel Probes for Correlative Light Electron Microscopy

Supervisor: Verkade, P. (Supervisor) & Gersen, H. (Supervisor)

Diabetes mellitus causes adiposopathy in bone marrow: investigation of the underpinning cellular and molecular mechanisms

Supervisor: Madeddu, P. (Supervisor) & Mellor, H. H. (Supervisor)

Directed evolution of artificial oxidoreductases.

Supervisor: Mulholland, A. (Supervisor) & Anderson, R. (Supervisor)

Dissecting stress resilience mechanisms during epithelial homeostasis and repair

Supervisor: Weavers, H. M. A. (Supervisor)

Dissecting the molecular and functional interactions of retromer

Supervisor: Cullen, P. (Supervisor)

Dissecting the Role of the PARylation Stress Response During Tissue Repair and Inflammation in Drosophila

Supervisor: Collinson, I. (Supervisor) & Weavers, H. (Supervisor)

Effects of organic cosolvents on a de novo designed heme peroxidase

Supervisor: Fermin, D. (Supervisor) & Anderson, R. (Supervisor)

Engineering of polychromatic photosystems for expanded solar energy conversion

Supervisor: Jones, M. (Supervisor) & Woolfson, D. (Supervisor)

Enzyme structure-function studies towards novel spirotetronates and materials

Supervisor: Race, P. R. (Supervisor), Curnow, P. (Supervisor) & Stach, J. E. M. (External person) (Supervisor)

Evaluating the use of neuronal cell culture models for investigating the molecular mechanisms underpinning Alzheimer’s Disease

Supervisor: Henley, J. M. (Supervisor)

Experimental and Computational Studies of PcrA helicase Interactions with Partner Proteins

Supervisor: Dillingham, M. (Supervisor), Cheung, A. (Supervisor) & Savery, N. (Supervisor)

Exploring the in vitro behaviour of endothelial cells in different cell culture models

Supervisor: Mellor, H. (Supervisor) & Gaston, K. (Supervisor)

Exploring the microclot-driven pre-metastatic niche: live imaging studies in zebrafish larvae

Supervisor: Martin, P. B. (Supervisor) & Nobes, C. D. (Supervisor)

Exploring the role of BCL-3 in colorectal cancer cell therapeutic resistance

Supervisor: Martin, P. (Supervisor), Cullen, P. (Supervisor) & Williams, A. (Supervisor)

Expression, Distribution, and Trafficking of Pore-Forming and Auxiliary Subunits of Kainate Receptors

Supervisor: Molnar, E. (Supervisor) & Henley, J. M. (Supervisor)

Ex vivo culture of neutrophils to examine neutrophil biology and disorders

Supervisor: Toye, A. M. (Supervisor)

Factors affecting Salmonella invasion of epithelial cells

Fatty acid construction within the biosynthesis of the polyketide antibiotic mupirocin.

Supervisor: Crump, M. P. (Supervisor), Willis, C. (External person) (Supervisor) & Race, P. R. (Supervisor)