latest research topics in microbiology

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Microbiology articles from across Nature Portfolio

Microbiology is the study of microscopic organisms, such as bacteria, viruses, archaea, fungi and protozoa. This discipline includes fundamental research on the biochemistry, physiology, cell biology, ecology, evolution and clinical aspects of microorganisms, including the host response to these agents.

Primal FEAR protects against infection

FEAR is an ancestral histone chaperone complex that can control virus infections in an interferon-independent manner.

• Derek Walsh

Extracellular vesicles block viral entryways

Extracellular vesicles carrying phosphatidylserine on their surface, found in large quantities in semen, saliva and breast milk, but not in blood, provide an innate defence strategy by blocking viral entry through competition for binding to cellular phosphatidylserine receptors, explaining why many viruses are transmitted by blood rather than by these body fluids.

• Leonid Margolis

Host species drive composition of mosquito virome

Metatranscriptomic data from more than 2,000 mosquitoes of 81 species show that the composition of mosquito viral communities is determined more by host phylogeny than by climate and land-use factors, which will help to inform arbovirus surveillance.

• Sarah François

Related Subjects

• Antimicrobials
• Applied microbiology
• Bacteriology
• Bacteriophages
• Biogeochemistry
• Cellular microbiology
• Clinical microbiology
• Microbial communities
• CRISPR-Cas systems
• Environmental microbiology
• Industrial microbiology
• Infectious-disease diagnostics
• Microbial genetics
• Parasitology
• Phage biology
• Policy and public health in microbiology

Latest Research and Reviews

Genome sequencing identifies “Limestone Canyon virus” as Montaño virus ( Hantaviridae: Orthohantavirus montanoense ) circulating in brush deermice in New Mexico

• Samuel M. Goodfellow
• Robert A. Nofchissey
• Steven B. Bradfute

The wound microbiota: microbial mechanisms of impaired wound healing and infection

In this Review, Uberoi, McCready-Vangi and Grice explore the diversity of microorganisms present in wounds and examine the mechanisms through which they invade skin tissues, impair skin repair and cause infection.

• Aayushi Uberoi
• Amelia McCready-Vangi
• Elizabeth A. Grice

A genome-centric view of the role of the Acropora kenti microbiome in coral health and resilience

This study provides insights into the functional roles of microbial symbionts within the reef-building coral Acropora kenti . The findings reveal molecular mechanisms underpinning coral health and adaptation to local environmental stressors, which may support host resilience in the face of anthropogenic climate change and pollution.

• Lauren F. Messer
• David G. Bourne
• Gene W. Tyson

Seroprevalence and molecular detection of foot and mouth disease virus in cattle in selected districts of Wolaita Zone, Southern Ethiopia

• Tamenech Bandaw
• Haben Fesseha Gebremeskel
• Isayas Asefa Kebede

Legume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification

Sustainability in agriculture can be improved harnessing biological N 2 fixation in legumes. Here, the authors combine different crops with peanut plants finding that maize and oilseed rape are the most successful combinations which have potential to enhance rhizosphere microbiota N 2 fixation.

• Mengjie Qiao

Discovery and description of novel phage genomes from urban microbiomes sampled by the MetaSUB consortium

• Vinicius S. Flores
• Deyvid E. Amgarten
• João Carlos Setubal

News and Comment

Making htlv-1 and those affected visible.

Carolina Rosadas explains why we need more research investigating human T lymphotropic virus type 1 (HTLV-1) infections, and why more public visibility is needed for those affected.

• Carolina Rosadas

Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance

• Wen-Jing Wang
• Xiang-Min Dong

Long COVID still has no cure — so these patients are turning to research

With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done.

• Rachel Fairbank

Gut bacteria break down cholesterol — hinting at probiotic treatments

Species in the human microbiome have enzymes that can metabolize a potentially dangerous lipid.

• Julian Nowogrodzki

The ‘Mother Tree’ idea is everywhere — but how much of it is real?

A popular theory about how trees cooperate has enchanted the public and raised the profile of forest conservation. But some ecologists think its scientific basis has been oversold.

• Aisling Irwin

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Six Key Topics in Microbiology: 2024

This collection from the FEMS journals presents the latest high-quality research in six key topic areas of microbiology that have an impact across the world. All of the FEMS journals aim to serve the microbiology community with timely and authoritative research and reviews, and by investing back into the science community . 

Interested in publishing your research relevant to the six key microbiology topics?

Learn more about why the FEMS journals are the perfect home for your microbiology research.  

Browse the collection categories: 

Antimicrobial resistance, environmental microbiology, pathogenicity and virulence, biotechnology and synthetic biology, microbiomes, food microbiology.

FEMS and Open Access: Embracing an Open Future

As of January 2024, FEMS has flipped four of its journals to fully open access (OA), making six out of its seven journals OA. FEMS Microbiology Letters remains a subscription journal and free to publish in. 

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Microbiology News

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• Key Gene for Toxic Alkaloid in Barley
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• Researchers Invent Artificial Intelligence Model to Design New Superbug-Fighting Antibiotics

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• As We Age, Our Cells Are Less Likely to Express Longer Genes
• Research Finds a Direct Communication Path Between the Lungs and the Brain
• Decoding the Plant World's Complex Biochemical Communication Networks

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• A Protein Found in Human Sweat May Protect Against Lyme Disease

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• Researchers Uncover Protein Responsible for Cold Sensation
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Page 1 of 109

Ultraviolet C inactivation of Coxiella burnetii for production of a structurally preserved whole cell vaccine antigen

Q fever, a worldwide-occurring zoonotic disease, can cause economic losses for public and veterinary health systems. Vaccines are not yet available worldwide and currently under development. In this regard, it...

• View Full Text

Neutrophil extracellular traps formation: effect of Leishmania major promastigotes and salivary gland homogenates of Phlebotomus papatasi in human neutrophil culture

Leishmaniasis as a neglected tropical disease (NTD) is caused by the inoculation of Leishmania parasites via the bite of phlebotomine sand flies. After an infected bite, a series of innate and adaptive immune res...

Assessment of bacterial profile, antimicrobial susceptibility status, and associated factors of isolates among hospitalized patients at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Antimicrobial resistant bacteria among hospitalized patients are becoming a major public health threat worldwide, mainly in developing countries. Infections by these multidrug resistant pathogens cause high ra...

A review of emerging health threats from zoonotic New World mammarenaviruses

Despite repeated spillover transmission and their potential to cause significant morbidity and mortality in human hosts, the New World mammarenaviruses remain largely understudied. These viruses are endemic to...

Impact of Limosilactobacillus fermentum probiotic treatment on gut microbiota composition in sahiwal calves with rotavirus diarrhea: A 16S metagenomic analysis study”

Diarrhea poses a major threat to bovine calves leading to mortality and economic losses. Among the causes of calf diarrhea, bovine rotavirus is a major etiological agent and may result in dysbiosis of gut micr...

Genetic characterizations of Cryptosporidium spp. from children with or without diarrhea in Wenzhou, China: high probability of zoonotic transmission

Cryptosporidium is a highly pathogenic parasite responsible for diarrhea in children worldwide. Here, the epidemiological status and genetic characteristics of Cryptosporidium in children with or without diarrhea...

Effect of stress urinary incontinence on vaginal microbial communities

Postpartum women often experience stress urinary incontinence (SUI) and vaginal microbial dysbiosis, which seriously affect women’s physical and mental health. Understanding the relationship between SUI and va...

Hospital distribution, seasonality, time trends and antifungal susceptibility profiles of all Aspergillus species isolated from clinical samples from 2015 to 2022 in a tertiary care hospital

Aspergillus species cause a variety of serious clinical conditions with increasing trend in antifungal resistance. The present study aimed at evaluating hospital epidemiology and antifungal susceptibility of all ...

Comparative analysis of proteomic adaptations in Enterococcus faecalis and Enterococcus faecium after long term bile acid exposure

All gastrointestinal pathogens, including Enterococcus faecalis and Enterococcus faecium , undergo adaptation processes during colonization and infection. In this study, we investigated by data-independent acquisi...

Influence of PhoPQ and PmrAB two component system alternations on colistin resistance from non- mcr colistin resistant clinical E. Coli strains

The current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of the upstream PmrAB and PhoPQ two-component system (TCS) control caused by ...

Staphylococcus aureus foldase PrsA contributes to the folding and secretion of protein A

Staphylococcus aureus secretes a variety of proteins including virulence factors that cause diseases. PrsA, encoded by many Gram-positive bacteria, is a membrane-anchored lipoprotein that functions as a foldase t...

Transcriptional dynamics during Rhodococcus erythropolis infection with phage WC1

Belonging to the Actinobacteria phylum, members of the Rhodococcus genus thrive in soil, water, and even intracellularly. While most species are non-pathogenic, several cause respiratory disease in animals and, m...

A hypervirulent Acinetobacter baumannii strain has robust anti-phagocytosis ability

Acinetobacter baumannii ( A. baumannii ) is associated with both hospital-acquired infections (HAP) and community-acquired pneumonia (CAP). In this study, we present a novel CAP-associated A. baumannii (CAP-AB) str...

Restoration of gut dysbiosis through Clostridium butyricum and magnesium possibly balance blood glucose levels: an experimental study

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by an elevated level of blood glucose due to the absence of insulin secretion, ineffectiveness, or lack of uptake of secreted insulin in the...

Bacillus subtilis SOM8 isolated from sesame oil meal for potential probiotic application in inhibiting human enteropathogens

While particular strains within the Bacillus species, such as Bacillus subtilis , have been commercially utilised as probiotics, it is critical to implement screening assays and evaluate the safety to identify pot...

Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy

Vancomycin-resistant enterococci (VRE) are major opportunistic pathogens and the causative agents of serious diseases, such as urinary tract infections and endocarditis. VRE strains mainly include species of Ente...

Comparison of integron mediated antimicrobial resistance in clinical isolates of Escherichia coli from urinary and bacteremic sources

Antimicrobial resistance (AMR) is a global threat driven mainly by horizontal gene transfer (HGT) mechanisms through mobile genetic elements (MGEs) including integrons. The variable region (VR) of an integron ...

Structure predictions and functional insights into Amidase_3 domain containing N -acetylmuramyl-L-alanine amidases from Deinococcus indicus DR1

N -acetylmuramyl-L-alanine amidases are cell wall modifying enzymes that cleave the amide bond between the sugar residues and stem peptide in peptidoglycan. Amidases play a vital role in septal cell wall cleavag.....

Profile of non-tuberculous mycobacteria amongst tuberculosis presumptive people in Cameroon

Cameroon is a tuberculosis (TB) burden country with a 12% positivity among TB presumptive cases. Of the presumptive cases with a negative TB test, some are infected with Non-tuberculous Mycobacteria (NTM). How...

In vitro investigation of relationship between quorum-sensing system genes, biofilm forming ability, and drug resistance in clinical isolates of Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic pathogen in the health-care systems and one of the primary causative agents with high mortality in hospitalized patients, particularly immunocompromised. The limitation ...

Relationship between heart failure and intestinal inflammation in infants with congenital heart disease

The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated.

Clostridium butyricum inhibits the inflammation in children with primary nephrotic syndrome by regulating Th17/Tregs balance via gut-kidney axis

Primary nephrotic syndrome (PNS) is a common glomerular disease in children. Clostridium butyricum ( C. butyricum), a probiotic producing butyric acid, exerts effective in regulating inflammation. This study was d...

Human-derived bacterial strains mitigate colitis via modulating gut microbiota and repairing intestinal barrier function in mice

Unbalanced gut microbiota is considered as a pivotal etiological factor in colitis. Nevertheless, the precise influence of the endogenous gut microbiota composition on the therapeutic efficacy of probiotics in...

In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153

The emergence of antimicrobial resistance in bacterial pathogens is a growing concern worldwide due to its impact on the treatment of bacterial infections. The "Trojan Horse" strategy has been proposed as a po...

HPV-associated cervicovaginal microbiome and host metabolome characteristics

Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and r...

Transcriptomic and physiological analyses of Trichoderma citrinoviride HT-1 assisted phytoremediation of Cd contaminated water by Phragmites australis

Plant growth promoting microbe assisted phytoremediation is considered a more effective approach to rehabilitation than the single use of plants, but underlying mechanism is still unclear. In this study, we co...

Long-term push–pull cropping system shifts soil and maize-root microbiome diversity paving way to resilient farming system

The soil biota consists of a complex assembly of microbial communities and other organisms that vary significantly across farming systems, impacting soil health and plant productivity. Despite its importance, ...

Pretreatment with an antibiotics cocktail enhances the protective effect of probiotics by regulating SCFA metabolism and Th1/Th2/Th17 cell immune responses

Probiotics are a potentially effective therapy for inflammatory bowel disease (IBD); IBD is linked to impaired gut microbiota and intestinal immunity. However, the utilization of an antibiotic cocktail (Abx) p...

High-throughput sequencing reveals differences in microbial community structure and diversity in the conjunctival tissue of healthy and type 2 diabetic mice

To investigate the differences in bacterial and fungal community structure and diversity in conjunctival tissue of healthy and diabetic mice.

High prevalence of ST5-SCC mec II-t311 clone of methicillin-resistant Staphylococcus aureus isolated from bloodstream infections in East China

Methicillin-resistant Staphylococcus aureus (MRSA) is a challenging global health threat, resulting in significant morbidity and mortality worldwide. This study aims to determine the molecular characteristics and...

Characteristics of the oral and gastric microbiome in patients with early-stage intramucosal esophageal squamous cell carcinoma

Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in ear...

The potential role of Listeria monocytogenes in promoting colorectal adenocarcinoma tumorigenic process

Listeria monocytogenes is a foodborne pathogen, which can cause a severe illness, especially in people with a weakened immune system or comorbidities. The interactions between host and pathogens and between patho...

Evaluation of clinical characteristics and risk factors associated with Chlamydia psittaci infection based on metagenomic next-generation sequencing

Psittacosis is a zoonosis caused by Chlamydia psittaci , the clinical manifestations of Psittacosis range from mild illness to fulminant severe pneumonia with multiple organ failure. This study aimed to evaluate t...

Characterization of the broad-spectrum antibacterial activity of bacteriocin-like inhibitory substance-producing probiotics isolated from fermented foods

Antimicrobial peptides, such as bacteriocin, produced by probiotics have become a promising novel class of therapeutic agents for treating infectious diseases. Selected lactic acid bacteria (LAB) isolated from...

Metagenomic gut microbiome analysis of Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance

Although the pathology of multiple chemical sensitivity (MCS) is unknown, the central nervous system is reportedly involved. The gut microbiota is important in modifying central nervous system diseases. Howeve...

The effect of in vitro simulated colonic pH gradients on microbial activity and metabolite production using common prebiotics as substrates

The interplay between gut microbiota (GM) and the metabolization of dietary components leading to the production of short-chain fatty acids (SCFAs) is affected by a range of factors including colonic pH and ca...

Gut microbial network signatures of early colonizers in preterm neonates with extrauterine growth restriction

Extrauterine growth restriction (EUGR) represents a prevalent condition observed in preterm neonates, which poses potential adverse implications for both neonatal development and long-term health outcomes. The...

Early transcriptional changes of heavy metal resistance and multiple efflux genes in Xanthomonas campestris pv. campestris under copper and heavy metal ion stress

Copper-induced gene expression in Xanthomonas campestris pv. campestris (Xcc) is typically evaluated using targeted approaches involving qPCR. The global response to copper stress in Xcc and resistance to metal i...

Whole-genome sequencing and analysis of Chryseobacterium arthrosphaerae from Rana nigromaculata

Chryseobacterium arthrosphaerae strain FS91703 was isolated from Rana nigromaculata in our previous study. To investigate the genomic characteristics, pathogenicity-related genes, antimicrobial resistance, and ph...

Changes in the nasopharyngeal and oropharyngeal microbiota in pediatric obstructive sleep apnea before and after surgery: a prospective study

To explore the changes and potential mechanisms of microbiome in different parts of the upper airway in the development of pediatric OSA and observe the impact of surgical intervention on oral microbiome for p...

Unveiling biological activities of biosynthesized starch/silver-selenium nanocomposite using Cladosporium cladosporioides CBS 174.62

Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible and multi-components nanocomposites have enhanced physicochemical cha...

Characterization of the major autolysin ( AtlC ) of Staphylococcus carnosus

Autolysis by cellular peptidoglycan hydrolases (PGH) is a well-known phenomenon in bacteria. During food fermentation, autolysis of starter cultures can exert an accelerating effect, as described in many studi...

Exploring Aeromonas dhakensis in Aldabra giant tortoises: a debut report and genetic characterization

Aeromonas dhakensis (A. dhakensis) is becoming an emerging pathogen worldwide, with an increasingly significant role in animals and human health. It is a ubiquitous bacteria found in terrestrial and aquatic milie...

Biotransformation of zearalenone to non-estrogenic compounds with two novel recombinant lactonases from Gliocladium

The mycotoxin zearalenone (ZEA) produced by toxigenic fungi is widely present in cereals and its downstream products. The danger of ZEA linked to various human health issues has attracted increasing attention....

Multidrug resistance among uropathogenic clonal group A E. Coli isolates from Pakistani women with uncomplicated urinary tract infections

Multi-drug resistance (MDR) has notably increased in community acquired uropathogens causing urinary tract infections (UTIs), predominantly Escherichia coli . Uropathogenic E. coli causes 80% of uncomplicated comm...

Uncovering the complexity of childhood undernutrition through strain-level analysis of the gut microbiome

Undernutrition (UN) is a critical public health issue that threatens the lives of children under five in developing countries. While evidence indicates the crucial role of the gut microbiome (GM) in UN pathoge...

RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates

The intrinsic concentration of RpoS, the second most abundant sigma factor, varies widely across the E. coli species. Bacterial isolates that express high levels of RpoS display high resistance to environmental s...

Fine-scale geographic difference of the endangered Big-headed Turtle ( Platysternon megacephalum ) fecal microbiota, and comparison with the syntopic Beale’s Eyed Turtle ( Sacalia bealei )

Studies have elucidated the importance of gut microbiota for an organism, but we are still learning about the important influencing factors. Several factors have been identified in helping shape the microbiome...

The activation impact of lactobacillus-derived extracellular vesicles on lipopolysaccharide-induced microglial cell

Perioperative neurocognitive dysfunction (PND) emerges as a common postoperative complication among elderly patients. Currently, the mechanism of PND remains unclear, but there exists a tendency to believe tha...

Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice

Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The “multiple hits hypothesi...

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2022 Citation Impact 4.2 - 2-year Impact Factor 4.7 - 5-year Impact Factor 1.131 - SNIP (Source Normalized Impact per Paper) 0.937 - SJR (SCImago Journal Rank)

2023 Speed 19 days submission to first editorial decision for all manuscripts (Median) 135 days submission to accept (Median)

2023 Usage  2,970,572 downloads 1,619 Altmetric mentions 

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BMC Microbiology

ISSN: 1471-2180

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Microbiology

Viral Genetics Confirms What On-the-Ground Activists Knew Early in the Mpox Outbreak

Molecular biology could have changed the mpox epidemic—and could stop future outbreaks

Joseph Osmundson

Cannibal Cells Inspire Cancer Treatment Improvement

Giving cells an appetite for cancer could enhance treatments

Kate Graham-Shaw

Is Raw-Milk Cheese Safe to Eat?

Recent bacterial outbreaks from consuming cheese made from unpasteurized milk, or “raw milk,” raise questions about the safety of eating these artisanal products

Riis Williams

Many Pregnancy Losses Are Caused by Errors in Cell Division

Odd cell divisions could help explain why even young, healthy couples might struggle to get pregnant

Gina Jiménez

'Microbiome of Death' Uncovered on Decomposing Corpses Could Aid Forensics

Microbes that lurk in decomposing human corpses could help forensic detectives establish a person's time of death

Christoph Schwaiger, LiveScience

Weird ‘Obelisks’ Found in Human Gut May be Virus-Like Entities

Rod-shaped fragments of RNA called “obelisks” were discovered in gut and mouth bacteria for the first time

Joanna Thompson

Semen Has Its Own Microbiome—And It Might Influence Fertility

Recent research found a species of bacteria living in semen that’s associated with infertility and has links to the vaginal microbiome

Andrew Chapman

Bacteria Make Decisions Based on Generational Memories

Bacteria choose to swarm based on what happened to their great-grandparents

Allison Parshall

Your Body Has Its Own Built-In Ozempic

Popular weight-loss and diabetes drugs, such as Ozempic and Wegovy, target metabolic pathways that gut microbes and food molecules already play a key role in regulating

Christopher Damman, The Conversation US

See Your Body’s Cells in Size and Number

The larger a cell type is, the rarer it is in the body—and vice versa—a new study shows

Clara Moskowitz, Jen Christiansen, Ni-ka Ford

Subterranean ‘Microbial Dark Matter’ Reveals a Strange Dichotomy

The genes of microbes living as deep as 1.5 kilometers below the surface reveal a split between minimalist and maximalist lifestyles

Stephanie Pappas

The Vaginal Microbiome May Affect Health More than We Thought

A recent study finds varying combinations of microbes in the vaginal microbiome may influence health outcomes such as risk of sexually transmitted disease and preterm birth

Lori Youmshajekian