The genetics of obesity: from discovery to biology
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity ...
Genetics of Obesity in Humans: A Clinical Review
The genetics of obesity could be classified into syndromic and non-syndromic obesity with or without congenital defects and developmental delay. For example, ... Another study conducted by the Fragile X Clinical and Research Consortium reported that patients with FXS had higher weights than in the general population .
Genetics and Epigenetics in Obesity: What Do We Know so Far?
Recent progress in genetics of polygenic traits, particularly represented by genome-wide association studies, led to the discovery of hundreds of genetic variants associated with obesity, which allows constructing polygenic risk scores (PGS). In addition, epigenome-wide association studies helped identifying novel targets and methylation sites ...
The genetics of obesity: from discovery to biology
Timeline of key discoveries in obesity genetics. ... Although no standard genetic testing panel is currently available for extreme and early-onset obesity, some clinics, research centres and pharmaceutical companies sequence well-known candidate genes to identify the functional mutation that may be the cause of a patient's excess body weight ...
Deciphering the genetic landscape of obesity: a data-driven ...
Our study informs future obesity research and guides future experimental assays to investigate mechanisms and targeted therapies. ... Loos RJF, Yeo GSH. The genetics of obesity: from discovery to ...
Genetics of Obesity: What We Have Learned Over Decades of Research
A central message from the global body of obesity genetics research is that people do not all have the same predisposition to gaining weight and developing obesity. The genetic component of BMI in a population comprising the whole range of BMI values accounts for about 40% to 50% of its variance adjusted for age and sex. However, the ...
Genetics of Obesity: What We Have Learned Over Decades of Research
1 Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. PMID: 33899337 DOI: 10.1002/oby.23116 Abstract There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially higher in the subpopulation of ...
The genetics of obesity: from discovery to biology
Abstract. The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and ...
The Biology and Genetics of Obesity
The Biology and Genetics of Obesity — A Century of Inquiries. Author: Chin Jou, Ph.D. Author Info & Affiliations. Published May 15, 2014. N Engl J Med 2014;370: 1874 - 1877.
Genetics of obesity: what genetic association studies have taught us
Although research into the genetics of common obesity was catalysed by genome-wide association studies (GWAS), the stage was set by genetic studies in monogenic obesity, which highlighted the leptin-melanocortin pathway as a key regulator of energy intake. 3. Yeo GS ;
Genetics and Obesity
The obesity epidemic around the world affects not only adults but also children. About 50% of the time, obesity in childhood is carried into adulthood in a phenomenon known as "tracking." Per the latest data from the World Health Organization, the number of overweight and obese children under five years of age is estimated to be close to 39 million. In the United States, 1 in 3 adult Americans ...
PDF The genetics of obesity: from discovery to biology
The candidate gene approach was first applied in the mid-1990s and aimed to validate genes identified through human and animal models of extreme obesity for a role in common obesity (fig. 3 ...
Genes Are Not Destiny
This work has illuminated several genetic factors that are responsible for very rare, single-gene forms of obesity. Emerging research has also begun to identify the genetic underpinnings of so-called "common" obesity, which is influenced by dozens, if not hundreds, of genes. ... Twin studies offer some insight into the genetics of common ...
The genetics of human obesity
Table 1 Phenotypes that are commonly used in obesity genetics research Full size table The relative contribution of energy intake and expenditure in the development of obesity has also been ...
Genetics of Obesity in Humans: A Clinical Review
The genetics of obesity could be classified into syndromic and non-syndromic obesity. Prader-Willi, fragile X, Bardet-Biedl, Cohen, and Albright Hereditary Osteodystrophy (AHO) syndromes are examples of syndromic obesity, which are associated with developmental delay and early onset obesity. Non-syndromic obesity could be monogenic, polygenic ...
Physical Activity and Incident Obesity Across the Spectrum of Genetic
Importance Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity. Objective To use activity, clinical, and genetic data from the All of Us Research Program (AoURP) to explore the association of genetic risk of higher body mass index (BMI ...
Genetics of Obesity in Humans: A Clinical Review
Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an increase in the worldwide prevalence of obesity in both developed and developing countries. The development of genome-wide association studies (GWAS) and next-generation sequencing (NGS) has increased the discovery of genetic associations and awareness of monogenic and polygenic causes of obesity ...
The Search for Human Obesity Genes
Research into the genetics of human obesity is continuing at a rapid pace , with the goal now increasingly focused on the identification of specific causative genes. There are at least three genome scanning efforts underway that have obesity phenotypes as a primary focus (the San Antonio Family Heart Study, the San Antonio Family Diabetes Study ...
The genetics of human obesity
Understanding the genetics of BMI determination and obesity holds great promise for delivering many more such targets in the relatively near future. ... research has begun to directly identify human disorders of energy balance that arise from defects in other loci, 60 including Prader-Willi, 61 Alström's, 62 and Bardet-Biedl syndromes. 63 ...
Scientists discover 14 genes that cause obesity
June 23, 2022 — Research looked at the long-term weight gain of more than 13,800 U.S. adults -- a rare data point unearthed in obesity research. The study shows more than half of American adults ...
Obesity and genetics
Abstract. Genetics is now known to play a substantial role in the predisposition to obesity and may contribute up to 70% risk for the disease. Over a hundred genes and gene variants related to excess weight have been discovered. Yet, genetic obesity risk does not always translate into actual obesity development, suggesting complex interactions ...
Genetic Determinants of Childhood Obesity
1.0. Introduction. Childhood obesity impacts over 17% of children in the United States and is associated with serious health outcomes [].Obesity is a key contributor to mortality, operating as a major risk factor for common diseases that include type 2 diabetes, cardiovascular diseases and hypertension [].Cases of childhood obesity are classified as syndromic or non-syndromic, with the latter ...
How Newly Discovered Genes Might Fit Into Obesity
Linking genetics to obesity is an active area of research. Stay tuned for more findings about how your specific obesity type might fit into your genes. Sources
COMMENTS
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity ...
The genetics of obesity could be classified into syndromic and non-syndromic obesity with or without congenital defects and developmental delay. For example, ... Another study conducted by the Fragile X Clinical and Research Consortium reported that patients with FXS had higher weights than in the general population .
Recent progress in genetics of polygenic traits, particularly represented by genome-wide association studies, led to the discovery of hundreds of genetic variants associated with obesity, which allows constructing polygenic risk scores (PGS). In addition, epigenome-wide association studies helped identifying novel targets and methylation sites ...
Timeline of key discoveries in obesity genetics. ... Although no standard genetic testing panel is currently available for extreme and early-onset obesity, some clinics, research centres and pharmaceutical companies sequence well-known candidate genes to identify the functional mutation that may be the cause of a patient's excess body weight ...
Our study informs future obesity research and guides future experimental assays to investigate mechanisms and targeted therapies. ... Loos RJF, Yeo GSH. The genetics of obesity: from discovery to ...
A central message from the global body of obesity genetics research is that people do not all have the same predisposition to gaining weight and developing obesity. The genetic component of BMI in a population comprising the whole range of BMI values accounts for about 40% to 50% of its variance adjusted for age and sex. However, the ...
1 Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. PMID: 33899337 DOI: 10.1002/oby.23116 Abstract There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially higher in the subpopulation of ...
Abstract. The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and ...
The Biology and Genetics of Obesity — A Century of Inquiries. Author: Chin Jou, Ph.D. Author Info & Affiliations. Published May 15, 2014. N Engl J Med 2014;370: 1874 - 1877.
Although research into the genetics of common obesity was catalysed by genome-wide association studies (GWAS), the stage was set by genetic studies in monogenic obesity, which highlighted the leptin-melanocortin pathway as a key regulator of energy intake. 3. Yeo GS ;
The obesity epidemic around the world affects not only adults but also children. About 50% of the time, obesity in childhood is carried into adulthood in a phenomenon known as "tracking." Per the latest data from the World Health Organization, the number of overweight and obese children under five years of age is estimated to be close to 39 million. In the United States, 1 in 3 adult Americans ...
The candidate gene approach was first applied in the mid-1990s and aimed to validate genes identified through human and animal models of extreme obesity for a role in common obesity (fig. 3 ...
This work has illuminated several genetic factors that are responsible for very rare, single-gene forms of obesity. Emerging research has also begun to identify the genetic underpinnings of so-called "common" obesity, which is influenced by dozens, if not hundreds, of genes. ... Twin studies offer some insight into the genetics of common ...
Table 1 Phenotypes that are commonly used in obesity genetics research Full size table The relative contribution of energy intake and expenditure in the development of obesity has also been ...
The genetics of obesity could be classified into syndromic and non-syndromic obesity. Prader-Willi, fragile X, Bardet-Biedl, Cohen, and Albright Hereditary Osteodystrophy (AHO) syndromes are examples of syndromic obesity, which are associated with developmental delay and early onset obesity. Non-syndromic obesity could be monogenic, polygenic ...
Importance Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity. Objective To use activity, clinical, and genetic data from the All of Us Research Program (AoURP) to explore the association of genetic risk of higher body mass index (BMI ...
Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an increase in the worldwide prevalence of obesity in both developed and developing countries. The development of genome-wide association studies (GWAS) and next-generation sequencing (NGS) has increased the discovery of genetic associations and awareness of monogenic and polygenic causes of obesity ...
Research into the genetics of human obesity is continuing at a rapid pace , with the goal now increasingly focused on the identification of specific causative genes. There are at least three genome scanning efforts underway that have obesity phenotypes as a primary focus (the San Antonio Family Heart Study, the San Antonio Family Diabetes Study ...
Understanding the genetics of BMI determination and obesity holds great promise for delivering many more such targets in the relatively near future. ... research has begun to directly identify human disorders of energy balance that arise from defects in other loci, 60 including Prader-Willi, 61 Alström's, 62 and Bardet-Biedl syndromes. 63 ...
June 23, 2022 — Research looked at the long-term weight gain of more than 13,800 U.S. adults -- a rare data point unearthed in obesity research. The study shows more than half of American adults ...
Abstract. Genetics is now known to play a substantial role in the predisposition to obesity and may contribute up to 70% risk for the disease. Over a hundred genes and gene variants related to excess weight have been discovered. Yet, genetic obesity risk does not always translate into actual obesity development, suggesting complex interactions ...
1.0. Introduction. Childhood obesity impacts over 17% of children in the United States and is associated with serious health outcomes [].Obesity is a key contributor to mortality, operating as a major risk factor for common diseases that include type 2 diabetes, cardiovascular diseases and hypertension [].Cases of childhood obesity are classified as syndromic or non-syndromic, with the latter ...
Linking genetics to obesity is an active area of research. Stay tuned for more findings about how your specific obesity type might fit into your genes. Sources